903,298 results match your criteria sex partners

Quantitation and evaluation of perinatal medium-chain and long-chain acylcarnitine blood concentrations in 12,000 full-term breastfed newborns.

J Pediatr Endocrinol Metab 2021 Jun 24. Epub 2021 Jun 24.

Department of Pharmacy, Laboratory of Pharm. Analysis, National and Kapodistrian University of Athens, Athens, Greece.

Objectives: Medium-chain (MCA) and long-chain acylcarnitine (LCA) blood concentrations play a significant role in the fatty acid (FA) oxidation process, especially during the first days of life. Identification of their abnormal concentrations, expanded newborn screening, can lead to the diagnosis of FA oxidation disorders. This study aimed to demonstrate MCA and LCA concentrations in Dried Blood Spots (DBS) of full-term breastfed infants, in relation to their birth weight (BW) perinatally. Read More

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The presentation of congenital adrenal hyperplasia in an unscreened population.

J Pediatr Endocrinol Metab 2021 Jun 24. Epub 2021 Jun 24.

Department of Paediatric Endocrinology, Children's Health Ireland at Temple Street, Dublin 1, Ireland.

Background: The aim of this study was to describe the incidence and spectrum of early clinical presentations of congenital adrenal hyperplasia (CAH) in an unscreened population.

Methods: A national retrospective observational study was undertaken to identify all children diagnosed with CAH in the Republic of Ireland, between January 2005 and December 2019. Reporting clinicians completed anonymized clinical questionnaires. Read More

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Molecular and Cellular Mechanisms Underlying Temperature-Dependent Sex Determination in Turtles.

Sex Dev 2021 Jun 24:1-9. Epub 2021 Jun 24.

Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico.

The discovery in mammals that fetal testes are required in order to develop the male phenotype inspired research efforts to elucidate the mechanisms underlying gonadal sex determination and differentiation in vertebrates. A pioneer work in 1966 that demonstrated the influence of incubation temperature on sexual phenotype in some reptilian species triggered great interest in the environment's role as a modulator of plasticity in sex determination. Several chelonian species have been used as animal models to test hypotheses concerning the mechanisms involved in temperature-dependent sex determination (TSD). Read More

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Might Gene Duplication and Neofunctionalization Contribute to the Sexual Lability Observed in Fish?

Sex Dev 2021 Jun 24:1-12. Epub 2021 Jun 24.

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Sex determination and differentiation varies widely across vertebrates, but is most dramatically diverse in fishes. Among fishes sex reversal and sex change are observed in 41 teleost families spanning 7 orders. These sex-changing fish perhaps highlight better than any other system that sex determination is not the narrow and fixed construct we once thought, but a plastic trait that is better viewed as a reaction norm. Read More

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Long-Term Prognosis of Tinnitus Associated with Idiopathic Sudden Sensorineural Hearing Loss.

Audiol Neurootol 2021 Jun 24:1-9. Epub 2021 Jun 24.

Department of Otolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, China.

Objective: To analyze the factors affecting the long-term prognosis of tinnitus accompanied by unilateral idiopathic sudden sensorineural hearing loss (SSNHL).

Methods: A total of 161 patients with sudden hearing loss (HL) accompanied by tinnitus were enrolled. All patients had two separate telephone follow-ups and were asked about changes in tinnitus. Read More

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Characteristics, Management, and Case-Fatality of Patients Hospitalized for Stroke with a Diagnosis of COVID-19 in France.

Neuroepidemiology 2021 Jun 24:1-7. Epub 2021 Jun 24.

Department of Non-Communicable Diseases, Cardiovascular Diseases and Stroke Program, Santé Publique France, Saint-Maurice, France.

Introduction: COVID-19 was found to be associated with an increased risk of stroke. This study aimed to compare characteristics, management, and outcomes of hospitalized stroke patients with or without a hospital diagnosis of CO-VID-19 at a nationwide scale.

Methods: This is a cross-sectional study on all French hospitals covering the entire French population using the French national hospital discharge databases (Programme de Médicalisation des Systèmes d'Information, included in the Système National des Données de Santé). Read More

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Use of wrist-worn accelerometers to quantify bilateral upper limb activity and asymmetry under free-living conditions in people with multiple sclerosis.

Mult Scler Relat Disord 2021 Jun 15;53:103081. Epub 2021 Jun 15.

Multiple Sclerosis Centre, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Background: Although upper limb (UL) dysfunctions are quite common among people with Multiple Sclerosis (pwMS), there is a scarcity of information about actual UL usage under free-living conditions. The aim of the present study is to quantitatively assess 'real-world' activity time, intensity and possible asymmetry of use among dominant and non-dominant ULs in pwMS.

Methods: Twenty-eight pwMS (20 women, 8 men, average EDSS 4. Read More

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Association of baseline diaphragm, rectus femoris and vastus intermedius muscle thickness with weaning from mechanical ventilation.

Respir Med 2021 Jun 12;185:106503. Epub 2021 Jun 12.

Division of Intensive Care Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. Electronic address:

Background: To determine whether baseline diaphragm (T), rectus femoris (RF) and vastus intermedius (VI) muscle thickness (T and T) are associated with weaning success.

Material And Methods: Right T, T and T were measured by ultrasonography within 36 h of intubation and diaphragmatic excursion (DE) was evaluated at the first spontaneous breathing trial in adult critically-ill patients. Reintubation or death within 7 days after extubation was defined as weaning failure. Read More

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Evaluation of Triclosan-induced reproductive impairments in the accessory reproductive organs and sperm indices in the mice.

Acta Histochem 2021 Jun 21;123(5):151744. Epub 2021 Jun 21.

Zoology Section, MMV, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

Highly effective antimicrobial properties of triclosan (TCS) make its use as a widely used preservative in different types of consumer products. TCS is reported as an emerging endocrine disruptor causing reproductive impairments in the males as well as in the females. The present study describes the adverse effects of various doses of TCS (40, 80, 160 and 320 mg/kg BW/day, for 42 consecutive days) on the weights and histopathology of the epididymis and seminal vesicle, sperm indices (motility, viability, count and morphology), concentrations of epididymal sialic acid and seminal vesicular fructose, along with TCS accumulated in these accessory reproductive organs of the laboratory mouse. Read More

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Differential item functioning of the Beck Anxiety Inventory in a rural, multi-ethnic cohort.

J Affect Disord 2021 Jun 12;293:36-42. Epub 2021 Jun 12.

University of Houston, Department of Psychology, Houston, TX, USA. Electronic address:

Background: Evaluating measurement bias is vital to ensure equivalent assessment across diverse groups. One approach for evaluating test bias, differential item functioning (DIF), assesses item-level bias across specified groups by comparing item-level responses between groups that have the same overall score. Previous DIF studies of the Beck Anxiety Inventory (BAI) have only assessed bias across age, sex, and disease duration in monolingual samples. Read More

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Evaluation of postural stability in patients screened for osteoporosis: A retrospective study of 1086 cases.

Gait Posture 2021 Jun 12;88:304-310. Epub 2021 Jun 12.

Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Background: Although the interactions between balance, falls and fracture risk have been demonstrated in various aspects, the clinical focus of fracture risk evaluation has been on bone properties, e.g., bone mineral density (BMD). Read More

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Brief Report: New Pulmonary Infiltrates Observed on Computed Tomography Based Image Guidance for Radiotherapy Warrant Diagnostic Workup for COVID-19.

J Thorac Oncol 2021 Jun 21. Epub 2021 Jun 21.

Department of Oncology and Pharmacology, Mayo Clinic, Rochester, MN, USA.

Introduction: Screening for COVID-19 exposure, coupled with engaged decision making to prioritize cancer treatment in parallel with reducing risk of exposure and infection, is crucial in the management of COVID-19 during cancer treatment. Following two reported case studies of imaging findings during daily computed tomography (CT) -based image guided radiotherapy scans, a call for submission of anonymized case reports was published with the objective of rapidly determining if there was a correlation between the onset of new pulmonary infiltrates seen during radiotherapy and COVID-19. We hereby report the results of the aggregate analysis. Read More

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Unfractionated Heparin TID Dosing Regimen is Associated with a Lower Rate of Pulmonary Embolism when Compared to BID Dosing in Patients Undergoing Craniotomy.

World Neurosurg 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Background: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), and intracranial hemorrhage (ICH) may complicate the post-operative course of patients undergoing craniotomy. While prophylaxis with unfractionated heparin (UFH) has been shown to reduce VTE rates, twice-daily (BID) and three-times-daily (TID) UFH dosing regimens have not been compared in neurosurgical procedures. The objective of this study was to explore the association between UFH dosing regimen and rates of VTE and ICH in craniotomy patients. Read More

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ADL-dependent older adults were identified in medico-administrative databases.

J Clin Epidemiol 2021 Jun 21. Epub 2021 Jun 21.

DRUGS-SAFE National Platform of Pharmacoepidemiology, Bordeaux, France; Univ. Bordeaux, Inserm UMR 1219, Bordeaux Population Health Research Center, team Psychoepidemiology of aging and chronic diseases, France. Electronic address:

Objective: . We aimed to develop an algorithm for the identification of basic Activities of Daily Living (ADL)-dependency in health insurance databases.

Study Design And Setting: . Read More

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Cerebral Perfusion and Metabolism with Mean Arterial Pressure 90 vs. 60 mmHg in a Porcine Post Cardiac Arrest Model with and without Targeted Temperature Management.

Resuscitation 2021 Jun 21. Epub 2021 Jun 21.

Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Aim: To determine whether targeting a mean arterial pressure of 90 mmHg (MAP90) would yield improved cerebral blood flow and less ischaemia compared to MAP 60 mmHg (MAP60) with and without targeted temperature management at 33 °C (TTM33) in a porcine post-cardiac arrest model.

Methods: After 10 minutes of cardiac arrest, 41 swine of either sex were resuscitated until return of spontaneous circulation (ROSC). They were randomised to TTM33 or no-TTM, and MAP60 or MAP90; yielding four groups. Read More

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Inflammatory and oxidative biomarkers as determinants of functional capacity in patients with COPD assessed by 6-min walk test-derived outcomes.

Exp Gerontol 2021 Jun 21:111456. Epub 2021 Jun 21.

Laboratório de Inflamação e Metabolismo - LIM - CIPq/Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil; Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil. Electronic address:

Introduction: Reduction in functional capacity is a negative clinical outcome of chronic obstructive pulmonary disease (COPD). Studies have shown association between inflammatory and oxidative stress biomarkers and functional capacity. However, it is unclear whether these biomarkers are associated with outcomes of functional capacity. Read More

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Matters of the heart: Cellular sex differences.

J Mol Cell Cardiol 2021 Jun 21. Epub 2021 Jun 21.

BioFrontiers Institute, University of Colorado, Boulder, CO 80303, United States of America; Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, United States of America. Electronic address:

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation, and outcomes. Until recently, most clinical trials were carried out in males, and many animal studies either failed to identify the sex of the animals or combined data obtained from males and females. Cellular sex in the heart is relatively understudied and many studies fail to report the sex of the cells used for in vitro experiments. Read More

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Risk factors for COVID-19 hospitalisation and death in people living with diabetes: a virtual cohort study from the Western Cape Province, South Africa.

Diabetes Res Clin Pract 2021 Jun 21:108925. Epub 2021 Jun 21.

Department of Medicine, Groote Schuur Hospital and University of Cape Town, South Africa.

Background: COVID-19 outcomes and risk factors, including comorbidities and medication regimens, in people living with diabetes (PLWD) are poorly defined for low- and middle-income countries.

Methods: The Provincial Health Data Centre (Western Cape, South Africa) is a health information exchange collating patient-level routine health data for approximately 4 million public sector health care seekers. Data from COVID-19 patients diagnosed between March and July 2020, including PLWD, were analysed to describe risk factors, including dispensed diabetes medications and comorbidities, and their association with COVID-19 outcomes in this population. Read More

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Contextual factors associated with cancer screening uptake: A systematic review of observational studies.

Prev Med 2021 Jun 21:106692. Epub 2021 Jun 21.

U1086 "ANTICIPE" INSERM-University of Caen Normandie, Centre François Baclesse: 3, Avenue du Général Harris, 14000 Caen, France.

We conducted a systematic review of a wide range of contextual factors related to cancer screening uptake that have been studied so far. Studies were identified through PubMed and Web of Science databases. An operational definition of context was proposed, considering as contextual factors: social relations directly aimed at cancer screening, health care provider and facility characteristics, geographical/accessibility measures and aggregated measures at supra-individual level. Read More

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Sex-specific longitudinal association between baseline physical activity level and cognitive decline in Chinese over 45 years old: Evidence from the China health and retirement longitudinal study.

Aging Ment Health 2021 Jun 24:1-9. Epub 2021 Jun 24.

School of Public Health, Medical College of Soochow University, Suzhou, China.

Objectives: To examine whether sex-specific associations between baseline PA level and follow up cognitive performance in Chinese subjects exist from the China Health and Retirement Longitudinal study (CHARLS).

Method: A total of 3395 adults aged 45 or old from the CHARLS were used for analysis. The combined scores of measurements of mental status and verbal episodic memory were utilized for assessing cognitive function at baseline in 2011 and the follow-up survey in 2015. Read More

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Survival and medical costs of melanoma patients with subsequent cancer diagnoses: A South Korean population-based retrospective cohort study.

Asia Pac J Clin Oncol 2021 Jun 24. Epub 2021 Jun 24.

BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea.

Aim: Subsequent cancers (SCs) after melanoma diagnosis further increases the risks of mortality and medical costs. This population-based analysis aimed to evaluate risk factors for SC, mortality, and medical costs of melanoma patients with SC.

Methods: A retrospective cohort analysis was conducted using a nationwide claims database during 2002-2017 in South Korea. Read More

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Genetic polymorphisms of regulatory T cell-related genes modulate systemic inflammation induced by viral hepatitis.

Kaohsiung J Med Sci 2021 Jun 24. Epub 2021 Jun 24.

Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Viral hepatitis is a devastating disease with the risk for cirrhosis and carcinogenicity. Regulatory T cells (Tregs) play important roles in the disease course of viral hepatitis via maintaining the balance between overt-immune responses and viral replications. We hypothesized that genetic polymorphisms of Treg-related genes, such as interleukin-2, transforming growth factor-β 1 (TGF-β1), forkhead box P3 (FOXP3), and adenylyl cyclase type 9 modulate the hosts' immune regulation under circumstances of viral hepatitis. Read More

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Roles of age, sex, and weight status in the muscular fitness of Chinese Tibetan children and adolescents living at altitudes over 3600 m: A cross-sectional study.

Am J Hum Biol 2021 Jun 24:e23624. Epub 2021 Jun 24.

Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, China.

Objective: This study aimed to assess the role of age, sex, and weight status in the development of muscular fitness in a large sample of Chinese Tibetan children and adolescents aged 7-18 years living in areas over 3600 m.

Method: A sample of 4673 Chinese Tibetan children and adolescents aged 7-18 years were recruited from 21 schools in three cities (Lhasa, Naqu, and Anduo) of Tibet, China. Grip strength, standing long jump, 30-s sit-ups, and 50-m dash were conducted to determine muscular fitness. Read More

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A partially sex-reversed giant kelp sheds light into the mechanisms of sexual differentiation in a UV sexual system.

New Phytol 2021 Jun 24. Epub 2021 Jun 24.

Sorbonne Université, UPMC Univ Paris 06, CNRS, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS, 90074, F-29688, Roscoff, France.

- In UV sexual systems, sex is determined during the haploid phase of the life cycle and males have a V chromosome whereas females have a U chromosome. Previous work in the brown alga Ectocarpus revealed that the V chromosome has a dominant role in male sex determination and suggested that the female developmental program may occur by 'default'. - Here, we describe the identification of a genetically male giant kelp strain presenting phenotypic features typical of a female, despite lacking the U-specific region. Read More

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Neutralizing Monoclonal Antibody Treatment Reduces Hospitalization for Mild and Moderate COVID-19: A Real-World Experience.

Clin Infect Dis 2021 Jun 24. Epub 2021 Jun 24.

Inova Medicine, Inova Health System, Falls Church, VA, USA.

Background: Neutralizing monoclonal antibody (NmAb) treatments have received emergency use authorization to treat patients with mild or moderate COVID-19 infection. To date, no real- world data about the efficacy of NmAb has been reported from clinical practice. We assessed the impact of NmAb treatment given in the outpatient clinical practice setting on hospital utilization. Read More

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Plasma Adiponectin And Blood Pressure Progression in African Americans: The Jackson Heart Study.

Am J Hypertens 2021 Jun 24. Epub 2021 Jun 24.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: Little is known on the association of plasma adiponectin with blood pressure (BP) changes in African Americans (AAs). We evaluated the associations between plasma adiponectin and BP progression among AAs.

Methods: We analyzed data from 1184 participants without hypertension at baseline (2000-2004) with ≥1 follow-up visits in the Jackson Heart Study. Read More

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'Missingness' in health care: Associations between hospital utilization and missed appointments in general practice. A retrospective cohort study.

PLoS One 2021 24;16(6):e0253163. Epub 2021 Jun 24.

Centre for Rural Health, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom.

Objectives: Are multiple missed appointments in general practice associated with increased use of hospital services and missingness from hospital care? This novel study explores this in a population representative sample for the first time.

Design, Setting, Participants: A large, retrospective cohort (n = 824,374) of patient records from a nationally representative sample of GP practices, Scotland, 2013-2016. Requested data were extracted by a Trusted Third Party for the NHS, anonymised and linked to a unique patient ID, in the NHS Safehaven for analysis using established NHS Scotland linkage. Read More

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Effectiveness of physiotherapy interventions for injury in ballet dancers: A systematic review.

PLoS One 2021 24;16(6):e0253437. Epub 2021 Jun 24.

Institute of Biomedical Engineering, Faculty of Electrical and Computer Engineering, TU Dresden, Dresden, Germany.

Background: The unique repetitive nature of ballet dancing, which often involves transgressing endurance limits of anatomical structures, makes dancers prone to injury. The following systematic review aims to assess the effectiveness of physiotherapy interventions in the treatment of injuries in ballet dancers.

Methods: The review was performed in line with the PRISMA statement on preferred reporting items for systematic reviews and meta-analyses. Read More

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