116 results match your criteria sex-specific sterility

Periconceptional maternal body mass index and the impact on post-implantation (sex-specific) embryonic growth and morphological development.

Int J Obes (Lond) 2021 Jul 21. Epub 2021 Jul 21.

Departments of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Objective: Women with obesity have an increased risk of pregnancy complications. Although complications generally present in the second and third trimester of pregnancy, most of them develop in the periconception period. Moreover, fetal sex also impacts pregnancy course and outcome. Read More

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Unconventional translation initiation factor EIF2A is required for Drosophila spermatogenesis.

Dev Dyn 2021 Jul 18. Epub 2021 Jul 18.

Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, California.

Background: EIF2A is an unconventional translation factor required for initiation of protein synthesis from non-AUG codons from a variety of transcripts, including oncogenes and stress related transcripts in mammalian cells. Its function in multicellular organisms has not been reported.

Results: Here, we identify and characterize mutant alleles of the CG7414 gene, which encodes the Drosophila EIF2A ortholog. Read More

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Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Nat Hum Behav 2021 Jul 1. Epub 2021 Jul 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Read More

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Aging, cardiovascular risk and SHBG levels in men and women from the general population.

J Clin Endocrinol Metab 2021 Jul 1. Epub 2021 Jul 1.

Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, the Netherlands.

Aims: Prior studies have reported inconsistent results for the association between sex hormone-binding globulin (SHBG) and cardiovascular disease among men and women. Although it is suggested that SHBG levels change with aging, the exact trend of SHBG across age and cardiovascular risk, and the underlying mechanisms of these changes remain to be elucidated.

Methods: Using data of 3264 men and women from a large population-based cohort study, we visualized the distribution of serum SHBG levels across age. Read More

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WNT4 Balances Development vs Disease in Gynecologic Tissues and Women's Health.

Endocrinology 2021 Jul;162(7)

Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.

The WNT family of proteins is crucial in numerous developmental pathways and tissue homeostasis. WNT4, in particular, is uniquely implicated in the development of the female phenotype in the fetus, and in the maintenance of müllerian and reproductive tissues. WNT4 dysfunction or dysregulation can drive sex-reversal syndromes, highlighting the key role of WNT4 in sex determination. Read More

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Evaluation of the Modified Reproductive Concerns Scale Among Emerging Adult Cancer Survivors.

J Adolesc Young Adult Oncol 2021 Mar 26. Epub 2021 Mar 26.

Aflac Cancer & Blood Disorders Center at Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

The reproductive concerns of emerging adult survivors of childhood cancer are not well described, and valid measurement tools tailored to this population are lacking. The purpose of this analysis was to evaluate a modified version of the Reproductive Concerns Scale (mRCS) among male and female survivors of childhood cancer. This is a secondary analysis of cross-sectional survey data collected from patients enrolled on an infertility-educational intervention study. Read More

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Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo.

G3 (Bethesda) 2021 04;11(4)

Department of Biochemistry & Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY.

One of the best examples of sexual dimorphism is the development and function of the gonads, ovaries and testes, which produce sex-specific gametes, oocytes, and spermatids, respectively. The development of these specialized germ cells requires sex-matched somatic support cells. The sexual identity of somatic gonadal cells is specified during development and must be actively maintained during adulthood. Read More

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Widespread misregulation of inter-species hybrid transcriptomes due to sex-specific and sex-chromosome regulatory evolution.

PLoS Genet 2021 03 5;17(3):e1009409. Epub 2021 Mar 5.

Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Canada.

When gene regulatory networks diverge between species, their dysfunctional expression in inter-species hybrid individuals can create genetic incompatibilities that generate the developmental defects responsible for intrinsic post-zygotic reproductive isolation. Both cis- and trans-acting regulatory divergence can be hastened by directional selection through adaptation, sexual selection, and inter-sexual conflict, in addition to cryptic evolution under stabilizing selection. Dysfunctional sex-biased gene expression, in particular, may provide an important source of sexually-dimorphic genetic incompatibilities. Read More

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Sperm proteins and cancer-testis antigens are released by the seminiferous tubules in mice and men.

FASEB J 2021 03;35(3):e21397

Hudson Institute of Medical Research, Clayton, VIC, Australia.

Sperm develop from puberty in the seminiferous tubules, inside the blood-testis barrier to prevent their recognition as "non-self" by the immune system, and it is widely assumed that human sperm-specific proteins cannot access the circulatory or immune systems. Sperm-specific proteins aberrantly expressed in cancer, known as cancer-testis antigens (CTAs), are often pursued as cancer biomarkers and therapeutic targets based on the assumption they are neoantigens absent from the circulation in healthy men. Here, we identify a wide range of germ cell-derived and sperm-specific proteins, including multiple CTAs, that are selectively deposited by the Sertoli cells of the adult mouse and human seminiferous tubules into testicular interstitial fluid (TIF) that is "outside" the blood-testis barrier. Read More

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Spinal muscular atrophy: Broad disease spectrum and sex-specific phenotypes.

Biochim Biophys Acta Mol Basis Dis 2021 04 5;1867(4):166063. Epub 2021 Jan 5.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA. Electronic address:

Spinal muscular atrophy (SMA) is one of the major genetic disorders associated with infant mortality. More than 90% of cases of SMA result from deletions of or mutations in the Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, does not compensate for the loss of SMN1 due to predominant skipping of exon 7. Read More

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The effects of assisted reproduction technologies on metabolic health and disease†.

Biol Reprod 2021 04;104(4):734-744

Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.

The increasing prevalence of metabolic diseases places a substantial burden on human health throughout the world. It is believed that predisposition to metabolic disease starts early in life, a period of great susceptibility to epigenetic reprogramming due to environmental insults. Assisted reproductive technologies (ART), i. Read More

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Production of donor-derived eggs after ovarian germ cell transplantation into the gonads of adult, germ cell-less, triploid hybrid fish†.

Biol Reprod 2020 12;103(6):1289-1299

Noto Center for Fisheries Science and Technology, Faculty of Biological Science and Technology, Kanazawa University, Ishikawa, Japan.

In animals, spermatogonial transplantation in sterile adult males is widely developed; however, despite its utility, ovarian germ cell transplantation is not well developed. We previously showed that the interspecific hybrid offspring of sciaenid was a suitable model for germ cell transplantation studies as they have germ cell-less gonads. However, all these gonads have testis-like characteristics. Read More

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December 2020

Lack of AR in LepRb Cells Disrupts Ambulatory Activity and Neuroendocrine Axes in a Sex-Specific Manner in Mice.

Endocrinology 2020 08;161(8)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

Disorders of androgen imbalance, such as hyperandrogenism in females or hypoandrogenism in males, increase risk of visceral adiposity, type 2 diabetes, and infertility. Androgens act upon androgen receptors (AR) which are expressed in many tissues. In the brain, AR are abundant in hypothalamic nuclei involved in regulation of reproduction and energy homeostasis, yet the role of androgens acting via AR in specific neuronal populations has not been fully elucidated. Read More

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Parthenogenesis as a Solution to Hybrid Sterility: The Mechanistic Basis of Meiotic Distortions in Clonal and Sterile Hybrids.

Genetics 2020 08 9;215(4):975-987. Epub 2020 Jun 9.

Laboratory of Fish Genetics, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Liběchov 277 21, Czech Republic

Hybrid sterility is a hallmark of speciation, but the underlying molecular mechanisms remain poorly understood. Here, we report that speciation may regularly proceed through a stage at which gene flow is completely interrupted, but hybrid sterility occurs only in male hybrids whereas female hybrids reproduce asexually. We analyzed gametogenic pathways in hybrids between the fish species and , and revealed that male hybrids were sterile owing to extensive asynapsis and crossover reduction among heterospecific chromosomal pairs in their gametes, which was subsequently followed by apoptosis. Read More

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Educational Intervention to Address Infertility-Related Knowledge Gaps Among Adolescent and Young Adult Survivors of Childhood Cancer.

J Adolesc Young Adult Oncol 2020 08 18;9(4):472-480. Epub 2020 Feb 18.

Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

This study evaluates the impact of a personalized educational session on survivors' knowledge of risk for infertility and describes preferences for reproductive health care. This was a two-phase prospective study of an individualized education session for adolescent and young adult (AYA) survivors aged 18-21 years. Sessions used sex-specific visual aids (phase I) or a personalized handout (phase II). Read More

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Variation in plastid genomes in the gynodioecious species Silene vulgaris.

BMC Plant Biol 2019 Dec 19;19(1):568. Epub 2019 Dec 19.

Plant Reproduction Laboratory, Institute of Experimental Botany v.v.i, Czech Academy of Sciences, Rozvojová 263, 16502, Prague, Czech Republic.

Background: Gynodioecious species exist in two sexes - male-sterile females and hermaphrodites. Male sterility in higher plants often results from mitonuclear interaction between the CMS (cytoplasmic male sterility) gene(s) encoded by mitochondrial genome and by nuclear-encoded restorer genes. Mitochondrial and nuclear-encoded transcriptomes in females and hermaphrodites are intensively studied, but little is known about sex-specific gene expression in plastids. Read More

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December 2019

Impact of maternal prepregnancy body mass index on cognitive and metabolic profiles of singletons born after in vitro fertilization/intracytoplasmic sperm injection.

Fertil Steril 2019 12;112(6):1094-1102.e2

Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Zhejiang, People's Republic of China.

Objective: To evaluate the effect of elevated maternal prepregnancy body mass index (BMI) on intelligence and growth of singletons after in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI).

Design: Cohort study.

Setting: University hospital. Read More

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December 2019

Mutation of doublesex in Hyphantria cunea results in sex-specific sterility.

Pest Manag Sci 2020 May 25;76(5):1673-1682. Epub 2019 Dec 25.

College of Forestry, Northwest A&F University, Yangling, China.

Background: The gene doublesex (dsx) plays pivotal roles in sex determination and controls sexually dimorphic development in certain insects. Importantly, it also displays a potential candidate target for pest management due to its sex-specific splicing. Therefore, we used CRISPR/Cas9-mediated gene disruption to investigate the function of dsx in Hyphantria cunea, an invasive forest pest. Read More

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Fresh versus frozen embryo transfer has no effect on childhood weight.

Fertil Steril 2019 10 29;112(4):684-690.e1. Epub 2019 Jul 29.

Division of Reproductive Endocrinology and Infertility, Mayo Clinic, Rochester, Minnesota.

Objective: To evaluate the effect of frozen, compared with fresh, embryo transfer on neonatal and pediatric weight and weight gain trajectory.

Design: Retrospective cohort study.

Setting: Academic medical center. Read More

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October 2019

Mutation of doublesex induces sex-specific sterility of the diamondback moth Plutella xylostella.

Insect Biochem Mol Biol 2019 09 3;112:103180. Epub 2019 Jul 3.

CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai, 200032, China. Electronic address:

DOUBLESEX (DSX): the downstream gene in the insect sex determination pathway, plays a critical role in sexual differentiation and development. The functions of dsx have been characterized in several model insect species. However, the molecular mechanism and functions of sex determination of dsx in Plutella xylostella, an agricultural pest, are still unknown. Read More

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September 2019

The role of glucagon-like peptide-1 in reproduction: from physiology to therapeutic perspective.

Hum Reprod Update 2019 07;25(4):504-517

Department of Endocrinology and Metabolism, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.

Background: Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) have become firmly established in the treatment of type 2 diabetes and obesity, disorders frequently associated with diminished reproductive health. Understanding of the role of GLP-1 and GLP-1 RAs in reproduction is currently limited and largely unaddressed in clinical studies.

Objective And Rationale: The purpose of this narrative review is to provide a comprehensive overview of the role of GLP-1 in reproduction and to address a therapeutic perspective that can be derived from these findings. Read More

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Regulation of present and future development by maternal regulatory signals acting on the embryo during the morula to blastocyst transition - insights from the cow.

Biol Reprod 2019 09;101(3):526-537

Instituto de Reproducción Animal Córdoba (IRAC), Zona Rural General Paz, Córdoba, Argentina.

The preimplantation embryo has a remarkable ability to execute its developmental program using regulatory information inherent within itself. Nonetheless, the uterine environment is rich in cell signaling molecules termed embryokines that act on the embryo during the morula-to-blastocyst transition, promoting blastocyst formation and programming the embryo for subsequent developmental events. Programming can not only affect developmental processes important for continuance of development in utero but also affect characteristics of the offspring during postnatal life. Read More

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September 2019

Temperature-Sensitive Reproduction and the Physiological and Evolutionary Potential for Mother's Curse.

Integr Comp Biol 2019 10;59(4):890-899

School of Biological Sciences, University of Nebraska-Lincoln, 1104 T Street, Lincoln, NE 68502, USA.

Strict maternal transmission of mitochondrial DNA (mtDNA) is hypothesized to permit the accumulation of mitochondrial variants that are deleterious to males but not females, a phenomenon called mother's curse. However, direct evidence that mtDNA mutations exhibit such sexually antagonistic fitness effects is sparse. Male-specific mutational effects can occur when the physiological requirements of the mitochondria differ between the sexes. Read More

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October 2019

A tale of two tracts: history, current advances, and future directions of research on sexual differentiation of reproductive tracts†.

Biol Reprod 2019 09;101(3):602-616

Reproductive Developmental Biology Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

Alfred Jost's work in the 1940s laid the foundation of the current paradigm of sexual differentiation of reproductive tracts, which contends that testicular hormones drive the male patterning of reproductive tract system whereas the female phenotype arises by default. Once established, the sex-specific reproductive tracts undergo morphogenesis, giving rise to anatomically and functionally distinct tubular organs along the rostral-caudal axis. Impairment of sexual differentiation of reproductive tracts by genetic alteration and environmental exposure are the main causes of disorders of sex development, and infertility at adulthood. Read More

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September 2019

Maternal smoking and high BMI disrupt thyroid gland development.

BMC Med 2018 10 23;16(1):194. Epub 2018 Oct 23.

Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.

Background: Maternal lifestyle factors, including smoking and increased body weight, increase risks of adult diseases such as metabolic syndrome and infertility. The fetal thyroid gland is essential for the control of fetal metabolic rate, cardiac output, and brain development. Altered fetal thyroid function may contribute to increased disease onset later in life. Read More

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October 2018

Mitochondrial genetic effects on reproductive success: signatures of positive intrasexual, but negative intersexual pleiotropy.

Proc Biol Sci 2018 05;285(1879)

School of Biological Sciences, Monash University, Victoria 3800, Australia.

Theory predicts that maternal inheritance of mitochondria will facilitate the accumulation of mtDNA mutations that are male biased, or even sexually antagonistic, in effect. While there are many reported cases of mtDNA mutations conferring cytoplasmic male sterility in plants, historically it was assumed such mutations would not persist in the streamlined mitochondrial genomes of bilaterian metazoans. Intriguingly, recent cases of mitochondrial variants exerting male biases in effect have come to light in bilaterians. Read More

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Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.

Proc Natl Acad Sci U S A 2018 06 21;115(23):E5326-E5333. Epub 2018 May 21.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 211166 Nanjing, People's Republic of China;

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of in either primordial or growing oocytes caused infertility but differentially affected oocyte quality, granulosa cell fate, and follicular development. cKO of in nongrowing primordial oocytes caused defective follicular development leading to progressive degeneration of oocytes and loss of granulosa cell identity coincident with the acquisition of immature Sertoli cell-like characteristics. Read More

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Updates on Women's Health Issues in Patients with Inflammatory Bowel Disease.

Curr Treat Options Gastroenterol 2018 Mar;16(1):86-100

Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.

Purpose Of Review: Inflammatory bowel disease affects approximately 800,000 women in the USA with the peak incidence between ages 15 to 40. Thus for many females, IBD can impact nearly every stage of their life from menarche to pregnancy, menopause, and beyond. This paper will review the most recent updates on the topics of sexual health, cervical cancer screening, menstruation, fertility, contraception, and menopause. Read More

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Chinmo prevents transformer alternative splicing to maintain male sex identity.

PLoS Genet 2018 02 1;14(2):e1007203. Epub 2018 Feb 1.

Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, New York, United States of America.

Reproduction in sexually dimorphic animals relies on successful gamete production, executed by the germline and aided by somatic support cells. Somatic sex identity in Drosophila is instructed by sex-specific isoforms of the DMRT1 ortholog Doublesex (Dsx). Female-specific expression of Sex-lethal (Sxl) causes alternative splicing of transformer (tra) to the female isoform traF. Read More

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February 2018

Sex differences in the late first trimester human placenta transcriptome.

Biol Sex Differ 2018 01 15;9(1). Epub 2018 Jan 15.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background: Development of the placenta during the late first trimester is critical to ensure normal growth and development of the fetus. Developmental differences in this window such as sex-specific variation are implicated in later placental disease states, yet gene expression at this time is poorly understood.

Methods: RNA-sequencing was performed to characterize the transcriptome of 39 first trimester human placentas using chorionic villi following genetic testing (17 females, 22 males). Read More

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January 2018