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What's the relative humidity in tropical caves?

PLoS One 2021 22;16(9):e0250396. Epub 2021 Sep 22.

Department of Environmental Science, American University, Washington, DC, United States of America.

Relative humidity (RH) was measured at hourly intervals for approximately one year in two caves at seven stations near Playa del Carmen in Quintana Roo, Mexico. Sistema Muévelo Rico is a 1.1 km long cave with 12 entrances and almost no dark zone. Read More

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September 2021

Validity and reliability of a checklist for patients with Behçet's disease based on the International Classification of Functioning, Disability and Health.

Rheumatol Int 2021 Sep 22. Epub 2021 Sep 22.

Department of Hygiene and Public Health, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.

In 2020, we reported the "BD-checklist 92" for patients with Behçet's disease (BD) based on the International Classification of Functioning, Disability and Health. The purpose of the present study was to evaluate the validity and reliability of this checklist. Questionnaires using the "BD-checklist 92" and the 36-item Short Form Survey (SF-36) were sent to ten affiliated institutions. Read More

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September 2021

The effect of Mirabegron and Duloxetine combination in mixed-type urinary incontinence treatment.

Rev Assoc Med Bras (1992) 2021 Jun;67(5):713-717

Prof. Dr. Cemil Taşcıoğlu City Hospital - Şişli, Istanbul. Turkey.

Objective: Stress-type and urgency-type urinary incontinence are seen together in mixed-type urinary incontinence. Treatment is usually chosen according to the predominant type of incontinence. The aim of this study is to evaluate the effect of mirabegron and duloxetine combination in the treatment of mixed-type urinary incontinence. Read More

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Multibiomarker responses in Danio rerio after exposure to sediment spiked with triclosan.

An Acad Bras Cienc 2021 20;93(suppl 3):e20201938. Epub 2021 Sep 20.

Universidad Nacional de Luján (UNLu), Grupo de estudios de Contaminación Antrópica en Peces, Instituto de Ecología y Desarrollo Sustentable (CONICET- UNLu), Departamento de Ciencias Básicas, Luján, Ruta 5 y Avenida Constitución, 6700, Buenos Aires, Argentina.

Triclosan (TCS) is an antimicrobial and antimycotic agent widely used in personal care products. In aquatic environments, both TCS and its biomethylated more persistent form, methyl-triclosan (MeTCS), are usually detected in wastewater effluents and rivers, where are commonly adsorbed to suspended solids and sediments. The aim of this study was to evaluate biochemical and physiological effects in Danio rerio after a short term (2 days) and prolonged (21 days) exposures to sediment spiked with TCS acting as the source of the pollutant in the assay. Read More

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September 2021

Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report.

Acta Neurol Taiwan 2021 Mar;30(1):35-38

Division of Dental Anesthesiology, Department of Control of Physical Function, Kyushu Dental University, Kitakyushu, Fukuoka, Japan.

Purpose: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is a rare form of primary headache, classified as trigeminal autonomic cephalalgia. Since the underlying mechanism of the pathogenesis has not yet been determined, a standardized therapeutic strategy for SUNCT is unavailable. We present a case of SUNCT syndrome with successful pain relief by intravenous administration of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist. Read More

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Cytosolic phosphofructokinases are important for sugar homeostasis in leaves of Arabidopsis thaliana.

Ann Bot 2021 Sep 22. Epub 2021 Sep 22.

Plant Physiology, University Bayreuth, Universitaetsstr. 30, 95440 Bayreuth, Germany.

Background And Aims: ATP-dependent phosphofructokinases (PFKs) catalyse phosphorylation of the carbon-1 position of fructose-6-phosphate, to form fructose-1,6-bisphosphate. In the cytosol, this is considered a key step in channelling carbon into glycolysis. Arabidopsis thaliana has seven genes encoding PFK isoforms, two chloroplastic and five cytosolic. Read More

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September 2021

Virtual Reality to Improve Sequelae of the Postintensive Care Syndrome: A Multicenter, Randomized Controlled Feasibility Study.

Crit Care Explor 2021 Sep 14;3(9):e0538. Epub 2021 Sep 14.

Department of Intensive Care, Erasmus Medical Centre, Rotterdam, The Netherlands.

Psychologic sequelae after critical illness, part of the postintensive care syndrome, significantly decrease quality of life. A robustly effective treatment intervention is currently lacking. Virtual reality has beneficial effects on several non-ICU-related psychologic disorders. Read More

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September 2021

The AWESCORE, a patient-reported outcome measure: development, feasibility, reliability, validity and responsiveness for adults with cystic fibrosis.

ERJ Open Res 2021 Jul 20;7(3). Epub 2021 Sep 20.

Monash University, School of Medicine, Prahran, Melbourne, Australia.

Background: Quality of life has improved dramatically over the past two decades in people with cystic fibrosis (CF). Quantification has been enabled by patient-reported outcome measures (PROMs); however, many are lengthy and can be challenging to use in routine clinical practice. We propose a short-form PROM that correlates well with established quality-of-life measures. Read More

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The Promising Future of Low-Molecular-Weight Heparin in Pediatric Cerebral Venous Sinus Thrombosis Occurring as a Rare Complication of Ulcerative Colitis.

Cureus 2021 Aug 13;13(8):e17168. Epub 2021 Aug 13.

Pediatrics, Gujarat Medical Education And Research Society (GMERS) Medical College, Gandhinagar, IND.

Pediatric cerebral venous sinus thrombosis (CVST) is a rare complication of ulcerative colitis. Ulcerative colitis is a form of inflammatory bowel disease which accentuates hypercoagulation, thereby leading to thrombosis. Herein, we report a case of a 10-year-old girl who presented with chief complaints of headache, confusion, and new-onset seizure activity for one month as progressively worsening sequelae of ulcerative colitis. Read More

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Predisease Physical Activity Level and Current Functional Capacity in Patients With COVID-19: Relationship With Pneumonia and Oxygen Requirement.

J Phys Act Health 2021 Sep 21:1-6. Epub 2021 Sep 21.

Background: During the COVID-19 pandemic, restrictive measures can reduce physical activity. The purpose of this study was to evaluate predisease physical activity and current functional capacity in patients with and without the presence of pneumonia and oxygen requirement in Turkish survivors of COVID-19.

Methods: Among the COVID-19 patients admitted to the hospital, 100 patients were selected. Read More

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September 2021

Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension.

RMD Open 2021 Sep;7(3)

Department of Medicine and Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Objectives: To report the impact of burosumab on patient-reported outcomes (PROs) and ambulatory function in adults with X-linked hypophosphataemia (XLH) through 96 weeks.

Methods: Adults diagnosed with XLH were randomised 1:1 in a double-blinded trial to receive subcutaneous burosumab 1 mg/kg or placebo every 4 weeks for 24 weeks (NCT02526160). Thereafter, all subjects received burosumab every 4 weeks until week 96. Read More

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September 2021

Long-term functional and psychosocial outcome in adolescents and young adults treated for lower urinary tract dysfunction in childhood.

J Pediatr Urol 2021 Sep 3. Epub 2021 Sep 3.

Department of Medical Psychology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen, the Netherlands. Electronic address:

Background: Lower urinary tract dysfunction (LUTD) in childhood might affect lower urinary tract function and psychological wellbeing later in life. This study presents long-term functional outcome, psychological outcome and quality of life (QOL) of adolescents and young adults treated for childhood LUTD compared to healthy age-matched controls. In addition, association with past treatment outcomes is evaluated. Read More

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September 2021

Characterisation of SARS-CoV-2 Clades based on Signature SNPs unveils Continuous Evolution.

Methods 2021 Sep 18. Epub 2021 Sep 18.

Department of Electronics and Communication Engineering, Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.

Since the emergence of SARS-CoV-2 in Wuhan, China more than a year ago, it has spread across the world in a very short span of time. Although, different forms of vaccines are being rolled out for vaccination programs around the globe, the mutation of the virus is still a cause of concern among the research communities. Hence, it is important to study the constantly evolving virus and its strains in order to provide a much more stable form of cure. Read More

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September 2021

Validity and Reliability Study of the Turkish Version of the 'A Sport Fitness Index'.

Int J Clin Pract 2021 Sep 21:e14898. Epub 2021 Sep 21.

Dept. of Sports Medicine, Süleyman Demirel University, Isparta, Turkey.

Background: The aim of this study is to adapt the 'Sport Fitness Index' into Turkish and to ensure its validity and reliability.

Methods: After obtaining the necessary permissions, the Sports Fitness Index was independently translated from its English original to Turkish by 4 different physicians specializing in sports medicine. The content validity of index v. Read More

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September 2021

The Danish Purpose in Life test-Short Form (PIL-SF): Validation and age effects.

Scand J Psychol 2021 Sep 21. Epub 2021 Sep 21.

Department of Psychology and Behavioural Sciences, Center for Livskvalitet, Aarhus University, Aarhus, Denmark.

The present article reports a study conducted to develop and validate a Danish translation of the Purpose in Life test-Short Form (PIL-SF) and examine age effects on this eudemonic measure. The study examined the reliability, unidimensionality, and construct validity of the Danish PIL-SF using a large and representative sample (N = 4,849). The results indicated that the Danish PIL-SF is a reliable and valid measure of meaning and purpose in life, positively associated with but distinct from hedonic well-being. Read More

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September 2021

LiTaO-Based Flexible Piezoelectric Nanogenerators for Mechanical Energy Harvesting.

ACS Appl Mater Interfaces 2021 Sep 21. Epub 2021 Sep 21.

Department of Electronics and Information Convergence Engineering, Institute for Wearable Convergence Electronics, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin-si, Gyeonggi-do 17104, Republic of Korea.

Mechanical energy is one of the freely available green energy sources that could be harvested to meet the small-scale energy demand. Piezoelectric nanogenerators can be used to harvest the biomechanical energy that is available in everyday human life and power various portable electronics. Herein, a ferroelectric material, i. Read More

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September 2021

Self-Poled Poly(vinylidene fluoride)/MXene Piezoelectric Energy Harvester with Boosted Power Generation Ability and the Roles of Crystalline Orientation and Polarized Interfaces.

ACS Appl Mater Interfaces 2021 Sep 21. Epub 2021 Sep 21.

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu, Sichuan 610065, China.

Micropiezoelectric devices have become one of the most competitive candidates for use in self-powered flexible and portable electronic products because of their instant response and mechanic-electric conversion ability. However, achievement of high output performance of micropiezoelectric devices is still a significant and challenging task. In this study, a poly(vinylidene fluoride) (PVDF)/MXene piezoelectric microdevice was fabricated through a microinjection molding process. Read More

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September 2021

A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement.

JAMA 2021 Sep;326(11):1045-1056

School of Public Health, University of Sydney, Sydney, Australia.

Importance: Mediation analyses of randomized trials and observational studies can generate evidence about the mechanisms by which interventions and exposures may influence health outcomes. Publications of mediation analyses are increasing, but the quality of their reporting is suboptimal.

Objective: To develop international, consensus-based guidance for the reporting of mediation analyses of randomized trials and observational studies (A Guideline for Reporting Mediation Analyses; AGReMA). Read More

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September 2021

Efficient Ternary Polymer Solar Cells with Tunable Crystallinity and Phase Separation of Active Layers via Incorporating GHK-Cu.

ACS Appl Mater Interfaces 2021 Sep 21. Epub 2021 Sep 21.

School of Physics and Optoelectronics, South China University of Technology, 510640 Guangzhou, P. R. China.

The crystallinity of a nonfullerene small-molecule acceptor plays an important function in the bimolecular recombination and carrier transfer of polymer solar cells (PSCs). However, because of the competition between the donor (PBDB-T) and acceptor (ITIC) in processes of phase separation and crystallization, the PBDB-T preferentially forms a crystalline network, which limits the molecular diffusion of ITIC and leads to the weak crystallinity of ITIC, eventually restricting the photoelectric conversion efficiency (PCE) of PSCs. Therefore, in our work, a small-molecule biomaterial, Gly-His-Lys-Cu (SMBM GHK-Cu), is incorporated into binary PBDB-T:ITIC to construct a PBDB-T:ITIC:GHK-Cu ternary system. Read More

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September 2021

Variation in human herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals.

Elife 2021 Sep 21;10. Epub 2021 Sep 21.

University of Leicester, Leicester, United Kingdom.

Human herpesviruses 6A and 6B (HHV-6A/6B) are ubiquitous pathogens that persist lifelong in latent form and can cause severe conditions upon reactivation. They are spread by community-acquired infection of free virus (acqHHV6A/6B) and by germline transmission of inherited chromosomally-integrated HHV-6A/6B (iciHHV-6A/6B) in telomeres. We exploited a hypervariable region of the HHV-6B genome to investigate the relationship between acquired and inherited virus and revealed predominantly maternal transmission of acqHHV-6B in families. Read More

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September 2021

Evaluating early maladaptive schemas and depression levels in living kidney and liver donors.

Psychol Health Med 2021 Sep 21:1-10. Epub 2021 Sep 21.

Department of Psychiatry, Başkent University Hospital, Ankara, Turkey.

Living organ donation is a stressful process, both in terms of physical and mental consequences after the operation. Studies have found that cumulative depression prevalence in 5-year follow-up after the organ donation is 4.2% in 1 year and 11. Read More

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September 2021

Loneliness, social isolation, and pain following the COVID-19 outbreak: data from a nationwide internet survey in Japan.

Sci Rep 2021 09 20;11(1):18643. Epub 2021 Sep 20.

Cancer Control Center, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

The aim of cross-sectional study was to investigate the association between loneliness, increased social isolation, and pain following the COVID-19 outbreak. A total of 25,482 participants, aged 15-79 years, were assessed using an internet survey; the University of California, Los Angeles Loneliness Scale (Version 3), Short Form 3-item (UCLA-LS3-SF3) was used to assess loneliness, and a modified item of the UCLA-LS3-SF3 was used to measure the perception of increased social isolation during the pandemic. The outcome measures included the prevalence/incidence of pain (i. Read More

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September 2021

Alternative splicing regulation of cell cycle genes by SPF45/SR140/CHERP complex controls cell proliferation.

RNA 2021 Sep 20. Epub 2021 Sep 20.

CRG

The regulation of pre-mRNA processing has important consequences for cell division and the control of cancer cell proliferation but the underlying molecular mechanisms remain poorly understood. We report that three splicing factors, SPF45, SR140 and CHERP form a tight physical and functionally coherent complex that regulates a variety of alternative splicing events, frequently by repressing short exons flanked by suboptimal 3' splice sites. These comprise alternative exons embedded in genes with important functions in cell cycle progression, including the G2/M key regulator FOXM1 and the spindle regulator SPDL1. Read More

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September 2021

Physical activity and the progression of coronary artery calcification.

Heart 2021 Sep 20. Epub 2021 Sep 20.

Division of Cardiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Background: The association of physical activity with the development and progression of coronary artery calcium (CAC) scores has not been studied. This study aimed to evaluate the prospective association between physical activity and CAC scores in apparently healthy adults.

Methods: Prospective cohort study of men and women free of overt cardiovascular disease who underwent comprehensive health screening examinations between 1 March 2011 and 31 December 2017. Read More

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September 2021

Quality of life in women with urinary incontinence seeking care using e-health.

BMC Womens Health 2021 Sep 20;21(1):337. Epub 2021 Sep 20.

Department of Public Health and Clinical Medicine, Umeå University, 905 81, Umeå, Sweden.

Background: Quality of life (QoL) in women with urinary incontinence (UI) is mainly affected by UI severity, but it is also affected by the UI subtype, comorbidities, age, and socioeconomic status. e-Health is a new method for providing UI treatment. This study aimed to identify factors with the highest impact on QoL in women that turned to e-health for UI self-management. Read More

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September 2021

Effectiveness of pregabalin treatment for trigger points in patients with comorbid myofascial pain syndrome and fibromyalgia syndrome: a randomized controlled trialIntroduction.

Somatosens Mot Res 2021 Sep 20:1-6. Epub 2021 Sep 20.

Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

Aim Of The Study: Myofascial pain syndrome (MPS) is a common problem in the general population. MPS should not be a local/peripheral painful syndrome and considered to be a syndrome of central sensitivity. We aimed to investigate the effect of pregabalin in patients with MPS in this study. Read More

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September 2021

Cross-cultural adaptation and psychometric validation of the Indonesian version of the Oxford Hip Score.

Bone Jt Open 2021 Sep;2(9):765-772

Orthopaedic and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia.

Aims: The aim of this study was to perform a cross-cultural adaptation of Oxford Hip Score (OHS) to Indonesian, and to evaluate its psychometric properties.

Methods: We performed a cross-cultural adaptation of Oxford Hip Score into Indonesian language (OHS-ID) and determined its internal consistency, test-retest reliability, measurement error, floor-ceiling effect, responsiveness, and construct validity by hypotheses testing of its correlation with Harris Hip Score (HHS), vsual analogue scale (VAS), and Short Form-36 (SF-36). Adults (> 17 years old) with chronic hip pain (osteoarthritis or osteonecrosis) were included. Read More

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September 2021

Patient-Reported Outcomes for Fractures of the Acetabulum: A Comparison Between Patient-Reported Outcomes Information System and Traditional Instruments.

J Am Acad Orthop Surg 2021 Sep 17. Epub 2021 Sep 17.

From the Department of Orthopaedics and Sports Medicine, University of Cincinnati, Cincinnati, OH.

Introduction: The objective of this study was to compare instruments from the Patient-Reported Outcomes Information System (PROMIS) with previously validated acetabulum fracture outcome instruments.

Methods: This study included adult patients presenting for routine follow-up at least 3 months after surgical treatment of an acetabulum fracture. Participants completed four different patient-reported outcomes in a randomized order: PROMIS Mobility, PROMIS Physical Function, Short Form 36 (SF-36), and Short Musculoskeletal Functional Assessment (SMFA). Read More

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September 2021

Improving Targeted Delivery and Antitumor Efficacy with Engineered Tumor Necrosis Factor-Related Apoptosis Ligand-Affibody Fusion Protein.

Mol Pharm 2021 Sep 20. Epub 2021 Sep 20.

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, People's Republic of China.

Tumor necrosis factor-related apoptosis ligand (TRAIL) is a promising protein candidate for selective apoptosis of a variety of cancer cells. However, the short half-life and a lack of targeted delivery are major obstacles for its application in cancer therapy. Here, we propose a simple strategy to solve the targeting problem by genetically fusing an anti-HER2 affibody to the C-terminus of the TRAIL. Read More

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September 2021

Repetitive transcranial magnetic stimulation for fibromyalgia patients: A Systematic Review with Meta-Analysis.

Pain Med 2021 Sep 20. Epub 2021 Sep 20.

Department of Rehabilitation, Yueyang Integrated traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of traditional Chinese Medicine, Shanghai, 200437, P. R. China.

Objective: Fibromyalgia is a poorly understood pain syndrome. Repetitive transcranial magnetic stimulation is a noninvasive brain stimulation therapy and is commonly applied for the management of fibromyalgia. However, controversy regarding its efficacy remains. Read More

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September 2021