13,806 results match your criteria shifts medical


Intracellular Localization of the Proteins Encoded by Some Type II Toxin-Antitoxin Systems in Escherichia coli.

mBio 2021 Aug 3:e0141721. Epub 2021 Aug 3.

Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Bacterial toxin-antitoxin (TA) systems encode a toxin and an antitoxin that counteracts the toxin. Such TA systems are found abundantly on bacterial chromosomes and on extrachromosomal genetic elements. The toxin is always a protein. Read More

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Learning domain-agnostic visual representation for computational pathology using medically-irrelevant style transfer augmentation.

IEEE Trans Med Imaging 2021 Aug 2;PP. Epub 2021 Aug 2.

Suboptimal generalization of machine learning models on unseen data is a key challenge which hampers the clinical applicability of such models to medical imaging. Although various methods such as domain adaptation and domain generalization have evolved to combat this challenge, learning robust and generalizable representations is core to medical image understanding, and continues to be a problem. Here, we propose STRAP (Style TRansfer Augmentation for histoPathology), a form of data augmentation based on random style transfer from non-medical style sources such as artistic paintings, for learning domain-agnostic visual representations in computational pathology. Read More

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Relationships Between 24-hour LH and Testosterone Concentrations and With Other Pituitary Hormones in Healthy Older Men.

J Endocr Soc 2021 Sep 29;5(9):bvab075. Epub 2021 Apr 29.

Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Objective: To investigate the relationship between LH and testosterone (T), which characteristics associate with the strength of this relationship, and their interrelationships with GH, TSH, cortisol, and ACTH.

Design: Hormones were measured in serum samples collected every 10 minutes during 24 hours from 20 healthy men, comprising 10 offspring of long-lived families and 10 control subjects, with a mean (SD) age of 65.6 (5. Read More

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September 2021

Exogenous Ketone Salt Supplementation and Whole-Body Cooling Do Not Improve Short-Term Physical Performance.

Front Nutr 2021 15;8:663206. Epub 2021 Jul 15.

Laboratory of Environmental Exercise Physiology, School of Kinesiology and Health Sciences, Laurentian University, Sudbury, ON, Canada.

Exogenous ketone supplementation and whole-body cooling (WBC) have shown to independently influence exercise metabolism. Whether readily available ketone salts, with and without WBC, would provide similar metabolic benefits during steady-state aerobic and time-trial performances was investigated. Nine active males (VO: 56. Read More

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Focal Neurologic Deficit After Epidural Catheter Removal Leads to Meningioma Diagnosis.

Cureus 2021 Jun 29;13(6):e16015. Epub 2021 Jun 29.

Anesthesiology, State University of New York Upstate Medical University, Syracuse, USA.

We present an unusual case of a 60-year-old female who developed subtle, new-onset left upper and lower extremity weakness on day five of perioperative thoracic epidural placement. The onset of a focal neurological deficit after epidural placement usually raises suspicion for the presence of an epidural hematoma, abscess, or traumatic cord lesion. However, in this patient, brain imaging revealed a large, previously undiagnosed intracranial mass. Read More

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One, No One and One Hundred Thousand: Patterns of chronic prostatic inflammation and infection.

Exp Ther Med 2021 Sep 7;22(3):966. Epub 2021 Jul 7.

Urology Secondary Care Clinic, ASST-Nord, I-20092 Milan, Italy.

Chronic prostatic inflammation may be classified into three types that share similar symptoms and are distinguished on the basis of microbiological findings. In the present study, consecutive cases of chronic prostatic inflammation and infection were retrospectively reviewed in order to explore the clinical course and long-term outcomes. The cohort consisted of patients with symptoms of prostatitis who visited the Urology Clinic of the Tzaneion Hospital (Piraeus, Greece) between March 2009 and March 2019. Read More

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September 2021

Self-Care and Storytelling for Radiologists: A Feasibility Study.

Curr Probl Diagn Radiol 2021 Jul 4. Epub 2021 Jul 4.

Department of Radiology, MedStar Georgetown University Hospital, Washington, DC.

Rationale And Objectives: Physician wellness and burnout mitigation strategies have become priority practices in recent years. Despite these efforts, however, physicians living with the psychological effects of the current COVID-19 global pandemic, political stressors, and social injustices, face ever increasing threats to their personal and professional well-being. This manuscript investigates the process of storytelling as a self-care practice for radiologists. Read More

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Task shifting in primary care to tackle healthcare worker shortages: An umbrella review.

Eur J Gen Pract 2021 Dec;27(1):198-210

School of Pharmacy, Monash University Malaysia, Selangor, Malaysia.

Background: Task shifting is an approach to help address the shortage of healthcare workers through reallocating human resources but its impact on primary care is unclear.

Objectives: To provide an overview of reviews describing task shifts from physicians to allied healthcare workers in primary care and its impact on clinical outcomes.

Methods: Six electronic databases were searched up to 15 December 2020, to identify reviews describing task shifting in primary care. Read More

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December 2021

Recurrent assessment of lymphocyte subsets in 32 patients with multisystem inflammatory syndrome in children (MIS-C).

Pediatr Allergy Immunol 2021 Jul 31. Epub 2021 Jul 31.

Department of Pediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, Poland.

Background: Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS-C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS-C.

Methods: In this prospective cross-sectional study, we performed peripheral lymphocyte phenotyping in 32 patients with MIS-C. Read More

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Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation.

Nat Commun 2021 07 30;12(1):4644. Epub 2021 Jul 30.

RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, UMass Medical School, Worcester, MA, USA.

Frameshifting of mRNA during translation provides a strategy to expand the coding repertoire of cells and viruses. How and where in the elongation cycle +1-frameshifting occurs remains poorly understood. We describe seven ~3. Read More

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Evaluating real-world national and regional trends in definitive closure in US burn care: A survey of US Burn Centers.

J Burn Care Res 2021 Jul 30. Epub 2021 Jul 30.

Avita Medical, Valencia, CA.

To better understand trends in burn treatment patterns related to definitive closure, this study sought benchmark real-world survey data with national data contained within the National Burn Repository version 8.0 (NBR v8.0) across key burn center practice patterns, resource utilization, and clinical outcomes. Read More

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Chronic angiotensin receptor activation promotes hepatic triacylglycerol accumulation during an acute glucose challenge in obese-insulin-resistant OLETF rats.

Endocrine 2021 Jul 29. Epub 2021 Jul 29.

School of Natural Sciences, University of California, Merced, CA, USA.

Purpose: Angiotensin receptor blockers (ARBs) can ameliorate metabolic syndrome (MetS)-associated dyslipidemia, hepatic steatosis, and glucose intolerance, suggesting that angiotensin receptor (AT1) over-activation contributes to impaired lipid and glucose metabolism, which is characteristic of MetS. The aim of this study was to evaluate changes in the lipid profile and proteins of fatty acid uptake, triacylglycerol (TAG) synthesis, and β-oxidation to better understand the links between AT1 overactivation and non-alcoholic fatty liver disease (NAFLD) during MetS.

Methods: Four groups of 25-week-old-rats were used: (1) untreated LETO, (2) untreated OLETF, (3) OLETF + angiotensin receptor blocker (ARB; 10 mg olmesartan/kg/d × 8 weeks) and (4) OLETF ± ARB (MINUS; 10 mg olmesartan/kg/d × 4 weeks, then removed until dissection). Read More

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Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation .

Front Immunol 2021 13;12:674334. Epub 2021 Jul 13.

Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, United States.

Background: Newborns exhibit distinct immune responses and are at high risk of infection. Neonatal immunization with BCG, the live attenuated vaccine against tuberculosis (TB), is associated with broad protection against a range of unrelated pathogens, possibly reflecting vaccine-induced training of innate immune cells ("innate memory"). However, little is known regarding the impact of age on BCG-induced innate responses. Read More

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Evaluating preferences for colorectal cancer screening in individuals under age 50 using the Analytic Hierarchy Process.

BMC Health Serv Res 2021 Jul 29;21(1):754. Epub 2021 Jul 29.

Department of Behavioral and Community Health, School of Public Health, University of Maryland, College Park, USA.

Background: In 2021, the United States Preventive Services Task Force updated their recommendation, stating that individuals ages 45-49 should initiate screening for colorectal cancer. Since several screening strategies are recommended, making a shared decision involves including an individual's preferences. Few studies have included individuals under age 50. Read More

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Matching Digital Intervention Affordances with Tasks: The Case of a Zoom and WhatsApp Mental Health Intervention for Seniors during the COVID-19 Pandemic.

Health Commun 2021 Jul 30:1-13. Epub 2021 Jul 30.

The Spitzer Department of Social Work, Faculty of Humanities and Social Sciences, Ben-Gurion University of the Negev.

During the first COVID-19 wave, we conducted a Zoom and WhatsApp digital group intervention that promoted community-dwelling seniors' mental health. A total of 82 community-dwelling adults participated in this intervention. Based on the media richness theory (MRT) and the affordances approach, we used netnography to explore how group moderators and technical support team members (n = 9), but not the seniors themselves, perceived the ways Zoom and WhatsApp technological affordances/constraints matched intervention tasks and increased intervention performance. Read More

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Missed critical value callbacks due to middleware flaw.

Clin Biochem 2021 Jul 26. Epub 2021 Jul 26.

Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Objectives: In 2018, our clinical laboratory was alerted to back-to-back plasma sodium critical value callback failures on the same patient, occurring on different shifts and involving different technologists. Therefore, we set forth to investigate the root cause for the critical value callback failures.

Design And Methods: We conducted a thorough investigation focused on the processes associated with critical value identification and notification for plasma sodium measurement performed on the Siemens Vista. Read More

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MFGM components promote gut Bifidobacterium growth in infant and in vitro.

Eur J Nutr 2021 Jul 29. Epub 2021 Jul 29.

National Engineering Center of Dairy for Maternal and Child Health, Beijing Sanyuan Foods Co. Ltd., No. 8, Yingchang Street, Yinghai Town, Daxing District, Beijing, 100163, China.

Purpose: Infant gut microbiota which plays an important role in long-term health is mainly shaped by early life nutrition. However, the effect of nutrients on infants gut microbiota is less researched. Here, we present a study aiming to investigate in vitro a modified formula that is supplemented with milk fat globule membrane (MFGM) that were missing in common formulas when compared with human milk and to assess the impact of feeding scheme on microbiota and metabolism. Read More

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Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme.

Biomed Pharmacother 2021 Jul 19;141:111928. Epub 2021 Jul 19.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address:

Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000 cases recorded annually in the United States. Various clinical analyses and studies show that certain chronic diseases, including cancer, interact between cell-reactive radicals rise and pathogenesis. Reactive oxygen and nitrogenous sources include endogenous (physiological processes), and exogenous sources contain reactive oxygen and nitrogen (xenobiotic interaction). Read More

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Lower body negative pressure reduces jugular and portal vein volumes, and counteracts the cerebral vein velocity elevation during long-duration spaceflight.

J Appl Physiol (1985) 2021 Jul 29. Epub 2021 Jul 29.

Dept of Orthopaedic Surgery, UCSD Medical Center, La Jolla, CA, United States.

Purpose: Cephalad fluid shifts in space have been hypothesized to cause the spaceflight-associated neuro-ocular syndrome (SANS) by increasing the intracranial-ocular translaminal pressure gradient. Lower body negative pressure (LBNP) can be used to shift upper-body blood and other fluids towards the legs during spaceflight. We hypothesized that microgravity would increase jugular vein volume (JVvol), portal vein cross-sectional area (PV), and intracranial venous blood velocity (MCV) and that 25mmHg LBNP application would return these variables towards preflight levels. Read More

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COVID-19 Pandemic as an Excellent Opportunity for Global Health Diplomacy.

Front Public Health 2021 12;9:655021. Epub 2021 Jul 12.

Daniel K. Inouye Asia-Pacific Center for Security Studies, Honolulu, HI, United States.

Undoubtedly, the COVID-19 pandemic is not the first and most frightening global pandemic, and it may not be the last. At the very least, this phenomenon has though seriously challenged the health systems of the world; it has created a new perspective on the value of national, regional, and international cooperation during crises. The post-coronavirus world could be a world of intensified nationalist rivalries on the economic revival and political influence. Read More

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Laxative Abuse Cessation Leading to Severe Edema.

Cureus 2021 Jun 23;13(6):e15847. Epub 2021 Jun 23.

Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA.

Stimulant laxatives are a common class of laxatives that is abused by patients with eating disorders. We present a case of a 30-year-old female who presented with dyspnea, peripheral edema and weight gain who had been chronically using laxatives. Her symptoms were consistent with rebound edema caused by sodium and free water shifts with abrupt cessation of excessive stimulant laxative use. Read More

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Mapping drug epidemiology futures.

Int J Drug Policy 2021 Jul 25:103378. Epub 2021 Jul 25.

Bristol Medical School, University of Bristol, UK.

Epidemiology is a core discipline generating evidence to inform and drive drug policy. In this essay, we speculate on what the future of drug epidemiology might become. We highlight for attention two areas shaping the future of drug epidemiology: nesting epidemiology within a 'syndemic' and 'relational' approach; and innovating in relation to causal inference in the face of complexity. Read More

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The pacemaker of snake heart is localized near the sinoatrial valve.

J Exp Biol 2021 Jul 28. Epub 2021 Jul 28.

Section of Zoophysiology, Institute of Biology, University of Aarhus, Aarhus, Denmark.

To provide the first description of the exact location of primary pacemaker of the squamate heart, we used sharp microelectrode impalements and optical mapping of isolated sinus venosus preparations from Burmese pythons. We located the dominant pacemaker site at the base of the right leaflet of the sinoatrial valve (SAV), but latent pacemakers were also identified in a circular region around the SAV. Acetylcholine (10-5M) or noradrenaline (10-6M) induced shifts of the leading pacemaker site to other points near the SAV. Read More

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Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.

Nat Commun 2021 07 26;12(1):4515. Epub 2021 Jul 26.

Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.

The in vivo phenotypic profile of T cells reactive to severe acute respiratory syndrome (SARS)-CoV-2 antigens remains poorly understood. Conventional methods to detect antigen-reactive T cells require in vitro antigenic re-stimulation or highly individualized peptide-human leukocyte antigen (pHLA) multimers. Here, we use single-cell RNA sequencing to identify and profile SARS-CoV-2-reactive T cells from Coronavirus Disease 2019 (COVID-19) patients. Read More

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Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus.

Proc Natl Acad Sci U S A 2021 Aug;118(32)

DANTE - Diet and Ancient Technology Laboratory, Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, 00161 Rome, Italy;

Archaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of oral microbiota across time in response to processes that impacted our culture and biology, such as the rise of farming during the Neolithic. However, the extent to which the human oral flora changed from prehistory until present has remained elusive due to the scarcity of data on the microbiomes of prehistoric humans. Here, we present our reconstruction of oral microbiomes via shotgun metagenomics of dental calculus in 44 ancient foragers and farmers from two regions playing a pivotal role in the spread of farming across Europe-the Balkans and the Italian Peninsula. Read More

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Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines.

J Cell Commun Signal 2021 Jul 26. Epub 2021 Jul 26.

Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014, India.

The G-quadruplexes (G4s) are a class of DNA secondary structures with guanine rich DNA sequences that can fold into four stranded non-canonical structures. At the genomic level, their pivotal role is well established in DNA replication, telomerase functions, constitution of topologically associating domains, and the regulation of gene expression. Genome instability mediated by altered G4 formation and assembly has been associated with multiple disorders including cancers and neurodegenerative disorders. Read More

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Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy.

Biol Reprod 2021 Jul 26. Epub 2021 Jul 26.

Department of Ob/Gyn and Cecil H. and Ida Green Center for Reproductive Biological Science, The University of Texas Southwestern Medical Center, Dallas, TX.

During gestation, the female reproductive tract must maintain pregnancy while concurrently preparing for parturition. Here, we explore the transitions in gene expression and protein turnover (fractional synthesis rates [FSR]) by which the cervix implements a transition from rigid to compliant. Shifts in gene transcription to achieve immune tolerance and alter epithelial cell programs begin in early pregnancy. Read More

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A Brownian ratchet model for DNA loop extrusion by the cohesin complex.

Elife 2021 Jul 26;10. Epub 2021 Jul 26.

Chromosome Segregation Laboratory, The Francis Crick Institute, London, United Kingdom.

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities. Read More

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A Comparative Study of the Registry System effect on Patients Satisfaction Rate in Two Emergency Department Settings.

Bull Emerg Trauma 2021 Jul;9(3):138-144

Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objective: To assess the patient's satisfaction rate during two distinct registry procedures in the emergency department.

Methods: A cross-sectional study was conducted in educational hospitals with a high volume of patient's admission in Tabriz-Iran and Erzurum-Turkey. In this study, we used a Press Ganey questionnaire as a data collection tool that was filled out with patients or their companions before discharging or referred to other areas (wards). Read More

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A Comprehensive Assessment to Enable Recovery of the Homeless: The HOP-TR Study.

Front Public Health 2021 9;9:661517. Epub 2021 Jul 9.

Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands.

Homelessness is an increasing problem in Western European countries. In the Netherlands, policy reforms and austerity measures induced an urgent need for management information on local homeless citizens. Municipal authorities initiated cross-sectional reviews of Homeless Service (HS) users. Read More

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