Life Sci 2021 Mar 31;277:119468. Epub 2021 Mar 31.
Department of Digestive Diseases, Xijing Hospital, the Fourth Military Medical University, 127th Changle West Road, Xi'an 710032, Shaanxi, China; Department of Colorectal Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, 79th Qingchun Road, Hangzhou 310003, Zhejiang, China. Electronic address:
Aim: Small bowel transplantation (SBT) is the only therapy for end-stage short bowel syndrome. However, complicated pathological changes and an increased risk of postoperative infections in the perioperative period are major obstacles to patient survival, but the associated mechanisms remain unclear.
Methods: To explore perioperative alterations in the intestinal microbiota and their functional changes after SBT, 16S rRNA sequencing of ileostomy effluents and plasma analysis were performed pre-SBT and periodically post-SBT. Read More