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Computed Tomography-Based Radiomics Nomogram: Potential to Predict Local Recurrence of Gastric Cancer After Radical Resection.

Front Oncol 2021 2;11:638362. Epub 2021 Sep 2.

Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Objective: Accurate prediction of postoperative recurrence risk of gastric cancer (GC) is critical for individualized precision therapy. We aimed to investigate whether a computed tomography (CT)-based radiomics nomogram can be used as a tool for predicting the local recurrence (LR) of GC after radical resection.

Materials And Methods: 342 patients (194 in the training cohort, 78 in the internal validation cohort, and 70 in the external validation cohort) with pathologically proven GC from two centers were included. Read More

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September 2021

Circ-SFMBT2 drives the malignant phenotypes of esophageal cancer by the miR-107-dependent regulation of SLC1A5.

Cancer Cell Int 2021 Sep 16;21(1):495. Epub 2021 Sep 16.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe East Road, Erqi District, Zhengzhou, Henan, 450052, People's Republic of China.

Background: Increasing studies focused on the regulatory roles of circular RNAs (circRNAs) in diverse cancers. This study was to evaluate the function and mechanism of circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) in esophageal cancer (EC).

Methods: The circ-SFMBT2, microRNA-107 (miR-107) and solute-linked carrier family A1 member 5 (SLC1A5) levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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September 2021

Segregation on the nanoscale coupled to liquid water polyamorphism in supercooled aqueous ionic-liquid solution.

J Chem Phys 2021 Sep;155(10):104502

Department of Physical and Chemical Sciences, University of L'Aquila, via Vetoio (Coppito 1), 67010 L'Aquila, Italy.

The most intriguing hypothesis explaining many water anomalies is a metastable liquid-liquid phase transition (LLPT) at high pressure and low temperatures, experimentally hidden by homogeneous nucleation. Recent infrared spectroscopic experiments showed that upon addition of hydrazinium trifluoroacetate to water, the supercooled ionic solution undergoes a sharp, reversible LLPT at ambient pressure, possible offspring of that in pure water. Here, we calculate the temperature-dependent signature of the OH-stretching band, reporting on the low/high density phase of water, in neat water and in the same experimentally investigated ionic solution. Read More

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September 2021

Experimental demonstration of a broadband optoelectronic chaos system based on highly nonlinear configuration of IQ modulator.

Opt Lett 2021 Sep;46(18):4654-4657

We experimentally investigated a novel broadband optoelectronic chaos generation scheme. The proposed system is achieved by adopting the highly nonlinear operation of an electro-optical exclusive-NOR (XNOR) logic gate and two delayed feedback loops that refer to the Boolean chaos model. The XNOR gate is established by a commercial use inphase and quadrature-phase (IQ) modulator that works at a specific bias point. Read More

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September 2021

Mammography-based radiomics for predicting the risk of breast cancer recurrence: a multicenter study.

Br J Radiol 2021 Sep 14:20210348. Epub 2021 Sep 14.

Department of Radiology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China.

Objective: This study aimed to establish a mammography-based radiomics model for predicting the risk of estrogen receptor (ER)-positive, lymph node (LN)-negative invasive breast cancer recurrence based on Oncotype DX and validated it by using multicenter data.

Methods: A total of 304 potentially eligible patients with pre-operative mammography images and available Oncotype DX score were retrospectively enrolled from two hospitals. The patients were grouped as training set (168 patients), internal test set (72 patients), and external test set (64 patients). Read More

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September 2021

Quantitative image features from radiomic biopsy differentiate oncocytoma from chromophobe renal cell carcinoma.

J Med Imaging (Bellingham) 2021 Sep 7;8(5):054501. Epub 2021 Sep 7.

Mayo Clinic Arizona, Department of Radiology, Phoenix, Arizona, United States.

: To differentiate oncocytoma and chromophobe renal cell carcinoma (RCC) using radiomics features computed from spherical samples of image regions of interest, "radiomic biopsies" (RBs). : In a retrospective cohort study of 102 CT cases [68 males (67%), 34 females (33%); mean age ± SD, ], we pathology-confirmed 42 oncocytomas (41%) and 60 chromophobes (59%). A board-certified radiologist performed two RB rounds. Read More

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September 2021

Ferroptosis-related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma.

Cancer Sci 2021 Sep 10. Epub 2021 Sep 10.

Department of Orthopedic Surgery, Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Xiangya Hospital, Central South University, Changsha, 410008, China.

Osteosarcoma has been the most common malignant bone tumor in children and adolescent, while the 5-year survival of osteosarcoma patients gained no significant improvement over the past decades. This study aims to explore the role of ferroptosis-related genes (FRGs) in the development and prognosis of osteosarcoma. The datasets of osteosarcoma patients including RNA sequencing data and clinical information were acquired from the TRGET and GEO databases. Read More

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September 2021

A Novel Intercellular Communication-Associated Gene Signature for Prognostic Prediction and Clinical Value in Patients With Lung Adenocarcinoma.

Front Genet 2021 23;12:702424. Epub 2021 Aug 23.

Department of Blood Transfusion, The Third Xiangya Hospital of Central South University, Changsha, China.

Background: Lung cancer remains the leading cause of cancer death globally, with lung adenocarcinoma (LUAD) being its most prevalent subtype. This study aimed to identify the key intercellular communication-associated genes (ICAGs) in LUAD.

Methods: Eight publicly available datasets were downloaded from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Read More

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Decoding of Electroencephalogram Signals Shows No Evidence of a Neural Signature for Subitizing in Sequential Numerosity.

J Cogn Neurosci 2021 Jul;33(8):1535-1548

University of Massachusetts, Amherst.

Numerosity perception is largely governed by two mechanisms. The first so-called subitizing system allows one to enumerate a small number of items (up to three or four) without error. The second system allows only an approximate estimation of larger numerosities. Read More

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RISC in Entamoeba histolytica: Identification of a Protein-Protein Interaction Network for the RNA Interference Pathway in a Deep-Branching Eukaryote.

mBio 2021 Sep 7:e0154021. Epub 2021 Sep 7.

Division of Infectious Diseases, Department of Internal Medicine, Stanford Universitygrid.168010.e School of Medicine, Stanford, California, USA.

Entamoeba histolytica is a protozoan parasite that causes amebiasis in humans and is a major health concern in developing countries. Our previous work revealed a functional RNA interference (RNAi) pathway in . Several unusual features encompass the RNAi pathway in the parasite, including small RNAs (sRNAs) with a 5'-polyphosphate structure (identified to date only in and nematodes) and the conspicuous absence of a canonical Dicer enzyme. Read More

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September 2021

Spleen Radiomics Signature: A Potential Biomarker for Prediction of Early and Late Recurrences of Hepatocellular Carcinoma After Resection.

Front Oncol 2021 13;11:716849. Epub 2021 Aug 13.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Objectives: To explore the usefulness of spleen radiomics features based on contrast-enhanced computed tomography (CECT) in predicting early and late recurrences of hepatocellular carcinoma (HCC) patients after curative resection.

Methods: This retrospective study included 237 HCC patients who underwent CECT and curative resection between January 2006 to January 2016. Radiomic features were extracted from CECT images, and then the spleen radiomics signatures and the tumor radiomics signatures were built. Read More

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Radiomic Score as a Potential Imaging Biomarker for Predicting Survival in Patients With Cervical Cancer.

Front Oncol 2021 16;11:706043. Epub 2021 Aug 16.

Department of Radiology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Objectives: Accurate prediction of prognosis will help adjust or optimize the treatment of cervical cancer and benefit the patients. We aimed to investigate the incremental value of radiomics when added to the FIGO stage in predicting overall survival (OS) in patients with cervical cancer.

Methods: This retrospective study included 106 patients with cervical cancer (FIGO stage IB1-IVa) between October 2017 and May 2019. Read More

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Predicting Drug-Induced Liver Injury Using Machine Learning on a Diverse Set of Predictors.

Front Pharmacol 2021 18;12:648805. Epub 2021 Aug 18.

Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND, United States.

A major challenge in drug development is safety and toxicity concerns due to drug side effects. One such side effect, drug-induced liver injury (DILI), is considered a primary factor in regulatory clearance. The Critical Assessment of Massive Data Analysis (CAMDA) 2020 CMap Drug Safety Challenge goal was to develop prediction models based on gene perturbation of six preselected cell-lines (CMap L1000), extended structural information (MOLD2), toxicity data (TOX21), and FDA reporting of adverse events (FAERS). Read More

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Piquerism in homicide: A knife wound analysis of a sexually motivated serial killer.

Mark Pettigrew

J Forensic Sci 2021 Sep 4. Epub 2021 Sep 4.

Arden University, Coventry, UK.

As part of a wider research project into paraphilic disorders and homicide, a case is presented of a piquerist who achieved sexual satisfaction through the infliction of stabbing wounds. Against a background of sexual domination with willing and unwilling sexual partners, the offender stabbed four men to death. A study of the resulting autopsy reports, in association with the offender's testimony and crime scene documentation, was undertaken to discern a piquerist crime scene signature. Read More

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September 2021

Review on target domains and natural compound-based inhibitors of fatty acid synthase for anticancer drug discovery.

Chem Biol Drug Des 2021 Aug 30. Epub 2021 Aug 30.

Department of Pharmacy, Birla Institute of Technology and Science (BITS)-Pilani, Hyderabad, India.

Cancer cells require a higher amount of energy in the form of fatty acids for their uncontrolled proliferation and growth. Fatty acid synthase (FASN) plays a crucial role in the synthesis of palmitate, which is involved in most of the critical malignant pathways. Hence, by targeting FASN, tumour growth can be controlled. Read More

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An Automatic Deep Learning-Based Workflow for Glioblastoma Survival Prediction Using Preoperative Multimodal MR Images: A Feasibility Study.

Adv Radiat Oncol 2021 Sep-Oct;6(5):100746. Epub 2021 Jul 1.

Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Purpose: Most radiomic studies use the features extracted from the manually drawn tumor contours for classification or survival prediction. However, large interobserver segmentation variations lead to inconsistent features and hence introduce more challenges in constructing robust prediction models. Here, we proposed an automatic workflow for glioblastoma (GBM) survival prediction based on multimodal magnetic resonance (MR) images. Read More

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Insights into the aggregation mechanism of RNA recognition motif domains in TDP-43: a theoretical exploration.

R Soc Open Sci 2021 Aug 18;8(8):210160. Epub 2021 Aug 18.

Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.

The transactive response DNA-binding protein 43 (TDP-43) is associated with several diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) due to pathogenic aggregations. In this work, we examined the dimer, tetramer and hexamer models built from the RRM domains of TDP-43 using molecular dynamics simulations in combination with the protein-protein docking. Our results showed that the formations of the dimer models are mainly achieved by the interactions of the RRM1 domains. Read More

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Privacy-Preserving and Lightweight Selective Aggregation with Fault-Tolerance for Edge Computing-Enhanced IoT.

Sensors (Basel) 2021 Aug 9;21(16). Epub 2021 Aug 9.

Key Laboratory of Communication and Information Systems, School of Electronic Information Engineering, Beijing Jiaotong University, Beijing 100044, China.

Edge computing has been introduced to the Internet of Things (IoT) to meet the requirements of IoT applications. At the same time, data aggregation is widely used in data processing to reduce the communication overhead and energy consumption in IoT. Most existing schemes aggregate the overall data without filtering. Read More

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Detection of soluble biomarkers of pancreatic cancer in endoscopic ultrasound-guided fine-needle aspiration samples.

Endoscopy 2021 Aug 26. Epub 2021 Aug 26.

Tumor Microenvironment and Resistance-to-Treatment Laboratory, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Montpellier, France.

Background:  Biomarkers are urgently needed for pancreatic ductal adenocarcinoma (PDAC). Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the cornerstone for diagnosing PDAC. We developed a method for discovery of PDAC biomarkers using the discarded EUS-FNA liquid. Read More

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Platinum resistance in gynecologic malignancies: Response, disease free and overall survival are predicted by biochemical signature: A metabolomic analysis.

Gynecol Oncol 2021 Aug 23. Epub 2021 Aug 23.

Nagourney Cancer Institute, 750 East 29th Street, 90806 Long Beach, CA, USA; Metabolomycs, Inc., 750 East 29th Street, 90806 Long Beach, CA, USA; Memorial Medical Center of Long Beach, Todd Cancer Institute, 2810 Long Beach Blvd, Long Beach 90806, CA, USA; Department of Obstetrics and Gynecology, University of California Irvine (UCI) School of Medicine, 101 The City Drive South, Orange 92868, CA, USA.

Objective: Platinum resistance, defined as the lack of response or relapse within six months of platinum-based chemotherapy, is an important determinant of survival in gynecologic cancer. We used quantitative Mass Spectrometry to identify metabolic signatures that predict platinum resistance in patients receiving chemotherapy for gynecologic cancers.

Methods: In this study 47 patients with adenocarcinoma of the ovary or uterus who were candidates for carboplatin plus paclitaxel submitted blood for quantitation of metabolites and surgical specimens for the isolation 3-dimensional organoids used to measure individual patient platinum resistance, ex vivo. Read More

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Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast.

Int J Mol Sci 2021 Aug 9;22(16). Epub 2021 Aug 9.

Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.

Optogenetic switches allow light-controlled gene expression with reversible and spatiotemporal resolution. In , optogenetic tools hold great potential for a variety of metabolic engineering and biotechnology applications. In this work, we report on the modular optimization of the fungal light-oxygen-voltage (FUN-LOV) system, an optogenetic switch based on photoreceptors from the fungus . Read More

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Building Pluripotency Identity in the Early Embryo and Derived Stem Cells.

Cells 2021 Aug 10;10(8). Epub 2021 Aug 10.

Laboratory of Developmental Biology, Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.

The fusion of two highly differentiated cells, an oocyte with a spermatozoon, gives rise to the zygote, a single totipotent cell, which has the capability to develop into a complete, fully functional organism. Then, as development proceeds, a series of programmed cell divisions occur whereby the arising cells progressively acquire their own cellular and molecular identity, and totipotency narrows until when pluripotency is achieved. The path towards pluripotency involves transcriptome modulation, remodeling of the chromatin epigenetic landscape to which external modulators contribute. Read More

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Prediction of acute coronary syndrome within 3 years using radiomics signature of pericoronary adipose tissue based on coronary computed tomography angiography.

Eur Radiol 2021 Aug 25. Epub 2021 Aug 25.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

Objectives: To evaluate whether radiomics signature of pericoronary adipose tissue (PCAT) based on coronary computed tomography angiography (CCTA) could improve the prediction of future acute coronary syndrome (ACS) within 3 years.

Methods: We designed a retrospective case-control study that patients with ACS (n = 90) were well matched to patients with no cardiac events (n = 1496) during 3 years follow-up, then which were randomly divided into training and test datasets with a ratio of 3:1. A total of 107 radiomics features were extracted from PCAT surrounding lesions and 14 conventional plaque characteristics were analyzed. Read More

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Lipid-based and protein-based interactions synergize transmembrane signaling stimulated by antigen clustering of IgE receptors.

Proc Natl Acad Sci U S A 2021 Aug;118(35)

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853

Antigen (Ag) crosslinking of immunoglobulin E-receptor (IgE-FcεRI) complexes in mast cells stimulates transmembrane (TM) signaling, requiring phosphorylation of the clustered FcεRI by lipid-anchored Lyn tyrosine kinase. Previous studies showed that this stimulated coupling between Lyn and FcεRI occurs in liquid ordered (Lo)-like nanodomains of the plasma membrane and that Lyn binds directly to cytosolic segments of FcεRI that it initially phosphorylates for amplified activity. Net phosphorylation above a nonfunctional threshold is achieved in the stimulated state but not in the resting state, and current evidence supports the hypothesis that this relies on Ag crosslinking to disrupt a balance between Lyn and tyrosine phosphatase activities. Read More

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Discovery and validation of a three-gene signature to distinguish COVID-19 and other viral infections in emergency infectious disease presentations: a case-control and observational cohort study.

Lancet Microbe 2021 Aug 16. Epub 2021 Aug 16.

Department of Infectious Disease, Imperial College London, London, UK.

Background: Emergency admissions for infection often lack initial diagnostic certainty. COVID-19 has highlighted a need for novel diagnostic approaches to indicate likelihood of viral infection in a pandemic setting. We aimed to derive and validate a blood transcriptional signature to detect viral infections, including COVID-19, among adults with suspected infection who presented to the emergency department. Read More

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A differential subcellular localization of two copper transporters from the COPT family suggests distinct roles in copper homeostasis in Physcomitrium patens.

Plant Physiol Biochem 2021 Aug 13;167:459-469. Epub 2021 Aug 13.

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Cuernavaca, Morelos, 62210, Mexico. Electronic address:

The moss Physcomitrium (Physcomitrella) patens is a bryophyte that provides genetic information about the adaptation to the life on land by early Embryophytes and is a reference organism for comparative evolutionary studies in plants. Copper is an essential micronutrient for every living organism, its transport across the plasma membrane is achieved by the copper transport protein family COPT/CTR. Two genes related to the COPT family were identified in Physcomitrella patens, PpaCOPT1 and PpaCOPT2. Read More

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Molecular remission at T cell level in patients with rheumatoid arthritis.

Sci Rep 2021 Aug 17;11(1):16691. Epub 2021 Aug 17.

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

While numerous disease-modifying anti-rheumatic drugs (DMARDs) have brought about a dramatic paradigm shift in the management of rheumatoid arthritis (RA), unmet needs remain, such as the small proportion of patients who achieve drug-free status. The aim of this study was to explore key molecules for remission at the T cell level, which are known to be deeply involved in RA pathogenesis, and investigate the disease course of patients who achieved molecular remission (MR). We enrolled a total of 46 patients with RA and 10 healthy controls (HCs). Read More

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Computational study for identifying promising therapeutic agents of hydroxychloroquine analogues against SARS-CoV-2.

J Biomol Struct Dyn 2021 Aug 16:1-15. Epub 2021 Aug 16.

Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, India.

Hydroxychloroquine (HCQ) and its derivatives have recently gained tremendous attention as a probable medicinal agent in the COVID-19 outbreak caused by SARS-CoV-2. An efficient agent to act directly in inhibiting the SARS-CoV-2 replication is yet to be achieved. Thus, the goal is to investigate the dynamic nature of HCQ derivatives against SARS-CoV-2 main protease and spike proteins. Read More

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Non-small cell lung carcinoma histopathological subtype phenotyping using high-dimensional multinomial multiclass CT radiomics signature.

Comput Biol Med 2021 Sep 8;136:104752. Epub 2021 Aug 8.

Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211 Geneva 4, Switzerland; Geneva University Neurocenter, Geneva University, Geneva, Switzerland; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands; Department of Nuclear Medicine, University of Southern Denmark, Odense, Denmark. Electronic address:

Objective: The aim of this study was to identify the most important features and assess their discriminative power in the classification of the subtypes of NSCLC.

Methods: This study involved 354 pathologically proven NSCLC patients including 134 squamous cell carcinoma (SCC), 110 large cell carcinoma (LCC), 62 not other specified (NOS), and 48 adenocarcinoma (ADC). In total, 1433 radiomics features were extracted from 3D volumes of interest drawn on the malignant lesion identified on CT images. Read More

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September 2021

An examination of handwritten signatures forged using photosensitive signature stamp.

Zhen Li Xinlai Liu

Forensic Sci Res 2021 3;6(2):168-182. Epub 2021 May 3.

Department of Documents Examination, Criminal Investigation Police University of China, Shenyang, China.

Signature examination is the most common examination performed by any document examiner. Determination of the authenticity of a handwritten signature on a questioned document is an important task for forensic document examiners in the forensic science field. As a result of continuous developments in technology, a signature stamp can now be created using a photosensitive seal to enable the reproduction of a handwritten signature. Read More

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