9,931 results match your criteria sevoflurane


MicroRNA-1297 suppressed the Akt/GSK3 signaling pathway and stimulated neural apoptosis in an sevoflurane exposure model.

J Int Med Res 2021 Apr;49(4):300060520982104

Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Objective: Common inhalation anesthetics used for clinical anesthesia (such as sevoflurane) may induce nerve cell apoptosis during central nervous system development. Furthermore, anesthetics can produce cognitive impairments, such as learning and memory impairments, that continue into adulthood. However, the precise mechanism remains largely undefined. Read More

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A comparative study of desflurane versus sevoflurane in obese patients: Effect on recovery profile.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):541-545. Epub 2021 Jan 18.

Department of Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Background And Aims: Anesthesia in obese patients is difficult due to associated comorbidities and altered physiology. Desflurane and sevoflurane have a low fat-blood solubility coefficient and are better suited in these patients to achieve a rapid emergence. We studied BIS guided drug titration to compare the postoperative recovery characteristics and cognitive function of desflurane versus sevoflurane in obese patients undergoing laparoscopic abdominal surgeries. Read More

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January 2021

Randomized double-blind trial comparing effects of low-flow vs high-flow anesthesia on postoperative lung functions using respirometer.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):535-540. Epub 2021 Jan 18.

Department of Anesthesiology, Shri Sathya Sai Medical College and Research Institute, (Sri Balaji Vidyapeeth, Deemed to be University), Kancheepuram, Tamil Nadu, India.

Background And Aims: Modern anesthetic practice utilizes low-flow anesthesia with evolving evidence on its pulmonary effects. Studies comparing measurement of vital capacity and inspiratory reserve volume using respirometer in both low-flow and high-flow anesthesia are sparse. We evaluated the effects of low-flow and high-flow anesthesia on postoperative pulmonary functions using respirometer. Read More

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January 2021

EC of sevoflurane for classic laryngeal mask airway insertion in children at different time points: A randomized blind trial.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):489-493. Epub 2021 Jan 18.

Department of Ophthalmology, PGIMER, Chandigarh, India.

Background And Aims: Literature documents EC (End-tidal) of sevoflurane for CLMA (Classic Laryngeal Mask airway) insertion between 1.5 and 2% and most of these studies suggest maintaining the required end-tidal sevoflurane concentration for 10-25 minutes before LMA insertion. Waiting for this long interval for blood brain sevoflurane equilibration may not be feasible in children especially during failed ventilation. Read More

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January 2021

Fatal hepatotoxicity due to sevoflurane use in a paediatric patient after aortic repair: reality or fiction? A case of pharmacovigilance.

Eur J Hosp Pharm 2021 Apr 8. Epub 2021 Apr 8.

Cardiac Surgery Unit, Cardiac, Thoracic, Vascular and Public Health Science Department, Padova University Hospital, Padova, Italy.

Hepatotoxicity secondary to exposure of volatile anaesthetics is an exceptional finding, but its clinical interest depends on their frequent use, unpredictable appearance and potential severity. Halothane is the volatile anaesthetic most frequently involved in the development of liver dysfunction, especially after re-exposure. Sevoflurane has rarely been related to this life-threatening complication. Read More

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[Effect of Long-time Postnatal Exposure to Sevoflurane on Causing Attention-deficit/Hyperactivity Disorder in Rats].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):207-215

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To investigate whether long-term exposure to inhaled sevoflurane, a volatile anesthetic, causes abnormal activities and memory impairment related to attention-deficit/hyperactivity disorder (ADHD) in neonatal rats.

Methods: On postnatal day 5 (P5), Sprague-Dawley rats were randomly assigned to two sevoflurane subgroups and two control subgroups and underwent experimental intervention. The two sevoflurane (SEVO) subgroups were exposed to 3% sevoflurane for 2 h and 4 h respectively, while the two control subgroups were given pure oxygen for the same amount and duration. Read More

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Effect of anesthesia on electrocorticography for localization of epileptic focus: Literature review and future directions.

Epilepsy Behav 2021 Apr 1;118:107902. Epub 2021 Apr 1.

Comprehensive Epilepsy Center, Dept. of Neurology, School of Medicine, Yale University, Yale New Haven Hospital, New Haven, CT, United States; Human Brain Mapping Program, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.

Intraoperative electrocorticography (ECoG) is a useful technique to guide resections in epilepsy surgery and is mostly performed under general anesthesia. In this systematic literature review, we seek to investigate the effect of anesthetic agents on the quality and reliability of ECoG for localization of the epileptic focus. We conducted a systematic search using PubMed and EMBASE until January 2019, aiming to review the effects of anesthesia on ECoG yield. Read More

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Sevoflurane halothane for induction of anesthesia in pediatric and adult patients.

Med Gas Res 2021 Apr-Jun;11(2):53-57

Department of Anesthesiology, Krishna Institute of Medical Sciences (Deemed to be) University, Karad, Maharashtra, India.

Induction of anesthesia using an inhalation agent remains a fundamental technique due to its rapid induction and emergence. Sevoflurane is preferred over halothane for its faster induction of anesthesia and lesser complications. Studies on sevoflurane in pediatrics have established it as safe and effective. Read More

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Effects of Sevoflurane Inhalation Anesthesia on the Intestinal Microbiome in Mice.

Front Cell Infect Microbiol 2021 18;11:633527. Epub 2021 Mar 18.

Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, China.

In recent years, more and more attention has been paid to intestinal microbiome. Almost all operations will go through the anesthesia process, but it is not clear whether the intervention of anesthesia alone will affect the change in the intestinal microbiome. The purpose of this study was to verify the effect of sevoflurane inhalation anesthesia on the intestinal microbiome. Read More

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Role of Sox2 in Learning, Memory, and Postoperative Cognitive Dysfunction in Mice.

Cells 2021 Mar 24;10(4). Epub 2021 Mar 24.

Department of Anesthesiology, University of Virginia, Charlottesville, VA 22901, USA.

Postoperative cognitive dysfunction (POCD) is a significant clinical issue. Its neuropathogenesis has not been clearly identified and effective interventions for clinical use to reduce POCD have not been established. This study was designed to determine whether environmental enrichment (EE) or cognitive enrichment (CE) reduces POCD and whether sex-determining region Y-box-2 regulated by sirtuin 1, plays a role in the effect. Read More

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Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation.

Int J Mol Sci 2021 Mar 8;22(5). Epub 2021 Mar 8.

Department of Surgery, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion phase; therefore, the intra-operative period seems an attractive window of opportunity to modulate IRI and improve short- and potentially long-term graft outcome. Commonly used volatile anesthetics such as sevoflurane and isoflurane have been shown to interfere with many of the pathophysiological processes involved in the injurious cascade of IRI. Read More

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Effects of smoking on the optimal effect-site concentration of remifentanil required for preventing cough during anesthetic emergence in male patients undergoing laparoscopic or robotic cholecystectomy.

Medicine (Baltimore) 2021 Apr;100(13):e25288

Department of Anesthesiology and Pain Medicine.

Abstract: Target-controlled infusion of remifentanil is known to reduce cough effectively during emergence from general anesthesia. The effect of smoking on emergence cough remains controversial. Therefore, we aimed to investigate the effect-site concentration (Ce) of remifentanil in the male patients undergoing laparoscopic or robotic cholecystectomy for suppressing emergence cough in smokers and non-smokers. Read More

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Sevoflurane inhibits cell proliferation and migration of glioma by targeting the miR‑27b/VEGF axis.

Mol Med Rep 2021 Jun 31;23(6). Epub 2021 Mar 31.

Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

Poor prognosis in patients with glioma is primarily due to rapid tumor growth and cell invasion and migration. In addition, microRNA (miR)‑27b is decreased in metastatic glioma. The present study investigated whether sevoflurane inhibited glioma cell progression by targeting miR‑27b. Read More

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Control of Hemodynamic Responses and Perioperative Outcomes in Transsphenoidal Pituitary Surgery: A Qualitative Systematic Review of the Available Evidence.

J Neurosurg Anesthesiol 2021 Mar 23. Epub 2021 Mar 23.

Departments of Anesthesiology and Critical Care Neurosurgery, AHEPA University Hospital, Aristotle University of Thessaloniki, School of Medicine, University Campus Department of Neurosurgery, Hippokratio General Hospital, Aristotle University of Thessaloniki, School of Medicine, Konstantinoupoleos, Thessaloniki, Greece Department of Anesthesiology and Critical Care, Sapienza University of Rome, Rome, Italy.

Transnasal transsphenoidal (TNTS) pituitary surgery is associated with short-lived but intense nociceptive stimuli which cause substantial hemodynamic perturbations that may increase blood loss and impair visualization of the surgical field. This systematic review aimed to critically appraise the clinical evidence for the efficacy and safety of various anesthetic techniques, other pharmacological modalities, and supplementary interventions by assessing intraoperative systemic hemodynamics, use of adjunct medications, quality of the surgical field, intraoperative blood loss, and recovery profiles in patients undergoing TNTS pituitary surgery. Relevant randomized clinical trials and observational studies were identified in a systematic literature search; 16 studies (13 randomized clinical trials, 3 observational studies) enrolling a total of 907 patients were identified for inclusion in this review. Read More

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Sevoflurane inhibits ferroptosis: A new mechanism to explain its protective role against lipopolysaccharide-induced acute lung injury.

Life Sci 2021 Mar 24;275:119391. Epub 2021 Mar 24.

Department of Anesthesiology, No. 989 Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army, Luoyang 471003, Henan Province, China.

Sevoflurane (Sev) has protective effects in acute lung injury (ALI), but the relevant mechanisms are still not fully understood. The present study aimed to determine whether Sev exerts a protective effect on lipopolysaccharide (LPS)-induced ALI by regulating ferroptosis. In this study, we found that Sev could protect mice from lung injury caused by LPS stimulation, including extenuating lung histological damage, pulmonary edema and pulmonary vascular permeability, and the content of inflammatory factors in Bronchoalveolar lavage fluid (BALF), as well as improving the survival rate of ALI mice, which was in line with the effects of ferroptosis inhibitor ferrostatin-1. Read More

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Transient changes in white matter microstructure during general anesthesia.

PLoS One 2021 26;16(3):e0247678. Epub 2021 Mar 26.

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

Cognitive dysfunction after surgery under general anesthesia is a well-recognized clinical phenomenon in the elderly. Physiological effects of various anesthetic agents have been studied at length. Very little is known about potential effects of anesthesia on brain structure. Read More

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Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague-Dawley offspring rats.

Exp Ther Med 2021 May 8;21(5):469. Epub 2021 Mar 8.

Department of Anesthesiology, Taian City Central Hospital, Taishan, Taian, Shandong 271000, P.R. China.

The aim of the present study was to investigate the effect of exposure to sevoflurane general anesthesia during early pregnancy on interferon-inducible protein AIM2 (AIM2) expression in the hippocampus and parietal cortex of the offspring Sprague-Dawley (SD) rats. A total of 18 SD rats at a gestational age of 5-7 days were randomly divided into three groups: i) A control group (control); ii) 2-h sevoflurane general anesthesia, group 1 (S1); and iii) 4-h sevoflurane general anesthesia, group 2 (S2). The six offspring rats in each group were maintained for 30 days and assessed by Morris water maze testing. Read More

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Falsely predictive EEG and clinical signs after post-anoxic brain injury under sevoflurane anesthesia.

Clin Neurophysiol 2021 Mar 10;132(5):1080-1082. Epub 2021 Mar 10.

Department of Neurology Erasme Hospital, Université Libre de Bruxelles, Route de Lennik, 808, 1070 Brussels, Belgium.

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Feasibility and diagnostic accuracy of intra-operative monitoring of motor evoked potentials in children <2 years of age undergoing tethered cord surgery: results in 100 children.

Childs Nerv Syst 2021 Mar 24. Epub 2021 Mar 24.

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, 632004, India.

Objective: This study documents the monitorability using different anesthesia regimes and accuracy of muscle motor evoked potentials (mMEPs) in children ≤2 years of age undergoing tethered cord surgery (TCS).

Methods: Intraoperative mMEP monitoring was attempted in 100 consecutive children, ≤2 years of age, undergoing TCS. MEP monitoring was done under 4 different anesthetic regimes: (Total intravenous anesthesia (TIVA); balanced anesthesia with sevoflurane and ketamine; balanced anesthesia with isoflurane and ketamine; and balanced anesthesia with sevoflurane). Read More

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Effect of general inhalational anesthesia on intraocular pressure measurements in normal and glaucomatous children.

Int Ophthalmol 2021 Mar 23. Epub 2021 Mar 23.

Faculty of Medicine, Cairo University, 16 Abd El-Hady Street, Manial, Cairo, 11451, Egypt.

Purpose: To investigate the agreement between the intraocular pressure (IOP) measurements in the awake condition and under different stages of general inhalational anesthesia using sevoflurane in both glaucomatous and normal children.

Methods: A prospective study was performed on 43 glaucomatous children and 30 age-matched controls. Baseline IOP of one eye was measured immediately before general anesthesia using Perkins tonometer and then re-measured under light, intermediate, and deep anesthesia, and then after intubation. Read More

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Effects of Intravenous Anesthetics vs Inhaled Anesthetics on Early Postoperative Sleep Quality and Complications of Patients After Laparoscopic Surgery Under General Anesthesia.

Nat Sci Sleep 2021 15;13:375-382. Epub 2021 Mar 15.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Objective: Decreased postoperative sleep quality remains a serious problem in surgical settings at present. The purpose of our study was to compare the effect of propofol vs sevoflurane on early postoperative sleep quality and complications of patients receiving laparoscopic surgery after general anesthesia.

Methods: Seventy-four patients undergoing selective laparoscopic surgery under general anesthesia were randomly assigned to the propofol group or sevoflurane group. Read More

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Maternal anesthesia with sevoflurane during the mid-gestation induces social interaction deficits in offspring C57BL/6 mice.

Biochem Biophys Res Commun 2021 Mar 20;553:65-71. Epub 2021 Mar 20.

Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, 215006, China. Electronic address:

Sevoflurane anesthesia in pregnant mice could induce neurotoxicity in the developing brain and disturb learning and memory in the offspring mice. Whether it could impair social behaviors in the offspring mice is uncertain. Therefore, we assessed the neurobehavioral effect of in-utero exposure to sevoflurane on social interaction behaviors in C57BL/6 mice. Read More

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Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation.

BMC Anesthesiol 2021 Mar 9;21(1):71. Epub 2021 Mar 9.

Division of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, 369 Fulham Rd, London, SW10 9NH, UK.

Background: microRNAs (miRNAs) are single-stranded and noncoding RNA molecules that control post-transcriptional gene regulation. miRNAs can be tumor suppressors or oncogenes through various mechanism including cancer cell biology, cell-to-cell communication, and anti-cancer immunity.

Main Body: Anesthetics can affect cell biology through miRNA-mediated regulation of messenger RNA (mRNA). Read More

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Effects of sevoflurane exposure on apoptosis and cell cycle of peripheral blood lymphocytes, and immunologic function.

BMC Anesthesiol 2021 Mar 20;21(1):87. Epub 2021 Mar 20.

Department of Pathology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.

Background: Waste anesthetic gases (WAGs) leaked from new-type halogenated inhalational anesthetics such as sevoflurane have been were reported to pose a risk for the health of operating room personnel. The effects of WAGs on peripheral blood lymphocytes, however, remain yet controversial. The present study was undertaken to examine the effects of occupational sevoflurane exposure on the peripheral blood lymphocytes of medical personnel who work in the operating room. Read More

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