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Clinical characteristics and outcome of bacteremia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences.

J Glob Antimicrob Resist 2021 May 5. Epub 2021 May 5.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/ Virgen del Rocío University Hospital, Seville, Spain.

Introduction: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of the Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. Read More

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Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer.

Stem Cell Reports 2021 May 5. Epub 2021 May 5.

Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University, 265 Campus Drive, Stanford, CA 94305, USA. Electronic address:

Induced pluripotent stem cells (iPSCs) and cancer cells share cellular similarities and transcriptomic profiles. Here, we show that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8 T cell effector and memory responses, induced cancer-specific humoral immune responses, reduced immunosuppressive CD4 T regulatory cells, and prevented tumor formation in 75% of pancreatic ductal adenocarcinoma (PDAC) mice. We demonstrate that shared gene expression profiles of "iPSC-cancer signature genes" and others are overexpressed in mouse and human iPSC lines, PDAC cells, and multiple human solid tumor types compared with normal tissues. Read More

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The curious incident of the dog in the nighttime: The effects of pet-human co-sleeping and bedsharing on sleep dimensions of children and adolescents.

Sleep Health 2021 Apr 29. Epub 2021 Apr 29.

Pediatric Public Health Psychology Laboratory, Concordia University, Montréal, Québec, Canada. Electronic address:

Background: Pets are often thought to be detrimental to sleep. Up to 75% of households with children have a pet, and 30-50% of adults and children regularly share their bed with their pets. Despite these high rates, few studies have examined the effect of pet-human co-sleeping on pediatric sleep. Read More

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Toxicological Assessment of Oral Co-Exposure to Bisphenol A (BPA) and Bis(2-ethylhexyl) Phthalate (DEHP) in Juvenile Rats at Environmentally Relevant Dose Levels: Evaluation of the Synergic, Additive or Antagonistic Effects.

Int J Environ Res Public Health 2021 Apr 26;18(9). Epub 2021 Apr 26.

Center for Gender-Specific Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.

Background: The general population (including children) is exposed to chemical mixtures. Plasticizers such as Bisphenol A (BPA) and Phthalates (mainly Bis(2-ethylhexyl) phthalate-DEHP) are widespread contaminants classified as endocrine disrupters which share some toxicological profiles and coexist in food and environment.

Methods: To identify hazards of DEHP and BPA mixtures, the juvenile toxicity test-where rodents are in peripubertal phase of development, resembling childhood-was selected using exposure data from biomonitoring study in children. Read More

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Impact of Pandemic on European Well-Being: Visualizing Scenarios from the SHARE Database.

Int J Environ Res Public Health 2021 04 27;18(9). Epub 2021 Apr 27.

Statistics Department, Universidad Carlos III de Madrid, 28903 Getafe, Spain.

The objective of this study is to analyse the effect of a pandemic shock on the well-being of the European population aged 50 or over. Data comes from wave 7 of the Survey of Health, Ageing and Retirement in Europe (SHARE), carried out in 28 countries and representing over 170 million aged individuals in Europe. We start by designing two indicators in order to capture the risk of being unhealthy and economically vulnerable; next, we combine them with socio-demographic information and obtain the vulnerability profiles by means of the -prototypes clustering algorithm. Read More

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Differences in PARP Inhibitors for the Treatment of Ovarian Cancer: Mechanisms of Action, Pharmacology, Safety, and Efficacy.

Int J Mol Sci 2021 Apr 19;22(8). Epub 2021 Apr 19.

Department of Oncology and Hemato-Oncology, School of Medicine, University of Milan, 20122 Milan, Italy.

Poly(ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for PARP cofactor (NAD+) and trapping PARP on the DNA. In this way, they inhibit single-strand DNA damage repair. Read More

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A Scoping Review of Cognitive Training in Neurodegenerative Diseases via Computerized and Virtual Reality Tools: What We Know So Far.

Brain Sci 2021 Apr 21;11(5). Epub 2021 Apr 21.

Faculty of Psychology, eCampus University, 22060 Novedrate, Italy.

Most prevalent neurodegenerative diseases such as Alzheimer's disease, frontotemporal dementia, Parkinson's disease and multiple sclerosis are heterogeneous in their clinical profiles and underlying pathophysiology, although they typically share the presence of cognitive impairment that worsens significantly during the course of the disease. Viable pharmacological options for cognitive symptoms in these clinical conditions are currently lacking. In recent years, several studies have started to apply Computerized Cognitive Training (CCT) and Virtual Reality (VR) tools to try and contrast patients' cognitive decay over time. Read More

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Profiles of potential behavioral addictions' severity and their associations with gender, personality, and well-being: A person-centered approach.

Addict Behav 2021 Apr 2;119:106941. Epub 2021 Apr 2.

University of Gdańsk, Gdańsk, Poland, Bażyńskiego 4, 80-309 Gdańsk, Poland. Electronic address:

Background: Addictions share common etiological factors associated with personality vulnerabilities such as narcissism or emotional instability. Also, there are gender differences in the type of and risk for addiction (e.g. Read More

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Metabolomic profiles discriminating anxiety from depression.

Acta Psychiatr Scand 2021 Apr 29. Epub 2021 Apr 29.

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Amsterdam, Public Health research institute and Amsterdam Neuroscience, Amsterdam, the Netherlands.

Objective: Depression has been associated with metabolomic alterations. Depressive and anxiety disorders are often comorbid diagnoses and are suggested to share etiology. We investigated whether differential metabolomic alterations are present between anxiety and depressive disorders, and which clinical characteristics of these disorders are related to metabolomic alterations. Read More

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Resistance Profiles and Biological Characteristics of Rifampicin-Resistant Small-Colony Variants.

Infect Drug Resist 2021 21;14:1527-1536. Epub 2021 Apr 21.

Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, People's Republic of China.

Background: () is a major contributor to nosocomial and community-acquired infections. small colony variants (SCVs) which changed in relevant phenotype have made more limited and difficult for therapeutic options against infections increasingly. Rifampicin is considered as the "last-resort" antibiotic against . Read More

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Extracellular matrix proteins produced by stromal cells in idiopathic pulmonary fibrosis and lung adenocarcinoma.

PLoS One 2021 27;16(4):e0250109. Epub 2021 Apr 27.

Research Unit of Internal Medicine, University of Oulu, Oulu, Finland.

Idiopathic pulmonary fibrosis (IPF) and lung cancer share common risk factors, epigenetic and genetic alterations, the activation of similar signaling pathways and poor survival. The aim of this study was to examine the gene expression profiles of stromal cells from patients with IPF and lung adenocarcinoma (ADC) as well as from normal lung. The gene expression levels of cultured stromal cells derived from non-smoking patients with ADC from the tumor (n = 4) and the corresponding normal lung (n = 4) as well as from patients with IPF (n = 4) were investigated with Affymetrix microarrays. Read More

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The Metabolic Relevance of Type of Locomotion in Anaerobic Testing: Bosco Continuous Jumping Test Versus Wingate Anaerobic Test of the Same Duration.

Int J Sports Physiol Perform 2021 Apr 22:1-7. Epub 2021 Apr 22.

Purpose: To evaluate the metabolic relevance of type of locomotion in anaerobic testing by analyzing and comparing the metabolic profile of the Bosco Continuous Jumping Test (CJ30) with the corresponding profile of the Wingate Anaerobic Test (WAnT).

Methods: A total of 11 well-trained, male team-sport athletes (age = 23.7 [2. Read More

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Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.

Neuropharmacology 2021 Apr 17:108571. Epub 2021 Apr 17.

Department of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center College of Medicine, Bryan, TX 77807.

Status epilepticus (SE) is a medical emergency with continuous seizure activity that causes profound neuronal damage, morbidity, or death. SE incidents can arise spontaneously, but mostly are elicited by seizurogenic triggers. Chemoconvulsants such as the muscarinic agonist pilocarpine and organophosphates (OP), such as the pesticide diisopropylfluorophosphate (DFP) and the nerve agent soman, can induce SE. Read More

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Fast-acting insulin aspart (Fiasp®) improves glycemic outcomes when used with MiniMed 670G hybrid closed-loop system in simulated trials compared to NovoLog®.

Comput Methods Programs Biomed 2021 Apr 8;205:106087. Epub 2021 Apr 8.

Medtronic Diabetes, United States.

Introduction: Medtronic has developed a virtual patient simulator for modeling and predicting insulin therapy outcomes for people with type 1 diabetes (T1D). An enhanced simulator was created to estimate outcomes when using the MiniMed 670G system with standard NovoLog® (EU: NovoRapid, US: NovoLog) versus Fiasp ® by using clinical data.

Methods: Sixty-seven participants' PK profiles were generated per type of insulin (Total of 134 PK profiles). Read More

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Well tolerability and highly effective treatment response for hepatitis C virus-human immunodeficiency virus-coinfected patients treated by all-oral direct-acting antivirals.

J Chin Med Assoc 2021 May;84(5):465-471

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection is common because the two pathogens share their transmission route. Studies have suggested that coinfection is associated with accelerated hepatic fibrosis, increased hepatic decompensation, and hepatocellular carcinoma development. Historically, the sustained virological response (SVR) rates for patients undergoing pegylated interferon (PEG-IFN)-based therapy are poor owing to advanced liver disease, immune dysfunction, and poor medical adherence. Read More

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Comparative Whole Genome Analysis of O157:H7 Isolates From Feedlot Cattle to Identify Genotypes Associated With the Presence and Absence of Genes.

Front Microbiol 2021 1;12:647434. Epub 2021 Apr 1.

Center for Meat Safety and Quality, Department of Animal Sciences, Colorado State University, Fort Collins, CO, United States.

A comparative whole genome analysis was performed on three newly sequenced O157:H7 strains with different profiles, previously isolated from feedlot cattle [C1-010 (, +), C1-057 (), and C1-067 (+, +)], as well as five foodborne outbreak strains and six -negative strains from NCBI. Phylogenomic analysis demonstrated that the -carrying C1-010 and -negative C1-057 strains were grouped with the six NCBI -negative O157:H7 strains in Cluster 1, whereas the -carrying C1-067 and five foodborne outbreak strains were clustered together in Cluster 2. Based on different clusters, we selected the three newly sequenced strains, one -carrying strain, and the six NCBI -negative strains and identify their prophages at the insertion sites. Read More

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Myeloid-Derived Suppressor Cells in Immune Microenvironment Promote Progression of Esophagogastric Junction Adenocarcinoma.

Front Oncol 2021 29;11:640080. Epub 2021 Mar 29.

Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Adenocarcinoma of the esophagogastric junction (AEG) is a fatal disease. Accumulating evidence indicates that, for a comprehensive understanding of AEG, studies should be conducted not only to investigate tumor cells, but also the tumor microenvironment (TME). In this study, we collected AEG patient data from The Cancer Genome Atlas, and used the CIBERSORT algorithm to analyze tumor-infiltrating immune cell profiles. Read More

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Safety and Tolerability of Cariprazine in Patients with Schizophrenia: A Pooled Analysis of Eight Phase II/III Studies.

Neuropsychiatr Dis Treat 2021 7;17:957-970. Epub 2021 Apr 7.

Medical Division, Gedeon Richter Plc, Budapest, Hungary.

Background: Long-term treatment with antipsychotic agents is indicated for patients with schizophrenia, but treatment is associated with adverse events (AEs) that contribute to medication discontinuation and nonadherence. Understanding drug safety profiles is critical to avoid unwanted side effects. Cariprazine is a potent dopamine D/D receptor partial agonist that is approved for the treatment of adults with schizophrenia (EU, US) and acute manic/mixed and depressive episodes associated with bipolar I disorder (US). Read More

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Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus.

Mol Ther 2021 May 19;29(5):1668-1682. Epub 2021 Apr 19.

Department Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address:

Cancer gene therapies are usually designed either to express wild-type copies of tumor suppressor genes or to exploit tumor-associated phenotypic changes to endow selective cytotoxicity. However, these approaches become less relevant to cancers that contain many independent mutations, and the situation is made more complex by our increased understanding of clonal evolution of tumors, meaning that different metastases and even regions of the same tumor mass have distinct mutational and phenotypic profiles. In contrast, the relatively genetically stable tumor microenvironment (TME) therefore provides an appealing therapeutic target, particularly since it plays an essential role in promoting cancer growth, immune tolerance, and acquired resistance to many therapies. Read More

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Collaborative Profile-QSAR: A Natural Platform for Building Collaborative Models among Competing Companies.

J Chem Inf Model 2021 Apr 12;61(4):1603-1616. Epub 2021 Apr 12.

Novartis Institute for Biomedical Research, 5959 Horton Street, Emeryville, California 94608-2916, United States.

Massively multitask bioactivity models that transfer learning between thousands of assays have been shown to work dramatically better than separate models trained on each individual assay. In particular, the applicability domain for a given model can expand from compounds similar to those tested in that specific assay to those tested across the full complement of contributing assays. If many large companies would share their assay data and train models on the superset, predictions should be better than what each company can do alone. Read More

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Characterization of simultaneous uptake of xylose and glucose in Caldicellulosiruptor kronotskyensis for optimal hydrogen production.

Biotechnol Biofuels 2021 Apr 8;14(1):91. Epub 2021 Apr 8.

Division of Applied Microbiology, Lund University, P.O. Box 124, 221 00, Lund, Sweden.

Background: Caldicellulosiruptor kronotskyensis has gained interest for its ability to grow on various lignocellulosic biomass. The aim of this study was to investigate the growth profiles of C. kronotskyensis in the presence of mixtures of glucose-xylose. Read More

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Sequencing error profiles of Illumina sequencing instruments.

NAR Genom Bioinform 2021 Mar 27;3(1):lqab019. Epub 2021 Mar 27.

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.

Sequencing technology has achieved great advances in the past decade. Studies have previously shown the quality of specific instruments in controlled conditions. Here, we developed a method able to retroactively determine the error rate of most public sequencing datasets. Read More

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Functional divergence and adaptive selection of gene family in plants.

Open Life Sci 2020 14;15(1):346-363. Epub 2020 Jun 14.

College of Life Sciences, Capital Normal University, Beijing, 100048, China.

KNOTTED-like homeodomain () genes are transcriptional regulators that play an important role in morphogenesis. In the present study, a comparative analysis was performed to investigate the molecular evolution of the characteristics of the gene family in 10 different plant species. We identified 129 gene family members, which were categorized into two subfamilies based on multiple sequence alignment and phylogenetic tree reconstruction. Read More

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Content Analysis and Characterization of Medical Tweets During the Early Covid-19 Pandemic.

Cureus 2021 Feb 27;13(2):e13594. Epub 2021 Feb 27.

Division of Critical Care, University of Ottawa, Ottawa, CAN.

Objective The novel coronavirus disease 2019 (Covid-19) has infected millions worldwide and impacted the lives of many folds more. Many clinicians share new Covid-19-related resources, research, and ideas within the online Free Open Access to Medical Education (FOAM) community of practice. This study provides a detailed content and contributor analysis of Covid-19-related tweets among the FOAM community during the first months of the pandemic. Read More

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February 2021

Multiple Unhealthy Behaviors Share Equivalent Profiles of Readiness for Change in Patients with Type 2 Diabetes.

Int J Environ Res Public Health 2021 03 31;18(7). Epub 2021 Mar 31.

School of Public Health and Nutrition, Autonomous University of Nuevo Leon, Monterrey 64460, Mexico.

Few studies have considered more than one behavior, despite the tendency towards multiple behaviors, and there are none that have focused on a Latino population. We determined the concurrence of four unhealthy behaviors related to glycemic control and identified common cognitive factors at advanced stages of readiness for change in patients with type 2 diabetes treated in primary care. A cross-sectional study was carried out during August-December 2018 in northeastern Mexico. Read More

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Medial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology.

Biomolecules 2021 Mar 10;11(3). Epub 2021 Mar 10.

CIEN Foundation and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Institute of Health Carlos III, 28031 Madrid, Spain.

Human prion and non-prion neurodegenerative diseases share pathogenic mechanisms and neuropathological features. The lesion profile of a particular entity results from specific involvement of vulnerable neuron populations and connectivity circuits by a pathogenic protein isoform with strain-like properties. The lesion profile of the medial temporal lobe (MTL) was studied in postmortem tissue of 143 patients with human prion disease (HPD) including sporadic, genetic, and acquired forms. Read More

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Characterization of two group III potato CDPKs, StCDPK22 and StCDPK24, that contain three EF-Hand motifs in their CLDs.

Plant Physiol Biochem 2021 May 9;162:716-729. Epub 2021 Mar 9.

Laboratorio de Transducción de Señales en Plantas, Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires (C.A.B.A.), Argentina; Departamento de Química Biológica, UBA, C.A.B.A, Argentina. Electronic address:

Four members of the potato (Solanum tuberosum L.) calcium-dependent protein kinase (CDPK) family StCDPK22/23/24 and StCDPK27, present three functional EF-hands motifs in their calmodulin-like domain (CLD). StCDPK22/23/24 are clustered in clade III-b1 with tomato and Arabidopsis CDPKs that lack the first EF-hand motif, while StCDPK27 is clustered in clade III-b3 with CDPKs that lack EF-hand 2. Read More

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Phenotypically independent profiles relevant to mental health are genetically correlated.

Transl Psychiatry 2021 Apr 1;11(1):202. Epub 2021 Apr 1.

NORMENT, KG Jebsen Centre for Neurodevelopmental Disorders, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Genome-wide association studies (GWAS) and family-based studies have revealed partly overlapping genetic architectures between various psychiatric disorders. Given clinical overlap between disorders, our knowledge of the genetic architectures underlying specific symptom profiles and risk factors is limited. Here, we aimed to derive distinct profiles relevant to mental health in healthy individuals and to study how these genetically relate to each other and to common psychiatric disorders. Read More

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Integrated analysis of lncRNA, miRNA and mRNA profiles reveals potential lncRNA functions during early HIV infection.

J Transl Med 2021 04 1;19(1):135. Epub 2021 Apr 1.

NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, No 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning, China.

Background: Long noncoding RNAs (lncRNAs) can regulate gene expression in a cis-regulatory fashion or as "microRNA sponges". However, the expression and functions of lncRNAs during early human immunodeficiency virus (HIV) infection (EHI) remain unclear.

Methods: 3 HAART-naive EHI patients and 3 healthy controls (HCs) were recruited in this study to perform RNA sequencing and microRNA (miRNA) sequencing. Read More

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Comparison of macaque and human L- and M-cone driven electroretinograms.

Exp Eye Res 2021 May 29;206:108556. Epub 2021 Mar 29.

Department of Vision Sciences, College of Optometry, University of Houston, Houston, TX, USA.

Purpose: The macaque retina is often used as a model for the human retina. However, there are only a handful of direct in vivo comparisons of the retinal physiology in humans and macaques. In the current study, ERG responses to luminance, L-cone isolating and M-cone isolating stimuli with sinusoidal, sawtooth and square wave temporal profiles were measured. Read More

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