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Analysis of Cryopreservation Protocols and Their Harmful Effects on the Endothelial Integrity of Human Corneas.

Int J Mol Sci 2021 Nov 22;22(22). Epub 2021 Nov 22.

Grupo de Investigación en Terapia Celular e Medicina Rexenerativa, Departamento de Fisioterapia, Medicina e Ciencias Biomédicas, Facultade de Ciencias da Saúde, Universidade da Coruña (UDC), Campus de Oza, 15006 A Coruña, Spain.

Corneal cryopreservation can partially solve the worldwide concern regarding donor cornea shortage for keratoplasties. In this study, human corneas were cryopreserved using two standard cryopreservation protocols that are employed in the Tissue Bank of the Teresa Herrera Hospital (Spain) to store corneas for tectonic keratoplasties (TK protocol) and aortic valves (AV protocol), and two vitrification protocols, VS55 and DP6. Endothelial viability and general corneal state were evaluated to determine the protocol that provides the best results. Read More

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November 2021

Impact of Epidemic-Affected Labor Shortage on Food Safety: A Chinese Scenario Analysis Using the CGE Model.

Foods 2021 Nov 3;10(11). Epub 2021 Nov 3.

Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Human food safety should be given priority during a major public health crisis. As the primary element of agricultural production, labor tends to suffer the most during a period of public health concern. Studying the impact of epidemic-affected labor shortages on agricultural production, trade, and prices has important implications for food security. Read More

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November 2021

Towards effective and sustainable global academic partnerships through a maturity model informed by the capability approach.

Global Health 2021 Nov 20;17(1):131. Epub 2021 Nov 20.

Global Health & Infection Department, Brighton and Sussex Medical School, Brighton, UK.

Background: Shortage of skilled workforce is a global concern but represents a critical bottleneck to Africa's development. While global academic partnerships have the potential to help tackle this development bottleneck, they are criticised for inadequate attention to equity, impact, and sustainability. We propose a new values-driven partnership model for sustainable and equitable global partnerships that achieve impact. Read More

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November 2021

COVID-19 vaccines mix-and-match: The concept, the efficacy and the doubts.

J Med Virol 2021 Nov 19. Epub 2021 Nov 19.

Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

The search for developing effective vaccines against SARS-CoV-2 began with the start of the COVID-19 pandemic, and the first vaccine dose was administered in December 2020. Today, full vaccination of most of the world's population is considered the most important means to overcome the COVID-19 pandemic. Vaccination has been associated with various struggles. Read More

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November 2021

Projected US Urology Workforce per Capita, 2020-2060.

JAMA Netw Open 2021 Nov 1;4(11):e2133864. Epub 2021 Nov 1.

Department of Urology, Michigan Medicine, University of Michigan, Ann Arbor.

Importance: Projections to 2035 have demonstrated concern regarding a worsening urology workforce shortage.

Objective: To project the size and demographic characteristics of the urology workforce per capita into 2060 and to anticipate the timing and degree of the impending urology workforce shortage.

Design, Setting, And Participants: This population-based cross-sectional study used the 2019 American Urological Association Annual Census data and the Accreditation Council for Graduate Medical Education's Data Resource Book from 2007 to 2018. Read More

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November 2021

Evaluation of diabetic peer support in Malawi.

Malawi Med J 2021 Jun;33(2):108-113

University of Pittsburgh School of Medicine.

Background: Type 2 diabetes is a major health concern worldwide and requires urgent attention from health care providers and policy makers. Due to shortage of health care workers in low-income countries, peer support programs have been viewed as a viable option in management of diabetes and have shown to be effective in sub-Saharan Africa.

Objective: The aim of this study is to assess and evaluate the Kamuzu Central Hospital (KCH) diabetic peer support program's (DPSP) impact 4 years after its establishment by assessing knowledge, self-efficacy and behaviours of DPSP members compared to non-members. Read More

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The Impact of COVID-19 Pandemic on Blood Transfusion Services: A Perspective from Health Professionals and Donors.

J Multidiscip Healthc 2021 2;14:3063-3071. Epub 2021 Nov 2.

Department of Pathology and Laboratory Medicine, King Abdullah Hospital, Bisha, Saudi Arabia.

Purpose: Since the emergence of the COVI9-19 pandemic, there has been concern about the availability and sufficiency of blood transfusions to meet patient needs. Also, the adequate and safe blood supply is a major issue to fulfill present demands. This study aims to determine the impact of the COVID-19 pandemic on the blood transfusion service and identify solutions to overcome this impact from the perspective of blood donors and healthcare professionals. Read More

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November 2021

Factors related to job burnout among older nurses in Guizhou province, China.

PeerJ 2021 21;9:e12333. Epub 2021 Oct 21.

Nursing Department, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, Guizhou, China.

Background: The nursing workforce shortage has long been a global concern, and with the aging of nurses, this problem has become more prominent. Nursing is recognized as a high-stress occupation, and nurses experience high levels of job burnout, which reduces their professional identity. Older nurses are an indispensable talent force for nursing teams and are extremely important for the stability of nursing teams and improvement in nursing quality. Read More

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October 2021

Global water shortage and potable water safety; Today's concern and tomorrow's crisis.

Authors:
Maryam Salehi

Environ Int 2021 Oct 14;158:106936. Epub 2021 Oct 14.

Department of Civil Engineering, The University of Memphis, 3815 Central Avenue, 108C Engineering Science Bldg, Memphis, TN 38152, United States. Electronic address:

Climate change, severe droughts, population growth, demand increase, and poor management during the recent decades have further stressed the scarce freshwater resources worldwide and resulted in severe water shortages in many regions. The water utilities address the water shortage by providing alternative source of water, augment the supplied water, supply intermittently, and even bulk water delivery under severe water shortage conditions. On the other hand, many households store water in building storage tanks to cope with insufficient delivery of potable water due to frequent interruptions. Read More

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October 2021

Development and evaluation of a telehealth-based simulation to improve breastfeeding education and skills among nursing students.

Nurse Educ Pract 2021 Oct 2;57:103226. Epub 2021 Oct 2.

Palm Beach Atlantic University, 901 S Flagler Dr, West Palm Beach, FL 33401, USA. Electronic address:

Aim: The aim of this study was to evaluate undergraduate nursing students' perceptions of using telehealth-based simulations for practicing their breastfeeding education skills.

Background: Telehealth can help bridge the gap between the high need for healthcare services and the limited access to these services, such as breastfeeding mothers in rural settings. However current literature suggests that there is lack of telehealth education among healthcare providers, as well as, a shortage of adequately trained nurses on breastfeeding, making it difficult to provide new mothers with the support they need to successfully breastfeed. Read More

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October 2021

COVID-19 and antimicrobial resistance: A cross-study.

Sci Total Environ 2021 Oct 8;807(Pt 2):150873. Epub 2021 Oct 8.

Block I, Room # 135, Department of Biochemical Engineering & Biotechnology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. Electronic address:

Antimicrobial resistance (AMR) is emerging as a severe concern due to the escalating instances of resistant human pathogens encountered by health workers. Consequently, there is a shortage of antibiotics to treat Multidrug Resistance (MDR) and Extensively Drug Resistance (XDR) patients. The primary cause of AMR is the vast array of anthropogenic disturbances in natural microfauna brought about by the extensive use of antibiotics. Read More

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October 2021

Environmental rethinking of wastewater drains to manage environmental pollution and alleviate water scarcity.

Nat Hazards (Dordr) 2021 Sep 27:1-28. Epub 2021 Sep 27.

Department of Civil Engineering, Faculty of Engineering, Suez Canal University, PO Box 41522, Ismailia, Egypt.

The conservation of water resources in developed countries has become an increasing concern. In integrated water resource management, water quality indicators are critical. The low groundwater quality quantitates mainly attributed to the absence of protection systems for polluted streams that collect and recycle the untreated wastewater. Read More

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September 2021

Quantifying ethanol in ethanol-based hand sanitizers by headspace gas chromatography with flame ionization detector (HS-GC/FID).

J AOAC Int 2021 Sep 21. Epub 2021 Sep 21.

Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto-Universidade de São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto-, SP, 14040-900, Brazil.

Background: The COVID-19 pandemic sharply increased the demand for ethanol-based gel hand sanitizers, leading to a shortage of these products. Consequently, regulatory health agencies worldwide have altered their regulatory guidelines, on ethanol quality, to meet this high demand, raising concern about the products quality.

Objective: The aim of this study was to quantify ethanol content and to qualitatively assess common impurities in ethanol-based gel hand sanitizers by headspace gas chromatography with flame ionization detector (HS-GC/FID). Read More

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September 2021

A Library of Old Photos Supporting Conversation of Two Generations Serving Reminiscence Therapy.

Front Psychol 2021 31;12:704236. Epub 2021 Aug 31.

Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, Japan.

In Japan, a shift in family patterns has led to a sense of social isolation among older people, which increases the risk of major neurocognitive disorder. Interventions for them using old photos to implement reminiscence therapy (RT) have been proved to be effective. A super-aged society has in turn led to a shortage of medical resources and older people prefer home care over institutional care. Read More

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Dynamically monitoring cellular γ-H2AX reveals the potential of carcinogenicity evaluation for genotoxic compounds.

Arch Toxicol 2021 Nov 12;95(11):3559-3573. Epub 2021 Sep 12.

State Key Laboratory of Toxicology and Medical Countermeasures, and Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, 27 Taiping Road, Haidian District, Beijing, 100850, China.

Amongst all toxicological endpoints, carcinogenicity might pose the greatest concern. Genetic damage has been considered an important underlying mechanism for the carcinogenicity of chemical substances. The demand for in vitro genotoxic tests as alternative approaches is growing rapidly with the implementation of new regulations for compounds. Read More

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November 2021

Novel carrier-free, charge-reversal and DNA-affinity nanodrugs for synergistic cascade cancer chemo-chemodynamic therapy.

J Colloid Interface Sci 2022 Jan 24;606(Pt 2):1488-1508. Epub 2021 Aug 24.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150090, China. Electronic address:

The combination of chemotherapy (CT) and chemodynamic therapy (CDT) is an emerging therapeutic strategy for tumors; however, its therapeutic efficacy is usually impaired by the shortage of high-efficiency intracellular catalysts for CDT and the poor tumor selectivity of CT. To address this concern, novel carrier-free nanodrugs (CMC-DD2) self-assembled from the natural melanin complex (CMC) with a superior CDT performance, and dehydroabietic acid hexamer (DD2) displaying a potent antitumor activity were proposed for the synergistic combination of CT and CDT. CMC-DD2 preferred to enter tumor cells and localize in the nucleus after lysosome escape due to its pH-dependent charge-reversal properties. Read More

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January 2022

[Evaluation of implementation of the response to the public health emergency of microcephaly in Pernambuco State, Brazil].

Cad Saude Publica 2021 30;37(8):e00271020. Epub 2021 Aug 30.

Programa de Pós-graduação em Ciências da Saúde, Universidade de Pernambuco, Recife, Brasil.

This study aimed to assess the degree of implementation of the response to the emergency of microcephaly associated with Zika virus in Pernambuco State, Brazil. This was a normative evaluative study conducted in the initial epicenter of the public health emergency of international concern, from October 2015 to July 2017. A logical model was produced for the intervention under analysis, with the components of Management, Surveillance, and Care in the dimensions of structure, process, and result, based on technical publications and institutional guidelines, in addition to a corresponding log frame of indicators for assessment. Read More

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September 2021

Reproductive Health During the COVID-19 Pandemic.

Authors:
Usha R Krishna

J Obstet Gynaecol India 2021 Aug 30:1-5. Epub 2021 Aug 30.

Research Society Breach Candy Hospital, Mumbai, India.

Globally reproductive health services such as contraception and abortion are impacted and are not accessible to a considerable population. The International Planned Parenthood Federation reported anticipated shortage of contraception as the lockdown measures led to reduction in the manufacturing of contraceptives. A recent analysis by the Guttmacher Institute estimated the potential effects of the pandemic. Read More

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The Impact of the COVID-19 Pandemic on Future Nursing Career Turnover Intention Among Nursing Students.

Risk Manag Healthc Policy 2021 27;14:3605-3615. Epub 2021 Aug 27.

Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, People's Republic of China.

Introduction: A shortage of nurses has been a major global concern, particularly during pandemics. Nursing students turning away from the nursing profession upon graduation may exacerbate nursing workforce shortfalls. The main objective of this study was to assess perceived occupational turnover intention among nursing students and associated factors (fear of COVID-19 and life satisfaction). Read More

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Single-dose mRNA vaccine effectiveness against SARS-CoV-2 in healthcare workers extending 16 weeks post-vaccination: a test-negative design from Quebec, Canada.

Clin Infect Dis 2021 Aug 30. Epub 2021 Aug 30.

Centre de Recherche du CHU de Quebec-Universite Laval, Quebec City, Quebec, Canada.

Introduction: In Canada, first and second doses of mRNA vaccines against SARS-CoV-2 were uniquely spaced 16 weeks apart, but the duration of single-dose protection remains uncertain. We estimated one- and two-dose mRNA vaccine effectiveness (VE) among healthcare workers (HCWs) in Quebec, Canada including protection against varying outcome severity, variants of concern (VOC), and the stability of single-dose protection out to 16 weeks post-vaccination.

Methods: A test-negative design compared vaccination among SARS-CoV-2 test-positive and weekly-matched (10:1), randomly-sampled, test-negative HCWs using linked surveillance and immunization databases. Read More

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Guidance on the critical shortage of sodium citrate coagulation tubes for hemostasis testing.

J Thromb Haemost 2021 11 2;19(11):2857-2861. Epub 2021 Sep 2.

Department of Pathology, University of New Mexico, Albuquerque, NM, USA.

Recent manufacturing problems and increased utilization has created a shortage of 3.2% sodium citrate blood collection tubes used for coagulation testing, causing stakeholders such as hospitals, clinics and laboratories, to find suitable alternatives. Considerations for in-house citrate blood collection tube preparations or purchasing commercial products from unknown manufacturing sources is of particular concern to laboratories that perform coagulation testing. Read More

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November 2021

Prevalence and Factors of the Performed or Scheduled COVID-19 Vaccination in a Chinese Adult General Population in Hong Kong.

Vaccines (Basel) 2021 Aug 2;9(8). Epub 2021 Aug 2.

Centre for Health Behaviours Research, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.

Background: Globally, COVID-19 vaccination programs have been rolled out. To inform health promotion, this study investigated the prevalence and associated factors of performance or being scheduled to perform at least one dose of COVID-19 vaccination (PSCV) in a Chinese adult general population.

Methods: An anonymous, random telephone survey interviewed 500 adults aged 18-75 in Hong Kong, China from 14-27 May 2021. Read More

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Frontline healthcare workers' experiences in implementing the TB-DM collaborative framework in Northern Ghana.

BMC Health Serv Res 2021 Aug 23;21(1):861. Epub 2021 Aug 23.

Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

Background: Over the past decade, global health policy has increased its focus on measures to halt further increase in tuberculosis (TB) incidence and management of diabetes mellitus (DM). However, the vertical management of these two diseases have not achieved much in addressing the adverse effects of the rising tuberculosis-diabetes co-epidemic. This necessitated the World Health Organisation and the International Union Against Tuberculosis and Lung Disease to develop a framework to manage this dual disease burden. Read More

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Disaster relief supply chain design for personal protection equipment during the COVID-19 pandemic.

Appl Soft Comput 2021 Nov 18;112:107809. Epub 2021 Aug 18.

Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Puebla, Mexico.

The global epidemic caused by novel coronavirus continues to be a crisis in the world and a matter of concern. The way the epidemic has wreaked havoc on the international level has become difficult for the healthcare systems to supply adequately personal protection equipment for medical personnel all over the globe. In this paper, considering the COVID-19 outbreak, a multi-objective, multi-product, and multi-period model for the personal protection equipment demands satisfaction aiming to optimize total cost and shortage, simultaneously, is developed. Read More

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November 2021

US deceased kidney transplantation: Estimated GFR, donor age and KDPI association with graft survival.

EClinicalMedicine 2021 Jul 23;37:100980. Epub 2021 Jun 23.

United Network for Organ Sharing, 700N 4th St, Richmond, VA 23219, United States.

Background: Despite a significant shortage of kidneys for transplantation in the US, kidneys from older deceased donors are infrequently transplanted. This is primarily over concern of graft quality and transplant durability.

Methods: The US national transplant database (2000-2018) was assessed for deceased donor kidney transplant patient and graft survival, graft durability and stratified by donor age (<65 years>), Kidney Donor Profile Index (KDPI) and estimated glomerual filtration rate (GFR) one year post-transplantation (eGFR-1) were calculated. Read More

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Antistaphylococcal Activity of the FtsZ Inhibitor C109.

Pathogens 2021 Jul 13;10(7). Epub 2021 Jul 13.

Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.

infections represent a great concern due to their versatility and involvement in different types of diseases. The shortage of available clinical options, especially to treat multiresistant strains, makes the discovery of new effective compounds essential. Here we describe the activity of the previously described cell division inhibitor C109 against methicillin-sensitive and -resistant strains. Read More

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Changes over 10 years in the nursing workforce in Guangdong province, China: Three-wave multisite surveys.

J Nurs Manag 2021 Nov 19;29(8):2630-2638. Epub 2021 Aug 19.

School of Nursing, Sun Yat-sen University, Guangzhou, China.

Aims: The study aimed to describe the changes in the nursing workforce in 2008-2018 in Guangdong province, China.

Background: A strong nursing workforce is important in the development of the health care system in China. However, whether the nursing workforce in China has improved is underexplored. Read More

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November 2021

Concerns and psychological well-being of healthcare workers during the COVID-19 pandemic in a tertiary care hospital in New South Wales.

Intern Med J 2021 09;51(9):1407-1413

Infectious Diseases Department, John Hunter Hospital, Newcastle, New South Wales, Australia.

Background: In early 2020, the impending COVID-19 pandemic placed a once-in-a-generation professional and personal challenge on healthcare workers. Publications on direct physical disease abound. The authors wanted to focus on doctors' psychological well-being. Read More

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September 2021

Long-term care system for older adults in China: policy landscape, challenges, and future prospects.

Lancet 2020 10;396(10259):1362-1372

Department of Global Health and Population, Harvard University, Boston, MA, USA. Electronic address:

In China, the population is rapidly ageing and the capacity of the system that cares for older people is increasingly a concern. In this Review, we provide a profile of the long-term care system and policy landscape in China. The long-term care system is characterised by rapid growth of the residential care sector, slow development of home and community-based services, and increasing involvement of the private sector. Read More

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October 2020