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Influence of hypertension and other risk factors on the onset of sublingual varices.

BMC Oral Health 2021 May 4;21(1):235. Epub 2021 May 4.

Department of Engineering and Architecture, University of Trieste, Trieste, Italy.

Background: Sublingual varices (SV) are dilatations of tortuous veins that increased with age. Previous studies showed that this pathology could be correlated to some risk factors such as hypertension, age, gender and diabetes mellitus. In this study we evaluated, on a large number of subjects, the relationship between SV and different grades of hypertension as well as some risk factors extending the analysis to new risk factors such as dyslipidemia, obesity and antihypertensive therapy, modelling a possible dependence of SV on all these factors. Read More

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Alterations in connectivity of the bed nucleus of the stria terminalis during early abstinence in individuals with alcohol use disorder.

Alcohol Clin Exp Res 2021 Apr 8. Epub 2021 Apr 8.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: For individuals with Alcohol Use Disorder (AUD), long-term recovery is difficult in part due to symptoms of anxiety that occur during early abstinence and can trigger relapse. Research in rodent models of AUD has identified the bed nucleus of the stria terminalis (BNST), a small, sexually dimorphic, subcortical region, as critical for regulating anxiety-like behaviors during abstinence, particularly in female mice. Furthermore, prolonged alcohol use and subsequent abstinence alter BNST afferent and efferent connections to other brain regions. Read More

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Gender may be related to the side of the motor syndrome and cognition in idiopathic Parkinson's disease.

Neurologia 2021 Mar 13. Epub 2021 Mar 13.

Fondazione Policlinico Universitario 'Agostino Gemelli' - IRCSS, 00168 Rome, Italy; Università Cattolica del Sacro Cuore, Department of Psychology, 20123 Milan, Italy.

Background: and Sex and cognitive profile may be related to the laterality of motor symptoms in idiopathic Parkinson's disease.

Introduction: Parkinson's disease (PD) is well recognised as an inherently asymmetric disease with unilateral onset of motor symptoms. The laterality of motor symptoms may be linked to sex, clinical and demographic variables, and neuropsychological disorders. Read More

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Cognitive reserve: a multidimensional protective factor in Parkinson's disease related cognitive impairment.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2021 Feb 25:1-16. Epub 2021 Feb 25.

Department of Psychology, Catholic University of Milan, Italy.

We explored the association between cognitive reserve (CR) and Parkinson' s disease (PD) related cognitive deterioration.Forty PD patients and 12 matched healthy controls (HC) were enrolled. The PD group was balanced for the presence/absence of cognitive impairment. Read More

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February 2021

Mammary duct ectasia without bloody nipple discharge in a five-year-old girl.

Pediatr Int 2021 Mar 13;63(3):346-347. Epub 2021 Feb 13.

Pediatric Surgery Unit, Department of Pediatric Surgery, Research Institute, Bambino Gesù Children's Hospital, Palidoro, Rome, Italy.

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Evaluation of educational value of YouTube videos addressing robotic pyeloplasty in children.

J Pediatr Urol 2021 Jan 13. Epub 2021 Jan 13.

Pediatric Urology Unit, "Santobono-Pausilipon" Children's Hospital, Naples, Italy.

Background/introduction: Ureteropelvic junction obstruction (UPJO) is the most frequent obstructive uropathy of the upper urinary tract in children. Video-sharing platforms have become a significant source of visual information for health care providers. Among these platforms, YouTube® (www. Read More

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January 2021

Immune cell labelling and tracking: implications for adoptive cell transfer therapies.

EJNMMI Radiopharm Chem 2021 Feb 3;6(1). Epub 2021 Feb 3.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Rome, Italy.

Background: The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer. In addition to conventional drugs, new cell-based therapies, like adoptive cell transfer, proved to be successful in humans. Indeed, after the approval of anti-CD19 CAR-T cell therapy, researchers are trying to extend this approach to other cancer or cell types. Read More

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February 2021

The role of the dorsal striatum in the recognition of emotions expressed by voice in Parkinson's disease.

Neurol Sci 2021 May 7;42(5):2085-2089. Epub 2021 Jan 7.

Department of Psychology, Catholic University, Largo A. Gemelli, 1, 20123, Milan, Italy.

Background And Purpose: Non-motor impairment such as emotion recognition deficit in both facial and vocal expressions has been previously reported in Parkinson's disease (PD). We investigated whether the decoding of emotional prosody is impaired in PD and whether this deficit is related to striatal damage.

Methods: Fifteen PD patients and 15 healthy controls (HCs) were requested to listen to six audio tracks and to recognize the emotions expressed by a professional actor while reading a meaning-neutral sentence. Read More

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Brain Activation during Memory Retrieval is Associated with Depression Severity in Women.

Psychiatry Res Neuroimaging 2021 01 9;307:111204. Epub 2020 Oct 9.

Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, MA, USA; Dept. of Psychiatry, Harvard Medical School, Boston, MA, USA.

Major depressive disorder (MDD) is a debilitating disorder that interferes with daily functioning, and that occurs at higher rates in women than in men. Structural and functional alterations in hippocampus and frontal lobe have been reported in MDD, which likely contribute to the multifaceted nature of MDD. One area impacted by MDD is hippocampal-mediated memory, which can be probed using a spatial virtual Morris water task (MWT). Read More

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January 2021

Women versus men: A critical comparison for understanding the neurobiology of memory.

Cogn Neurosci 2020 Dec 24:1-3. Epub 2020 Dec 24.

Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital , Belmont, MA, USA.

Spets and Slotnick present a meta-analysis on long-term memory and sex differences. Overall findings indicate greater brain activation in men than women during memory performance. Merits of the activation likelihood estimation meta-analysis include considering study parameters and equating performance to enhance interpretability of activation differences. Read More

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December 2020

Psychopathological profile in COVID-19 patients including healthcare workers: the implications.

Eur Rev Med Pharmacol Sci 2020 11;24(22):11964-11970

Clinical Psychology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: The effects of COVID-19 seem to extend beyond the physical pain and is showing psychiatric implications as well. Moreover, psychopathological implications seem to last also after patients' discharge. Our goal is to investigate the psychological impact and psychopathological outcome of patients affected by COVID-19. Read More

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November 2020

Effect of power feature covariance shift on BCI spatial-filtering techniques: A comparative study.

Comput Methods Programs Biomed 2021 Jan 21;198:105808. Epub 2020 Oct 21.

Department of Engineering and Architecture, University of Trieste, Via Alfonso Valerio 10, 34127, Trieste, Italy.

Background And Objective: The input data distributions of EEG-based BCI systems can change during intra-session transitions due to nonstationarity caused by features covariate shifts, thus compromising BCI performance. We aimed to identify the most robust spatial filtering approach, among most used methods, testing them on calibration dataset, and test dataset recorded 30 min afterwards. In addition, we also investigated if their performance improved after application of Stationary Subspace Analysis (SSA). Read More

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January 2021

Contribution of the Cerebellum and the Basal Ganglia to Language Production: Speech, Word Fluency, and Sentence Construction-Evidence from Pathology.

Cerebellum 2021 Apr 29;20(2):282-294. Epub 2020 Oct 29.

Department of Psychology, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 1, 20123, Milano, Italy.

Evidence reported in recent decades increasingly confirms that both the cerebellum and the basal ganglia, which are primarily involved in movement control, also have a significant role in a vast range of cognitive and affective functions. Evidence from pathology indicates that the disorders of some aspects of language production which follow damage of the cerebellum or respectively basal ganglia, i.e. Read More

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In Memoriam: Linda Patia Spear, PhD.

Authors:
Marisa M Silveri

Alcohol Clin Exp Res 2020 12 17;44(12):2618. Epub 2020 Nov 17.

From the, Neurodevelopmental Laboratory on Addictions and Mental Health, McLean Hospital, Belmont, Massachusetts.

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December 2020

Detection of subjects with ischemic heart disease by using machine learning technique based on heart rate total variability parameters.

Physiol Meas 2020 Oct 20. Epub 2020 Oct 20.

Cardiovascular Department, University of Trieste Clinical Department of Medical Surgical and Health Sciences, Trieste, Friuli-Venezia Giulia, ITALY.

Objective: Ischemic heart disease (IHD), in its chronic stable form, is a subtle pathology due to its silent behavior before developing in unstable angina, myocardial infarction or sudden cardiac death. The clinical assessment is based on typical symptoms and finally confirmed, invasively, by coronary angiography. Recently, heart rate variability (HRV) analysis as well as some machine learning algorithms like Artificial Neural Networks (ANNs) were used to identify cardiovascular arrhythmias and, only in few cases, to classify IHD segments in a limited number of subjects. Read More

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October 2020

Global attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study.

Br J Surg 2020 Oct 8. Epub 2020 Oct 8.

Department of General Surgery, University of Insubria, University Hospital of Varese, ASST Sette Laghi, Regione Lombardia, Varese, Italy.

Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Read More

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October 2020

Evaluation of Motor Imagery-Based BCI methods in neurorehabilitation of Parkinson's Disease patients.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:3058-3061

The study reports the performance of Parkinson's disease (PD) patients to operate Motor-Imagery based Brain-Computer Interface (MI-BCI) and compares three selected pre-processing and classification approaches. The experiment was conducted on 7 PD patients who performed a total of 14 MI-BCI sessions targeting lower extremities. EEG was recorded during the initial calibration phase of each session, and the specific BCI models were produced by using Spectrally weighted Common Spatial Patterns (SpecCSP), Source Power Comodulation (SPoC) and Filter-Bank Common Spatial Patterns (FBCSP) methods. Read More

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Writing errors in primary progressive aphasia.

Appl Neuropsychol Adult 2020 Sep 9:1-8. Epub 2020 Sep 9.

Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.

Peripheral errors in writing, that is errors produced download the spelling, have been occasionally described in primary progressive aphasia (PPA), but the possibility that these errors might be a marker of parkinsonism associated to some subtypes of PPA has not been explored. We investigated whether errors of peripheral nature characterize the writing disorder in PPA when associated with parkinsonian signs (PSs). Subgroups of PPA without PSs and with PSs were studied. Read More

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September 2020

Influence of ageing on circadian rhythm of heart rate variability in healthy subjects.

J Cardiovasc Med (Hagerstown) 2021 May;22(5):405-413

Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.

Background: The analysis of the circadian rhythm of heart rate variability (HRV) represents a relevant physiological tool to assess the vagal system. However, the influence of age (mostly >75 years) on HRV is not widely known.

Aims: The aim of this study was to evaluate the influence of age on HRV, particularly in the elderly and to identify a model of this relationship. Read More

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[Salter 1 medial collarbone epiphysiolysis with acute posterior displacement in the immature skeleton].

Acta Ortop Mex 2019 Nov-Dec;33(6):400-405

Clínica de Traumatología y Ortopedia Pediátrica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Sternoclavicular epiphysiolysis is a rare lesion, the posterior variant being even less common. Its clinical presentation may be subtle, or it may compromise mediastinal structures, either initially or during evolution, which is a serious and potentially fatal picture. This case report documents sternoclavicular dissociation in a patient with an immature skeleton, given by a Salter and Harris 1-type injury, which was surgically treated by open reduction and internal fixation with transosseous configuration with non-reabsorbable suture. Read More

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COVID-19 in rheumatic diseases in Italy: first results from the Italian registry of the Italian Society for Rheumatology (CONTROL-19).

Clin Exp Rheumatol 2020 Jul-Aug;38(4):748-753. Epub 2020 Jul 28.

Italian Society for Rheumatology, Milan, Italy.

Objectives: Italy was one of the first countries significantly affected by the coronavirus disease 2019 (COVID-19) epidemic. The Italian Society for Rheumatology promptly launched a retrospective and anonymised data collection to monitor COVID-19 in patients with rheumatic and musculoskeletal diseases (RMDs), the CONTROL-19 surveillance database, which is part of the COVID-19 Global Rheumatology Alliance.

Methods: CONTROL-19 includes patients with RMDs and proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) updated until May 3rd 2020. Read More

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Individualized robotic organ-sparing surgery in a paediatric case of renal perivascular epithelioid cell tumour.

Int J Med Robot 2020 Oct 14;16(5):1-4. Epub 2020 Aug 14.

Pediatric Urology and Surgery Unit, G. Salesi Children's Hospital, Ancona, Italy.

Background: Perivascular epithelioid cell tumours (PEComas) represent a rare group of mesenchymal tumours with an unpredictable outcome. They are usually observed in middle-aged women whilst they are very rare in children, with limited cases described. Due to the rare anatomical location in kidneys, a correct diagnosis and treatment is really challenging. Read More

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October 2020

What about the caregiver? A journey into Parkinson's disease following the burden tracks.

Aging Clin Exp Res 2021 Apr 2;33(4):991-996. Epub 2020 Jun 2.

Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.

Objectives: To investigate caregivers and patients characteristics related to different dimensions of burden in Parkinson's disease (PD).

Methods: 55 pairs of PD patients and caregivers were recruited. The burden was evaluated with the Caregiver Burden Inventory (CBI). Read More

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Uncinate fasciculus and word selection processing in Parkinson's disease.

Neuropsychologia 2020 09 30;146:107504. Epub 2020 May 30.

Department of Psychology, Catholic University, Largo A. Gemelli, 1, 20123, Milan, Italy.

We explored with Diffusion Tensor Imaging (DTI) technique whether the ability to select words among competitive alternatives during word production is related to the integrity of the left uncinate fasciculus (UF) in Parkinson's disease (PD). Nineteen PD patients (10 right-sided and 9 left-sided) and 17 matched healthy controls (HC) took part in the study. Participants were asked to derive nouns from verbs (reading from to read) or to generate verbs from nouns (to build from building). Read More

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September 2020

A Simplified Management of Transverse Testicular Ectopia in Patients with Persistent Mullerian Duct Syndrome.

Urol J 2020 05 27;0(0):237-239. Epub 2020 May 27.

Department of Pediatric Endocrinology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Persistent müllerian duct syndrome (PMDS) in the majority of cases is discovered during surgery for inguinal hernia or cryptorchidism. A transverse testicular ectopia (TTE) with cryptorchidism may be very rarely associated to PMDS. Assuming that müllerian remnants have a very low malignant degeneration potential if compared to the malignancy risk of an undescended and not relocated testis, we describe a simplified surgical technique of orchiopexy that avoids an extensive anatomical dissection, in this way minimizing the risk of losing the deferential blood supply to the testis. Read More

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Class-selective voltammetric determination of hydroxycinnamic acids structural analogs using a WS/catechin-capped AuNPs/carbon black-based nanocomposite sensor.

Mikrochim Acta 2020 04 28;187(5):296. Epub 2020 Apr 28.

Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, 64100, Teramo, Italy.

A high-performance screen-printed electrode (SPE) based nanocomposite sensor integrating tungsten disulfide (WS) flakes decorated with catechin-capped gold nanoparticles (AuNP-CT) and carbon black (CB) has been developed. The excellent antifouling properties of WS decorated with AuNP-CT into a high conductivity network of CB results in high selectivity, sensitivity, and reproducibility for the simultaneous determination of hydroxycinnamic acid (hCN) structural analogs: caffeic (CF), sinapic (SP), and p-coumaric acids (CM). Using differential pulse voltammetry (DPV), the target hCNs resulted in three well-resolved oxidation peaks at SPE-CB-WS/AuNP-CT sensor. Read More

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Valgus slipped capital femoral epiphysis: presentation, treatment, and clinical outcomes using patient-reported measurements.

J Pediatr Orthop B 2021 Mar;30(2):111-115

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Valgus slipped capital femoral epiphysis (SCFE), is rare. This study describes the diagnosis, treatment and outcome of valgus SCFE in Uruguay. The medical records and radiographs were reviewed in eight consecutive children [mean age 11. Read More

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Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network.

Addict Biol 2021 03 28;26(2):e12861. Epub 2020 Jan 28.

Vanderbilt Center for Addiction Research, Vanderbilt University School of Medicine, Nashville, TN, USA.

Alcohol Use Disorder (AUD) is a chronic, relapsing disease that impacts almost a third of Americans. Despite effective treatments for attaining sobriety, the majority of patients relapse within a year, making relapse a substantial barrier to long-term treatment success. A major factor contributing to relapse is heightened negative affect that results from the combination of abstinence-related increases in stress-reactivity and decreases in reward sensitivity. Read More

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Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity.

Elife 2020 01 20;9. Epub 2020 Jan 20.

Developmental Neuropsychobiology Laboratory, Department of Psychology, Northeastern University, Boston, United States.

Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have been identified with a clear need for individualized intervention strategies, the neurobiological substrates of ELA-attributable differences remain unknown due to a paucity of translational investigations taking both development and sex into account. Male and female rats exposed to maternal separation ELA were analyzed with anterograde tracing from basolateral amygdala (BLA) to PFC to identify sex-specific innervation trajectories through juvenility (PD28) and adolescence (PD38;PD48). Read More

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January 2020

Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention.

J Altern Complement Med 2020 Mar 14;26(3):190-197. Epub 2020 Jan 14.

Department of Psychiatry, Boston University School of Medicine, Boston, MA.

To determine if a 12-week yoga intervention (YI) was associated with increased gamma aminobutyric acid (GABA) levels and decreased depressive symptoms in participants with major depressive disorder (MDD). : Subjects were randomized to a high-dose group (HDG) of three YIs a week and a low-dose group (LDG) of two YIs a week. Thalamic GABA levels were obtained using magnetic resonance spectroscopy at Scan-1 before randomization. Read More

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