312,708 results match your criteria signs inflammation

Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer.

Environ Int 2021 Sep 17;157:106873. Epub 2021 Sep 17.

ISGlobal, Barcelona, Spain; CIBER epidemiología y salud pública (CIBERESP), Madrid, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Background: Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water associated with colorectal cancer risk but mechanisms are not well understood.

Objectives: We explored the association between exposure to THMs and nitrate in drinking water and inflammation markers, and the link with colorectal cancer risk.

Methods: A subset of 198 colorectal cancer cases and 205 controls from the multicase-control study MCC-Spain were included. Read More

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September 2021

Liver cirrhosis.

Lancet 2021 Sep 17. Epub 2021 Sep 17.

Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C infection, autoimmune diseases, cholestatic diseases, and iron or copper overload. Cirrhosis develops after a long period of inflammation that results in replacement of the healthy liver parenchyma with fibrotic tissue and regenerative nodules, leading to portal hypertension. The disease evolves from an asymptomatic phase (compensated cirrhosis) to a symptomatic phase (decompensated cirrhosis), the complications of which often result in hospitalisation, impaired quality of life, and high mortality. Read More

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September 2021

Evaluation of neutrophil functional activity for rhinosinusitis diagnosis.

Klin Lab Diagn 2021 Sep;66(9):552-557

Penza Institute for Further Training of Physicians - Branch Campus of the Federal State Budgetary Educational Institution of Further Professional Education «Russian Medical Academy of Continuing Professional Education» of the Ministry of Healthcare of the Russian Federation.

Bacterial rhinosinusitis (BRS) is a complicated form of rhinosinusitis, characterized by its acute course and tendency to chronicity. A significant role in pathogenetic mechanisms of HRS is played by functional state of neutrophils responsible for inflammation development at HRS. Investigation of neutrophils metabolic activity on external stimuli by chemiluminescence method in patients with acute and chronic forms of the disease will enable to develop method of differential diagnostics of BRS forms. Read More

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September 2021

The Effectiveness of Ischemia Modified Albumin in Determining Acute Cholecystitis and its Severity.

Clin Lab 2021 Sep;67(9)

Background: Acute cholecystitis (AC) is caused by chemical and bacterial inflammation of the gallbladder. The use of Tokyo guidelines is recommended in determining the diagnosis of AC and its clinical severity. In the early stages of AC, many cytokines are secreted due to the local inflammatory cell activation, leading to exacerbation of inflammation and organ failure. Read More

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September 2021

Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients.

Breast Cancer Res Treat 2021 Sep 20. Epub 2021 Sep 20.

Department of Microbiology, and Immunology and Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, 621 Rubin Building-HB7936, 1 Medical Center Drive, Lebanon, NH, 03756, USA.

Purpose: This study evaluated epidemiologic and immune factors associated with pathologic complete response (pCR), breast cancer-specific survival (BCSS) and disease-free survival (DFS) outcomes in inflammatory (IBC) and locally advanced breast cancer (LABC) patients.

Methods: Tumor-infiltrating lymphocytes (TILs) and CD20 B-cell frequencies (CD20), and PD-L1 expression on tumor (PD-L1carcinoma cells) and immune (PD-L1TILs) cells were analyzed by immunohistochemistry along with clinicopathologic factors as modifiers of pCR and outcomes in 221 IBC and 162 LABC patients. Analysis included Kaplan-Meier curves and Cox proportional hazard models. Read More

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September 2021

Ketogenic diet aggravates colitis, impairs intestinal barrier and alters gut microbiota and metabolism in DSS-induced mice.

Food Funct 2021 Sep 20. Epub 2021 Sep 20.

State Key Laboratory for Diagnosis, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease with a high incidence. Multiple factors including dietary composition contribute to its occurrence. Recently, ketogenic diet which consists of a high proportion of fat and low carbohydrates has gained great popularity. Read More

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September 2021

Ocular involvement and complications of lichen planus, lichen planus pigmentosus, and lichen planopilaris: a comprehensive review.

Dermatol Ther 2021 Sep 19. Epub 2021 Sep 19.

Universidad Autónoma de Nuevo León, Rheumatology Service, University Hospital "Dr. José Eleuterio González", Monterrey, Nuevo León, México.

Ocular involvement of lichenoid dermatoses, such as lichen planus (LP), lichen planus pigmentosus (LPP), and lichen planopilaris (LPL), although uncommon, is associated with skin manifestations. Isolated ocular involvement is very rare. When lesions are confined to the skin, the dermatologist inquires and evaluates for oral and genital symptoms and lesions, respectively; hence, eye manifestations are commonly neglected by the non-ophthalmologist. Read More

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September 2021

A triple-blind, placebo-controlled, randomized clinical trial to evaluate the effect of curcumin-containing nanomicelles on cellular immune responses subtypes and clinical outcome in COVID-19 patients.

Phytother Res 2021 Sep 19. Epub 2021 Sep 19.

Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

In COVID-19 patients, cytokine storm due to excessive immune responses can cause severe complications. In this study, we investigated the effect of curcumin nanomicelles on clinical outcome and cellular immune responses subtypes changes in COVID-19 patients. A randomized, triple-blinded, placebo-controlled study was done. Read More

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September 2021

Actinomyces Infection Mimicking Esophageal Cancer.

Cureus 2021 Aug 17;13(8):e17266. Epub 2021 Aug 17.

Surgery, Conemaugh Memorial Medical Center, Johnstown, USA.

Actinomycosis is a bacterial infection, which rarely affects the esophagus. Our patient presented with persistent acute blood loss anemia and epigastric pain despite previously negative upper endoscopy. He underwent repeat endoscopy a few months later showing what was thought to be malignant esophageal cancer at the gastroesophageal junction; however, the biopsy report revealed chronic inflammation with actinomycosis. Read More

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A Functional Variant of CXCL16 Is Associated With Predisposition to Sepsis and MODS in Trauma Patients: Genetic Association Studies.

Front Genet 2021 3;12:720313. Epub 2021 Sep 3.

Department of Trauma Medical Center, Daping Hospital, Army Medical University, Chongqing, China.

Purpose: CXC chemokines are mediators which mediate immune cells migration to sites of inflammation and injury. Chemokine C-X-C motif ligand 16 (CXCL16) plays an important role in the occurrence and development of sepsis through leukocyte chemotaxis, leukocyte adhesion and endotoxin clearance. In this study, we selected a set of tagging single nucleotide polymorphisms (tag SNPs) in the CXCL16 gene and investigated their clinical relevance to the development of sepsis and multiple organ dysfunction syndrome (MODS) in patients with major trauma in three independent Chinese Han populations. Read More

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September 2021

Targeting the Interleukin-23/Interleukin-17 Inflammatory Pathway: Successes and Failures in the Treatment of Axial Spondyloarthritis.

Front Immunol 2021 3;12:715510. Epub 2021 Sep 3.

Department of Medicine, University of Alberta, Edmonton, AB, Canada.

The IL-23/IL-17 pathway has been implicated in the etiopathogenesis of axial spondyloarthritis through studies of genetic polymorphisms associated with disease, an animal model with over-expression of IL-23 that resembles human disease, and observations that cytokines in this pathway can be found at the site of disease in both humans and animal models. However, the most direct evidence has emerged from clinical trials of agents targeting cytokines in this pathway. Monoclonal antibodies targeting IL-17A have been shown to ameliorate signs and symptoms, as well as MRI inflammation in the spine and sacroiliac joints, in patients with radiographic and non-radiographic axial spondyloarthritis. Read More

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September 2021

Effective Antidepressant Chronotherapeutics (Sleep Deprivation and Light Therapy) Normalize the IL-1β:IL-1ra Ratio in Bipolar Depression.

Front Physiol 2021 1;12:740686. Epub 2021 Sep 1.

Vita-Salute San Raffaele University, Milan, Italy.

Background: Mood disorders associate with peripheral markers of low-grade inflammation, among which circulating levels of interleukin-1β (IL-1β) consistently predict diagnosis and poor outcomes. Antidepressant chronotherapeutics (total sleep deprivation and light therapy, TSD+LT) prompts response in drug-resistant bipolar depression, but its effect on peripheral inflammation were never assessed. Here we explored the effects of TSD+LT on IL-1β signaling. Read More

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September 2021

The Association Between Risk Factors for Metabolic Syndrome and Meibomian Gland Disease in a Dry Eye Cohort.

Clin Ophthalmol 2021 11;15:3821-3832. Epub 2021 Sep 11.

Department of Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Purpose: Risk factors for metabolic syndrome include abdominal obesity, insulin resistance, hypertension, high triglycerides and/or low high-density lipoprotein cholesterol, and hyperglycemia. Risk factors for metabolic syndrome have been associated with dry eye disease; however, their association with meibomian gland disease (MGD), a subtype of dry eye, is unclear. In the present study, we investigated risk factors for metabolic syndrome in a dry eye cohort with and without MGD. Read More

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September 2021

Intestinal ischemic manifestations of SARS-CoV-2: Results from the ABDOCOVID multicentre study.

World J Gastroenterol 2021 Aug;27(32):5448-5459

Department of Gastroenterology and Endoscopy, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20122, Italy.

Background: Intestinal ischemia has been described in case reports of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (coronavirus disease 19, COVID-19).

Aim: To define the clinical and histological, characteristics, as well as the outcome of ischemic gastrointestinal manifestations of SARS-CoV-2 infection.

Methods: A structured retrospective collection was promoted among three tertiary referral centres during the first wave of the pandemic in northern Italy. Read More

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Artificial intelligence application in diagnostic gastrointestinal endoscopy - Deus ex machina?

World J Gastroenterol 2021 Aug;27(32):5351-5361

Department of Gastroenterology, Hospital Prof. Dr Fernando Fonseca, Lisbon 2720-276, Portugal.

The close relationship of medicine with technology and the particular interest in this symbiosis in recent years has led to the development of several computed artificial intelligence (AI) systems aimed at various areas of medicine. A number of studies have demonstrated that those systems allow accurate diagnoses with histological precision, thus facilitating decision-making by clinicians in real time. In the field of gastroenterology, AI has been applied in the diagnosis of pathologies of the entire digestive tract and their attached glands, and are increasingly accepted for the detection of colorectal polyps and confirming their histological classification. Read More

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Hematospermia Etiology, Diagnosis, Treatment, and Sexual Ramifications: A Narrative Review.

Sex Med Rev 2021 Sep 16. Epub 2021 Sep 16.

Tulane University School of Medicine, Department of Urology, New Orleans, LA, USA. Electronic address:

Introduction: Hematospermia (HS) is the presence of blood in ejaculatory fluid. It is a rare condition that is historically idiopathic or associated with sexual behavior. Technological advances have identified many of the etiologies behind HS, improving treatment. Read More

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September 2021

Hidden in plain sight: Is there a crucial role for enthesitis assessment in the treatment and monitoring of axial spondyloarthritis?

Semin Arthritis Rheum 2021 Jul 9;51(6):1147-1161. Epub 2021 Jul 9.

Department of Rheumatology, Centre for Adolescent Rheumatology Versus Arthritis, Department of Medicine, University College London, Rayne Building, London, United Kingdom.

Objective: To review the evidence surrounding the pathophysiology of enthesitis in axial spondyloarthritis (axSpA), its prevalence and contribution to the overall disease burden, and response to treatment at axial and peripheral sites.

Methods: Literature searches of the Cochrane Library, PubMed, and Embase / Medline using the terms "enthesitis", "enthesopathy", "spondyloarthritis", "axial spondyloarthritis", and "ankylosing spondylitis" were conducted. Publications mentioning enthesitis or enthesopathy in the context of pathophysiology, diagnosis, or treatment were included. Read More

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Population screening for liver fibrosis: towards early diagnosis and intervention for chronic liver diseases.

Hepatology 2021 Sep 19. Epub 2021 Sep 19.

Centre for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, and Institute for Clinical Research, University of Southern Denmark Odense, Denmark.

Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), although chronic hepatitis B and C infections are still major etiological factors in some areas of the world. Recent studies have shown that liver fibrosis can be assessed with relatively high accuracy non-invasively by serological tests, transient elastography, and radiological methods. Read More

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September 2021

The spectrum and differential diagnosis of acquired ocular motor nerve palsies: a clinical study of 502 patients.

J Neurol 2021 Sep 19. Epub 2021 Sep 19.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

Background: Ocular motor nerve palsies (OMNP) frequently cause patients to present in an emergency room. In the following study, we report the differential diagnosis of OMNP by use of magnetic resonance imaging (MRI) and CSF examination as a standard.

Method: We performed a data analysis of N = 502 patients who presented with oculomotor, trochlear, and/or abducens nerve palsy in the emergency room of the Department of Neurology, University of Ulm, between January 2006 and December 2019. Read More

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September 2021

Diagnostic tests based on pattern formation in drying body fluids - A mapping review.

Colloids Surf B Biointerfaces 2021 Sep 1;208:112092. Epub 2021 Sep 1.

Society for Cancer Research, 4144, Arlesheim, Switzerland; Institute for Integrative Medicine, University of Witten/Herdecke, Herdecke, Germany; University of Bern, Institute of Complementary and Integrative Medicine, Bern, Switzerland.

There are numerous diagnostic tests based on pattern formation in desiccating body fluids, where the pattern or some of its characteristics constitute the diagnostic test outcome. However, partially due to the development in different time periods, and partially due to publications in languages different from English, most of these diagnostic tests exist as separate approaches and have never been grouped, systematized, nor compared with each other. In the present mapping review, we performed a wide literature search with the aim to collect all diagnostic tests based on pattern formation in desiccating body fluids. Read More

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September 2021

First detection and phylogenetic analysis of porcine circovirus 3 in female donkeys with reproductive disorders.

BMC Vet Res 2021 Sep 18;17(1):308. Epub 2021 Sep 18.

Research Institute of Donkey High-efficiency Breeding and Ecological Feeding, College of Agronomy, Liaocheng University, Liaocheng, China.

Background: PCV3 is a pathogen associated with porcine dermatitis and nephropathy syndrome (PDNS)-like clinical signs, reproductive failure, and cardiac and multiorgan inflammation, which was newly identified in 2016 in sows in USA. Recently, PCV3 has also been identified from several non-porcine species like (cattle, dog, wild boar, deer, mice and ticks). However, PCV3 infection in donkey is not well established. Read More

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September 2021

Central neuroinflammation in Covid-19: a systematic review of 182 cases with encephalitis, acute disseminated encephalomyelitis, and necrotizing encephalopathies.

Rev Neurosci 2021 Sep 17. Epub 2021 Sep 17.

Research Center for Immunodeficiencies, Tehran University of Medical Sciences (TUMS), Children's Medical Center Hospital, Dr. Qarib St., Keshavarz Blvd, Tehran, 14194, Iran.

Growing evidence demonstrates the association of encephalitis, meningoencephalitis or encephalomyelitis, with SARS-CoV-2 infection. This study aims to determine the profile and possible mechanisms behind CNS inflammatory diseases in the context of Covid-19. We conducted a systematic review of case reports on Covid-19-related encephalitis, meningoencephalitis, acute necrotizing encephalitis, and acute disseminated encephalomyelitis in adults, published before January 2021. Read More

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September 2021

The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy 2021 Sep 18. Epub 2021 Sep 18.

Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Service d'allergie, Québec, QC, Canada.

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. Read More

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September 2021

The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!

Clin Rev Allergy Immunol 2021 Sep 18. Epub 2021 Sep 18.

Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.

Immunoglobulin E (IgE) is a well-known key factor in allergic airway disease; however, its central role in non-allergic airway inflammation is often underestimated. In some airway diseases, IgE is produced as a result of allergic sensitization. However, in others, IgE production occurs despite the lack of a specific allergen. Read More

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September 2021

Acute myocarditis after COVID-19 vaccination with mRNA-1273 in a patient with former SARS-CoV-2 infection.

ESC Heart Fail 2021 Sep 18. Epub 2021 Sep 18.

Department of Medicine I, Jena University Hospital, Friedrich Schiller University Jena, Am Klinikum 1, Jena, 07747, Germany.

We describe a case of a 20-year-old healthy man developing chest pain and classical symptoms of vaccine reactogenicity 12 h after receiving the first dose of mRNA-1273 (Moderna). Cardiac troponin T was increased, and subepicardial inflammation and focal contractile dysfunction were detected by cardiac magnetic resonance imaging and echocardiography. We confirmed the diagnosis of acute myocarditis by endomyocardial biopsy demonstrating significant infiltration of monocytes and T lymphocytes. Read More

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September 2021

Genome-Wide Association Study of NAFLD Using Electronic Health Records.

Hepatol Commun 2021 Sep 17. Epub 2021 Sep 17.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edingburgh, Scotland.

Genome-wide association studies (GWAS) have identified several risk loci for nonalcoholic fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and have assessed quantitative traits. We performed a case-control GWAS in the UK Biobank using recorded diagnosis of NAFLD based on diagnostic codes recommended in recent consensus guidelines. Read More

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September 2021

What is the precaecocolic fascia?

Clin Anat 2021 Sep 18. Epub 2021 Sep 18.

Anatomy Facility, School of Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Introduction: The precaecocolic fascia, previously known as Jackson's membrane, is a variable vascular peritoneal fold between the ascending colon and the right posterolateral abdominal wall. First described in 1913, it was originally thought to be of developmental or inflammatory origin and associated with abdominal pain. This investigation aimed to review its frequency, form and structure and look for evidence of association with malformation of the bowel, or previous inflammation. Read More

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September 2021

Laparoscopic ovariohysterectomy for dogs under 5 kg body weight.

Tokio Matsunami

Vet Surg 2021 Sep 17. Epub 2021 Sep 17.

Matsunami Animal Medical Center, Nagoya, Japan.

Objective: To describe the surgical method, operative time, safety, and usefulness of 3-port laparoscopic ovariohysterectomy (LOHE) using an ultrasonic coagulation and incision device in dogs <5 kg.

Study Design: Retrospective study.

Animals: Female dogs (n = 147). Read More

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September 2021

Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model.

Int J Cardiovasc Imaging 2021 Sep 18. Epub 2021 Sep 18.

Cardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.

Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Read More

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September 2021

Delirium and neuropsychological outcomes in critically Ill patients with COVID-19: a cohort study.

BMJ Open 2021 Sep 17;11(9):e050045. Epub 2021 Sep 17.

Anesthesiology, Michigan Medicine, Ann Arbor, Michigan, USA

Objective: To characterise the clinical course of delirium for patients with COVID-19 in the intensive care unit, including postdischarge neuropsychological outcomes.

Design: Retrospective chart review and prospective survey study.

Setting: Intensive care units, large academic tertiary-care centre (USA). Read More

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September 2021