J Bone Joint Surg Am 2021 May 12. Epub 2021 May 12.
Departments of Orthopaedic Surgery (E.L.Y., J.D.K., and R.W.W.), Surgery (E.L.Y. and G.A.C.), Genetics (S.J.L. and N.L.S.), and General Medical Studies (B.A.E.), Washington University School of Medicine, St. Louis, Missouri.
Background: While evidence indicates that familial predisposition influences the risk of developing degenerative rotator cuff disease (RCD), knowledge of specific genetic markers is limited. We conducted a genome-wide association study of RCD surgery using the UK Biobank, a prospective cohort of 500,000 people (40 to 69 years of age at enrollment) with genotype data.
Methods: Cases with surgery for degenerative RCD were identified using linked hospital records. Read More