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Fatty acids activate the transcriptional coactivator YAP1 to promote liver fibrosis via p38 mitogen-activated protein kinase.

Cell Mol Gastroenterol Hepatol 2021 Jun 9. Epub 2021 Jun 9.

Liver Center, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Background & Aims: Patients with simple steatosis (SS) and nonalcoholic steatohepatitis (NASH) can develop progressive liver fibrosis, which is associated with liver-related mortality. The mechanisms contributing to liver fibrosis development in SS, however, are poorly understood. SS is characterized by hepatocellular free fatty acid (FFA) accumulation without lobular inflammation seen in NASH. Read More

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Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist.

Pediatr Radiol 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA.

The ability to provide prompt, real-time, easily accessible and radiation-free diagnostic assessments makes ultrasound (US) one of the most versatile imaging modalities. The introduction and development of stable microbubble-based ultrasound contrast agents (UCAs) in the early 1990s improved visualization of complex vascular structures, overcoming some of the limitations of B-mode and Doppler imaging. UCAs have been used extensively in the adult population to visualize vasculature and to evaluate perfusion and blood flow dynamics in organs and lesions. Read More

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Prognostic impact of histological review of high-grade endometrial carcinomas in a large Danish cohort.

Virchows Arch 2021 Jun 11. Epub 2021 Jun 11.

Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen University, Borgmester Ib Juuls Vej 73, 2730, Herlev, Denmark.

The aim of this study was to investigate the outcome of histological subtype review of high-grade endometrial carcinoma (EC) and its prognostic impact in a large well-documented Danish nationwide cohort. From the Danish Gynecological Cancer Database (DGCD) 2005-2012 cohort, we included 425 patients with an original diagnosis of high-grade EC, independent of histologic subtype. Of these, at least one hematoxylin and eosin (H&E)-stained slide from 396 cases (93. Read More

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A facile and one-pot aqueous phase transfer of oleylamine capped Au NP with aminophenylboronic acid used as transfer and targeting ligand.

Enzyme Microb Technol 2021 Aug 25;148:109810. Epub 2021 Apr 25.

Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, 38039, Kayseri, Turkey. Electronic address:

Although various phase transfer techniques have been used to make hydrophobic nanoparticles (NPs) water-soluble. However, these techniques have been limited by inefficient surface modification strategy that often stable NPs in aqueous solutions. Herein, we report the use of 3-aminophenylboronic acid (3-APBA) as a hydrophilic ligand for phase transfer of oleylamine (OA) capped Au NPs ([email protected] NPs) from non-hydrolytic system into aqueous solutions. Read More

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Glucose oxidase-mediated sodium alginate gelation: Equipment-Free detection of glucose in fruit samples.

Enzyme Microb Technol 2021 Aug 22;148:109805. Epub 2021 Apr 22.

School of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 401331, China. Electronic address:

In this study, a paper-based sensor, combined with a visual distance-readout method, was developed to determine glucose in fruit samples based on the glucose oxidase-mediated sodium alginate gelation. The type of filter paper, the concentration of sodium alginate and the enzymatic reaction conditions were systematically investigated. Under optimal conditions, the increase in diffusion diameter showed a good linear relationship with glucose concentration between 1. Read More

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Near-GeV Electron Beams at a Few Per-Mille Level from a Laser Wakefield Accelerator via Density-Tailored Plasma.

Phys Rev Lett 2021 May;126(21):214801

State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-intense Laser Science, Shanghai Institute of Optics and Fine Mechanics (SIOM), Chinese Academy of Sciences (CAS), Shanghai 201800, China.

A simple, efficient scheme was developed to obtain near-gigaelectronvolt electron beams with energy spreads of few per-mille level in a single-stage laser wakefield accelerator. Longitudinal plasma density was tailored to control relativistic laser-beam evolution, resulting in injection, dechirping, and a quasi-phase-stable acceleration. With this scheme, electron beams with peak energies of 780-840 MeV, rms energy spreads of 2. Read More

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Why have aggregative multicellular organisms stayed simple?

Curr Genet 2021 Jun 10. Epub 2021 Jun 10.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Multicellularity has evolved numerous times across the tree of life. One of the most fundamental distinctions among multicellular organisms is their developmental mode: whether they stay together during growth and develop clonally, or form a group through the aggregation of free-living cells. The five eukaryotic lineages to independently evolve complex multicellularity (animals, plants, red algae, brown algae, and fungi) all develop clonally. Read More

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Preparation and Applications of Metal-Organic Frameworks (MOFs): A Laboratory Activity and Demonstration for High School and/or Undergraduate Students.

J Chem Educ 2020 Apr 27;97(4):1109-1116. Epub 2020 Mar 27.

Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, Arkansas, 72701, United States.

The chemistry of metal-organic frameworks (MOFs), a new class of emerging crystalline porous solids with three-dimensional (3D) networks composed of metals and multidentate organic molecules, was introduced by using three differently-shaped crystals. We reported new and mild MOF synthesis methods that are simple and devised to be performed in high school or primarily undergraduate school settings. MOF applications were demonstrated by use of our synthesized MOFs in the capture of iodine as a potentially hazardous molecule from solution and as a drug delivery system. Read More

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Pre-operative Neutrophil to Lymphocyte Ratio is Associated With 30 Day Death or Amputation After Revascularisation for Acute Limb Ischaemia.

Eur J Vasc Endovasc Surg 2021 Jun 7. Epub 2021 Jun 7.

Internal Medicine Department, Centro Hospitalar de Vila Nova de Gaia/Espinho, Portugal; Departamento de Medicina da Comunidade, Informação e Decisão em Saúde (MEDCIDS), Faculty of Medicine of Porto University, Portugal.

Objective: Inflammation is an early feature of acute limb ischaemia (ALI), hence the potential prognostic significance of inflammatory biomarkers. This study aimed to assess the value of pre-operative inflammatory biomarkers, specifically the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR), for predicting an adverse outcome after revascularisation for ALI.

Methods: All patients submitted to lower limb revascularisation for Rutherford IIa or IIb ALI at the authors' institution between 2009 and 2019 were screened retrospectively. Read More

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Evaluation of the potential of total proanthocyanidin content in feces as an intake biomarker.

Food Res Int 2021 Jul 12;145:110390. Epub 2021 May 12.

Dpt. Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), Madrid, Spain; Dpt. Nutrition, Food Sciences and Gastronomy, XaRTA, INSA-UB, School of Pharmacy and Food Sciences, University of Barcelona, Barcelona, Spain. Electronic address:

Due to the health benefits associated with proanthocyanidins (PAs), it is useful to identify dietary PA biomarkers that can be determined by simple methods. Since increased levels of circulating PA metabolites are associated with increased fecal PA content, this study explores the spectrophotometric measurement of fecal PA content and its use as a biomarker of PA intake. To this end, fecal PA content was measured using an adaptation of Porter's spectrophotometric method in samples from a preclinical study and an observational study. Read More

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Improved Risk Stratification for Ventricular Arrhythmias and Sudden Death in Patients With Nonischemic Dilated Cardiomyopathy.

J Am Coll Cardiol 2021 Jun;77(23):2890-2905

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Cardiology, North West Heart Centre, Manchester University NHS Foundation Trust, Wythenshawe Campus, Manchester, United Kingdom.

Background: Risk stratification for ventricular arrhythmias (VA) and sudden death in nonischemic dilated cardiomyopathy (DCM) remains suboptimal.

Objectives: The goal of this study was to provide an improved risk stratification algorithm for VA and sudden death in DCM.

Methods: This was a retrospective cohort study of consecutive patients with DCM who underwent cardiac magnetic resonance with late gadolinium enhancement (LGE) at 2 tertiary referral centers. Read More

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Approaching an undergraduate medical curriculum map: challenges and expectations.

BMC Med Educ 2021 Jun 10;21(1):341. Epub 2021 Jun 10.

University College London, London, UK.

Background: Feedback received from medical students at University College London Medical School (UCLMS) suggested a lack of clarity regarding the contents and subsequent assessment of the undergraduate curriculum. In order to address these issues, a specialist team was established with the aim of designing and implementing a Curriculum Map (CM), which have been recognised in their ability to provide a centralised, visual representation of the curriculum. While multiple perspectives from educators to stakeholders can be considered here, the need for the CM to remain student centred was identified as key at UCLMS. Read More

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Direct Comparison of Three Buckling-Based Methods to Measure the Elastic Modulus of Nanobiocomposite Thin Films.

ACS Appl Mater Interfaces 2021 Jun 10. Epub 2021 Jun 10.

Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada.

To engineer tunable thin-film materials, the accurate measurement of their mechanical properties is crucial. However, characterizing the elastic modulus with current methods is particularly challenging for sub-micrometer thick films and hygroscopic materials because they are highly sensitive to environmental conditions and most methods require free-standing films which are difficult to prepare. In this work, we directly compared three buckling-based methods to determine the elastic moduli of supported thin films: (1) biaxial thermal shrinking, (2) uniaxial thermal shrinking, and (3) the mechanically compressed, strain-induced elastic buckling instability for mechanical measurements (SIEBIMM) method. Read More

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Porous Anionic Co(II) Metal-Organic Framework, with a High Density of Amino Groups, as a Superior Luminescent Sensor for Turn-on Al(III) Detection.

Chemistry 2021 Jun 10. Epub 2021 Jun 10.

Indian Institute of Technology Kharagpur, Dept. of Chemistry, Dept. of Chemistry, 721302, Kharagpur, INDIA.

Accumulation of high concentrations of Al(III) in body has a direct impact on health and therefore, the trace detection of Al(III) has been a matter for substantial concern. An anionic metal organic framework ({[Me2NH2]0.5[Co(DATRz)0. Read More

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True Accuracy of Fast Scoring Functions to Predict High-Throughput Screening Data from Docking Poses: The Simpler the Better.

J Chem Inf Model 2021 Jun 10. Epub 2021 Jun 10.

Laboratoire d'Innovation Thérapeutique, UMR 7200 CNRS-Université de Strasbourg, 67400 Illkirch, France.

Hundreds of fast scoring functions have been developed over the last 20 years to predict binding free energies from three-dimensional structures of protein-ligand complexes. Despite numerous statistical promises, we believe that none of them has been properly validated for daily prospective high-throughput virtual screening studies, mostly because screening challenges usually employ artificially built and biased datasets. We here carry out a fully unbiased evaluation of four scoring functions (Pafnucy, ΔRF, IFP, and GRIM) on an in-house developed data collection of experimental high-confidence screening data (LIT-PCBA) covering about 3 million data points on 15 diverse pharmaceutical targets. Read More

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What is the effect of supervised rehabilitation regime vs. self-management instruction following unicompartmental knee arthroplasty? - a pilot study in two cohorts.

J Exp Orthop 2021 Jun 9;8(1):38. Epub 2021 Jun 9.

University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

Purpose: The optimal rehabilitation strategy after a unicompartmental knee arthroplasty (UKA) is unclear. This study aims to compare the effect of transitioning from a supervised to a self-management rehabilitation regime by pilot study of patient outcomes subsequent to UKA surgery.

Methods: Fifty consecutive patients scheduled to undergo unilateral UKA surgery at our institution between 22 February 2016 and 18of January 2017 were prospectively identified via local medical database and included. Read More

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Dynamic Acoustic Levitator Based On Subwavelength Aperture Control.

Adv Sci (Weinh) 2021 Jun 9:e2100888. Epub 2021 Jun 9.

Max Planck Institute for Intelligent Systems, Heisenbergstr. 3, Stuttgart, 70569, Germany.

Acoustic levitation provides a means to achieve contactless manipulation of fragile materials and biological samples. Most acoustic levitators rely on complex electronic hardware and software to shape the acoustic field and realize their dynamic operation. Here, the authors introduce a dynamic acoustic levitator that is based on mechanically controlling the opening and (partial) closing of subwavelength apertures. Read More

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Visible light-induced alkylpyridylation of styrenes a reductive radical three-component coupling.

Org Biomol Chem 2021 Jun 9. Epub 2021 Jun 9.

School of Pharmaceutical and Materials Engineering, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China.

A visible light-induced and metal-free strategy for the intermolecular three-compoment alkylpyridylation of styrenes is reported. Hantzsch ester was found to be key to initiate the overall reductive radical coupling reaction. This radical process realized difunctionalization of styrenes, selectively yielding alkylated pyridines in good to excellent yields with a wide tolerance of functional groups, mild reaction conditions and simple operation. Read More

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Silver nanoparticle-decorated titanium dioxide nanowire systems bioinspired poly(L-DOPA) thin film as a surface-enhanced Raman spectroscopy (SERS) platform, and photocatalyst.

Phys Chem Chem Phys 2021 Jun 9. Epub 2021 Jun 9.

Department of Chemical Engineering, Ataturk University, 25240 Erzurum, Turkey. and East Anatolia High Technology Application and Research Center (DAYTAM), Ataturk University, 25240 Erzurum, Turkey and Department of Nanoscience and Nanoengineering, Ataturk University, 25240 Erzurum, Turkey.

Silver nanostructure decorated-titanium dioxide (TiO2) nanocomposite systems with their unique characteristics provide extraordinary performance in various applications including surface-enhanced Raman spectroscopy (SERS), and photocatalysis. Despite the recent progress, novel, simple, effective, low-cost, reducing and stabilizing agent-free, and easy-to-tune approaches are heavily demanded for the preparation of these nanocomposites. In this context, we propose the fabrication of silver nanostructure decorated TiO2 nanowires (TiO2 NWs) through a thin interphase layer of the polymer of 3,4-dihydroxyphenyl-l-alanine (PLDOPA). Read More

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Large Low-Field Magnetoresistance (LFMR) Effect in Free-Standing LaSrMnO Films.

ACS Appl Mater Interfaces 2021 Jun 9. Epub 2021 Jun 9.

Beijing National Laboratory of Condensed Matter Physics & Institute of Physics, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.

The realization of a large low-field magnetoresistance (LFMR) effect in free-standing magnetic oxide films is a crucial goal toward promoting the development of flexible, low power consumption, and nonvolatile memory devices for information storage. LaSrMnO (LSMO) is an ideal material for spintronic devices due to its excellent magnetic and electronic properties. However, it is difficult to achieve both a large LFMR effect and high flexibility in LSMO films due to the lack of research on LFMR-related mechanisms and the strict LSMO growth conditions, which require rigid substrates. Read More

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An Artificial Polyacrylonitrile Coating Layer Confining Zinc Dendrite Growth for Highly Reversible Aqueous Zinc-Based Batteries.

Adv Sci (Weinh) 2021 Jun 30;8(11):e2100309. Epub 2021 Mar 30.

Department of Chemistry, University of Venda, Thohoyandou, 0950, South Africa.

Aqueous rechargeable zinc-metal-based batteries are an attractive alternative to lithium-ion batteries for grid-scale energy-storage systems because of their high specific capacity, low cost, eco-friendliness, and nonflammability. However, uncontrollable zinc dendrite growth limits the cycle life by piercing the separator, resulting in low zinc utilization in both alkaline and mild/neutral electrolytes. Herein, a polyacrylonitrile coating layer on a zinc anode produced by a simple drop coating approach to address the dendrite issue is reported. Read More

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Magnetoencephalography reveals increased slow-to-fast alpha power ratios in patients with chronic pain.

Pain Rep 2021 Jul-Aug;6(2):e928. Epub 2021 Jun 3.

Center for Pain Medicine, Department of Anesthesiology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Introduction: Objective disease markers are a key for diagnosis and personalized interventions. In chronic pain, such markers are still not available, and therapy relies on individual patients' reports. However, several pain studies have reported group-based differences in functional magnetic resonance imaging, electroencephalography, and magnetoencephalography (MEG). Read More

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Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis.

Clin Interv Aging 2021 1;16:1013-1022. Epub 2021 Jun 1.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Purpose: Previous studies have shown a rising incidence of early-onset symptomatic intracranial atherosclerosis (sICAS), which has brought a severe economic burden to social development. This study aimed to evaluate the molecular biomarkers associated with early-onset sICAS and to seek possible intervention strategies for early prevention.

Patients And Methods: We consecutively recruited patients with sICAS and divided them into two groups based on age: early-onset sICAS group as age ≤60 years old and late-onset sICAS group as age >60 years old. Read More

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On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy.

J Immunother Cancer 2021 Jun;9(6)

Head and Neck Unit, Royal Marsden Hospital NHS Trust, London, UK.

Background: Previous studies have suggested that inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH) and fibrinogen) are prognostic biomarkers in patients with a variety of solid cancers, including those treated with immune checkpoint inhibitors (ICIs). We aimed to develop a model that predicts response and survival in patients with relapsed and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy.

Methods: Analysis of 100 consecutive patients with unresectable R/M HNSCC who were treated with ICI. Read More

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Forecasting Individual Patient Response to Radiotherapy in Head and Neck Cancer with a Dynamic Carrying Capacity Model.

Int J Radiat Oncol Biol Phys 2021 Jun 5. Epub 2021 Jun 5.

Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL; Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL. Electronic address:

Purpose: In order for radiotherapy to enter the realm of personalized medicine it will be necessary to model and predict individual patient responses to radiotherapy.

Methods And Materials: Here we model tumor dynamics as logistic growth and the effect of radiation as a reduction in the tumor carrying capacity, motivated by the impact of radiation on the tumor microenvironment. The model was assessed on weekly tumor volume data collected for two independent cohorts of head and neck cancer patients from XXXX1 and XXXX2 that received 66-70 Gy in standard daily fractions or with accelerated fractionation. Read More

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Low-grade fibromyxoid sarcoma with pulmonary metastasis. A rare case report.

Rev Med Inst Mex Seguro Soc 2020 ;58(2):221-225

Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Servicio de Tumores de Tórax, Ciudad de México, México.

Background: Low-grade fibromyxoid sarcoma is a very rare tumor that tends to develop in deep soft tissues of young adults and has the potential for local recurrence and distant metastasis.

Clinical Case: We present the case of a 36-year-old man with a low-grade fibromyxoid sarcoma in the right shoulder, which was initially reported as a 4-year-old tumor, undergoing extensive resection with a histopathological report of low-grade fibromyxoid sarcoma, whose deep surgical edge was in bony contact. A simple and contrasted axial tomography was performed where an 8 mm left lung lesion was observed in the upper lobe lower lingular segment of heterogeneous content, hyperdense with contrast medium reinforcement. Read More

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January 2020

A colorimetric sensing platform for azodicarbonamide detection in flour based on MnO nanosheets oxidative system.

Anal Bioanal Chem 2021 Jun 8. Epub 2021 Jun 8.

Institute of Biomedical Photonics and Sensing, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, Shaanxi, China.

Azodicarbonamide (ADA), as a dough conditioner food additive in flour, can be turned into toxic biurea and semicarbazide after high temperature processing. Hence, the using of ADA in food material should be strictly controlled, and the detection of ADA is very important for consumers' safety and health. Herein, a simple and fast colorimetric strategy has been developed for ADA detection based on the MnO nanosheets-3,3',5,5'-tetramethylbenzidine (TMB)-glutathione (GSH) as oxidative sensing system (MnO-TMB-GSH). Read More

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A Simple Technique to Correct Lumpectomy Deformities Using Free Nipple Grafting.

Ann Plast Surg 2021 Jun;86(6S Suppl 5):S567-S570

From the Department of Plastic Surgery, University of South Florida Morsani College of Medicine.

Background: Lumpectomy followed by radiation can lead to severe breast asymmetry. Many surgeons are hesitant to perform traditional mastopexies on irradiated breasts due to increased complication rates. An alternative approach to achieve breast symmetry is presented. Read More

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Robotic Resection and Reconstruction of the Superior Mesenteric Vein Without Graft During Pancreatoduodenectomy (with Video).

J Gastrointest Surg 2021 Jun 7. Epub 2021 Jun 7.

Nove de Julho Hospital, Rua Dona Adma Jafet 74 cj 102 - 01308-050, São Paulo, Brazil.

Background: Pancreatoduodenectomy is the procedure of choice for tumors in the head of the pancreas. Invasion of major vessels is a relative contraindication for minimally invasive approach. We present a video of a robotic resection and reconstruction of the superior mesenteric vein (SMV) without the use of a graft during pancreatoduodenectomy. Read More

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[Study on the effect of antibiotics application in perioperative period on carotid artery and serum interleukin-6 in periodontitis rats with hyperlipidemia or diabetes].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jun;56(6):557-564

Department of Periodontology, Shanxi Medical University School and Hospital of Stomatology & Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, China.

To investigate the effect of antibiotics application in perioperative period on carotid artery and serum interluekin-6 (IL-6) in chronic periodontitis (CP) rats with hyperlipidemia (HL) or diabetes mellitus (DM). The models of CP rats with HL or DM were established in different batches. The rats were divided into groups as follows: A and A' were normal control groups, =7 in each group; B(HL) and B'(DM) were groups of HL and DM, =7 in each; C(HL+CP) and C'(DM+CP) were groups of CP with HL and CP with DM, =21 in each. Read More

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