Microbiome 2021 04 30;9(1):97. Epub 2021 Apr 30.
Division of Periodontology, College of Dentistry, The Ohio State University, 3180 Postle Hall, 305 W 12th Avenue, Columbus, OH, 43210, USA.
Background: Although localized aggressive periodontitis (LAP), generalized aggressive periodontitis (GAP), and chronic periodontitis (CP) are microbially driven diseases, our inability to separate disease-specific associations from those common to all three forms of periodontitis has hampered biomarker discovery. Therefore, we aimed to map the genomic content of, and the biological pathways encoded by, the microbiomes associated with these clinical phenotypes. We also estimated the extent to which these biomes are governed by the Anna Karenina principle (AKP), which states that eubiotic communities are similar between individuals while disease-associated communities are highly individualized. Read More