Viruses 2021 Jun 18;13(6). Epub 2021 Jun 18.
Southeast Poultry Research Laboratory, USA National Poultry Research Center, Agricultural Research Service, USA, Department of Agriculture, 934 College Station Road, Athens, GA 30605, USA.
In March 2017, highly pathogenic (HP) and low pathogenic (LP) avian influenza virus (AIV) subtype H7N9 were detected from poultry farms and backyard birds in several states in the southeast United States. Because interspecies transmission is a known mechanism for evolution of AIVs, we sought to characterize infection and transmission of a domestic duck-origin H7N9 LPAIV in chickens and genetically compare the viruses replicating in the chickens to the original H7N9 clinical field samples used as inoculum. The results of the experimental infection demonstrated virus replication and transmission in chickens, with overt clinical signs of disease and shedding through both oral and cloacal routes. Read More