43,449 results match your criteria sexual dysfunction


Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for hospitalised patients with mild or moderate COVID-19 pneumonia: a structured summary of a study protocol for a randomised controlled trial.

Trials 2021 Apr 12;22(1):270. Epub 2021 Apr 12.

Imperial College, London and Imperial NHS Trust, London, UK.

Objectives: The primary objective of MATIS is to determine the efficacy of ruxolitinib (RUX) or fostamatinib (FOS) compared to standard of care (SOC) with respect to reducing the proportion of hospitalised patients progressing from mild or moderate to severe COVID-19 pneumonia. Secondary objectives, at 14 and 28 days, are to: Determine the efficacy of RUX or FOS to reduce mortality Determine the efficacy of RUX or FOS to reduce the need for invasive ventilation or ECMO Determine the efficacy of RUX or FOS to reduce the need for non-invasive ventilation Determine the efficacy of RUX or FOS to reduce the proportion of participants suffering significant oxygen desaturation Determine the efficacy of RUX or FOS to reduce the need for renal replacement therapy Determine the efficacy of RUX and FOS to reduce the incidence of venous thromboembolism Determine the efficacy of RUX and FOS to reduce the severity of COVID-19 pneumonia [graded by a 9-point modified WHO Ordinal Scale* Determine the efficacy of RUX or FOS to reduce systemic inflammation Determine the efficacy of RUX or FOS to the incidence of renal impairment Determine the efficacy of RUX or FOS to reduce duration of hospital stay Evaluate the safety of RUX and FOS for treatment of COVID-19 pneumonia.

Trial Design: A multi-arm, multi-stage (3-arm parallel-group, 2-stage) randomised controlled trial that allocates participants 1:1:1 and tests for superiority in experimental arms versus standard of care. Read More

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Effect of a three-piece inflatable penile prosthesis combined with a phosphodiesterase-5 inhibitor on erectile dysfunction.

J Int Med Res 2021 Apr;49(4):300060520985365

Department of Urology, the Second People's Hospital of Nantong City, Nantong City, Jiangsu Province, China.

Objective: To investigate the therapeutic effect of implanting a three-piece inflatable penile prosthesis (IPP) combined with the phosphodiesterase-5 inhibitor sildenafil in severe erectile dysfunction (ED) patients.

Methods: This randomized controlled study included 123 ED patients. Sixty-two patients received the IPP implantation and 61 patients received the IPP implantation and the phosphodiesterase-5 inhibitor sildenafil. Read More

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Symptoms affecting quality of life after sphincter-saving rectal cancer surgery: A systematic review.

Eur J Oncol Nurs 2021 Mar 22;52:101934. Epub 2021 Mar 22.

Kings College London, James Clerk Maxwell Building, 57 Waterloo Road, Lambeth, London, SE1 8WA, UK.

Purpose: Rectal cancer is common and is frequently treated with surgery which removes the rectum but retains anal sphincters. After sphincter-saving rectal cancer surgery, which can result in a reduced rectal storage capacity and nerve damage, symptoms frequently occur.

Method: A systematic review was undertaken to determine which symptoms occur and their effect on quality of life. Read More

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Transcutaneous Temperature-Controlled Radiofrequency Treatment: Improvement in Female Genital Appearance, Sexual Dysfunction, and Stress Urinary Incontinence.

Aesthet Surg J 2021 Apr 12. Epub 2021 Apr 12.

Department of Dermatology, Alpert Medical School of Brown University, Providence, RI, USA.

Background: Transcutaneous temperature-controlled radiofrequency (TTCRF) is an emerging modality for vulvovaginal rejuvenation. Still, the clinical experience with this modality is limited.

Objectives: The aim of this study was to examine the efficacy of TTCRF in improving female genital appearance, sexual function, and stress urinary incontinence (SUI). Read More

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Substances of abuse consumption among patients seeking medical help for uro-andrological purposes: a sociobehavioral survey in the real-life scenario.

Asian J Androl 2021 Apr 6. Epub 2021 Apr 6.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, via Olgettina 60, Milan 20131, Italy.

Substances of abuse (SoA), as well as smoking and alcohol consumption, are well known for their impact on male fertility status, erectile function, and ejaculation. We assessed SoA consumption habits in a cohort of men seeking medical attention for uro-andrological purposes. Data from 7447 men seeking medical attention for the first time for uro-andrological purposes were analyzed. Read More

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Vaginal Fractional Carbon Dioxide Laser Treatment and Changes in Vaginal Biomechanical Parameters.

Lasers Surg Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, 3525408, Israel.

Background And Objectives: Vaginal fractional carbon dioxide (CO ) laser treatment has emerged in the past two decades as a non-surgical option for vaginal tightening. Mounting evidence supports the effectiveness and safety of this treatment for female sexual dysfunction. A newly developed vaginal tactile imaging (VTI) technique accurately evaluates the biomechanical parameters of the female pelvic floor and vagina, including tissue elasticity, pelvic support, and pelvic muscle function in high definition. Read More

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Sexual Dysfunction and Preferences for Discussing Sexual Health Concerns Among Veteran Primary Care Patients.

J Am Board Fam Med 2021 Mar-Apr;34(2):357-367

From the Center for Integrated Healthcare, Syracuse VA Medical Center, Syracuse, NY (RLS, LDM, JSF); Department of Psychology, Syracuse University, Syracuse, NY (RLS, LDM, JSF); Rochester Institute of Technology, Institute of Health Sciences and Technology, Rochester, NY (NT, CAC); Canandaigua Veterans Affairs Medical Center, Canandaigua, NY (CAC); Center of Excellence for Suicide Prevention, Canandaigua VA Medical Center, Canandaigua, NY (DC); and the Department of Psychiatry, University of Rochester, Rochester, New York (JSF).

Background: Sexual health is an important, yet often overlooked, aspect of overall health. Veterans may be particularly at risk for sexual dysfunction. The objectives of this study were to assess the prevalence and correlates of sexual dysfunction and examine preferences among veterans for discussing sexual problems. Read More

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Risk factors for sexual dysfunction after rectal cancer surgery in 948 consecutive patients: A prospective cohort study.

Eur J Surg Oncol 2021 Mar 29. Epub 2021 Mar 29.

Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address:

Background: Sexual dysfunctions seriously affect the quality of life of patients. The aim of this study was to identify the risk factors for sexual dysfunction after rectal cancer surgery.

Methods: A total of 948 consecutive patients undergoing rectal cancer radical resection were included between January 2012 and August 2019. Read More

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Efficacy and safety of a new vaginal gel for the treatment of symptoms associated with vulvovaginal atrophy in postmenopausal women: A double-blind randomized placebo-controlled study.

Maturitas 2021 May 4;147:34-40. Epub 2021 Mar 4.

Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause, Obstetrics and Gynecology Unit, IRCCS S. Matteo Foundation, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Viale Camillo Golgi, 19, 27100 Pavia, Italy. Electronic address:

Objective: The aim of the present randomized placebo-controlled single-center study was to assess the efficacy and safety of a new vaginal gel (Meclon Idra - Alfasigma) in the treatment of vulvovaginal atrophy (VVA). The gel is composed of sea buckthorn (Hippophaë rhamnoides) oil, aloe vera, 18β-glycyrrhetic acid, hyaluronic acid and glycogen. The study assessed whether the gel can reduce VVA symptoms (vaginal dryness, itching, burning sensation) and improve sexual function in postmenopausal women over 12 weeks. Read More

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Premature Ejaculation and Endocrine Disorders: A Literature Review.

World J Mens Health 2021 Mar 22. Epub 2021 Mar 22.

Department of Urology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey.

Premature ejaculation (PE) is the most common male sexual dysfunction, with 30% of men experiencing PE worldwide. According to the generally accepted classification, there are two types of PE: lifetime PE and acquired PE. Various biological and psychological causes are known to be involved in the etiology of PE. Read More

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The prevalence and impact of maltreatment of child laborers in the context of four South Asian countries: A scoping review.

Child Abuse Negl 2021 Apr 5;117:105052. Epub 2021 Apr 5.

College of Nursing and Health Sciences, Flinders University, SA, 5042, Australia. Electronic address:

Background: Child maltreatment is a global health concern, which adversely affects millions of children. Among them, child laborers are highly susceptible to maltreatment due to their economic vulnerability and workplace practices.

Objectives: This review seeks to identify the extent, risk factors and psychological impairments associated with the maltreatment of child laborers in four South East Asian countries. Read More

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Feasibility of a cognitive behavioral online intervention for women with Sexual Interest/Arousal Disorder.

J Clin Psychol 2021 Apr 8. Epub 2021 Apr 8.

Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: Difficulties with sexual desire and arousal are common in women, but most lack access to effective treatment such as cognitive-behavioral therapy (CBT). eSense is a recently created online CBT intervention for sexual difficulties with promising evidence of usability. The current study assessed the feasibility of women completing the full eSense CBT program without guidance. Read More

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Impact of Allogeneic Stem Cell Transplantation on Testicular and Sexual Function.

Transplant Cell Ther 2021 Feb 14;27(2):182.e1-182.e8. Epub 2020 Dec 14.

Transition Unit for Childhood Cancer Survivors, Città della Salute e della Scienza Hospital, Turin, Italy. Electronic address:

High-dose chemotherapy and radiotherapy, administered as a conditioning regimen before stem cell transplantation, are known to negatively impact testicular function and sexuality. However, to date, only a few studies have simultaneously analyzed the real prevalence of these complications in this clinical setting. Therefore, this study aimed to assess the prevalence of testicular dysfunction and sexual impairment in a cohort of males who underwent allogeneic stem cell transplantation in adulthood. Read More

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February 2021

Sexual inhibition and sexual excitation in a sample of Polish women.

PLoS One 2021 6;16(4):e0249560. Epub 2021 Apr 6.

Department of Sexology, Andrzej Frycz Modrzewski Krakow University, Cracow, Poland.

The contemporary concept of sexual counseling for women with sexual problems, distress, and female sexual dysfunction (FSD) includes tailored medical and/or psychological intervention. The dual control model and the Sexual Excitation/Sexual Inhibition Inventory for Women (SESII-W) are helpful for identifying risk factors and tailoring therapy for FSD. The current study aimed to (1) validate the Polish translation of the SESII-W in a sample of Polish women, and (2) verify the usefulness of the SESII-W in clinical practice. Read More

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Self-Reported Shorter Than Desired Ejaculation Latency and Related Distress-Prevalence and Clinical Correlates: Results From the European Male Ageing Study.

J Sex Med 2021 Apr 2. Epub 2021 Apr 2.

Endocrinology Unit, Mario Serio" Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy. Electronic address:

Background: Few data have looked at the occurrence and clinical correlates of self-reported shorter than desired ejaculation latency (rapid ejaculation, RE) and its related distress in the general population.

Aim: To determine the prevalence and clinical correlates of self-reported RE and RE- related distress in middle age and older European men.

Methods: Subjects were recruited from population samples of men aged 40-79 years across 8 European centers. Read More

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[Effect of Tadalafil SZ on endothelial function in patients with erectile dysfunction].

Urologiia 2021 Mar(1):50-54

Federal State Government-Financed Educational Institution of Higher Education Volgograd State Medical University of the Ministry of Healthcare of the Russian Federation, Volgograd, Russia.

The aim of the study was to assess the efficacy and safety of taking tadalafil at a dose of 5 mg per day or 20 mg "on demand" for the state of endothelial function, the severity of erectile dysfunction (ERD) and urodynamics in men with mild to moderate ERD.

Materials And Methods: The study included 60 male patients with benign prostatic hyperplasia aged 44 to 60 years with erectile dysfunction and cardiovascular pathology (arterial hypertension, ischemic heart disease). All patients were divided into 3 groups of 20 people. Read More

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Ultrasound aspects of symptomatic versus asymptomatic forms of male accessory gland inflammation.

Andrology 2021 Apr 5. Epub 2021 Apr 5.

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: The ultrasound (US) evaluation of the Male Sex Accessory Gland Inflammation (MAGI) helps the clinicians to understand the severity of this condition, allowing them to distinguish the uncomplicated form (prostatitis) from the complicated ones (prostate-vesiculitis and prostate-vesiculitis-epididymitis), as well as the unilateral from the bilateral forms, the fibrosclerotic and the hypertrophic-congestive form.

Objective: This retrospective study aimed to evaluate the US features of MAGI patients with active symptoms compared to patients without sexual, voiding, and ejaculatory dysfunction.

Materials/methods: To achieve this aim, an analysis of the prevalence of MAGI US criteria was carried out on a very large series of over 500 patients diagnosed with MAGI classified according to the different symptom profile evaluated through a dedicated questionnaire (previously conceived and published by our group) arbitrarily named "structured interview about MAGI" (SI-MAGI) for sexual, voiding, and ejaculatory disorders reported by these patients. Read More

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Sexual Dysfunction in Gay and Bisexual Prostate Cancer Survivors: A Concept Analysis.

J Homosex 2021 Apr 5:1-21. Epub 2021 Apr 5.

Daphne Cockwell School of Nursing, Ryerson University, Toronto, Ontario, Canada.

Sexual dysfunction is a common side effect of prostate cancer (PCa) treatment, yet it remains poorly defined in the literature. Current definitions are based on heteronormative assumptions which do not consider the unique experiences of gay and bisexual (GBM) PCa survivors. The purpose of this paper is to use Walker and Avant's method to conduct a concept analysis of sexual dysfunction among GBM in the context of PCa survivorship. Read More

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A Comparison of Erectile Dysfunction Improvement Between Patients With Regular Hemodialysis and Patients With Continuous Ambulatory Peritoneal Dialysis.

J Sex Med 2021 Apr 1. Epub 2021 Apr 1.

Anesthesiology and Intensive Care Department, Faculty of Medicine, Udayana University, Bali - Indonesia. Electronic address:

Background: Erectile dysfunction (ED) is one of the sexual dysfunctions that are often encountered as a complication of male patients with stage 5 chronic kidney disease (stage 5 CKD). ED can be caused by psychological factors in patients with regular dialysis therapy. Currently, Hemodialysis (HD) therapy is the first choice in dialysis therapy and only 2% of stage 5 CKD patients are using Continuous Ambulatory Peritoneal Dialysis (CAPD) as a dialysis therapy. Read More

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International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.

J Sex Med 2021 Mar 29. Epub 2021 Mar 29.

Andrology, Women's Endocrinology & Gender Incongruence Unit, Department of "Excellence" Experimental and Clinical Biomedical Sciences "Mario Serio"-Careggi Hospital-University of Florence, Florence, Italy; Consorzio Interuniversitario I.N.B.B., Rome, Italy.

Background: The Global Consensus Position Statement on the Use of Testosterone Therapy for Women (Global Position Statement) recommended testosterone therapy for postmenopausal women with hypoactive sexual desire disorder (HSDD).

Aim: To provide a clinical practice guideline for the use of testosterone including identification of patients, laboratory testing, dosing, post-treatment monitoring, and follow-up care in women with HSDD.

Methods: The International Society for the Study of Women's Sexual Health appointed a multidisciplinary panel of experts who performed a literature review of original research, meta-analyses, review papers, and consensus guidelines regarding testosterone use in women. Read More

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Evaluation of Minimal Important Difference and Responder Definition in the EORTC QLQ-PAN26 Module for Assessing Health-Related Quality of Life in Patients with Surgically Resected Pancreatic Adenocarcinoma.

Ann Surg Oncol 2021 Apr 3. Epub 2021 Apr 3.

Mayo Clinic, Scottsdale, AZ, USA.

Background: Although the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-PAN26 is widely used to assess health-related quality of life (HRQoL), its group-level minimal important difference (MID) and individual-level responder definition (RD) are not established; we calculated MID and RD using HRQoL data from the APACT trial in patients with surgically resected pancreatic cancer who received adjuvant chemotherapy.

Methods: HRQoL was assessed using EORTC QLQ-C30 and QLQ-PAN26 at baseline, during treatment, at end of treatment, and during follow-up. Distribution-based MIDs were estimated using 0. Read More

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HIV and Sexual Dysfunction in Men.

J Clin Med 2021 Mar 5;10(5). Epub 2021 Mar 5.

Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via Giardini 1355, 41126 Modena, Italy.

Sexual issues tend to go unaddressed in human immunodeficiency virus (HIV) management, although overt sexual dysfunctions are more prevalent in people living with HIV than uninfected people. Erectile dysfunction is the most frequent sexual problem, with a prevalence of 30-50% even in men <40 years of age, but other issues such as loss of libido and ejaculatory disorders should not be overlooked. Peculiar factors related to HIV infection (e. Read More

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Sexual Function and Sexual Quality of Life in Premenopausal Women with Controlled Type 1 and 2 Diabetes-Preliminary Study.

Int J Environ Res Public Health 2021 Mar 4;18(5). Epub 2021 Mar 4.

Department of Gerontology and Geriatric Nursing, Faculty of Health Sciences, Medical University of Silesia, 40-635 Katowice, Poland.

Sexual dysfunction is more common in women with diabetes than in women without diabetes. The aim of the study was to determine sexual function and the level of the quality of sex life in premenopausal women with controlled, uncomplicated type 1 and type 2 diabetes taking into account the stages of the menstrual cycle and mood level. The study included 163 women with type 1 and type 2 diabetes and 115 controls without diabetes. Read More

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Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women.

Pharmacy (Basel) 2021 Mar 27;9(2). Epub 2021 Mar 27.

Department of Pharmacy Practice, School of Pharmacy, D'Youville College, Buffalo, NY 14201, USA.

This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, International Pharmaceutical Abstracts, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature were searched using keywords "arginine", "Lady Prelox", "ArginMax", "Stronvivo", "Ristela", "hypoactive sexual desire disorder", "female sexual interest arousal disorder", "female sexual arousal disorder", "sexual dysfunction", "sexual behavior", "dyspareunia", "libido", and permutations thereof. Relevant records were retained if they were primary literature, conducted in women with HSDD or related conditions, and published as full text in English. Read More

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The Stanley Prostate-cancer Treatment Protocol for Erectile Dysfunction After Prostatectomy and/or Radiotherapy: A Case Report.

Int J Pharm Compd 2021 Mar-Apr;25(2):94-98

Stanley Specialty Pharmacy, Charlotte, North Carolina.

Even when a diagnosis of prostate cancer is anticipated, many patients are unprepared for the persistence and severity of sequelae such as erectile dysfunction, which frequently results from lifesaving treatment for that disease. Erectile dysfunction in particular can exert a powerful impact on quality of life as the patient's self-esteem diminishes, intimacy erodes, and a sustained level of stress and anxiety that impairs work performance and personal relationships becomes a part of his everyday experience. The Stanley Prostate-cancer Protocol for treating erectile dysfunction after prostatectomy and/or radiotherapy was developed to better assist the underserved patient population faced with that challenge. Read More

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The Effect of Sexual Dysfunction on Health-Related Quality of Life in Men Following Traumatic Pelvic Fractures.

J Trauma Acute Care Surg 2021 Mar 23. Epub 2021 Mar 23.

Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA, USA Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA Department of Pediatrics, University of Washington, Seattle, WA, USA.

Background: Pelvic trauma disproportionately affects a younger population and has the potential to cause long-term sexual dysfunction. We hypothesized that the presence of sexual dysfunction after traumatic pelvic fracture negatively impacts health-related quality of life in men.

Methods: 228 patients with traumatic pelvic fractures treated at a level 1 trauma center between 2012 and 2017 completed a survey that evaluated post-injury health-related quality of life and sexual function. Read More

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