20,216 results match your criteria shandong province


Diagnostic value of dual-source spiral CT in patients with diabetic lower limb arteriosclerosis obliterans.

J Biol Regul Homeost Agents 2021 Jul 30;35(Special Issue on Internal Medicine n.1). Epub 2021 Jul 30.

Department of Endocrinology, Changyi People's Hospital, Weifang, Shandong Province, China.

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CT-Based Hand-crafted Radiomic Signatures Can Predict PD-L1 Expression Levels in Non-small Cell Lung Cancer: a Two-Center Study.

J Digit Imaging 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Here, we used pre-treatment CT images to develop and evaluate a radiomic signature that can predict the expression of programmed death ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC). We then verified its predictive performance by cross-referencing its results with clinical characteristics. This two-center retrospective analysis included 125 patients with histologically confirmed NSCLC. Read More

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MRI of nasopharyngeal carcinoma: parapharyngeal subspace involvement has prognostic value and influences T-staging in the IMRT era.

Eur Radiol 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, 651 Dongfeng Road East, Guangzhou, Guangdong, 510060, People's Republic of China.

Objectives: To identify the prognosis of parapharyngeal space involvement (PPSI) based on the number of subspaces involved (pre-styloid space, carotid space (CS), areas outside the CS) and explore its significance for current T-staging in patients with nasopharyngeal carcinoma (NPC).

Methods: PPSI was retrospectively identified in 1224 patients with non-disseminated NPC at two centers on MRI and separated into four invasion patterns: pattern A (only post-styloid space), pattern B (post-styloid space, CS extension), pattern C (post-styloid space, pre-styloid space extension), and pattern D (all spaces). The Kaplan-Meier analysis and multivariate Cox regression models were used. Read More

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Detachable string magnetically controlled capsule endoscopy for detecting high-risk varices in compensated advanced chronic liver disease (CHESS1801): A prospective multicenter study.

Lancet Reg Health West Pac 2021 Jan 11;6:100072. Epub 2020 Dec 11.

Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Background: Gastroesophageal varices is a serious complication of compensated advanced chronic liver disease (cACLD). Primary prophylaxis to reduce the risk of variceal hemorrhage is recommended if high-risk varices (HRV) are detected. We performed this study to compare the accuracy, patients' satisfaction and safety of detection of HRV by detachable string magnetically controlled capsule endoscopy (DS-MCCE) with esophagogastroduodenoscopy (EGD) as the reference. Read More

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January 2021

Burden of maternal disorders in China from 1990 to 2019: Analysis of the Global Burden of Disease Study 2019.

Lancet Reg Health West Pac 2021 Jun 27;11:100141. Epub 2021 Apr 27.

National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 27# Nanwei Rd, Xicheng District, 100050 Beijing, PR China.

Background: Efforts to quantify the burden of maternal disorders at the national and provincial levels are valuable for resource allocation and for development and adoption of public health policies.

Methods: Following the methods of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, the prevalence of maternal disorders and the resulting disability-adjusted life years (DALYs), years lived with disability(YLD), deaths, and years of life lost (YLL) at the national and provincial levels in China were examined for the 1990-2019 period. Estimated annual percentage changes (EAPCs) were calculated to estimate the trends of age-standardized rate (ASR) of prevalence, DALYs, death, and YLD due to maternal disorders and its main subcategories from 1990 to 2019. Read More

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Immunogenicity of two-dose and three-dose vaccination schedules with Sabin inactivated poliovirus vaccine in China: An open-label, randomized, controlled trial.

Lancet Reg Health West Pac 2021 May 16;10:100133. Epub 2021 Apr 16.

Chinese Center for Disease Control and Prevention, Beijing, China.

Background: We assessed immunogenicity of three-dose and two-dose immunization schedules with a Sabin-strain inactivated poliovirus vaccine (sIPV) produced by one Chinese vaccine manufacturer.

Methods: This was an open label, randomized, controlled trial conducted in 16 vaccination clinics in Shandong province. Infants were allocated randomly to either a 3-dose study arm (sIPV administered at 2, 3, and 4 months of age) or a 2-dose arm (sIPV administered at 4 and 8-11 months of age). Read More

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Role of perceived family support in psychological distress for pregnant women during the COVID-19 pandemic.

World J Psychiatry 2021 Jul 19;11(7):365-374. Epub 2021 Jul 19.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused major public panic in China. Pregnant women may be more vulnerable to stress, which may cause them to have psychological problems.

Aim: To explore the effects of perceived family support on psychological distress in pregnant women during the COVID-19 pandemic. Read More

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Multi-omics: Opportunities for research on mechanism of type 2 diabetes mellitus.

World J Diabetes 2021 Jul;12(7):1070-1080

Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China.

Type 2 diabetes mellitus (T2DM) is a burdensome global disease. In-depth understanding of its mechanism will help to optimize diagnosis and treatment, which reduces the burden. Multi-omics research has unparalleled advantages in contributing to the overall understanding of the mechanism of this chronic metabolic disease. Read More

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Comprehensive overview of human serum albumin glycation in diabetes mellitus.

World J Diabetes 2021 Jul;12(7):1057-1069

Department of Endocrinology, The Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China.

The presence of excess glucose in blood is regarded as a sweet hurt for patients with diabetes. Human serum albumin (HSA) is the most abundant protein in human plasma, which undergoes severe non-enzymatic glycation with glucose in patients with diabetes; this modifies the structure and function of HSA. Furthermore, the advanced glycation end products produced by glycated HSA can cause pathological damage to the human body through various signaling pathways, eventually leading to complications of diabetes. Read More

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Predictive Value of High ICAM-1 Level for Poor Treatment Response to Low-Dose Decitabine in Adult Corticosteroid Resistant ITP Patients.

Front Immunol 2021 13;12:689663. Epub 2021 Jul 13.

Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease. Endothelial cell activation/injury has been found in some autoimmune diseases including SLE, systemic sclerosis, and rheumatoid arthritis, but its role in ITP pathogenesis remains unclear. This study attempted to elucidate the correlation between endothelial dysfunction and disease severity of ITP and find related markers to predict response to low-dose decitabine treatment. Read More

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A two-transcript biomarker of host classifier genes for discrimination of bacterial from viral infection in acute febrile illness: a multicentre discovery and validation study.

Lancet Digit Health 2021 Aug;3(8):e507-e516

Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:

Background: Acute febrile illness is one of the main reasons for outpatient hospital visits worldwide. However, differential diagnosis between bacterial and viral causes is challenging and misdiagnosis can result in antimicrobial overuse and hinder prompt treatment. We aimed to build and validate a diagnostic model to discriminate bacterial from viral infection in acute febrile illness by evaluating the expression of potential classifier host genes. Read More

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Application of Comprehensive Artificial intelligence Retinal Expert (CARE) system: a national real-world evidence study.

Lancet Digit Health 2021 Aug;3(8):e486-e495

Guangdong Medical Devices Quality Surveillance and Test Institute, Guangzhou, Guangdong, China.

Background: Medical artificial intelligence (AI) has entered the clinical implementation phase, although real-world performance of deep-learning systems (DLSs) for screening fundus disease remains unsatisfactory. Our study aimed to train a clinically applicable DLS for fundus diseases using data derived from the real world, and externally test the model using fundus photographs collected prospectively from the settings in which the model would most likely be adopted.

Methods: In this national real-world evidence study, we trained a DLS, the Comprehensive AI Retinal Expert (CARE) system, to identify the 14 most common retinal abnormalities using 207 228 colour fundus photographs derived from 16 clinical settings with different disease distributions. Read More

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Relationship between peripapillary choroidal thickness and retinal nerve fiber layer in young people with myopia.

J Int Med Res 2021 Jul;49(7):3000605211032780

Department of Ophthalmology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China.

Aim: To study the characteristics and relationship between peripapillary retinal nerve fiber layer (RNFL) and choroidal thickness in young people with myopia.

Methods: We retrospectively analyzed 92 cases (52 myopia, 40 emmetropia) regarding age, sex, refractive power, axial length (AL), and intraocular pressure. Peripapillary RNFL and choroidal thicknesses were measured by optical coherence tomography (OCT) in six sectors. Read More

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Novel label-free fluorescence aptasensor for chloramphenicol detection based on a DNA four-arm junction-assisted signal amplification strategy.

Food Chem 2021 Jul 21;366:130648. Epub 2021 Jul 21.

Key Laboratory of Animal Resistance Biology of Shandong Province, Institute of Biomedical Sciences, Key Laboratory of Food Nutrition and Safety of Shandong Normal University, College of Life Science, Shandong Normal University, Jinan 250014, PR China. Electronic address:

A novel label-free fluorescence aptasensor was established for chloramphenicol (CAP) detection by DNA four-arm junction-assisted target recycling and SYBR Green I dye-aided fluorescence-signal amplification. The CAP aptamer was hybridized to its complementary strand (primer) to form a double-stranded primer/aptamer complex. In the presence of CAP, aptamers can specifically bind with CAP to dissociate primers, which can trigger the self-assembly of four hairpins to continuously generate DNA four-arm junctions. Read More

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The impact of tyrosine kinase inhibitors on allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

Leuk Res 2021 Jun 18;109:106647. Epub 2021 Jun 18.

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Heping District, Tianjin, 300020, China. Electronic address:

In the tyrosine kinase inhibitor (TKI) era, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is still the most potential approach for cure of adult patients with Philadelphia chromosome-positive acute lymphocytic leukemia (Ph ALL). TKI plus chemotherapy has strikingly increased response rates and depth of response, and facilitated allo-HSCT, which decreases relapse and improves survival eventually. Meanwhile, for those with older age or comorbidities at diagnosis, TKI in combination with reduced-intensity chemotherapy or chemotherapy-free strategy reduces treatment-related mortality, deferred intensive chemotherapy increases molecular responses and reduced-intensity conditioning (RIC) allo-HSCT improves survival finally. Read More

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Characterizing the binding interactions of sodiumbenzoatewithlysozymeat the molecular level using multi-spectroscopy, ITC and modeling methods.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 22;263:120213. Epub 2021 Jul 22.

School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong, 266237, PR China. Electronic address:

In this paper, we mainly study the interaction mechanism between food additives and antioxidant enzymes. Spectral methods were used to study the effect of sodium benzoate on the structure and function of lysozyme at the molecular level. Multi-spectroscopic results showed that sodium benzoate statically quenched the intrinsic fluorescence of lysozyme, formed complexes with lysozyme, increased the polarity of the aromatic amino acid, effected the molecular skeleton of lysozyme and stretched the secondary structure. Read More

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Modeling and dynamics of physiological and behavioral resistance of Asian citrus psyllid.

Math Biosci 2021 Jul 26:108674. Epub 2021 Jul 26.

LAMPS and CCDM, Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada. Electronic address:

The Asian citrus psyllid (ACP) survival in the presence of contact insecticides may be through physiological adaptations or by behaviorally avoiding. Curiously, although the first alternative is the object of frequent attention, the second was often neglected, but both may lead to insecticide resistance. In this paper, we characterize the growth dynamics of ACP population using a novel impulsive differential equation model to account for the effect of physiological and behavioral resistance, and investigate the threshold conditions for the extinction of ACP population. Read More

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The relationship between serum 25-hydroxyvitamin-D level and sweat function in patients with type 2 diabetes mellitus.

J Endocrinol Invest 2021 Jul 29. Epub 2021 Jul 29.

Department of Endocrinology, Jinling Hospital, Nanjing Medical University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China.

Aims: The objective of this study is to explore the relationship between serum 25-hydroxyvitamin-D(25-(OH)D) level and sweat function in patients with type 2 diabetes mellitus (T2DM).

Methods: A cross-sectional study of 1021 patients with T2DM who underwent 25-(OH)D level detections and sweat function tests was carried out. These individuals were divided into deficient groups (n = 154 cases), insufficient groups (n = 593 cases) and sufficient groups (n = 274 cases). Read More

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Preimplantation genetic testing is not a preferred recommendation for patients with X chromosome abnormalities.

Hum Reprod 2021 Jul 27. Epub 2021 Jul 27.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Study Question: Should women with X chromosome abnormalities (XCAs) be recommended to have embryos selected by both morphological and cytogenetic assessment through preimplantation genetic testing (PGT) rather than morphological assessment only in conventional IVF/ICSI treatment?

Summary Answer: PGT is not a preferred recommendation for women with XCAs in the absence of other PGT indications.

What Is Known Already: XCAs are the most frequent sort of chromosomal aberrations in infertile women. Patients with a complete or partial absence of one X chromosome, diagnosed as Turner Syndrome (TS), demonstrate low spontaneous pregnancy rates (5-7%) and high miscarriage rates (22. Read More

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Bio-dissolution process and mechanism of copper phosphate hybrid nanoflowers by Pseudomonas aeruginosa and its bacteria-toxicity in life cycle.

J Hazard Mater 2021 Jun 25;419:126494. Epub 2021 Jun 25.

China-America CRC for Environment & Health of Shandong Province, School of Environmental Science and Engineering, Shandong University, 72# Jimo Binhai Road, Qingdao, Shandong 266237, PR China; Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China; Shandong Provincial Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, 72# Jimo Binhai Road, Qingdao, Shandong 266237, PR China. Electronic address:

Copper phosphate hybrid nanoflowers (HNF) have been widely used in chemical industries and wastewater treatment owing to its excellent catalytic activity and high stability. However, their fate and ecological risks have not received due attention after being discharged into natural environment. The significance of bacteria on the dissolution and fate of HNF and its toxicity to bacteria was evaluated from the perspective of its life cycle. Read More

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sp. nov., isolated from seashore sediment of a forest and emended descriptions of the genus Park . 2016.

Int J Syst Evol Microbiol 2021 Jul;71(7)

Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources of PR China, State Key Laboratory Breeding Base of Marine Genetic Resources; Key Laboratory of Marine Genetic Resources of Fujian Province, Xiamen 361005, PR China.

An aerobic, Gram-stain-negative, bacterium, designated CLL3-39 was isolated from seashore sediment collected at a forest in the Marine Ecology Special Reserve of Changyi, Shandong Province, PR China. Cells of strain CLL3-39 were olive-shaped and no flagellum was observed. Strain CLL3-39 grew optimally at 33 °C, pH 7. Read More

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High Interfacial-Energy and Lithiophilic Janus Interphase Enables Stable Lithium Metal Anodes.

Small 2021 Jul 29:e2102196. Epub 2021 Jul 29.

College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.

The stability of solid electrolyte interphase (SEI) layers is critical for developing lithium (Li) metal batteries. However, the fabrication of stable SEI layers is plagued by un-controlled structures, properties, and functions. Here a controllable design of an ordered LiF-rich and lithiophilic hybrid Janus interphase (LiF-HJI) is reported using organic fluorination reagent as a functional SEI precursor. Read More

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High Concentrations of Triglycerides are Associated with Diabetic Kidney Disease in New-onset Type 2 Diabetes in China: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.

Diabetes Obes Metab 2021 Jul 28. Epub 2021 Jul 28.

Karamay Municipal People's Hospital, Xinjiang, China.

Aims: The aims of this study were to evaluate the associations of metabolic abnormalities with incident DKD and to explore whether dyslipidemia, especially high fasting triglyceride (TG), was associated with the development of DKD.

Methods: A total of 11 142 new-onset type 2 diabetes patients with a baseline estimated glomerular filtration rates (eGFR) ≥60 mL/min/1.73 m were followed up during 2011-2016. Read More

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Overexpression of ROCK1 promotes cancer cell proliferation and is associated with poor prognosis in human urothelial bladder cancer.

Mamm Genome 2021 Jul 28. Epub 2021 Jul 28.

Department of Oncology, Binzhou Medical University Hospital, No 661 Huanghe 2nd Road, Binzhou, 256603, Shandong, China.

Rho-associated protein kinase 1 (ROCK1) has been reported to be overexpressed in many types of tumors, but its role in urothelial bladder cancer is poorly understood. The study aims to investigate the role of ROCK1 in urothelial bladder cancer and explored the underlying mechanism. Protein and mRNA levels of ROCK1 were detected in 64 urothelial bladder cancer patients using western blot, immunohistochemistry and qRT-PCR. Read More

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Looking into key bacterial proteins involved in gut dysbiosis.

Authors:
Xin-Yu Zeng Ming Li

World J Methodol 2021 Jul 20;11(4):130-143. Epub 2021 Jul 20.

Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China.

The gastrointestinal microbiota plays a pivotal role in health and has been linked to many diseases. With the rapid accumulation of pyrosequencing data of the bacterial composition, the causal-effect relationship between specific dysbiosis features and diseases is now being explored. The aim of this review is to describe the key functional bacterial proteins and antigens in the context of dysbiosis related-diseases. Read More

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Parent-Adolescent Communication Quality and Life Satisfaction: The Mediating Roles of Autonomy and Future Orientation.

Psychol Res Behav Manag 2021 21;14:1091-1099. Epub 2021 Jul 21.

Department of Education, Shandong Women's University, Jinan, Shandong Province, People's Republic of China.

Background: Previous studies have suggested that family communication quality is an important factor that can influence adolescents' life satisfaction. However, relatively few studies have examined this relationship in the Chinese cultural context or explored the potential mechanisms underlying this relationship. Therefore, the purpose of this study was to investigate whether family communication quality is closely linked to Chinese adolescents' life satisfaction and whether this link was mediated by autonomy and future orientation. Read More

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Efficacy of Acupuncture-Related Therapy in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials.

J Pain Res 2021 19;14:2209-2228. Epub 2021 Jul 19.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, People's Republic of China.

Objective: Knee osteoarthritis (KOA) is prevalent in middle-aged and elderly people. This condition negatively affects the quality of life of patients. Although non-steroidal anti-inflammatory drugs (NSAIDs) are often used to relieve symptoms associated with KOA, it is associated with many side effects. Read More

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Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.

BMC Med Genomics 2021 Jul 28;14(1):193. Epub 2021 Jul 28.

Department of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 38 Dengzhou Road, Shibei District, Qingdao, 266021, Shandong Province, People's Republic of China.

Background: Age-related hearing impairment (ARHI) has attracted increasing attention recently. It is caused by genetic and environmental factors. A number of ARHI-related genes have been found. Read More

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A Ratiometric, Fast-Responsive and Single-Wavelength Excited Fluorescent Probe for the Discrimination of Cys and Hcy.

Anal Chem 2021 Jul 28. Epub 2021 Jul 28.

College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China.

The ratiometric detection of cysteine (Cys) and homocysteine (Hcy) is very challenging because of their highly similar chemical structures and properties. By introducing the phenylethynyl group into a coumarin dye as the sensing group, the ratiometric fluorescent probe was developed to selectively and rapidly discriminate between Cys and Hcy. With a single-wavelength excitation, the presence of Cys or Hcy induced the probe to produce distinct ratiometric fluorescence changes: from red (λ = 608 nm) to blue (λ = 485 nm) toward Cys and from red to mixed red/blue toward Hcy. Read More

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