16,572 results match your criteria short irradiation

Sustained effect of two antioxidants (oxothiazolidine and δ-tocopheryl glucoside) for immediate and long-term sun protection in a sunscreen emulsion based on their different penetrating properties.

Int J Cosmet Sci 2021 Apr 13. Epub 2021 Apr 13.

Pierre Fabre Dermo-cosmétique, Centre R&D Pierre Fabre, Innovation et Développement Pharmacologie, Avenue Hubert Curien, Cedex 01, 31025, Toulouse, France.

Objective: We investigated the dermal bioavailability and antioxidative properties of a sunscreen formulation containing two antioxidants, oxothiazolidine (OTZ) and δ-tocopheryl glucoside (DTG). OTZ reacts directly with reactive oxygen species to form taurine, while DTG is metabolized in δ-tocopherol to achieve antioxidative activities.

Methods: After topical application to a hair follicle-derived reconstructed human epidermis (RHE) model, followed by solar-simulated radiation, kinetics of bioavailability and antioxidative responses were measured over 24 h. Read More

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Assessment of the expression and response of PD-1, LAG-3, and TIM-3 after neoadjuvant radiotherapy in rectal cancer.

Neoplasma 2021 Apr 13. Epub 2021 Apr 13.

Department of Radiation Oncology, Xiamen Humanity Hospital, Xiamen, China.

Many studies have verified the safety of combined radiotherapy and immune checkpoint blockades (ICBs) without the specific radiation dose or sequencing of combination. We aimed to evaluate the expression and response of PD-1, TIM-3, LAG-3 after neoadjuvant radiotherapy (NRT) and explore the possibility and optimal schedule of combining immunotherapy with radiotherapy in treating rectal cancer. Immunohistochemistry was performed to detect the expression of PD-1, TIM-3, LAG-3, CD8, and CD3. Read More

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Short-range UV-LED irradiation in postmenopausal osteoporosis using ovariectomized mice.

Sci Rep 2021 Apr 12;11(1):7875. Epub 2021 Apr 12.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Postmenopausal osteoporosis is crucial condition that reduces the QOL of affected patients just like aged type osteoporosis. The aim of this study was to evaluate the effectiveness of short-range UV-LED irradiation in postmenopausal osteoporosis using ovariectomized mice. Preliminary experiments identified the time of onset of osteoporosis after ovariectomy (8 weeks) in our model. Read More

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Thermal Ablation as an Alternative for Surgical Resection of Small (≤ 2 cm) Breast Cancers: A Meta-Analysis.

Clin Breast Cancer 2021 Mar 17. Epub 2021 Mar 17.

Department of Surgery, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.

Women with early-stage breast cancer have an excellent prognosis with current therapy, but could presumably be treated less invasively, without the need for surgery. The primary goal of this meta-analysis was to examine whether thermal ablation is an effective method to treat early-stage breast cancer. Studies reporting on complete ablation rate after thermal ablation as a treatment of small breast cancers (≤ 2 cm) were included. Read More

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E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma apoptosis and invasion through promoting FOXR2 degradation.

Biochem Biophys Res Commun 2021 Apr 8;556:106-113. Epub 2021 Apr 8.

Department of Oncology, The People's Hospital of Jianyang, No.180 Hospital Road, Jianyang City, Sichuan Province, China.

Among all lung cancer cases, lung adenocarcinoma (LAC) represents nearly 40% and remains the leading cause of cancer deaths worldwide. Although the combination therapy of surgical treatment with radiotherapy, chemotherapy, and immunotherapy, has been used to treat LAC, unfortunately, high recurrence rates and poor survival remain. Therefore, novel prognostic markers and new targets for molecular targeted therapy in LAC is urgently needed. Read More

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Simultaneous ultrasound- and microwave-assisted one-pot 'click' synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation.

Mol Divers 2021 Apr 8. Epub 2021 Apr 8.

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India.

An environment friendly, high yielding, promising one-pot protocol for the click reaction of N-propargyl-3-formylindole 2(a-b), chloroacetic acid/ester 3(a-b) and sodium azide, leading to the formation of 3-formyl-indole clubbed 1,4-disubstituted-1,2,3-triazole derivatives 4(a-b), 5(a-b) and 6(a-f) aided by CuI catalyst accomplished under acceleration of simultaneous ultrasound and microwave irradiation in a very short reaction time has been described. Further, acid derivative 4(a-b) is subjected to acid-amine coupling reaction with secondary amine (p-t) in the presence of HATU to afford 6(p-t) and 7(p-t). The perspective of this protocol is to get rid of the hectic preparation and handling of organic azide which are generated in situ. Read More

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Therapeutic outcome and related predictors of stereotactic body radiotherapy for small liver-confined HCC: a systematic review and meta-analysis of observational studies.

Radiat Oncol 2021 Apr 8;16(1):68. Epub 2021 Apr 8.

Department of Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, No. 181 Hanyu Road, Shapingba District, Chongqing, 400030, China.

Background And Purpose: Stereotactic body radiotherapy (SBRT) is a promising ablative modality for hepatocellular carcinoma (HCC) especially for those with small-sized or early-stage tumors. This study aimed to synthesize available data to evaluate efficacy and explore related predictors of SBRT for small liver-confined HCC (≤ 3 lesions with longest diameter ≤ 6 cm).

Materials And Methods: A systematic search were performed of the PubMed and Cochrane Library databases. Read More

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Auger: The future of precision medicine.

Nucl Med Biol 2021 Mar 19;96-97:50-53. Epub 2021 Mar 19.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Radiology, Weill Cornell Medical College, New York, NY 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York City, NY 10065, USA. Electronic address:

First reported by Lise Meitner in 1922 and independently by Pierre Auger in 1923, the Auger effect has been explored as a potential source for targeted radiotherapy. The Auger effect is based on the emission of a low energy electron (typically <25 keV) from an atom post electron capture (EC), internal conversion (IC), or incident X-rays excitation. This phenomenon can cause the emission of a primary electron and multiple electron tracks typically in the nearest proximity of the emission site (2-500 nm). Read More

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Dual Antibacterial Effect of In Situ Electrospun Curcumin Composite Nanofibers to Sterilize Drug-Resistant Bacteria.

Nanoscale Res Lett 2021 Apr 7;16(1):54. Epub 2021 Apr 7.

Collaborative Innovation Center for Nanomaterials and Devices, College of Physics, Qingdao University, Qingdao, 266071, China.

Bacterial infection especially caused by multidrug-resistant bacteria still endangers human life. Photodynamic therapy (PDT) can effectively kill bacteria, and nanofiber-based PDT can effectively reduce damage to normal tissues. However, current photosensitizers coated on the surfaces of fibers would release to the wound, causing some side effects. Read More

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Short term results of stapled versus conventional hemorrhoidectomy within 1 year follow-up.

Int J Burns Trauma 2021 15;11(1):69-74. Epub 2021 Feb 15.

Assistant Professor of Radiotherapy, Department of Radiology, Tehran University of Medical Sciences, Imam Khomeini Hospital Tehran, Iran.

Background: Conventional hemorrhoidectomy is still used for patients but a variety of less invasive treatments are also developed. Stapled hemorrhoidectomy is known as a beneficial technique. Here we aimed to evaluate and compare the results of stapled hemorrhoidectomy with conventional methods in patients who require hemorrhoidectomy. Read More

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February 2021

Feasibility of Proton Beam Therapy for Infants with Brain Tumours: Experiences from the Prospective KiProReg Registry Study.

Clin Oncol (R Coll Radiol) 2021 Apr 2. Epub 2021 Apr 2.

Department of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen, West German Cancer Centre, Essen, Germany; Department of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ), German Cancer Consortium (DKTK), Essen, Germany.

Aims: Proton beam therapy (PBT) has increasingly been applied for the treatment of young children when radiotherapy is needed. The treatment requires intensive multimodality care and is logistically demanding. In this analysis, we evaluated our experiences in treating infants with tumours of the central nervous system with PBT. Read More

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Palliative radiation therapy for children with cancer.

Pediatr Blood Cancer 2021 May;68 Suppl 2:e28292

Division of Radiation Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts.

Radiation therapy (RT) is often used as a palliative treatment for children with recurrent malignant disease to ameliorate or prevent symptoms. However, no guidelines exist regarding the clinical indications or dose fractionation for palliative RT. The goal of this report is to provide guidelines for the use of palliative RT in children with cancer. Read More

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Optimal management of pulmonary atresia with intact ventricular septum in a developing country: the art of pulmonary valve mechanical perforation in the era of CTO hardware.

Am J Cardiovasc Dis 2021 15;11(1):21-28. Epub 2021 Feb 15.

Hotel Dieu de France University Medical Center, Department of Pediatric Cardiology, Saint Joseph University Beirut, Lebanon.

Background: Transcatheter valve mechanical perforation (TVMP) in pulmonary atresia with intact ventricular septum (PAIVS) is an acceptable yet challenging alternative to radiofrequency.

Aims: To evaluate and compare safety, feasibility, and efficiency of two TVMP techniques.

Methods: Clinical data of neonates with PAIVS who underwent an attempt for TVMP between 2009 and 2019 were retrospectively reviewed. Read More

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February 2021

The role of reoperation after recurrence of Cushing's disease.

Best Pract Res Clin Endocrinol Metab 2021 Feb 6:101489. Epub 2021 Feb 6.

USC Pituitary Center, Department of Neurosurgery, Keck School of Medicine of University of Southern California, 1300 N. State Street, Suite 3300, Los Angeles, CA, 90033, USA; Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of University of Southern California, 1333 San Pablo Street, BMT-B11, Los Angeles, CA, 90033, USA. Electronic address:

Surgical failure or recurrence of Cushing's disease can be treated with medical therapy, radiotherapy, adrenalectomy, and/or repeat transsphenoidal surgery, all of which have their respective benefits and drawbacks. Redo transsphenoidal surgery has been shown to achieve at least short-term remission in about 40-80% of patients and is associated with low rates of morbidity and near-zero mortality, albeit higher rates of postoperative hypopituitarism, diabetes insipidus, and cerebrospinal fluid leak than initial resection. Despite this, recurrence may ensue in 50% of patients. Read More

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February 2021

Complete pathological response in rectal cancer utilising novel treatment strategies for neo-adjuvant therapy: A systematic review.

Eur J Surg Oncol 2021 Mar 24. Epub 2021 Mar 24.

Peter MacCallum Cancer Centre, Department of Surgical Oncology, Australia; Sir Peter MacCallum Dept. of Oncology, University of Melbourne, Australia.

Background: Locally advanced rectal cancer is routinely treated with neo-adjuvant long course chemoradiotherapy or short course radiotherapy, followed by total mesorectal excision. Not all patients respond to this treatment and there has been an emergence of novel treatment strategies designed to improve outcomes for these patients. This systematic review aims to assess the current novel neo-adjuvant treatment strategies being utilised in the treatment of patients with rectal cancer and how these impact pathological complete response (pCR) rates. Read More

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Short-term results of the combined application of neodymium-doped yttrium aluminum garnet (Nd:YAG) laser and erbium-doped yttrium aluminum garnet (Er:YAG) laser in the treatment of periodontal disease: a randomized controlled trial.

Clin Oral Investig 2021 Apr 4. Epub 2021 Apr 4.

Division of Conservative Dentistry and Periodontology, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria.

Objectives: Nd:YAG and Er:YAG lasers have been previously used as an adjunct in periodontal therapy. The aim of this single-blinded randomized controlled clinical trial was to evaluate the efficacy of a combined application of Nd:YAG and Er:YAG laser irradiation in periodontal treatment.

Materials And Methods: Twenty-two patients with at least one site of ≥ 6 mm periodontal probing depth (PPD) after mechanical debridement with curettes and sonic instruments at periodontal reevaluation were included in the study. Read More

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Rapid 4D-MRI reconstruction using a deep radial convolutional neural network: Dracula.

Radiother Oncol 2021 Apr 1. Epub 2021 Apr 1.

Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Downs Road, SM2 5PT, London, United Kingdom. Electronic address:

Background And Purpose: 4D and midposition MRI could inform plan adaptation in lung and abdominal MR-guided radiotherapy. We present deep learning-based solutions to overcome long 4D-MRI reconstruction times while maintaining high image quality and short scan times.

Methods: Two 3D U-net deep convolutional neural networks were trained to accelerate the 4D joint MoCo-HDTV reconstruction. Read More

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Transcriptomic and Metabolomic Basis of Short- and Long-Term Post-Harvest UV-C Application in Regulating Grape Berry Quality Development.

Foods 2021 Mar 16;10(3). Epub 2021 Mar 16.

College of Enology, Northwest A&F University, Yangling 712100, China.

In this study, ultraviolet-C (UV-C) was utilized to improve the quality of post-harvest grape berries, and the transcriptomic and metabolomic basis of this improvement was elucidated. Berries of the red grape variety 'Zicui' and the white variety 'Xiangfei' were chosen to evaluate the effect of short- and long-term UV-C irradiation. Post-harvest UV-C application promoted malondialdehyde (MDA) and proline accumulation, and reduced the soluble solid content in berries. Read More

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