5,306 results match your criteria shares common

Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.

BMJ 2021 May 11;373:n1038. Epub 2021 May 11.

Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, South Korea.

Objective: To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.

Design: Multinational network cohort study.

Setting: Hospital electronic health records from the United States, Spain, and China, and nationwide claims data from South Korea. Read More

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Barriers to initiation of hepatitis C virus therapy in Germany: A retrospective, case-controlled study.

PLoS One 2021 10;16(5):e0250833. Epub 2021 May 10.

Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.

Despite the availability of highly effective and well-tolerated direct-acting antivirals, not all patients with chronic hepatitis C virus infection receive treatment. This retrospective, multi-centre, noninterventional, case-control study identified patients with chronic hepatitis C virus infection initiating (control) or not initiating (case) treatment at 43 sites in Germany from September 2017 to June 2018. It aimed to compare characteristics of the two patient populations and to identify factors involved in patient/physician decision to initiate/not initiate chronic hepatitis C virus treatment, with a particular focus on historical barriers. Read More

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The blueprint of disaster: COVID-19, the Flint water crisis, and unequal ecological impacts.

Lancet Planet Health 2021 05;5(5):e309-e315

Program on the Global Environment, University of Chicago, Chicago, IL, USA.

COVID-19 is unique in the scope of its effects on morbidity and mortality. However, the factors contributing to its disparate racial, ethnic, and socioeconomic effects are part of an expansive and continuous history of oppressive social policy and marginalising geopolitics. This history is characterised by institutionally generated spatial inequalities forged through processes of residential segregation and neglectful urban planning. Read More

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Pathophysiological Bases of Comorbidity in Migraine.

Front Hum Neurosci 2021 20;15:640574. Epub 2021 Apr 20.

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.

Despite that it is commonly accepted that migraine is a disorder of the nervous system with a prominent genetic basis, it is comorbid with a plethora of medical conditions. Several studies have found bidirectional comorbidity between migraine and different disorders including neurological, psychiatric, cardio- and cerebrovascular, gastrointestinal, metaboloendocrine, and immunological conditions. Each of these has its own genetic load and shares some common characteristics with migraine. Read More

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Evolution of complex I-like respiratory complexes.

J Biol Chem 2021 May 3:100740. Epub 2021 May 3.

Department of Structural Biology, Van Andel Institute, Grand Rapids, Michigan, USA. Electronic address:

The modern-day respiratory complex I shares a common ancestor with the membrane-bound hydrogenase (MBH) and membrane-bound sulfane sulfur reductase (MBS). MBH and MBS use protons and sulfur as their respective electron sinks, which helped to conserve energy during early life in the Proterozoic era when the Earth's atmosphere was low in oxygen. MBH and MBS likely evolved from an integration of an ancestral, membrane-embedded, multiple resistance and pH (Mrp) antiporter and a soluble redox-active module encompassing a [NiFe] hydrogenase. Read More

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Integrating Ethnobotany, Phytochemistry, and Pharmacology of and : What Predictions can be Made for the European Smoketree?

Front Pharmacol 2021 19;12:662852. Epub 2021 Apr 19.

Department of Toxicology, Faculty of Pharmacy, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

The smoketree () is a historically known medicinal plant from Southeast Europe. Its ethnomedicinal use in skin and mucosal lesions is commonly accepted across countries. Other utilizations reported locally include fever reduction, cardiac diseases, hypertension, urinary diseases, cough, asthma, hemorrhoids, diabetes, numbness of arm, liver disease, and cancer. Read More

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Frequency and origin of the c.2090T>G p.(Leu697Trp) MYO3A variant associated with autosomal dominant hearing loss.

Eur J Hum Genet 2021 May 6. Epub 2021 May 6.

Centro de Pesquisas sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brasil.

We recently described a novel missense variant [c.2090T>G:p.(Leu697Trp)] in the MYO3A gene, found in two Brazilian families with late-onset autosomal dominant nonsyndromic hearing loss (ADNSHL). Read More

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Transitions in symbiosis: evidence for environmental acquisition and social transmission within a clade of heritable symbionts.

ISME J 2021 May 3. Epub 2021 May 3.

Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

A dynamic continuum exists from free-living environmental microbes to strict host-associated symbionts that are vertically inherited. However, knowledge of the forces that drive transitions in symbiotic lifestyle and transmission mode is lacking. Arsenophonus is a diverse clade of bacterial symbionts, comprising reproductive parasites to coevolving obligate mutualists, in which the predominant mode of transmission is vertical. Read More

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Anna Karenina and the subgingival microbiome associated with periodontitis.

Microbiome 2021 04 30;9(1):97. Epub 2021 Apr 30.

Division of Periodontology, College of Dentistry, The Ohio State University, 3180 Postle Hall, 305 W 12th Avenue, Columbus, OH, 43210, USA.

Background: Although localized aggressive periodontitis (LAP), generalized aggressive periodontitis (GAP), and chronic periodontitis (CP) are microbially driven diseases, our inability to separate disease-specific associations from those common to all three forms of periodontitis has hampered biomarker discovery. Therefore, we aimed to map the genomic content of, and the biological pathways encoded by, the microbiomes associated with these clinical phenotypes. We also estimated the extent to which these biomes are governed by the Anna Karenina principle (AKP), which states that eubiotic communities are similar between individuals while disease-associated communities are highly individualized. Read More

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Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study.

Lancet Infect Dis 2021 Apr 27. Epub 2021 Apr 27.

Department of Twin Research & Genetic Epidemiology, King's College London, London, UK.

Background: The Pfizer-BioNTech (BNT162b2) and the Oxford-AstraZeneca (ChAdOx1 nCoV-19) COVID-19 vaccines have shown excellent safety and efficacy in phase 3 trials. We aimed to investigate the safety and effectiveness of these vaccines in a UK community setting.

Methods: In this prospective observational study, we examined the proportion and probability of self-reported systemic and local side-effects within 8 days of vaccination in individuals using the COVID Symptom Study app who received one or two doses of the BNT162b2 vaccine or one dose of the ChAdOx1 nCoV-19 vaccine. Read More

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The Potential of Sun-Dried Grape Pomace as a Multi-Functional Ingredient for Herbal Infusion: Effects of Brewing Parameters on Composition and Bioactivity.

Antioxidants (Basel) 2021 Apr 10;10(4). Epub 2021 Apr 10.

Department of Anatomy-Histology-Embryology, Faculty of Medicine, University of Ioannina, 45110 Ioannina, Greece.

Wine and by-products are essential elements of a Mediterranean diet and considered as a reservoir of bioactive compounds with various health effects. Grape pomace, an easily available natural material of low cost, shares a similar wealth of health benefiting bioactive phytochemicals. The objective of this study was to explore the utilization of grape pomace from Commandaria dessert wine as main ingredient for functional infusions. Read More

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Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York.

bioRxiv 2021 Apr 22. Epub 2021 Apr 22.

Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. Variants first detected in the United Kingdom, South Africa, and Brazil have spread to multiple countries. We developed the software tool, Variant Database (VDB), for quickly examining the changing landscape of spike mutations. Read More

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Large-scale annotation and evolution analysis of miRNA in insects.

Genome Biol Evol 2021 Apr 26. Epub 2021 Apr 26.

State Key Laboratory of Rice Biology & Ministry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou, 310058, China.

Insects are among the most diverse and successful groups of animals and exhibit great morphological diversity and complexity. The innovation of wings and metamorphosis are some examples of the fascinating biological evolution of insects. Most miRNAs contribute to canalization by conferring robustness to gene networks and thus increase the heritability of important phenotypes. Read More

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First Report of Barley virus G in the United States and California.

Plant Dis 2021 Apr 27. Epub 2021 Apr 27.

University of California Davis, 8789, Plant Pathology, Davis, California, United States;

Barley (Hordeum vulgare) is a valuable annual cereal crop grown widely throughout the United States and the world. The majority of barley grown commercially in California and throughout the U.S. Read More

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The Role of Physician Professional Networks in Physicians' Receipt of Pharmaceutical and Medical Device Industries' Payments.

J Gen Intern Med 2021 Apr 26. Epub 2021 Apr 26.

Gillings School of Global Public Health, Department of Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: Financial relationships between physicians and the pharmaceutical and medical device industries are common, but the factors associated with physicians receiving payments are unknown.

Objective: The objective of this study is to evaluate the influence of physicians' professional networks' characteristics on the receipt of payments among physicians.

Design: Network analysis of cross-sectional data PARTICIPANTS: US physicians who shared Medicare patients with other physicians in 2015 (N=357,813). Read More

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Genome-wide toxicogenomic study of the lanthanides sheds light on the selective toxicity mechanisms associated with critical materials.

Proc Natl Acad Sci U S A 2021 May;118(18)

Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;

Lanthanides are a series of critical elements widely used in multiple industries, such as optoelectronics and healthcare. Although initially considered to be of low toxicity, concerns have emerged during the last few decades over their impact on human health. The toxicological profile of these metals, however, has been incompletely characterized, with most studies to date solely focusing on one or two elements within the group. Read More

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Concentrations of canine prostate specific esterase, CPSE, at baseline are associated with the relative size of the prostate at three-year follow-up.

BMC Vet Res 2021 Apr 26;17(1):173. Epub 2021 Apr 26.

Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054, SE-750 07, Uppsala, Sweden.

Background: Enlargement of the prostate is associated with prostatic diseases in dogs, and an estimation of prostatic size is a central part in the diagnostic workup. Ultrasonography is often the method of choice, but biomarkers constitute an alternative. Canine prostate specific esterase (CPSE) shares many characteristics with human prostate specific antigen (PSA) and is related to prostate size. Read More

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It's no skin off my nose: the relationship between the skin and allergic rhinitis.

Ann Allergy Asthma Immunol 2021 Apr 23. Epub 2021 Apr 23.

Queen's University, School of Medicine; Division of Dermatology, Department of Medicine, Queen's University, Kingston, Ontario, Canada. Electronic address:

Objective: Evidence supports the relationship between the skin barrier and allergic conditions. This narrative review examines what role the cutaneous barrier may play in the pathogenesis, disease course and management of allergic rhinitis (AR).

Data Sources: A literature review of the MEDLINE/PubMed, Embase, Cochrane and SCOPUS Sciverse databases was conducted to identify available evidence. Read More

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SHARP: enabling generation of real-world evidence on a pan-European scale to improve the lives of individuals with severe asthma.

ERJ Open Res 2021 Apr 19;7(2). Epub 2021 Apr 19.

Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.

Real-world evidence is important to help unravel unanswered problems in severe asthma and is valuable to better understand the patient experience and common clinical practice. The Severe Heterogeneous Asthma Registry, Patient-centred (SHARP) Clinical Research Collaboration is created as a network of national registries and severe asthma centres that work together to perform registry based real-world research and clinical studies on a pan-European scale. Such collaboration requires a new, innovative design to overcome the many issues that arise with large-scale data collection across national borders. Read More

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Transcriptome analysis of early stages of sorghum grain mold disease reveals defense regulators and metabolic pathways associated with resistance.

BMC Genomics 2021 Apr 22;22(1):295. Epub 2021 Apr 22.

Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, 47907, USA.

Background: Sorghum grain mold is the most important disease of the crop. The disease results from simultaneous infection of the grain by multiple fungal species. Host responses to these fungi and the underlying molecular and cellular processes are poorly understood. Read More

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Shared ancestry of core-histone subunits and non-histone plant proteins containing the Histone Fold Motif (HFM).

J Bioinform Comput Biol 2021 Apr 21;19(2):2140001. Epub 2021 Apr 21.

National Institute of Plant Genome Research, New Delhi, India.

The three helical Histone Fold Motif (HFM) of core histone proteins provides an evolutionarily favored site for the protein-DNA interface. Despite significant variation in sequence, the HFM retains a distinctive structural fold that has diversified into several non-histone protein families. In this work, we explore the ancestry of non-histone HFM containing families in the plant kingdom. Read More

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Rift Valley Fever and West Nile virus vectors in Morocco: Current situation and future anticipated scenarios.

Transbound Emerg Dis 2021 Apr 20. Epub 2021 Apr 20.

Laboratoire de Lutte contre les Maladies Infectieuses, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.

Rift Valley Fever (RVF) and West Nile virus (WNV) are two important emerging Arboviruses transmitted by Aedes and Culex mosquitoes, typically Ae. caspius, Ae. detritus and Cx. Read More

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Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis.

J Biol Chem 2021 Apr 14:100670. Epub 2021 Apr 14.

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

The voltage-gated potassium (Kv) 1.3 channel plays a crucial role in the immune responsiveness of T-lymphocytes and macrophages, presenting a potential target for treatment of immune- and inflammation related-diseases. FS48, a protein from the rodent flea Xenopsylla cheopis, shares the three disulfide bond feature of scorpion toxins. Read More

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Sex Differences in Glioblastoma Immunotherapy Response.

Neuromolecular Med 2021 Apr 17. Epub 2021 Apr 17.

Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, USA.

Glioblastoma (GBM), the most common primary malignant brain tumor, remains difficult to treat and shares phenotypes, including an aberrant immune response, with other neurological disorders. Understanding the cellular and molecular mechanisms underlying this pathological immune response remains a priority, particularly as standard of care for advanced cancers evolves to include immunotherapies, which have yet to show strong clinical efficacy in GBM. Epidemiological evidence supports a sex difference in GBM, with increased prevalence in males, and recent studies identified differences between males and females ranging from genetic aberrations to cellular programs. Read More

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Towards enhanced understanding of idiopathic ketotic hypoglycemia: a literature review and introduction of the patient organization, Ketotic Hypoglycemia International.

Orphanet J Rare Dis 2021 Apr 13;16(1):173. Epub 2021 Apr 13.

Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: Idiopathic Ketotic hypoglycemia (IKH) is a diagnosis of exclusion. Although considered as the most frequent cause of hypoglycemia in childhood, little progress has been made to advance the understanding of IKH since the medical term was coined in 1964. We aimed to review the literature on ketotic hypoglycemia (KH) and introduce a novel patient organization, Ketotic Hypoglycemia International (KHI). Read More

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New aspects of microbial vitamin K2 production by expanding the product spectrum.

Microb Cell Fact 2021 Apr 13;20(1):84. Epub 2021 Apr 13.

Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Vitamin K2 (menaquinone, MK) is an essential lipid-soluble vitamin with critical roles in blood coagulation and bone metabolism. Chemically, the term vitamin K2 encompasses a group of small molecules that contain a common naphthoquinone head group and a polyisoprenyl side chain of variable length. Among them, menaquinone-7 (MK-7) is the most potent form. Read More

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Genetic justification of severe COVID-19 using a rigorous algorithm.

Clin Immunol 2021 05 13;226:108726. Epub 2021 Apr 13.

Hematology Division, Department of Internal Medicine, Johns Hopkins University, Baltimore, USA.

Recent studies suggest excessive complement activation in severe coronavirus disease-19 (COVID-19). The latter shares common characteristics with complement-mediated thrombotic microangiopathy (TMA). We hypothesized that genetic susceptibility would be evident in patients with severe COVID-19 (similar to TMA) and associated with disease severity. Read More

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Worsening Heart Failure Episodes Outside a Hospital Setting in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial.

JACC Heart Fail 2021 May 7;9(5):374-382. Epub 2021 Apr 7.

Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Objectives: This study sought to evaluate the frequency and prognostic implications of urgent heart failure (HF) visits in a large global clinical trial of HF with preserved ejection fraction (HFpEF).

Background: Episodes of worsening HF managed without hospitalization are common and prognostically important in HF with reduced ejection fraction (EF). The significance of these ambulatory worsening HF events in HFpEF is uncertain. Read More

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Detection and genomic characterization of hepatitis E virus genotype 3 from pigs in Ghana, Africa.

One Health Outlook 2020 20;2:10. Epub 2020 Jul 20.

Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Virology, Berlin, Germany.

Background: Hepatitis E virus (HEV) is a major cause of human hepatitis worldwide. Zoonotic genotypes of the virus have been found in diverse animal species with pigs playing a major role. Putative risk of zoonotic infection from livestock particularly swine in Sub-Saharan Africa including Ghana is poorly understood due to scarcity of available data, especially HEV sequence information. Read More

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Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action.

PLoS One 2021 7;16(4):e0249687. Epub 2021 Apr 7.

Department of Bioinformatics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a large portion of the population, currently without cure. The shared characteristic these diseases feature is their uncontrollable fibrogenesis deemed responsible for the accumulated damage in the susceptible tissues. Idiopathic Pulmonary Fibrosis, an interstitial lung disease, is one of the most common and studied fibrotic diseases and still remains an active research target. Read More

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