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Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical presentations include acute liver failure or chronic liver failure with liver cirrhosis, which are cruelly progressive and fatal. We report six cases of LT for acute liver failure diagnosed pathogenic MPV17 variants. Read More

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September 2021

Direct immunofluorescence analysis of oral Tzanck smears for pemphigus vulgaris: A diagnostic test.

J Oral Pathol Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Background: Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune blistering disease. Direct immunofluorescence (DIF) is an important method for PV diagnosis, but oral tissue biopsy for DIF analysis is difficult to perform because of the fragile characteristics of oral mucosa. However, no well-designed diagnostic studies addressing the validity of DIF analysis of oral Tzanck smears for the diagnosis of PV exist. Read More

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September 2021

Recent improvement in survival outcomes and reappraisal of prognostic factors in pediatric living donor liver transplantation.

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Department of Pediatrics, Asan Medical Center Children's Hospital, University Ulsan College of Medicine, Seoul, Korea.

Background: Living donor liver transplantation (LDLT) is a significant advancement for the treatment of children with end-stage liver disease given the shortage of deceased donors. The ultimate goal of pediatric LT is to achieve complete donor safety and zero recipient mortality.

Methods: We conducted a retrospective, single center assessment of the outcomes as well as the clinical factors that may influence graft and patient survival after primary LDLTs conducted between 1994 and 2020. Read More

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September 2021

Efficacy and safety of immune checkpoint inhibitors in elderly patients (≥70 years) with squamous cell carcinoma of the head and neck.

Eur J Cancer 2021 Sep 15;157:190-197. Epub 2021 Sep 15.

Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Recent meta-analysis showed that immune checkpoint inhibitors (ICIs) have comparable activity between younger and older patients. However, little is known about efficacy and safety of ICI in elderly patients with relapsed/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). The aim of this study is to compare the efficacy of ICI for patients aged ≥70 y to that for younger patients, while taking into account potential confounding factors. Read More

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September 2021

Efficacy of needle aspiration in patients with oral-maxillofacial abscesses: A retrospective study of 15 consecutive patients.

Am J Otolaryngol 2021 Sep 11;43(1):103216. Epub 2021 Sep 11.

Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai, China; National Center for Stomatology, Shanghai, China; National Clinical Research Center for oral Diseases, Shanghai, China; Shanghai Key Laboratory of Stomatalogy, Shanghai, China. Electronic address:

The aim of this study was to determine the adequacy and safety of needle aspiration (NA) as an alternative to open surgical drainage for oral-maxillofacial abscesses. Fifteen consecutive patients who were diagnosed with oral-maxillofacial abscesses via contrast-enhanced CT from January 2020 to December 2020 were included. All patients were on antibiotics and treated with NA under local anaesthesia using a 20 mL syringe. Read More

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September 2021

Artificial intelligence-based hybrid deep learning models for image classification: The first narrative review.

Comput Biol Med 2021 Aug 27;137:104803. Epub 2021 Aug 27.

Stroke Diagnosis and Monitoring Division, AtheroPoint™, Roseville, CA, USA. Electronic address:

Background: Artificial intelligence (AI) has served humanity in many applications since its inception. Currently, it dominates the imaging field-in particular, image classification. The task of image classification became much easier with machine learning (ML) and subsequently got automated and more accurate by using deep learning (DL). Read More

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Psychiatric disorders, depression and quality of life in patients with psychogenic non-epileptic seizures and drug resistant epilepsy living in Argentina.

Seizure 2021 Sep 10;92:174-181. Epub 2021 Sep 10.

Universidad de Buenos Aires (UBA), Facultad de Medicina, IBCN (Instituto de Biología Celular y Neurociencias) - Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina (CONICET), Argentina; Universidad de Buenos Aires (UBA), Facultad de Medicina, Centro de Epilepsia del Hospital Ramos Mejía, Buenos Aires, Argentina. Electronic address:

Objectives: Psychiatric disorders are frequently found in both patients with PNES and DRE, making the differential diagnosis even more complex. The aim of this study was to analyze and compare psychiatric aspects and the quality of life in patients with psychogenic non-epileptic seizures (PNES) and drug resistant epilepsy (DRE).

Methods: Patients admitted to video-electroencephalograpy (VEEG) unit with confirmed PNES and DRE were included. Read More

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September 2021

Designing of various biosensor devices for determination of apoptosis: A comprehensive review.

Biochem Biophys Res Commun 2021 Sep 9;578:42-62. Epub 2021 Sep 9.

Hacettepe University, Institute of Science, Division of Bioengineering, Ankara, Turkey; Hacettepe University, Faculty of Science, Department of Chemistry, Ankara, Turkey. Electronic address:

Apoptosis is a type of cell death caused by the occurrence of both pathological and physiological conditions triggered by ligation of death receptors outside the cell or triggered by DNA damage and/or cytoskeleton disruption. Timely monitoring of apoptosis can effectively help early diagnosis of related diseases and continuous assessment of the effectiveness of drugs. Detecting caspases, a protease family closely related to cellular apoptosis, and its identification as markers of apoptosis is a popular procedure. Read More

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September 2021

Distinct phosphorylation profiles of tau in brains of patients with different tauopathies.

Neurobiol Aging 2021 Aug 21;108:72-79. Epub 2021 Aug 21.

Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Tokyo, Japan; Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan. Electronic address:

Tauopathies are neurodegenerative diseases that are characterized by pathological accumulation of tau protein. Tau is hyperphosphorylated in the brain of tauopathy patients, and this phosphorylation is proposed to play a role in disease development. However, it has been unclear whether phosphorylation is different among different tauopathies. Read More

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Predictors of Infarction in Tuberculous Meningitis in Indian Patients.

J Stroke Cerebrovasc Dis 2021 Sep 15;30(11):106088. Epub 2021 Sep 15.

Department OF Neurology, AIIMS, New Delhi. Electronic address:

Background: Stroke is a devastating complication of tuberculous meningitis (TBM) and is an important determinant of its outcome. We propose a model which would help to predict development of infarction or cerebrovascular events in patients of TBM.

Methods: A prospective study with n=129 patients of TBM were evaluated for predictors and outcomes of stroke. Read More

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September 2021

Neuromyelitis optica spectrum disorder (NMOSD) associated with cancer: A systematic review.

Mult Scler Relat Disord 2021 Aug 27;56:103227. Epub 2021 Aug 27.

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

NMOSD: is a disease shown to be highly associated with other diseases such as autoimmune diseases. There are a few reports of this association with cancer. So, this systematic review aimed to obtain a broad understanding on the cancers associated in NMOSD, including the source of common perceptions and assumptions in this regard. Read More

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Racial and ethnic disparities in treatment response and tolerability in multiple sclerosis: A comparative study.

Mult Scler Relat Disord 2021 Sep 9;56:103248. Epub 2021 Sep 9.

Division of Multiple Sclerosis and Neuroimmunology, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Inter-individual response and tolerability profiles associated with available disease-modifying treatments (DMTs) are an important aspect of the therapeutic decision-making process in multiple sclerosis (MS). In the absence of racially diverse clinical studies, the possible effect of race and ethnicity on treatment outcome remains uncertain. This study aims to compare disease outcome among Hispanic, Black, and White patients with MS, and assess the impact of race/ethnicity on long-term outcome. Read More

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September 2021

Locally advanced anorectal malignant melanoma in septuagenarian patient treated by laparoscopic abdominoperineal resection: A case report.

Int J Surg Case Rep 2021 Sep 6;87:106378. Epub 2021 Sep 6.

University of Tsukuba, Faculty of Medicine, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, 1-1-1 Tennnodai, Tsukuba-shi, Ibaraki-ken 305-8575, Japan. Electronic address:

Introduction: Anorectal malignant melanoma (ARMM) is a rare disease with a poor prognosis. In cases involving locally advanced disease, the treatment strategy is difficult, especially in octogenarian patients, because the prognosis is poor, despite the corresponding decrease or loss of the anal function.

Presentation Of Case: A 78-year-old woman was admitted to a local hospital with chief complaints of severe anal discomfort due to an egg-sized tumor that was protruding out of the anus and melena. Read More

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September 2021

Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19.

Int Immunopharmacol 2021 Sep 9;100:108127. Epub 2021 Sep 9.

Department of Biochemistry, Faculty of Medicine, Van Yuzuncu Yıl University, 65080-Van, Turkey. Electronic address:

Background: Early detection of oxidant-antioxidant levels and special care in severe patients are important in combating the COVID-19 epidemic. However, this process is costly and time consuming. Therefore, there is a need for faster, reliable and economical methods. Read More

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September 2021

Diagnosis of tuberculous pleural effusions: A review.

Respir Med 2021 Sep 6;188:106607. Epub 2021 Sep 6.

Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Tuberculous pleural effusion (TPE) is the second most common presentation of extrapulmonary tuberculosis. The paucibacillary nature of the effusion poses diagnostic challenges. Biomarkers like adenosine deaminase and interferon-γ have some utility for diagnosing TPEs, as do cartridge-based polymerase chain reaction (PCR) methods. Read More

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September 2021

Revisiting tuberculosis screening: An insight to complementary diagnosis and prospective molecular approaches for the recognition of the dormant TB infection in human and cattle hosts.

Angel H Alvarez

Microbiol Res 2021 Aug 26;252:126853. Epub 2021 Aug 26.

Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco A.C. (CIATEJ), Consejo Nacional de Ciencia y Tecnología (CONACYT), Av. Normalistas 800 C.P. 44270, Guadalajara, Jalisco, Mexico. Electronic address:

Tuberculosis (TB) is defined as a chronic infection in both human and cattle hosts and many subclinical cases remain undetected. After the pathogen is inhaled by a host, phagocyted bacilli can persist inside macrophages surviving intracellularly. Hosts develop granulomatous lesions in the lungs or lymph nodes, limiting infection. Read More

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In-depth learning of automatic segmentation of shoulder joint magnetic resonance images based on convolutional neural networks.

Comput Methods Programs Biomed 2021 Jul 31;211:106325. Epub 2021 Jul 31.

Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, 166 Yulong Road West, Tinghu District, China; The First People's Hospital of Yancheng, 166 Yulong Road West, Tinghu District, China.

Objective: Magnetic resonance imaging (MRI) is gradually replacing computed tomography (CT) in the examination of bones and joints. The accurate and automatic segmentation of the bone structure in the MRI of the shoulder joint is essential for the measurement and diagnosis of bone injuries and diseases. The existing bone segmentation algorithms cannot achieve automatic segmentation without any prior knowledge, and their versatility and accuracy are relatively low. Read More

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DR-MIL: deep represented multiple instance learning distinguishes COVID-19 from community-acquired pneumonia in CT images.

Comput Methods Programs Biomed 2021 Sep 9;211:106406. Epub 2021 Sep 9.

Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. Electronic address:

Background And Objective: Given that the novel coronavirus disease 2019 (COVID-19) has become a pandemic, a method to accurately distinguish COVID-19 from community-acquired pneumonia (CAP) is urgently needed. However, the spatial uncertainty and morphological diversity of COVID-19 lesions in the lungs, and subtle differences with respect to CAP, make differential diagnosis non-trivial.

Methods: We propose a deep represented multiple instance learning (DR-MIL) method to fulfill this task. Read More

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September 2021

Fusion of CNN1 and CNN2-based magnetic resonance image diagnosis of knee meniscus injury and a comparative analysis with computed tomography.

Comput Methods Programs Biomed 2021 Jul 22;211:106297. Epub 2021 Jul 22.

The first People's Hospital of Changzhou, China. Electronic address:

Purpose: We used convolutional neural network (CNN) technology to improve the accuracy of diagnosis of knee meniscus injury and shorten the diagnosis time.

Method: We propose a meniscus detection method based on Fusion of CNN1 and CNN2 (CNNf), which uses Magnetic Resonance Imaging (MRI) and Computer tomography (CT) to compare the diagnosis results, verifies the proposed method through 2460 images collected from 205 patients in the hospital. We used accuracy, sensitivity, specificity, receiver operating characteristics (ROC), and damage total rate to evaluate performance. Read More

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The Central Cord Score: A Novel Classification and Scoring System Specific to Acute Traumatic Central Cord Syndrome.

World Neurosurg 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, Banner University of Arizona Medical Center - Tucson, Tucson, AZ.

Background: Acute traumatic central cord syndrome (ATCCS) remains the most common form of spinal cord injury (SCI) in the United States. Its treatment remains controversial and is a consequence of ATCCS having an inherently different natural history from conventional SCI, thus requiring a separate classification system. We devised a novel Central Cord Score (CCscore) that both guides treatment and tracks improvement over time with symptoms specific to ATCCS. Read More

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September 2021

Comparative analysis of 5 inspection techniques for the application in the diagnosis and treatment of osteoarticular tuberculosis.

Int J Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Wuhan Pulmonary Hospital, Wuhan Institute for Tuberculosis Control, No. 28 Baofeng Road, Qiaokou District, Wuhan City, Hubei Province, China. Electronic address:

Objective: To evaluate 5 inspection techniques in the diagnosis and treatment of osteoarticular tuberculosis.

Methods: We collected the microbiological samples from a total of 284 patients during the period from August 2017 to December 2019 in Wuhan Pulmonary Hospital. The specimens were examined by AFB smear microscopy. Read More

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September 2021

The acute surgical unit: An updated systematic review and meta-analysis.

Int J Surg 2021 Sep 15:106109. Epub 2021 Sep 15.

Adelaide Medical School, University of Adelaide, Adelaide, Australia; Dept of Surgery, Royal Adelaide, Hospital, Adelaide, Australia. Electronic address:

Objective: To systematically review comparative studies on the acute surgical unit (ASU) model.

Methods: Searches were performed of Cochrane, Embase, Medline and grey literature. Eligible articles were comparative studies of the Acute Surgical Unit (ASU) model published 01/01/2000-12/03/2020. Read More

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September 2021

Ventricular Arrhythmias in Athletes: Role of a Comprehensive Diagnostic Workup.

Heart Rhythm 2021 Sep 15. Epub 2021 Sep 15.

Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Background: Ventricular arrhythmias (VAs) represent a critical issue concerning sports eligibility assessment in athletes. The ideal diagnostic evaluation of competitive and leisure-time athletes with complex VAs has not been clearly defined.

Objective: To assess the clinical implications of invasive electrophysiological assessments and endomyocardial biopsy (EMB) among athletes with VAs. Read More

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September 2021

Transfusion-related respiratory complications in intensive care: a diagnosis challenge.

Transfus Clin Biol 2021 Sep 15. Epub 2021 Sep 15.

Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

Transfusion-related respiratory complications can be challenging to diagnose especially in mechanically-ventilated patients in the intensive care unit (ICU) due to the concurrent respiratory symptoms associated with the patients' primary diagnoses. In this narrative review, transfusion-related respiratory complications, including transfusion-associated dyspnea (TAD), transfusion-related acute lung injury (TRALI), transfusion-associated circulatory overload (TACO), and transfusion-related allergic reaction (TRAR), are briefly presented in light of the recent consensus or experts' definitions; and the diagnosis issues for ICU patients are discussed. Acute respiratory failure occurring during, or within 6 to 24 hours, of transfusion might be a transfusion-related respiratory complication. Read More

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September 2021

Distress in a Pandemic - The Association of the Coronavirus Disease-2019 (COVID-19) Pandemic with Distress and Quality of Life in Hematopoietic Stem Cell Transplantation (HSCT).

Transplant Cell Ther 2021 Sep 15. Epub 2021 Sep 15.

Harvard Medical School, Boston MA; Massachusetts General Hospital, Boston MA.

Background: The global coronavirus disease 2019 (COVID-19) pandemic has drastically disrupted cancer care, potentially exacerbating patients' distress levels. Patients undergoing HSCT may be especially vulnerable to this pandemic stress. However, the associations of the COVID-19 pandemic with distress, fatigue, and QOL are not well understood in this population. Read More

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September 2021

Blood cell respiration rates and mtDNA copy number: a promising tool for the diagnosis of mitochondrial disease.

Mitochondrion 2021 Sep 15. Epub 2021 Sep 15.

Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Uruguay. Electronic address:

Human mitochondrial diseases are a group of heterogeneous diseases caused by defects in oxidative phosphorylation, due to mutations in mitochondrial (mtDNA) or nuclear DNA. The diagnosis of mitochondrial disease is challenging since mutations in multiple genes can affect mitochondrial function, there is considerable clinical variability and a poor correlation between genotype and phenotype. Herein we assessed mitochondrial function in peripheral blood mononuclear cells (PBMCs) and platelets from volunteers without known metabolic pathology and patients with mitochondrial disease. Read More

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September 2021

Pulmonary hypertension among children with in-hospital cardiac arrest: a multicenter study.

Resuscitation 2021 Sep 15. Epub 2021 Sep 15.

Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Aims: To determine the prevalence of pulmonary hypertension (PH) among children with in-hospital cardiac arrest (IHCA) and its association with survival.

Methods: Children (<18 years) admitted to ICUs participating in the Virtual Pediatric Systems multicenter registry between January 2011 and December 2017 who had an IHCA during their hospitalization were included. Patients were classified by whether they had a documented diagnosis of PH at the time of IHCA. Read More

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September 2021

A review of Liquid biopsy as a tool to assess Epigenetic, cfDNA and miRNA variability as Methotrexate response predictors in patients with Rheumatoid Arthritis.

Pharmacol Res 2021 Sep 15:105887. Epub 2021 Sep 15.

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, SA, Australia.

Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease affecting 0.5-1% of adults worldwide. Achieving long term remission or low disease activity is possible through early diagnosis, rapid initiation of disease modifying anti-rheumatic drugs (DMARDs) and implementation of a treat to target approach. Read More

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September 2021

Foundations of Osteoarthritis Section 3: Clinical Monitoring in OA Chapter 15: Biomarkers.

Osteoarthritis Cartilage 2021 Sep 15. Epub 2021 Sep 15.

Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark.

Objective: The purpose of this overview of osteoarthritis (OA) biomarkers is to provide the non-specialist with a toolbox, based on experience acquired by biomarker researchers over many years, to understand biomarkers in general and their use in the OA field.

Methods: We provide an update on this subject since the OARSI Primer on osteoarthritis (OA) nearly a decade ago.

Results: Since the last update, the importance of molecular biomarkers has been increasingly recognized in the field, but no OA-related biomarkers have been adopted for routine use in clinical practice. Read More

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September 2021

Eye-preserving therapies for advanced retinoblastoma: a multicenter cohort of 1678 patients in China.

Ophthalmology 2021 Sep 15. Epub 2021 Sep 15.

Department of Ophthalmology, Hainan Eye Hospital and Key laboratory of ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University.

Purpose: Multiple eye-preserving treatments have been widely used in China for the last 15 years, however, controversy remains on using eye-preserving therapies for advanced retinoblastoma (The International Intraocular Retinoblastoma Classification: groups D and E). This study attempts to estimate the impact of eye-preserving therapies for the long-term prognosis of advanced retinoblastoma with regard to overall survival and ocular salvage.

Design: A retrospective cohort study covering all 31 provinces (38 retinoblastoma treating centers) of Chinese mainland. Read More

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September 2021