122,419 results match your criteria severity score


Long-Term Benefit-Risk Profiles of Treatments for Moderate-to-Severe Plaque Psoriasis: A Network Meta-Analysis.

Dermatol Ther (Heidelb) 2021 Dec 4. Epub 2021 Dec 4.

Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Carrer de Sant Quintí, 89, 08041, Barcelona, Spain.

Introduction: The long-term benefit-risk profiles of licensed and investigational treatments for moderate-to-severe plaque psoriasis have not been fully characterized.

Methods: Randomized controlled trials (RCTs) of licensed and investigational treatments for moderate-to-severe plaque psoriasis were identified through a systematic literature review through 2 May 2021. Bayesian network meta-analyses (NMAs) were conducted to compare the efficacy (Psoriasis Area and Severity Index [PASI] 75/90/100 [at least a 75/90/100% reduction in PASI score from baseline] response) and safety outcomes (any adverse event [AE], any serious AE [SAE], and AEs leading to treatment discontinuation) of each treatment evaluated between weeks 48 and 56 after baseline. Read More

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December 2021

Meibomian gland dysfunction is highly prevalent among first-time visitors at a Norwegian dry eye specialist clinic.

Sci Rep 2021 Dec 3;11(1):23412. Epub 2021 Dec 3.

National Centre for Optics, Vision and Eye Care, Department of Optometry, Radiography and Lighting Design, Faculty of Health and Social Sciences, University of South-Eastern Norway, Notodden, Norway.

To investigate the prevalence of meibomian gland dysfunction (MGD) in patients presenting with subjective dry eye-related symptoms at their first-time consultation in a Norwegian specialized ocular surface clinic. Additionally, to explore the accuracy of the ocular surface disease index score (OSDI) as an extensively applied tool to assess the severity of dry eye symptoms and MGD diagnosis. Patients with subjective dry eye-related complaints (n = 900) attending the clinic for the first time, from 2012 to 2016, were included in the study. Read More

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December 2021

Exploring the factor structure of the mini-ICF-APP in an inpatient clinical sample, according to the psychiatric diagnosis.

Rev Psiquiatr Salud Ment (Engl Ed) 2021 Oct-Dec;14(4):186-195

Centre for Integrative Psychiatry, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital of Zurich, University of Zurich, Zurich, Switzerland.

Introduction: Psychosocial functioning is a key factor determining prognosis, severity, impairment and quality of life in people who have a mental disorder. The mini-ICF-APP was developed to provide a standardised classification of functioning and disability. However, despite its gaining popularity little is known about its structure and performance. Read More

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December 2019

Characteristics of older adult hospitalized patients with bronchial asthma: a retrospective study.

Allergy Asthma Clin Immunol 2021 Dec 3;17(1):122. Epub 2021 Dec 3.

Department of Respiratory Diseases, General Hospital of Northern Theater Command, 83 Wenhua Road, Shenhe District, Shenyang, China.

Background: Bronchial asthma is a chronic inflammation of the airways. Older adult patients with bronchial asthma are defined as patients older than 65 and with a previous or current clear diagnosis of asthma. The purpose of this study was to determine the characteristics of older adult hospitalized patients with bronchial asthma. Read More

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December 2021

The relationship between IL-6 levels and the angiographic severity of coronary artery disease following percutaneous coronary intervention in acute coronary syndrome patients.

BMC Cardiovasc Disord 2021 Dec 3;21(1):578. Epub 2021 Dec 3.

Department of Cardiology, Yijishan Hospital Affiliated To Wannan Medical College, 2# West Zhe Shan Road, Wuhu, 241000, China.

Background: The present investigation was developed for the exploration of the association between IL-6 levels and acute coronary syndrome (ACS) findings upon angiographic evaluation.

Methods: A retrospective review of 346 patients suffering from chest discomfort that underwent coronary angiography was performed. The SYNergy between Percutaneous Coronary Intervention with TAXus and cardiac surgery (SYNTAX) score (SS) and SS II were used to gauge ACS severity, with ACS patients being stratified into two groups based on an SS value of 22 and the median SS II value. Read More

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December 2021

Regular feedback on inter-hospital transfer improved the clinical outcome and survival in patients with multiple trauma: a retrospective cohort study.

BMC Emerg Med 2021 Dec 3;21(1):150. Epub 2021 Dec 3.

Division of General Surgery, Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.

Background: Undertriage of major trauma patients is unavoidable, especially in the trauma system of rural areas. Timely stabilization and transfer of critical trauma patients remains a great challenge for hospitals with limited resources. No definitive measure has been proven to improve the outcomes of patients transferred with major trauma. Read More

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December 2021

Prolonged sitting time links to subclinical atherosclerosis.

J Chin Med Assoc 2021 Nov 30. Epub 2021 Nov 30.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: This study investigates the association between daily sitting time and subclinical atherosclerosis by using coronary computed tomography angiography (CCTA).

Methods: The study enrolled 203 subjects (age 57.6 ± 8. Read More

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November 2021

Correlation of the symbol digit modalities test with the quality of life and depression in Japanese patients with multiple sclerosis.

Mult Scler Relat Disord 2021 Nov 24;57:103427. Epub 2021 Nov 24.

School of Economics and Management, Kochi University of Technology, Kochi, Japan.

Background: This study aimed to evaluate the association between cognitive impairment and health-related quality of life (HRQOL), fatigue, and depression in Japanese patients with multiple sclerosis (MS).

Methods: The Brief International Cognitive Assessment for MS (BICAMS) was performed in 184 Japanese patients with MS. The Functional Assessment of MS (FAMS), Fatigue Severity Scale (FSS), and Beck Depression Inventory-Second Edition (BDI-II) were used to evaluate HRQOL, fatigue, and depression, respectively. Read More

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November 2021

Longitudinal evaluation of patients with isolated head tremor.

Parkinsonism Relat Disord 2021 Nov 26;94:10-12. Epub 2021 Nov 26.

Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy; IRCCS NEUROMED, Via Atinense 18, 86077, Pozzilli, Italy. Electronic address:

Introduction: Isolated head tremor, a pathological condition characterized by head tremor without dystonic postures or tremor in other body parts, has recently been suggested to be a form of dystonia. It is however still unclear whether isolated head tremor precedes dystonia or remains unmodified overtime.

Methods: We enrolled 20 patients with isolated head tremor. Read More

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November 2021

Mandibular distraction to correct severe non-isolated mandibular hypoplasia: The role of drug-induced sleep endoscopy (DISE) in decision making.

Int J Pediatr Otorhinolaryngol 2021 Nov 13;152:110968. Epub 2021 Nov 13.

Department of Otorhinolaryngology, Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address:

Objectives: In patients with mandibular hypoplasia, mandibular distraction osteogenesis (MDO) aims to relieve tongue-based airway obstruction. Drug-induced sleep endoscopy (DISE) provides a dynamic assessment of the upper airway and visualizes anatomical site and cause of airway obstruction. The aim of this study was to evaluate the effect of MDO on tongue-based airway obstruction found by DISE within a non-isolated patient population with severe upper airway obstruction (UAO). Read More

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November 2021

Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial.

Lancet 2021 Nov 30. Epub 2021 Nov 30.

Novartis Pharma, Basel, Switzerland.

Background: Sjögren's syndrome is an autoimmune disease characterised by dry eyes and mouth, systemic features, and reduced quality of life. There are no disease-modifying treatments. A new biologic, ianalumab (VAY736), with two modes of suppressing B cells, has previously shown preliminary efficacy. Read More

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November 2021

The effects of intraoperative magnesium sulfate administration on emergence agitation and delirium in pediatric patients: a systematic review and meta-analysis of randomized controlled trials.

Paediatr Anaesth 2021 Dec 3. Epub 2021 Dec 3.

Department of Anesthesiology & Pain Medicine, Seoul National University Bundang Hospital, Seongnam, 13620, Korea.

Background: The role of intraoperative magnesium for the prevention of emergence agitation or delirium is unclear as there have been conflicting results reported by several randomized controlled trials.

Aims: The aim of this study was to investigate the effect of magnesium sulfate on emergence agitation or emergence delirium in pediatric patients.

Methods: Electronic databases, including PubMed, EMBASE, CENTRAL, CINAHL, Scopus, and Web of Science, were searched to identify studies which evaluated the effects of magnesium on postoperative emergence agitation or emergence delirium. Read More

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December 2021

Knowledge, Awareness, and Practices (KAP) towards COVID-19 among the marine fishers of Maharashtra State of India: An online cross-sectional Analysis.

PLoS One 2021 3;16(12):e0261055. Epub 2021 Dec 3.

Department of Fisheries Resources Economics, Statistics and Extension Education, College of Fisheries, Ratnagiri (Dr. B. S. Konkan Krishi Vidyapeeth, Dapoli, Ratnagiri), Maharashtra, India.

The knowledge, awareness, and practices (KAP) about COVID-19 among the marine fishers who are engaged in the high-risk occupations and depend on the vulnerable sources of income in the Maharashtra state of India, were investigated to understand the behavioral changes and vulnerability among the respondents because of COVID-19. Data were collected through an online survey from 1st July to 30th July 2020 during the first peak of COVID-19 in the study area by using the questionnaire. Authors based on the latest recommendations by the World Health Organization (WHO) developed the questionnaire and covered the KAP aspects under study. Read More

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December 2021

Psychological distress of patients with end-stage kidney disease undergoing dialysis during the 2019 coronavirus disease pandemic: A cross-sectional study in a University Hospital.

PLoS One 2021 3;16(12):e0260929. Epub 2021 Dec 3.

Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Introduction: Previous studies have revealed that the COVID-19 pandemic can cause psychological distress such as depression and anxiety. Patients with chronic kidney disease (CKD) might be more vulnerable to psychological distress due to the COVID-19 pandemic. Its impact could be different according to dialysis modality. Read More

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December 2021

Longevity of anti-spike and anti-nucleocapsid antibodies after COVID-19 in solid organ transplant recipients compared to immunocompetent controls.

Am J Transplant 2021 Dec 3. Epub 2021 Dec 3.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data on dynamics and duration of antibody response in SOTRs are limited. This longitudinal study examined the longevity of both anti-spike (S)- and anti-nucleocapsid (N)-specific IgG-antibodies after COVID-19 in SOTRs compared to matched immunocompetent persons. Read More

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December 2021

Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus.

Immunol Res 2021 Dec 3. Epub 2021 Dec 3.

Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Centre, No. 76 Yanta West Road, Xi'an, 710061, Shanxi, China.

Reliable noninvasive biomarkers are needed to accurately assess disease activity and prognosis in patients with systemic lupus erythematosus (SLE). The purpose of this study was to investigate the clinical relevance of Wnt5A with disease activity and severity with cutaneous involvement in particular in SLE patients; its concentrations in plasma and urine were examined and analyzed. In the cross-sectional study, the clinical relevance of Wnt5A protein was evaluated in both plasma and urine of SLE patients and healthy cohorts using commercial enzyme-linked immunosorbent assays (ELISA). Read More

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December 2021

Neurological manifestation with special reference to HIV-associated neurocognitive disorder (HAND) among people on anti-retroviral treatment in India.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):6999-7004

Department of Community Medicine/Public Health, College of Medicine, Majmaah University, Al Majmaah, Saudi Arabia.

Objective: The neurological manifestations and their severity in patients on antiretroviral treatment (ART) are currently unexplained. ‎We aimed at studying the prevalence of HIV Associated Neurological Disorders (HAND) among people on antiretroviral treatment, using the International HIV Dementia Scale (IHDS).

Patients And Methods: A predesigned and pretested proforma including the International HIV Dementia Scale (IHDS) was administered to 100 HIV patients attending to ART center of KIMS teaching Hospital (Koppal, Karnataka) from January 2020 to March 2020. Read More

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November 2021

The effect of extracorporeal shockwave myocardial revascularization therapy to myocardial perfusion and function in indicated CABG-stable angina pectoris patients: case series.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):6959-6966

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Dr. Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.

Objective: Many studies have found a beneficial effect of Extracorporeal Shockwave Myocardial Revascularization (ESMR) therapy for refractory angina patients. However, clinical studies ESMR therapy for indicated coronary artery bypass grafting (CABG)-stable angina pectoris (SAP) patients are limited.

Patients And Methods: Four indicated CABG-SAP patients CCS class I-III reviewed in this study. Read More

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November 2021

Comparison of Effects of Extubation in Prone and Supine Positions in Patients Operated for Lumbar Disk Herniation.

Turk Neurosurg 2021 Nov 10. Epub 2021 Nov 10.

Dokuz Eylul University, School of Medicine, Department of Anesthesiology and Intensive Care, Izmir, Turkey.

Aim: At the end of lumbar disk operations conducted in the prone position, the extubation period can result in serious respiratory and hemodynamic side effects. In this study, we aimed to observe the effects of prone position extubation on respiratory side effects and hemodynamic parameters.

Material And Methods: This prospective observational study included 60 patients extubated in either the prone (n = 30) or supine (n = 30) positions. Read More

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November 2021

[Comparison of three albumin assay methods: a need for standardization within a healthcare area].

Ann Biol Clin (Paris) 2021 Dec 1. Epub 2021 Dec 1.

Laboratoire de biologie médicale, Groupe hospitalier Bretagne-Sud, Lorient.

Albumin is a main biomarker of denutrition severity. Since 2019, the French National Authority of Health (HAS) recommends an immunologic technique as a reference for measuring albuminemia. In a context of partial recovery by the laboratory of GHBS (using colorimetric method with bromcresol purple) of the biological activity of the dialysis center, until then carried out by the Ouest biology - Biolor laboratory (using colorimetric method with bromcresol green) and in order to standardize practices in the healthcare sector, we compared 3 albumin assay techniques: immunoturbidimetric (Diagam), BCG (Siemens), BCP (Siemens) on Siemens Atellica PLCs. Read More

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December 2021

Distinguishing Between Multisystem Inflammatory Syndrome, Associated With COVID-19 in Children and the Kawasaki Disease: Development of Preliminary Criteria Based on the Data of the Retrospective Multicenter Cohort Study.

Front Pediatr 2021 10;9:787353. Epub 2021 Nov 10.

Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia.

Diagnostic between multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C) and Kawasaki disease (KD) can make difficulties due to many similarities. Our study aimed to create a Kawasaki/MIS-C differentiation score (KMDscore) allowing discrimination of MIS-C and KD. The retrospective multicenter cohort study included clinical, laboratory, and instrumental information about MIS-C ( = 72) and KD ( = 147). Read More

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November 2021

Ponseti treated idiopathic clubfoot - outcome predictive factors in the test of time: analysis of 500 feet followed for five to 20 years.

J Child Orthop 2021 Oct;15(5):426-432

Department of Pediatric Orthopaedic Surgery, Dana Children's -Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of -Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate a set of risk factors on the outcome of Ponseti treated idiopathic clubfeet (ICF).

Methods: This study was approved by the institutional review board. A retrospective analysis of prospectively gathered data over a 20-year period, at a single dedicated clubfoot clinic. Read More

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October 2021

The Status and Influencing Factors of Cyberchondria During the COVID-19 Epidemic. A Cross-Sectional Study in Nanyang City of China.

Front Psychol 2021 11;12:712703. Epub 2021 Nov 11.

The Second Xiangya Hospital of Central South University, Changsha, China.

Cyberchondria is considered "the anxiety-amplifying effects of online health-related searches." During the COVID-19 pandemic, people are likely to search health-related information online for reassurance because of fear and related physical symptoms, while cyberchondria may be triggered due to the escalation of health anxiety, different online seeking behavior preference, information overload, and insufficient e-health literacy. This study aimed to investigate the status and influencing factors of cyberchondria in residents in China during the epidemic period of COVID-19. Read More

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November 2021

Decreased Plasma Hydrogen Sulfide Level Is Associated With the Severity of Depression in Patients With Depressive Disorder.

Front Psychiatry 2021 11;12:765664. Epub 2021 Nov 11.

Biological Psychiatry Laboratory, Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University, Nanchang, China.

Accumulating evidence has suggested a dysfunction of synaptic plasticity in the pathophysiology of depression. Hydrogen sulfide (HS), an endogenous gasotransmitter that regulates synaptic plasticity, has been demonstrated to contribute to depressive-like behaviors in rodents. The current study investigated the relationship between plasma HS levels and the depressive symptoms in patients with depression. Read More

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November 2021

Electroencephalogram-Based Complexity Measures as Predictors of Post-operative Neurocognitive Dysfunction.

Front Syst Neurosci 2021 10;15:718769. Epub 2021 Nov 10.

Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC, United States.

Physiologic signals such as the electroencephalogram (EEG) demonstrate irregular behaviors due to the interaction of multiple control processes operating over different time scales. The complexity of this behavior can be quantified using multi-scale entropy (MSE). High physiologic complexity denotes health, and a loss of complexity can predict adverse outcomes. Read More

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November 2021

Correlation between elastic modulus and clinical severity of pathological scars: a cross-sectional study.

Sci Rep 2021 Dec 2;11(1):23324. Epub 2021 Dec 2.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.

Though widely used to assess pathological scars, the modified Vancouver Scar Scale (mVSS) is neither convenient nor objective. Shear wave elastography (SWE) is used to evaluate the stiffness of pathological scars. We aimed to determine the correlation between mVSS score and elastic modulus (EM) measured by SWE for pathological scars. Read More

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December 2021

Association of a Healthy Lifestyle With All-Cause and Cause-Specific Mortality Among Individuals With Type 2 Diabetes: A Prospective Study in UK Biobank.

Diabetes Care 2021 Dec 2. Epub 2021 Dec 2.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China

Objective: To evaluate the association of a healthy lifestyle, involving seven low-risk factors mentioned in diabetes management guidelines (no current smoking, moderate alcohol consumption, regular physical activity, healthy diet, less sedentary behavior, adequate sleep duration, and appropriate social connection), with all-cause and cause-specific mortality among individuals with type 2 diabetes.

Research Design And Methods: This study included 13,366 participants with baseline type 2 diabetes from the UK Biobank free of cardiovascular disease (CVD) and cancer. Lifestyle information was collected through a baseline questionnaire. Read More

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December 2021

Increased serum levels of cyclophilin a and matrix metalloproteinase-9 are associated with cognitive impairment in patients with obstructive sleep apnea.

Sleep Med 2021 Oct 21. Epub 2021 Oct 21.

Liaocheng People's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Department of Neurology, Liaocheng People's Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, PR China. Electronic address:

Objectives: To investigate the relationship between serum cyclophilin A (CyPA) and matrix metalloproteinase-9 (MMP-9) levels and mild cognitive impairment (MCI) in patients with obstructive sleep apnea (OSA).

Methods: Study subjects underwent whole-night in-laboratory polysomnography (PSG), and all participants were scored using a neuropsychological scale and peripheral blood samples were collected the next morning. The presence and severity of OSA were assessed with the apnea hypopnea index (AHI), and OSA was defined as AHI ≥5 events/hour. Read More

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October 2021

Elevated CD19Siglec-10 B cell levels are correlated with systemic lupus erythematosus disease activity.

Int Immunopharmacol 2021 Nov 30:108403. Epub 2021 Nov 30.

Department of Rheumatology and Immunology,The First Affiliated Hospital of Xi'an Jiaotong University, Yanta West Road No. 277, Xi'an, Shaanxi, China. Electronic address:

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell dysregulation and the breakdown of self-tolerance, leading to pathogenic autoantibody production. Human Siglec-10 is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family and a B cell surface coreceptor that inhibits B cell receptor-induced signalling. However, to date, no report has investigated CD19Siglec-10 B cells in SLE patients. Read More

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November 2021