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Chronic binge alcohol and ovariectomy-mediated impaired insulin responsiveness in SIV-infected female rhesus macaques.

Am J Physiol Regul Integr Comp Physiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Physiology, grid.279863.1Louisiana State University Health Sciences Center New Orleans, New Orleans, Louisiana, United States.

Objective: Aging people living with HIV (PLWH), especially post-menopausal women may be at higher risk of comorbidities associated with HIV, ART, hypogonadism and at-risk alcohol use. Our studies in simian immunodeficiency virus (SIV)-infected male macaques demonstrated that chronic binge alcohol (CBA) reduced acute insulin response to glucose (AIRG), and at-risk alcohol use decreased HOMA-β in PLWH. The objective of this study was to examine the impact of ovariectomy (OVX), on glucose-insulin dynamics and integrity of pancreatic endocrine function in CBA/SIV-infected female macaques. Read More

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September 2021

Menhaden fish oil attenuates postpartum depression in rat model via inhibition of NLRP3-inflammasome driven inflammatory pathway.

J Tradit Complement Med 2021 Sep 25;11(5):419-426. Epub 2021 Feb 25.

Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400, Serdang, Selangor, Malaysia.

Background And Aim: Postpartum depression (PPD) is a familiar problem which is associated with about 10-20% of women after child delivery. Fish oil (FO) has a therapeutic potentials to many diseases including mood disorders. However, there is paucity of data on the effects of FO supplementation on PPD rat model. Read More

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September 2021

Resveratrol Pretreatment Inhibits Myocardial Apoptosis in Rats Following Coronary Microembolization via Inducing the PI3K/Akt/GSK-3β Signaling Cascade.

Drug Des Devel Ther 2021 7;15:3821-3834. Epub 2021 Sep 7.

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University & Guangxi Key Laboratory Base of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention & Guangxi Clinical Research Center for Cardio-Cerebrovascular Diseases, Nanning, People's Republic of China.

Purpose: Coronary microembolization (CME) is associated with progressive cardiac dysfunction, myocardial inflammation, and apoptosis. Resveratrol (RES) has a considerable role in cardioprotection. However, the contribution and possible mechanisms of RES in CME have not been clearly understood. Read More

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September 2021

Ceftriaxone therapy attenuates brain trauma in rats by affecting glutamate transporters and neuroinflammation and not by its antibacterial effects.

BMC Neurosci 2021 Sep 14;22(1):54. Epub 2021 Sep 14.

Departments of Neurosurgery, Chi-Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan, Taiwan.

Background: Ceftriaxone is a β-lactam antibiotic used to treat central nervous system infections. Whether the neuroprotective effects of ceftriaxone after TBI are mediated by attenuating neuroinflammation but not its antibacterial actions is not well established.

Methods: Anesthetized male Sprague-Dawley rats were divided into sham-operated, TBI + vehicle, and TBI + ceftriaxone groups. Read More

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September 2021

Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells.

Korean J Intern Med 2021 Sep 16. Epub 2021 Sep 16.

Transplant Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background/aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) exert powerful therapeutic effects in renal ischemia. However, the efficacy of iMSC-derived exosomes (iExo) on I/R injuries remains largely unknown. Read More

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September 2021

Evaluation of local, regional and abscopal effects of Boron Neutron Capture Therapy (BNCT) combined with immunotherapy in an ectopic colon cancer model.

Br J Radiol 2021 Sep 14:20210593. Epub 2021 Sep 14.

Comisión Nacional de Energía Atómica (CNEA), Buenos Aires, Argentina.

Objective: The aim of the present study was to evaluate the local and regional therapeutic efficacy and abscopal effect of BNCT mediated by boronophenyl-alanine, combined with Bacillus Calmette-Guerin (BCG) as an immunotherapy agent in this model.

Methods: The local effect of treatment was evaluated in terms of tumor response in the irradiated tumor-bearing right hind flank. Metastatic spread to tumor-draining lymph nodes was analyzed as an indicator of regional effect. Read More

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September 2021

Adjuvant Priming Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Obsessive-Compulsive Disorder: In Search of a New Paradigm!

J ECT 2021 Sep 13. Epub 2021 Sep 13.

From the Geriatric Mental Health, King George Medical University, Lucknow, Uttar Pradesh Asha Hospital, Banjara Hills, Hyderabad, Telangana Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.

Objectives: Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic option for obsessive-compulsive disorder (OCD) in both clinical and research settings. There has been no consensus with regard to target area and other parameters, although 1-Hz rTMS over the supplementary motor area (SMA) is found to be promising. Priming stimulation, which involves high-frequency followed by low-frequency rTMS, has been shown to enhance neural response to low-frequency rTMS. Read More

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September 2021

Pain Modulation Induced by Electronic Wrist-ankle Acupuncture: A Functional Near-infrared Spectroscopy Study.

Pain Pract 2021 Sep 14. Epub 2021 Sep 14.

Changhai Hospital, Naval Medical University, Shanghai, 200433, China.

Background: As a new technology, electronic wrist-ankle acupuncture (E-WAA) combines the advantages of wrist-ankle acupuncture and transcutaneous electrical nerve stimulation, but the analgesic effect and mechanism need to be clarified. The purpose of this study was to identify the pain modulation caused by electronic wrist-ankle acupuncture by evaluating the response of prefrontal cortex (PFC) from the perspective of neurophysiology.

Methods: 50 male volunteers (age 25. Read More

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September 2021

miR-221, miR-190b, miR-363-3p, miR-200c are involved in rat liver ischemia-reperfusion injury through oxidative stress, apoptosis and endoplasmic reticulum stress.

Int J Clin Pract 2021 Sep 14:e14848. Epub 2021 Sep 14.

University of Health Sciences Turkey, Sultan Abdulhamid Han Training and Research Hospital, Department of Anesthesia and Reanimation.

Aim: In this study, it was aimed to investigate the relationship between expression levels of micrornas, endoplasmic reticulum (ER) stress, apoptosis and oxidative stress markers in hepatic ischemia reperfusion (IR) injury.

Methods: Sixteen rats were randomized into two groups: sham and IR group. In IR group, portal vein and hepatic artery were totally clamped with an atraumatic microvascular clamp and 60 minutes later unclamped and finally IR model was accomplished (60 min ischemia and 60 min reperfusion). Read More

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September 2021

An investigation of the effects of amniotic fluid on experimental ischemia/reperfusion damage in rat testes.

J Pediatr Urol 2021 Aug 12. Epub 2021 Aug 12.

Izmir Saglik Bilimleri University, Tepecik Training and Research Hospital, Department of Urology, Izmir, Turkey. Electronic address:

Introduction: Various agents have been tested as preventive treatments for ischemia/reperfusion (IR) damage. In this study, we have investigated for the first time in the literature the efficacy of injection of amniomax (AMX) into testicular parenchyma, which is a commercial medium of rat amniotic fluid, in preventing testicular IR damage related to testicular torsion.

Objective: This study aims to evaluate whether or not amniomax has an effect on experimental IR damage in rat testes using biochemical and histopathological methods based on data in the literature. Read More

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Metabolic maturation during postnatal right ventricular development switches to heart-contraction regulation due to volume overload.

J Cardiol 2021 Sep 10. Epub 2021 Sep 10.

Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. Electronic address:

Background: Metabolic maturation is one of the primary processes of postnatal cardiomyocyte development. How volume overload (VO), a pathological state of the right ventricle (RV) in children with congenital heart disease (CHD) and patients with heart failure, affects cardiomyocyte metabolic maturation is unclear.

Methods And Results: A fistula between the abdominal aorta and inferior vena cava on postnatal day 7 (P7) was created in a mouse model to induce a young-aged RV VO. Read More

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September 2021

Combined Effects of Low-Frequency Pulsed Electromagnetic Field and Melatonin on Ovariectomy-Induced Bone Loss in Mice.

Bioelectromagnetics 2021 Sep 13. Epub 2021 Sep 13.

Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.

Pulsed electromagnetic field (PEMF) therapy and melatonin (MEL) supplementation are expected to be important strategies for the treatment of osteoporosis. The aim of the current study was to investigate the efficacy of PEMF therapy, MEL supplementation, a combination of PEMF therapy, and MEL supplementation (PEMF + MEL) in mice with bilateral ovariectomy (OVX)-induced osteoporosis. Forty 12-week-old female C57/BL mice were randomly assigned to five groups (n = 8/group): OVX, PEMF, MEL, PEMF + MEL, and sham-operation (sham) groups. Read More

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September 2021

Low-intensity pulsed ultrasound therapy suppresses coronary adventitial inflammatory changes and hyperconstricting responses after coronary stent implantation in pigs in vivo.

PLoS One 2021 13;16(9):e0257175. Epub 2021 Sep 13.

Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Backgrounds: We demonstrated that coronary adventitial inflammation plays important roles in the pathogenesis of drug-eluting stent (DES)-induced coronary hyperconstricting responses in pigs in vivo. However, no therapy is yet available to treat coronary adventitial inflammation. We thus developed the low-intensity pulsed ultrasound (LIPUS) therapy that ameliorates myocardial ischemia by enhancing angiogenesis. Read More

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September 2021

Disrupted Blood-Brain Barrier and Mitochondrial Impairment by Autotaxin-Lysophosphatidic Acid Axis in Postischemic Stroke.

J Am Heart Assoc 2021 Sep 13:e021511. Epub 2021 Sep 13.

Department of Cellular Biology and Anatomy Louisiana State University Health Sciences Center Shreveport LA.

Background The loss of endothelial integrity increases the risk of intracerebral hemorrhage during ischemic stroke. Adjunct therapeutic targets for reperfusion in ischemic stroke are in need to prevent blood-brain barrier disruption. Recently, we have shown that endothelial permeability is mediated by lysophosphatidic acid (LPA), but the role of autotaxin, which produces LPA, remains unclear in stroke. Read More

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September 2021

Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study.

Andrologia 2021 Sep 12:e14245. Epub 2021 Sep 12.

Department of Urology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Testicular torsion is an emergency urological disease, and the treatment is immediate surgery. Despite emergency surgery, testicular damage may occur due to reperfusion. Therefore, a medical treatment to prevent this damage may be a rational idea. Read More

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September 2021

The Effects of Intermittent Hypoxic-Hyperoxic Exposures on Lipid Profile and Inflammation in Patients With Metabolic Syndrome.

Front Cardiovasc Med 2021 27;8:700826. Epub 2021 Aug 27.

Department of Cardiology, Functional and Ultrasound Diagnostics, N.V. Sklifosofsky, I. M. Sechenov First Moscow State Medical University, Moscow, Russia.

Patients with metabolic syndrome (MS) tend to suffer from comorbidities, and are often simultaneously affected by obesity, dysglycemia, hypertension, and dyslipidemia. This syndrome can be reversed if it is timely diagnosed and treated with a combination of risk factors-reducing lifestyle changes and a tailored pharmacological plan. Interval hypoxic-hyperoxic training (IHHT) has been shown as an effective program in reducing cardiovascular risk factors in patients with MS even in the absence of exercise. Read More

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900 MHz Radiofrequency Field Induces Mitochondrial Unfolded Protein Response in Mouse Bone Marrow Stem Cells.

Front Public Health 2021 26;9:724239. Epub 2021 Aug 26.

Department of Toxicology, School of Public Health, Medical College of Soochow University, Suzhou, China.

To examine whether exposure of mouse bone marrow stromal cells (BMSC) to 900 MHz radiofrequency fields used in mobile communication devices can induce mitochondrial unfolded protein response (UPR). BMSCs were exposed to continuous wave 900 MHz radiofrequency fields (RF) at 120 μW/cm power intensity for 4 h/d for 5 consecutive days. Cells in sham group (SH) were cultured in RF exposure system, but without RF radiation. Read More

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Effect of Anodal Transcranial Direct Current Stimulation Combined With Cognitive Training for Improving Cognition and Language Among Children With Cerebral Palsy With Cognitive Impairment: A Pilot, Randomized, Controlled, Double-Blind, and Clinical Trial.

Front Pediatr 2021 25;9:713792. Epub 2021 Aug 25.

Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

About 30-45% of cerebral palsy (CP) patients have cognitive impairment. Previous studies showed the evidence that transcranial direct current stimulation (tDCS) may have some benefits in attention-deficit/hyperactivity disorder, autism spectrum disorder, and motor development in CP. The aim of this study is to evaluate the effect of tDCS on cognition, language, and activities of daily living (ADL) among children with CP with cognitive impairment. Read More

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Microglial Activation of GLP-1R Signaling in Neuropathic Pain Promotes Gene Expression Adaption Involved in Inflammatory Responses.

Neural Plast 2021 31;2021:9923537. Epub 2021 Aug 31.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, School of Pharmacy, Shanghai 200240, China.

Background: Neuropathic pain is a common chronic pain, which is related to hypersensitivity to stimulus and greatly affects the quality of life of patients. Maladaptive gene changes and molecular signaling underlie the sensitization of nociceptive pathways. We previously found that the activation of microglial glucagon-like peptide 1 receptor (GLP-1R) could potently relieve formalin-, bone cancer-, peripheral nerve injury-, and diabetes-induced pain hypersensitivity. Read More

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Acupuncture as an Adjunctive Treatment for Post-stroke Epilepsy: Protocol for a Randomized Controlled Trial.

Front Neurol 2021 26;12:711390. Epub 2021 Aug 26.

Department of Acupuncture and Moxibustion for Encephalopathy, The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Acupuncture has been clinically used to treat epilepsy after stroke. However, most of the current clinical studies are observational studies, and there are few well-designed randomized controlled trials (RCTs). Hence, we designed a multicentre RCT to assess the advantages and efficacy of acupuncture for post-stroke epilepsy (PSE). Read More

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Glibenclamide Attenuates Neuroinflammation and Promotes Neurological Recovery After Intracerebral Hemorrhage in Aged Rats.

Front Aging Neurosci 2021 26;13:729652. Epub 2021 Aug 26.

Department of Neurosurgery, Southwest Hospital, Army Medical University, Chongqing, China.

Intracerebral hemorrhage (ICH) is a common disease in the elderly population. Inflammation following ICH plays a detrimental role in secondary brain injury, which is associated with a poor prognosis of patients with ICH, and no efficient pharmacological preventions are available. Here, we investigated the effects of glibenclamide (GLC) on neuroinflammation in an autoblood-induced aged rat (18 months old) model of ICH. Read More

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Modulating the Activity of the VMPFC With tDCS Alters the Social Framing Effect.

Front Behav Neurosci 2021 26;15:677006. Epub 2021 Aug 26.

Center for Economic Behavior and Decision-Making, Zhejiang University of Finance and Economics, Hangzhou, China.

Numerous experimental studies have replicated the social framing effect-the observation that people's decisions related to economic benefits and feelings depend on the method of presentation. Previous neuroimaging studies have shown that the ventromedial prefrontal cortex (VMPFC) plays a part in the influence of framing and how individuals think about the feelings of others. Based on this, we used transcranial direct current stimulation (tDCS) to modulate neuronal activity in the VMPFC to determine the likelihood of a direct association between VMPFC activity and the social framing effect. Read More

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Comparing the Therapeutic Effects of Crocin, Escitalopram and Co-Administration of Escitalopram and Crocin on Learning and Memory in Rats with Stress-Induced Depression.

Malays J Med Sci 2021 Aug 26;28(4):50-62. Epub 2021 Aug 26.

Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Depression affects various brain functions. According to previous studies, escitalopram influences brain functions in depression and crocin reduces memory impairments. Therefore, this study aimed to compare the therapeutic effects of using crocin and escitalopram (separately and in combination) on learning and memory in rats with stress-induced depression. Read More

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Thread-Embedding Acupuncture for the Treatment of Shoulder Instability: Protocol for a Randomized, Controlled, Patient-Assessor Blinded Pilot Study.

J Pain Res 2021 4;14:2729-2737. Epub 2021 Sep 4.

Department of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.

Purpose: This study aims to determine the feasibility of thread-embedding acupuncture (TEA) for the treatment of shoulder instability.

Patients And Methods: This is a patient-assessor blinded, randomized, sham-controlled trial with two parallel arms. A total of 40 patients with shoulder instability aged between 13 and 43 years will be recruited and screened using set inclusion and exclusion criteria. Read More

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September 2021

Dexmedetomidine and Phosphocreatine Post-treatment Provides Protection against Focal Cerebral Ischemia-reperfusion Injury in Rats.

Acta Histochem Cytochem 2021 Aug 7;54(4):105-113. Epub 2021 Jul 7.

Department of Anesthesiology, First Affiliated Hospital of the University of Science and Technology of China, No. 1 Swan Lake Road, Hefei 230036, Anhui, China.

In this study we investigated the neuroprotective efficacy of dexmedetomidine (Dex) and phosphocreatine (PCr) alone or in combination in a rat model of focal cerebral ischemia-reperfusion injury (I/R). I/R was induced by intraluminal middle cerebral artery occlusion (MCAO) and reperfusion. Male Sprague-Dawley rats were randomly allocated to the Sham group and I/R group, and the I/R group was further divided into three subgroups: Dex (9 μg. Read More

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Effects of amantadine and topiramate on neuronal damage in rats with experimental cerebral ischemia-reperfusion.

Adv Clin Exp Med 2021 Sep 9. Epub 2021 Sep 9.

Department of Histology and Embryology, Medical Faculty, Selçuk University, Konya, Turkey.

Background: Ischemia-reperfusion models are used to evaluate treatment options that may minimize cellular damage after ischemia.

Objectives: To investigate the effects of amantadine and topiramate on apoptosis and cellular oxidative damage.

Material And Methods: This experiment was performed using 30 male Wistar albino rats. Read More

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September 2021

Investigation of the Effect of Melatonin Administration on İnflammatory Mediators; MMP-2, TGF-β and VEGF Levels in Rats with Sepsis.

Int J Clin Pract 2021 Sep 12:e14832. Epub 2021 Sep 12.

Department of Biochemistry, Medical Faculty, Sakarya University, Sakarya, Turkey.

Aims: Sepsis causes life-threatening tissue and organ dysfunctions caused by endogenous mediators in response to infection. Melatonin is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage. This study aimed to evaluate the changes in serum and liver tissue levels of VEGF, TGF-β and MMP-2 in melatonin treated septic rats. Read More

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September 2021

Protective role of melatonin and spirulina in aortic occlusion-reperfusion model in rats.

J Food Biochem 2021 Sep 12:e13926. Epub 2021 Sep 12.

Saki Yenilli Experimental Animals Production Laboratory, Ankara, Turkey.

The aim of this experiment was to investigate the role of melatonin and spirulina on multiorgan damage induced by ischemia/reperfusion injury (IR) in a rat model. A total of 32 male rats weighing 200-220 g were allocated into 4 groups (n = 8/group) (Sham, Control-IR [CIR], Melatonin-IR [MIR], and Spirulina-IR [SIR]). Sham group underwent midline laparotomy and dissection of the aorta without injury. Read More

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September 2021

The effect of antiepileptic drugs on re-myelinization of axons: Phenytoin, levetiracetam, carbamazepine, and valproic acid, used following traumatic brain injury.

Clin Neurol Neurosurg 2021 Aug 31;209:106911. Epub 2021 Aug 31.

Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey. Electronic address:

Objective: Traumatic brain injury is a major health and socioeconomic problem and the first cause of young death worldwide. For this reason, the prevention of post-traumatic brain injury and the research of new methods for it are important today. In this study, we aimed to determine whether the use of antiepileptic drugs contributed to axonal healing after traumatic brain injury. Read More

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Technical Note: Modulation of fMRI brainstem responses by transcutaneous vagus nerve stimulation.

Neuroimage 2021 Sep 10;244:118566. Epub 2021 Sep 10.

Translational Neurocircuitry Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931, Cologne, Germany; Cluster of Excellence in Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, 50931, Cologne, Germany.

Our increasing knowledge about gut-brain interaction is revolutionising the understanding of the links between digestion, mood, health, and even decision making in our everyday lives. In support of this interaction, the vagus nerve is a crucial pathway transmitting diverse gut-derived signals to the brain to monitor of metabolic status, digestive processes, or immune control to adapt behavioural and autonomic responses. Hence, neuromodulation methods targeting the vagus nerve are currently explored as a treatment option in a number of clinical disorders, including diabetes, chronic pain, and depression. Read More

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September 2021