9,874 results match your criteria short complementary

Multi-exposure interferometric diffusing wave spectroscopy.

Opt Lett 2021 Sep;46(18):4498-4501

We present multi-exposure interferometric diffusing wave spectroscopy (MiDWS), which measures brain blood flow index (BFI) continuously and non-invasively. MiDWS employs interferometry to detect low light levels, probing the optical field autocorrelation indirectly by varying the sensor exposure time. Here MiDWS is compared with conventional interferometric diffusing wave spectroscopy and speckle contrast optical spectroscopy in phantoms. Read More

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September 2021

Homeopathic Treatment for COVID-19-Related Symptoms: A Case Series.

Complement Med Res 2021 Sep 14:1-6. Epub 2021 Sep 14.

Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Background: Severe acute respiratory syndrome due to coronavirus 2 (SARS CoV-2) is a novel infectious disease, which has quickly developed into a pandemic. The spectrum of COVID-19 symptoms is broad, ranging from a mild, self-limiting respiratory tract illness to severe progressive pneumonia, multi-organ failure and possible death. Despite much effort and multiple clinical trials, there are, to date, no specific therapeutic agents to treat or cure the coronavirus infection. Read More

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September 2021

Quotas and Gender Competence: Independent or Complementary Approaches to Gender Equality?

Front Sociol 2021 27;6:740462. Epub 2021 Aug 27.

Institute for Advanced Studies, Research Group Higher Education Research, Vienna, Austria.

Austrian gender equality policy in higher education is characterized by the successful implementation of a comprehensive set of gender equality policies and persistent gender imbalances. After the introduction of a legal quota for university bodies, for instance, female representation in decision-making bodies increased significantly within a short period of time. However, this did not lead to a cultural change or the abolishment of barriers to women's careers. Read More

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Cross cultural and global uses of a digital mental health app: results of focus groups with clinicians, patients and family members in India and the United States.

Glob Ment Health (Camb) 2021 24;8:e30. Epub 2021 Aug 24.

Division of Digital Psychiatry, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.

Background: Despite significant advancements in healthcare technology, digital health solutions - especially those for serious mental illnesses - continue to fall short of their potential across both clinical practice and efficacy. The utility and impact of medicine, including digital medicine, hinges on relationships, trust, and engagement, particularly in the field of mental health. This paper details results from Phase 1 of a two-part study that seeks to engage people with schizophrenia, their family members, and clinicians in co-designing a digital mental health platform for use across different cultures and contexts in the United States and India. Read More

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Coherent spin-wave transport in an antiferromagnet.

Nat Phys 2021 Sep 29;17(9):1001-1006. Epub 2021 Jul 29.

Kavli Institute of Nanoscience, Delft University of Technology, P.O. Box 5046, 2600 GA Delft, The Netherlands.

Magnonics is a research field complementary to spintronics, in which quanta of spin waves (magnons) replace electrons as information carriers, promising lower dissipation. The development of ultrafast nanoscale magnonic logic circuits calls for new tools and materials to generate coherent spin waves with frequencies as high, and wavelengths as short, as possible. Antiferromagnets can host spin waves at terahertz (THz) frequencies and are therefore seen as a future platform for the fastest and the least dissipative transfer of information. Read More

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September 2021

Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions.

Sci Rep 2021 Sep 9;11(1):17926. Epub 2021 Sep 9.

Institute of Zoology, Developmental Biology Unit, University of Cologne, Cologne, Germany.

The extracellular matrix architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins (Hmcn1 and Hmcn2) are ancient and very large members (> 600 kDa) of the fibulin family, whose short members are known to guide proper morphology and functional behavior of specialized cell types predominantly in elastic tissues. However, the tissue distribution and function of Hemicentins within the cellular microenvironment of connective tissues has remained largely unknown. Read More

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September 2021

Associations between ambient fine particulate matter and child respiratory infection: The role of particulate matter source composition in Dhaka, Bangladesh.

Environ Pollut 2021 Aug 30;290:118073. Epub 2021 Aug 30.

Center for Innovation in Global Health, Stanford University, USA.

Air pollution in the form of fine particulate matter (PM) has been linked to adverse respiratory outcomes in children. However, the magnitude of this association in South Asia and sources of PM that drive adverse health effects are largely unknown. This study evaluates associations between short-term variation in ambient PM and incidence of pneumonia and upper respiratory infections among children in Dhaka, Bangladesh. Read More

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Salience-Guided Iterative Asymmetric Mutual Hashing for Fast Person Re-Identification.

IEEE Trans Image Process 2021 14;30:7776-7789. Epub 2021 Sep 14.

Person Re-identification (ReID) aims to retrieve the pedestrian with the same identity across different views. Existing studies mainly focus on improving accuracy, while ignoring their efficiency. Recently, several hash based methods have been proposed. Read More

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September 2021

The Subjective Well-being and Health-Related Quality of Life of Australian Adults with Increased Intestinal Permeability and Associations with Treatment Interventions.

J Altern Complement Med 2021 Sep 7. Epub 2021 Sep 7.

Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.

The integrity and function of the gastrointestinal system is important in disease prevention and management. This study aims to describe the management methods used by Australian adults with suspected increased intestinal permeability (IP) and the association with subjective wellbeing (SWB) and health-related quality of life (HRQoL). Cross-sectional survey of Australian adults diagnosed with IP or have suspected (undiagnosed) IP. Read More

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September 2021

Complexes of β-lactoglobulin and high methyl-esterified pectin as a one-shot delivery system for reinforcing oil/water interfaces.

Soft Matter 2021 Sep 8. Epub 2021 Sep 8.

School of Fundamental Science, Massey University, Palmerston North, 4442, New Zealand.

Electrostatic complexation of negatively charged polysaccharides with β-lactoglobulin (β-lg) has been shown to bolster the protein films at oil/water interfaces thereby improving emulsion stability. However, recent sub-phase exchange experiments demonstrated that highly charged polysaccharides such as low methyl-esterified pectin are complementary only if sequentially introduced to a pre-formed interfacial β-lg film. In this study, results of transient interfacial shear rheology show that, by using high-methylesterified pectins instead, complexes can be formed in pre-mixed solutions with β-lg at pH 4 that can lead to reinforced protein films at dodecane/water interfaces. Read More

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September 2021

Lipid Peroxide-Derived Short-Chain Aldehydes are Involved in Aluminum Toxicity of Wheat () Roots.

J Agric Food Chem 2021 Sep 6;69(36):10496-10505. Epub 2021 Sep 6.

MOE Key Laboratory of Environment Remediation and Ecological Health, College of Environmental & Resource Sciences, Zhejiang University, Hangzhou 310058, China.

Lipid peroxidation is a common event during aluminum (Al) toxicity in plants, and it generates an array of aldehyde fragments. The present study investigated and compared the profile and physiological functions of lipid peroxide-derived aldehydes under Al stress in two wheat genotypes that differed in Al resistance. Under Al stress, the sensitive genotype Yangmai-5 suffered more severe plasma membrane damage and accumulated higher levels of aldehydes in roots than the Al-tolerant genotype Jian-864. Read More

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September 2021

Guiding immunotherapy combinations: who gets what?

Adv Drug Deliv Rev 2021 Sep 1:113962. Epub 2021 Sep 1.

Duke Cancer Institute, Durham, NC, 27710. Electronic address:

Although PD-1 and CTLA-4 inhibitors have proven successful in a range of malignancies, there are subsets of patients that do not respond to these agents due to upregulation of adaptive and innate resistance mechanisms by the tumor and its surrounding microenvironment. As new immunotherapeutic strategies are developed, there is a need for rational implementation of novel immunotherapy combinations that target complementary mechanisms of immunotherapy resistance intrinsic to each patient and tumor type. In this short review, we cover mechanisms by which tumors evade the immune system, as well as summarize available clinical data on emerging therapeutic agents that target these defense mechanisms. Read More

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September 2021

Short Read-Length Next Generation DNA Sequencing of Antibody CDR Combinations from Phage Selection Outputs.

Methods Mol Biol 2022 ;2313:127-141

Department of Pathology and Lab Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Phage display is commonly used to select target-binding antibody fragments from large libraries containing billions of unique antibody clones. In practice, selection outputs are often highly heterogenous, making it desirable to recover sequence information from the selected pool. Next Generation DNA Sequencing (NGS) enables the acquisition of sufficient sequencing reads to cover the pool diversity, however read-lengths are typically too short to capture paired antibody complementarity-determining regions (CDRs), which is needed to reconstruct target-binding antibody fragments. Read More

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January 2022

Assessing the Resolution of Methyltransferase-Mediated DNA Optical Mapping.

ACS Omega 2021 Aug 10;6(33):21276-21283. Epub 2021 Aug 10.

Molecular Imaging and Photonics Unit, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.

Interest in the human microbiome is growing and has been, for the past decade, leading to new insights into disease etiology and general human biology. Stimulated by these advances and in a parallel trend, new DNA sequencing platforms have been developed, radically expanding the possibilities in microbiome research. While DNA sequencing plays a pivotal role in this field, there are some technological hurdles that are yet to be overcome. Read More

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Building robust assemblages of bacteria in the human gut in early life.

Gerald W Tannock

Appl Environ Microbiol 2021 Sep 1:AEM0144921. Epub 2021 Sep 1.

Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

The neonatal body provides a range of potential habitats, such as the gut, for microbes. These sites eventually harbor microbial communities (microbiotas). A 'complete' (adult) gut microbiota is not acquired by the neonate immediately after birth. Read More

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September 2021

Access to ultra-long IgG CDRH3 bovine antibody sequences using short read sequencing technology.

Mol Immunol 2021 Aug 28;139:97-105. Epub 2021 Aug 28.

International Livestock Research Institute (ILRI), P.O. Box 30709 -00100, Nairobi, Kenya.

The advances in high-throughput DNA sequencing and recombinant antibody technologies has presented new methods for characterizing antibody repertoires and significantly increased our understanding on the functional role of antibodies in immunity and their use in diagnostics, vaccine antigen design and as biological therapeutics. A subset of Bos taurus antibodies possesses unique ultra-long third complementary-determining region of the heavy chain (CDRH3) and are of special interest because they are thought to have unique functional abilities of broadly neutralizing properties - a functional role that has not been fully explored in vaccine development. Next generation sequencing technologies that are widely used to profile immunoglobulin (Ig) repertoires are based on short-read methods such as the Illumina technology. Read More

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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia: targeted immunotherapy for acute lymphoblastic leukemia.

Front Med 2021 Aug 31. Epub 2021 Aug 31.

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. However, several studies showed that blinatumomab has a short plasma half-life due to its low molecular weight, and thus its clinical use is limited. Furthermore, multiple trials have shown that approximately 30% of blinatumomab-relapsed cases are characterized by CD19 negative leukemic cells. Read More

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Ultrasound and Fetal MRI Complementary Contributions to Appropriate Counseling in Small Bowel Obstruction.

Fetal Diagn Ther 2021 Aug 30:1-8. Epub 2021 Aug 30.

AP-HP, Hôpital Necker Enfants Malades, Service de Radiologie Pédiatrique, Paris, France.

Objective: Bowel obstructions beyond the duodenum represent a heterogeneous group of congenital anomalies with a highly variable prognosis, the main issue being postnatal short bowel syndrome (SBS). The objective of our study was to evaluate the contributions of fetal MRI in cases of bowel obstruction.

Materials And Methods: A retrospective analysis of all newborns, for whom both ante-natal ultrasound and fetal MRI were available, referred to our center for suspected bowel obstruction was performed. Read More

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Gut Microbiota Development: Influence of Diet from Infancy to Toddlerhood.

Ann Nutr Metab 2021 Aug 30:1-14. Epub 2021 Aug 30.

National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

Early life is a critical period as our gut microbiota establishes here and may impact both current and future health. Thus, it is of importance to understand how different factors govern the complex microbial colonization patterns in this period. The gut microbiota changes substantially during infancy and toddlerhood in terms of both taxonomic composition and diversity. Read More

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Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing.

Biologics 2021 21;15:353-361. Epub 2021 Aug 21.

Division of Biochemistry, Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in all living cells and utilized in many applied disciplines. Guide RNA (gRNA) and CRISPR-associated (Cas-9) proteins are the two essential components in CRISPR/Cas-9 system. The mechanism of CRISPR/Cas-9 genome editing contains three steps, recognition, cleavage, and repair. Read More

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Bioinspired artificial platelets: past, present and future.

Platelets 2021 Aug 30:1-13. Epub 2021 Aug 30.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.

Platelets are anucleate blood cells produced from megakaryocytes predominantly in the bone marrow and released into blood circulation at a healthy count of 150,000-400,00 per μL and circulation lifespan of 7-9 days. Platelets are the first responders at the site of vascular injury and bleeding, and participate in clot formation via injury site-specific primary mechanisms of adhesion, activation and aggregation to form a platelet plug, as well as secondary mechanisms of augmenting coagulation via thrombin amplification and fibrin generation. Platelets also secrete various granule contents that enhance these mechanisms for clot growth and stability. Read More

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Functional meta-omics provide critical insights into long- and short-read assemblies.

Brief Bioinform 2021 Aug 27. Epub 2021 Aug 27.

Luxembourg Centre for Systems Biomedicine, 7, avenue des Hauts-Fourneaux, Esch-sur-Alzette L-4362, Luxembourg.

Real-world evaluations of metagenomic reconstructions are challenged by distinguishing reconstruction artifacts from genes and proteins present in situ. Here, we evaluate short-read-only, long-read-only and hybrid assembly approaches on four different metagenomic samples of varying complexity. We demonstrate how different assembly approaches affect gene and protein inference, which is particularly relevant for downstream functional analyses. Read More

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A Critical Review of the Current Global Ex Situ Conservation System for Plant Agrobiodiversity. I. History of the Development of the Global System in the Context of the Political/Legal Framework and Its Major Conservation Components.

Plants (Basel) 2021 Jul 29;10(8). Epub 2021 Jul 29.

World Vegetable Center, 60 Yi-Min Liao, Shanhua, Tainan 74151, Taiwan.

The history of ex situ conservation is relatively short, not more than a century old. During the middle of last century, triggered by the realization that genetic erosion was threatening the existing landraces and wild relatives of the major food crops, global efforts to collect and conserve the genetic diversity of these threatened resources were initiated, predominantly orchestrated by FAO. National and international genebanks were established to store and maintain germplasm materials, conservation methodologies were created, standards developed, and coordinating efforts were put in place to ensure effective and efficient approaches and collaboration. Read More

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The Significance of the DUF283 Domain for the Activity of Human Ribonuclease Dicer.

Int J Mol Sci 2021 Aug 13;22(16). Epub 2021 Aug 13.

Department of Ribonucleoprotein Biochemistry, Institute of Bioorganic Chemistry Polish Academy of Sciences, 61-704 Poznan, Poland.

Dicers are multidomain proteins, usually comprising an amino-terminal putative helicase domain, a DUF283 domain (domain of unknown function), a PAZ domain, two RNase III domains (RNase IIIa and RNase IIIb) and a dsRNA-binding domain. Dicer homologs play an important role in the biogenesis of small regulatory RNAs by cleaving single-stranded precursors adopting stem-loop structures (pre-miRNAs) and double-strand RNAs into short RNA duplexes containing functional microRNAs or small interfering RNAs, respectively. Growing evidence shows that apart from the canonical role, Dicer proteins can serve a number of other functions. Read More

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Harnessing the Potential of CRISPR/Cas in Atherosclerosis: Disease Modeling and Therapeutic Applications.

Int J Mol Sci 2021 Aug 5;22(16). Epub 2021 Aug 5.

School of Biosciences, Taylor's University, Subang Jaya 47500, Malaysia.

Atherosclerosis represents one of the major causes of death globally. The high mortality rates and limitations of current therapeutic modalities have urged researchers to explore potential alternative therapies. The clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9) system is commonly deployed for investigating the genetic aspects of Atherosclerosis. Read More

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Development of a Scale to Measure Infant Eating Behaviour Worldwide.

Nutrients 2021 Jul 22;13(8). Epub 2021 Jul 22.

Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G31 2ER, UK.

In order to create a short, internationally valid scale to assess eating behaviour (EB) in young children at risk of undernutrition, we refined 15 phrases describing avidity or food refusal (avoidance). In study one, 149 parents matched phrases in English, Urdu, Cantonese, Indonesian or Greek to videos showing avidity and avoidance; 82-100% showed perfect agreement for the avidity phrases and 73-91% for the avoidant phrases. In study two, 575 parents in the UK, Cyprus and Indonesia (healthy) and in Kenya, Pakistan and Guatemala (healthy and undernourished) rated their 6-24 months old children using the same phrases. Read More

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Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects.

Micromachines (Basel) 2021 Jul 31;12(8). Epub 2021 Jul 31.

Biologically Inspired Sensors and Actuators Laboratory (BioSA), York University, Toronto, ON M3J 1P3, Canada.

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, this fatal disease has been the leading cause of the death of more than 3.9 million people around the world. This tragedy taught us that we should be well-prepared to control the spread of such infectious diseases and prevent future hazards. Read More

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Incremental learning of LSTM framework for sensor fusion in attitude estimation.

PeerJ Comput Sci 2021 4;7:e662. Epub 2021 Aug 4.

Symbiosis Centre for Applied Artificial Intelligence, Symbiosis International (Deemed University), Pune, Maharashtra, India.

This paper presents a novel method for attitude estimation of an object in 3D space by incremental learning of the Long-Short Term Memory (LSTM) network. Gyroscope, accelerometer, and magnetometer are few widely used sensors in attitude estimation applications. Traditionally, multi-sensor fusion methods such as the Extended Kalman Filter and Complementary Filter are employed to fuse the measurements from these sensors. Read More

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Thyroid cancer surgery during the coronavirus disease 2019 pandemic: perioperative management and oncological and anatomical considerations.

Future Oncol 2021 Aug 25. Epub 2021 Aug 25.

Department of Anatomy, Medical School, National & Kapodistrian University of Athens, Athens, 11527, Greece.

The coronavirus disease 2019 (COVID-19) pandemic has changed many aspects of our everyday lives and medical practice, including oncology treatment; thyroid cancer surgery is not an exception. The reported number of fine-needle aspirations performed during the first semester of 2020 was significantly reduced. Poorly differentiated, medullary and anaplastic thyroid tumors are considered important indications for immediate surgical intervention. Read More

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Water, sanitation, and hygiene as a priority intervention for stunting in under-five children in northwest Ethiopia: a community-based cross-sectional study.

Ital J Pediatr 2021 Aug 24;47(1):174. Epub 2021 Aug 24.

Department of Pharmacy, College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia.

Background: Stunting was a significant public health problem for under-five in developing countries including Ethiopia. Globally, it was estimated 21.9% or 149 million (81. Read More

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