224 results match your criteria silicate-based cements


Influence of Preoperative Pulp Inflammation in the Outcome of Full Pulpotomy Using a Dog Model.

J Endod 2021 Jul 3. Epub 2021 Jul 3.

Institute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Center for Innovation and Research in Oral Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Introduction: This study aimed to evaluate the impact of preoperative pulp inflammation on the histologic outcome of full pulpotomy performed in mature permanent posterior teeth using 4 different biomaterials.

Methods: Five beagle dogs (providing a total of 120 roots) were selected. Dentin exposure was performed in teeth from the second and third quadrants. Read More

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Tooth discoloration induced by apical plugs with hydraulic calcium silicate-based cements in teeth with open apices-a 2-year in vitro study.

Clin Oral Investig 2021 Jun 21. Epub 2021 Jun 21.

Department of Conservative Dentistry and Periodontology and Center of Dental Traumatology, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Objectives: To assess tooth discoloration induced by different hydraulic calcium silicate-based cements (HCSCs), including effects of blood and placement method.

Materials And Methods: Eighty bovine teeth cut to a length of 18 mm (crown 8 mm, root 10 mm) were randomly assigned to 10 groups (n = 8), receiving orthograde apical plug treatment (APT). Apical plugs were 4 mm in length and made of ProRoot MTA (Dentsply), Medcem MTA (Medcem), TotalFill BC RRM Fast Set Putty (Brasseler), or Medcem Medical Portland Cement (Medcem) plus bismuth oxide (Bi2O3) with and without bovine blood. Read More

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Biocompatibility and Antibiofilm Properties of Calcium Silicate-Based Cements: An In Vitro Evaluation and Report of Two Clinical Cases.

Biology (Basel) 2021 May 26;10(6). Epub 2021 May 26.

Department of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.

Calcium silicate-based cements have reached excellent levels of performance in endodontics, providing predictable and successful results. To better assess the properties of these bioactive materials, the present study aimed to compare the biocompatibility and antibiofilm properties of ProRoot MTA and Biodentine. Human osteogenic sarcoma (Saos-2) cells were cultured on ProRoot MTA and Biodentine samples or in the presence of both cement extracts. Read More

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Tooth Discoloration Induced by Different Calcium Silicate-Based Cements: A Two-Year Spectrophotometric and Photographic Evaluation in Vitro.

J Clin Pediatr Dent 2021 Apr;45(2):112-116

Objective: Calcium silicate-based cements (CSCs) may lead to coronal staining in young permanent teeth over the time. The purpose of this study was to evaluate and compare the long-term tooth discoloration induced by different CSCs.

Study Design: Ninety freshly-extracted human molars were assigned randomly into 6 groups (n=15/group) according to the CSC used as a pulpotomy material: ProRoot MTA, MTA Angelus, NeoMTA, EndoSequence Putty, Biodentine and Negative control (No cement). Read More

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Physicochemical and Biological Properties of Mg-Doped Calcium Silicate Endodontic Cement.

Materials (Basel) 2021 Apr 8;14(8). Epub 2021 Apr 8.

School of Materials Science and Engineering, Pusan National University, Busan 46241, Korea.

Calcium silicate-based cement has been widely used for endodontic repair. However, it has a long setting time and needs to shorten setting time. This study investigated the effects of magnesium (Mg) ion on the setting reaction, mechanical properties, and biological properties of calcium silicate cement (CSC). Read More

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Tooth Discoloration Using Calcium Silicate-Based Cements For Simulated Revascularization in Vitro.

Braz Dent J 2021 Jan-Feb;32(1):53-58

Postgraduate Program in Dentistry, School of Dentistry, University of Taubaté, Taubaté, Brazil.

The endodontic revascularization may be an alternative treatment for necrotic immature teeth, however, several treatment steps may cause tooth discoloration. This study evaluated the use of three calcium silicate-based cements with different radiopacifying agents on the color alteration (∆E) of extracted premolars after simulation of revascularization. Forty single rooted extracted premolars were shaped with #1-6 gates Glidden drills, rinsed with sodium hypochlorite, and filled with fresh human blood. Read More

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Effect of irrigation solutions on the coronal discoloration induced by mineral trioxide aggregate cements containing different radiopacifiers.

Dent Res J (Isfahan) 2020 Nov-Dec;17(6):447-451. Epub 2020 Dec 10.

Department of Prosthodontics, School of Dentistry, Islamic Azad University, Tehran, Iran.

Background: The aim of this study was to assess the discoloration of coronal tooth structure irrigated with different irrigation solutions and filled with calcium silicate-based materials containing bismuth oxide or calciumzirconia complex as radiopacifier.

Materials And Methods: In this study, 72 bovine enamel-dentin blocks were prepared and divided into three groups. The dentinal cavities in each group were irrigated with 5. Read More

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December 2020

Effect of different manipulations on the physical, chemical and microstructural characteristics of Biodentine.

Dent Mater 2021 07 15;37(7):e399-e406. Epub 2021 Apr 15.

School of Dentistry, University of Birmingham, Birmingham, UK.

Objective: The water to powder ratio and method of mixing is important for the properties of hydraulic cements. For this purpose a number of clinicians prefer premixed materials. Dental manufacturing companies provide predosed materials, however the manufacturer instructions are not always adhered to. Read More

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Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements.

BMC Oral Health 2021 03 9;21(1):106. Epub 2021 Mar 9.

Program of Molecular and Cell Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Background: This study aimed to evaluate the biological response of human apical papilla cells to different calcium hydroxide formulations and three tricalcium silicate-based materials.

Methods: Primary cells were obtained from explants of young immature premolars. 20,000 cells adhered for 24 h over discs of Biodentine™, ProRoot®MTA, BioRoot®RCS and calcium hydroxide mixed either with sodium chloride 0. Read More

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Effect of surface treatments on push-out bond strength of calcium silicate-based cements to fiber posts.

BMC Oral Health 2021 03 19;21(1):131. Epub 2021 Mar 19.

Department of Restorative Dental Sciences, Vision Colleges, Jeddah, Saudi Arabia.

Background: To evaluate the effect of surface treatments on the push-out bond strength of Biodentine (BD) and white mineral trioxide aggregate (WMTA) to fiber posts.

Methods: Two brands of fiber posts were used: Reblida post; RP and RelyX post; RX. Each type of post (n = 80/group) was divided into four groups (n = 20/group) and exposed to surface treatment as follows: Control (no treatment), sandblasting (SB), hydrofluoric acid (HF), and TiF 4 wt/v%. Read More

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Repair of a Perforation Defect With Calcium Silicate-Based Cement Using an Internal Matrix.

Compend Contin Educ Dent 2021 Feb;42(2):e1-e4

Reader, Department of Conservative Dentistry and Endodontics, K.D. Dental College and Hospital, Mathura, Delhi, India.

This case report describes the nonsurgical endodontic management of a distolingual floor perforation in a mandibular first molar using an internal matrix and mineral trioxide aggregate (MTA) cement. The pulp chamber was properly cleaned, and after placement of a synthetic collagen material that served as a barrier at the level of furcation, MTA was used to repair the perforation defect. Root canal treatment was completed and the tooth was restored with a composite restoration followed by a porcelain-fused-to-metal crown. Read More

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February 2021

A micro-computed tomographic study using a novel test model to assess the filling ability and volumetric changes of bioceramic root repair materials.

Restor Dent Endod 2021 Feb 8;46(1):e2. Epub 2020 Dec 8.

Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil.

Objectives: New premixed bioceramic root repair materials require moisture for setting. Using micro-computed tomography (micro-CT), this study evaluated the filling ability and volumetric changes of calcium silicate-based repair materials (mineral trioxide aggregate repair high-plasticity [MTA HP] and Bio-C Repair, Angelus), in comparison with a zinc oxide and eugenol-based material (intermediate restorative material [IRM]; Dentsply DeTrey).

Materials And Methods: Gypsum models with cavities 3 mm deep and 1 mm in diameter were manufactured and scanned using micro-CT (SkyScan 1272. Read More

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February 2021

Biomineralization of three calcium silicate-based cements after implantation in rat subcutaneous tissue.

Restor Dent Endod 2021 Feb 2;46(1):e1. Epub 2020 Dec 2.

Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada.

Objectives: The aim of this study was to evaluate the dystrophic mineralization deposits from 3 calcium silicate-based cements (Micro-Mega mineral trioxide aggregate [MM-MTA], Biodentine [BD], and EndoSequence Root Repair Material [ESRRM] putty) over time after subcutaneous implantation into rats.

Materials And Methods: Forty-five silicon tubes containing the tested materials and 15 empty tubes (serving as a control group) were subcutaneously implanted into the backs of 15 Wistar rats. At 1, 4, and 8 weeks after implantation, the animals were euthanized ( = 5 animals/group), and the silicon tubes were removed with the surrounding tissues. Read More

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February 2021

Influence of Ultrasonic Activation on the Physicochemical Properties of Calcium Silicate-Based Cements.

Int J Dent 2021 27;2021:6697988. Epub 2021 Jan 27.

School of Dentistry, University of Ribeirão Preto, Av. Costábile Romano, 2201-Nova Ribeirânia, Ribeirão Preto, SP 14096-900, Brazil.

Purpose: To evaluate the influence of ultrasonic activation on the physicochemical properties of setting time (ST), flow (FL), dimensional change (DC), and solubility (SL) of the cements: MTA, MTA Repair HP, and Biodentine®.

Materials And Methods: Two experimental groups were formed according to the cement activation protocol: without ultrasonic activation and with ultrasonic activation. Cements were manipulated according to the manufacturers' instructions. Read More

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January 2021

Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro studies.

Dent Mater 2021 04 8;37(4):e256-e268. Epub 2021 Feb 8.

Department of Stomatology, Faculty of Medicine and Dentistry, Universitat de València, 46010 Valencia, Spain. Electronic address:

Objective: To present a qualitative synthesis of in vitro studies which analyzed human dental stem cell (DSC) molecular signaling pathway activation in response to hydraulic calcium silicate-based cements (HCSCs).

Methods: A systematic electronic search was performed in Medline, Scopus, Embase, Web of Science and SciELO databases on January 20 and last updated on March 20, 2020. In vitro studies assessing the implication of signaling pathways in activity related marker (gene/protein) expression and mineralization induced by HCSCs in contact with human DSCs were included. Read More

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Correction: Rajasekharan, S., et al. Effect of Exposed Surface Area, Volume and Environmental pH on the Calcium Ion Release of Three Commercially Available Tricalcium Silicate Based Dental Cements. 2018, , 123.

Materials (Basel) 2021 Jan 12;14(2). Epub 2021 Jan 12.

Biomaterials Group, Department of Basic Medical Sciences, Ghent University, 9000 Ghent, Belgium.

The authors wish to make the following correction to the paper [... Read More

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January 2021

The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome.

Sci Rep 2021 01 12;11(1):645. Epub 2021 Jan 12.

Department of Basic And Applied Medical Sciences - Physiology Group, Ghent University, Ghent, Belgium.

Calcium (Ca) signalling plays an indispensable role in dental pulp and dentin regeneration, but the Ca responses of human dental pulp stem cells (hDPSCs) stimulated with tricalcium silicate-based (TCS-based) dental biomaterials remains largely unexplored. The objective of the present study was to identify and correlate extracellular Ca concentration, intracellular Ca dynamics, pH, cytotoxicity, gene expression and mineralization ability of human dental pulp stem cells (hDPSCs) stimulated with two different TCS-based biomaterials: Biodentine and ProRoot white MTA. The hDPSCs were exposed to the biomaterials, brought in contact with the overlaying medium, with subsequent measurements of extracellular Ca and pH, and intracellular Ca changes. Read More

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January 2021

Radiopacity quantification and spectroscopic characterization of OrthoMTA and RetroMTA.

Microsc Res Tech 2021 Jun 30;84(6):1233-1242. Epub 2020 Dec 30.

ARUM-Central Research Laboratory Application and Research Center, Eskisehir Osmangazi University, Eskisehir, Turkey.

The aim of this article was to investigate the unknown radiopacity performances of OrthoMTA and RetroMTA via means of a contemporary image analyzing methods and energy dispersive X-ray spectroscopy. Three commercial hydraulic calcium silicate-based cements and a calcium hydroxide-based paste were used. Pure-grade zirconium oxide, bismuth oxide, zinc oxide, barium sulfate, and calcium hydroxide were as references. Read More

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Retrograde filling material in periapical surgery: a systematic review.

Med Oral Patol Oral Cir Bucal 2021 Jul 1;26(4):e422-e429. Epub 2021 Jul 1.

School of Medicine and Health Sciences Campus de Bellvitge. University of Barcelona C/ Feixa Llarga s/n; Pavelló Govern, 2ª planta, Despatx 2.9 08907 - L'Hospitalet de Llobregat (Barcelona), Spain

Background: Periapical surgery focuses on the treatment of teeth with persistent periapical lesions when orthograde root canal treatment fails. Although MTA® is the gold standard material for retrograde filling, Biodentine® - a tricalcium silicate-based cement - has been proposed in order to resolve several of its limitations. A systematic review has been carried out to compare the physicochemical properties of Biodentine® versus MTA® as root-end filling material in periapical surgery. Read More

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Physicochemical, biological, and antibacterial evaluation of tricalcium silicate-based reparative cements with different radiopacifiers.

Dent Mater 2021 02 13;37(2):311-320. Epub 2020 Dec 13.

Department of Restorative Dentistry, São Paulo State University (UNESP), School of Dentistry, Araraquara, SP, Brazil. Electronic address:

Objective: To evaluate tricalcium silicate-based (TCS) experimental materials, associated with zirconium oxide (ZrO), calcium tungstate (CaWO) or niobium oxide (NbO) radiopacifiers, in comparison with MTA Repair HP (Angelus).

Methods: Physicochemical tests: setting time, radiopacity, pH and solubility. In vitro assays: cytotoxicity: MTT and Neutral Red - NR; cell bioactivity: alkaline phosphatase activity (ALP), Alzarin red staining (ARS) and real time PCR (qPCR). Read More

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February 2021

Cytocompatibility and Bioactive Properties of Hydraulic Calcium Silicate-Based Cements (HCSCs) on Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs): A Systematic Review of In Vitro Studies.

J Clin Med 2020 Nov 28;9(12). Epub 2020 Nov 28.

Cellular Therapy and Hematopoietic Transplant Research Group, Biomedical Research Institute, Virgen de la Arrixaca Clinical University Hospital, IMIB-Arrixaca, University of Murcia, 30120 Murcia, Spain.

The implementation of hydraulic calcium silicate-based endodontic cements (HCSCs) in biologically based endodontic procedures for the primary dentition has been recently investigated, focusing on the biological response of stem cells from human exfoliated deciduous teeth (SHEDs) towards them. The present systematic review aimed to present a qualitative synthesis of the available literature consisting of in vitro assays, which assessed the cytocompatibility and bioactive properties of HCSCs in direct contact with SHEDs. Following the PRISMA statement, an electronic database search was carried out in Medline, Scopus, Embase, Web of Science, and SciELO on March 31st and updated on November 16th, 2020. Read More

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November 2020

Effect of exposure to root canal irrigants on the push-out bond strength of calcium silicate-based cements.

Clin Oral Investig 2021 May 28;25(5):3267-3274. Epub 2020 Oct 28.

Departamento de Odontología Conservadora y Prótesis Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal, s/n. Ciudad Universitaria, 28040, Madrid, Spain.

Objectives: The aim of this study was to compare the push-out bond strength (POBS) of three calcium silicate-based cements (CSBC) after exposure to saline, sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA), and a mixture of NaOCl and etidronic acid (NaOCl+HEBP) in simulated perforation.

Materials And Methods: A total of 180 dentin slices were perforated and then filled with either Biodentine (BD), ProRoot MTA (PMTA), or Total Fill (TF). After 1 week, specimens in each group were divided into 4 subgroups (n = 15) according to the root canal irrigant (RCI) that their coronal surface was exposed to: saline, 5. Read More

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Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing.

Clin Oral Investig 2021 May 27;25(5):3181-3195. Epub 2020 Oct 27.

Department of Paediatric Dentistry & Special Care, PAECOMEDIS Research Cluster, Ghent University, Ghent University Hospital, 9000, Ghent, Belgium.

Objectives: Tricalcium silicate (TCS)-based biomaterials induce differentiation of human dental pulp cells (hDPCs) into odontoblasts/osteoblasts, which is regulated by the interplay between various intracellular pathways and their resultant secretome. The aim of this study was to compare the transcriptome-wide effects by next-generation RNA sequencing of custom-prepared hDPCs stimulated with TCS-based biomaterials: ProRoot white MTA (WMTA) (Dentsply, Tulsa; Tulsa, OK) and Biodentine (Septodont, Saint Maur des Fosses, France).

Methods: Self-isolated hDPCs were seeded in a 6-well plate at a density of 5 × 10 cells per well. Read More

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Evaluation of undergraduate Endodontic teaching in dental schools within Spain.

Int Endod J 2021 Mar 10;54(3):454-463. Epub 2020 Nov 10.

Section of Endodontics, Department of Stomatology, School of Dentistry, University of Sevilla, Sevilla, Spain.

Aim: To evaluate the current situation of undergraduate endodontic teaching in Spanish dental schools.

Methodology: An online version, translated into Spanish, of a survey conducted in the UK (Int Endod J 52, 2019, 1077) was sent via email to the undergraduate endodontic programme leads in all 23 Spanish dental schools.

Results: The response rate was 96%. Read More

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Effect of restorative timing on shear bond strength of composite resin/calcium silicate-based cements adhesive interfaces.

Clin Oral Investig 2021 May 12;25(5):3131-3139. Epub 2020 Oct 12.

Center for Innovation and Research in Oral Sciences (CIROS), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Objectives: The aim of this study was to evaluate the shear bond strength inherent to immediate and delayed definitive composite resin restorations, over three different biomaterials.

Methods: Fifty-four aluminum blocks were randomly assigned to six experimental groups (n = 9) according to the biomaterial (Biodentine, TotalFill BC Putty, or PCM) and restoration timing (immediate or 7 days delayed). Regarding the restorative procedures, a two-step self-etch bonding system (Clearfil SE Bond) was applied and subsequently restored using a flowable composite resin (SDR). Read More

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Wollastonite as filler of an experimental dental adhesive.

J Dent 2020 11 12;102:103472. Epub 2020 Sep 12.

Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul. Ramiro Barcelos Street, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil. Electronic address:

Objective: The aim of this study was to formulate experimental dental adhesives with wollastonite and evaluate the physical, chemical, and bioactivity properties of the resins.

Methods: Wollastonite was characterized by Fourier transform infrared spectroscopy, X-ray and laser diffraction analyses, and scanning electronic microscopy. An experimental adhesive resin was formulated, and wollastonite was used as filler at 0 (control group), 0. Read More

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November 2020

Physicochemical, antimicrobial, and biological properties of White-MTAFlow.

Clin Oral Investig 2021 Feb 31;25(2):663-672. Epub 2020 Aug 31.

Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas, Av. Limeira, 901, Areião, Piracicaba, São Paulo, CEP 13414-903, Brazil.

Objectives: To evaluate a new material containing tantalum oxide as an alternative radiopacifier, and a water-based gel for hydration, in comparison with two calcium silicate-based cement: ProRoot MTA and Biodentine.

Materials And Methods: ProRoot MTA (Dentsply), Biodentine (Septodont), and a new hydraulic calcium silicate cement White-MTAFlow (Ultradent) (in 'thin' consistency) were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS). The interaction with dentin was also assessed using SEM and EDS. Read More

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February 2021

Histological evaluation of the regenerative potential of a novel treated dentin matrix hydrogel in direct pulp capping.

Clin Oral Investig 2021 Apr 19;25(4):2101-2112. Epub 2020 Aug 19.

Oral Biology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.

Objectives: To produce a novel injectable treated dentin matrix hydrogel (TDMH) to be used as a novel pulp-capping agent for dentin regeneration compared with Biodentine and MTA.

Materials And Methods: Thirty intact fully erupted premolars scheduled to be extracted for orthodontic reasons were included. Pulps were mechanically exposed in the middle of the cavity floor. Read More

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Dental discoloration caused by Grey-MTAFlow cement: analysis of its physicochemical, biological and antimicrobial properties.

J Appl Oral Sci 2020 5;28:e20200269. Epub 2020 Aug 5.

Faculdade de Odontologia de Piracicaba, Universidade de Campinas, Piracicaba, São Paulo, Brasil.

Tricalcium silicate-based cement are materials used in reparative and regenerative procedures in endodontics. A recently proposed formulation aimed to enhance handling during clinical use with a versatile material applicable by syringe. Although, the use of bismuth oxide as radiopacifier and grey raw powder are drawbacks considering aesthetics. Read More

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October 2020

Micro-CT analysis of the marginal adaptation and porosity associated with ultrasonic activation of coronally placed tricalcium silicate-based cements.

Aust Endod J 2020 Dec 12;46(3):323-329. Epub 2020 Aug 12.

Faculty of Dentistry, Department of Endodontics, Baskent University, Ankara, Turkey.

This study aimed to evaluate the effect of ultrasonic activation on coronal marginal adaptation and microporosity of tricalcium silicate-based materials. Sixty freshly extracted human maxillary lateral incisor teeth were instrumented with ProTaper Next X2 files followed by Peeso-Reamer burs, sizes 1 to 5. The specimens were randomly divided into six groups (n = 10): Group 1, Biodentine + hand condensation; Group 2, Biodentine + ultrasonic activation; Group 3, NeoMTA Plus + hand condensation; Group 4, NeoMTA Plus + ultrasonic activation; Group 5, ProRoot WMTA + hand condensation; and Group 6, ProRoot WMTA + ultrasonic activation. Read More

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December 2020