Parasite Immunol 2021 Jul 26:e12874. Epub 2021 Jul 26.
Community Medicine Department, Federal University of Piauí, Intelligence Center in Emerging and Neglected Tropical Conditions (CIATEN).
The differences in morbidity and mortality patterns and life expectancy between the sexes are well established in different infectious and parasitic conditions, such as in leishmaniases, in which biological, genetic, sexual, and hormonal variations can modulate the immune response indicating greater infectivity, prevalence and clinical severity in men. In this regard, in seeking the understanding of factors related to protection and susceptibility to infection, this review aimed to discuss the influence of sex hormones on the immune response to leishmaniases. In the literature, sex hormone variations promote differences in the innate, humoral, and cell-mediated immune response, leading to greater susceptibility, mortality, and complications in males. Read More