34,364 results match your criteria severity growth


Excess mortality during the COVID-19 pandemic: a geospatial and statistical analysis in Mogadishu, Somalia.

Int J Infect Dis 2021 Sep 24. Epub 2021 Sep 24.

Somali Disaster Resilience Institute, Mogadishu, Somalia.

Background: While the impact of the COVID-19 pandemic has been well documented in high-income countries, much less is known about the health effects of the pandemic in Somalia where health systems are weak and vital registration is underdeveloped.

Methods: We used remote sensing and geospatial analysis to quantify the number of burials from January 2017 to September 2020 in Mogadishu. We imputed missing grave counts using surface area data. Read More

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September 2021

Improved growth of in aminoglycoside antibiotics by the toxin-antitoxin system.

J Bacteriol 2021 Sep 27:JB0040721. Epub 2021 Sep 27.

Department of Microbiology, University of Tennessee, Knoxville, Tennessee.

Type I toxin-antitoxin systems consist of a small protein (under 60 amino acids) whose overproduction can result in cell growth stasis or death, and a small RNA that represses translation of the toxin mRNA. Despite their potential toxicity, type I toxin proteins are increasingly linked to improved survival of bacteria in stressful environments and antibiotic persistence. While the interaction of toxin mRNAs with their cognate antitoxin sRNAs in some systems are well characterized, additional translational control of many toxins and their biological roles are not well understood. Read More

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September 2021

-Related Overgrowth Spectrum From Diagnosis to Targeted Therapy: A Case of CLOVES Syndrome Treated With Alpelisib.

Front Pediatr 2021 9;9:732836. Epub 2021 Sep 9.

Medical Genetics Unit, Meyer Children's University Hospital, Florence, Italy.

-related overgrowth spectrum (PROS) is an umbrella term referring to various clinical entities, which share the same pathogenetic mechanism. These conditions are caused by somatic gain-of-function mutations in , which encodes the 110-kD catalytic α subunit of PI3K (p110α). These mutations occur as post-zygotic events and lead to a gain of function of PI3K, with consequent constitutional activation of the downstream cascades (e. Read More

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September 2021

Alcohol and Cannabis Use and the Developing Brain.

Alcohol Res 2021 9;41(1):11. Epub 2021 Sep 9.

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina.

Purpose: Alcohol and cannabis are the most commonly used substances during adolescence and are typically initiated during this sensitive neurodevelopmental period. The aim of this review is to provide a comprehensive overview of the most recent literature focused on understanding how these substances affect the developing brain.

Search Methods: Articles included in this review were identified by entering 30 search terms focused on substance use, adolescence, and neurodevelopment into MEDLINE, Embase, PsycINFO, ProQuest Central, and Web of Science. Read More

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September 2021

A signal of competitive dominance in mid-latitude herbaceous plant communities.

R Soc Open Sci 2021 Sep 22;8(9):201361. Epub 2021 Sep 22.

Theoretical and Computational Ecology, Center for Advanced Studies (CEAB-CSIC), C. Accés Cala St. Francesc 14, 17300 Blanes, Catalonia, Spain.

Understanding the main determinants of species coexistence across space and time is a central question in ecology. However, ecologists still know little about the scales and conditions at which biotic interactions matter and how these interact with the environment to structure species assemblages. Here we use recent theoretical developments to analyse plant distribution and trait data across Europe and find that plant height clustering is related to both evapotranspiration (ET) and gross primary productivity. Read More

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September 2021

Induced pluripotent stem cells as suitable sensors for fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome.

World J Stem Cells 2021 Aug;13(8):1134-1150

Department of Pathology, Universidad Católica de Valencia San Vicente Mártir, Valencia 46001, Spain.

Background: Fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are devastating metabolic neuroimmune diseases that are difficult to diagnose because of the presence of numerous symptoms and a lack of specific biomarkers. Despite patient heterogeneity linked to patient subgroups and variation in disease severity, anomalies are found in the blood and plasma of these patients when compared with healthy control groups. The seeming specificity of these "plasma factors", as recently reported by Ron Davis and his group at Stanford University, CA, United States, and observations by our group, have led to the proposal that induced pluripotent stem cells (iPSCs) may be used as metabolic sensors for FM and ME/CFS, a hypothesis that is the basis for this in-depth review. Read More

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Persistent High Percentage of HLA-DRCD38 CD8 T Cells Associated With Immune Disorder and Disease Severity of COVID-19.

Front Immunol 2021 9;12:735125. Epub 2021 Sep 9.

Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background: The global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases. Progressive lymphopenia, especially in T cells, was a prominent clinical feature of severe COVID-19. Activated HLA-DRCD38 CD8 T cells were enriched over a prolonged period from the lymphopenia patients who died from Ebola and influenza infection and in severe patients infected with SARS-CoV-2. Read More

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September 2021

The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis.

Front Immunol 2021 8;12:710977. Epub 2021 Sep 8.

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.

Growth differentiation factor 15 (GDF15) is involved in the occurrence and development of many diseases, and there are few studies on its relationship with sepsis. This article aims to explore the clinical value of GDF15 in sepsis and to preliminarily explore its prospective regulatory effect on macrophage inflammation and its functions. We recruited 320 subjects (132 cases in sepsis group, 93 cases in nonsepsis group, and 95 cases in control group), then detected the serum GDF15 levels and laboratory indicators, and further investigated the correlation between GDF15 and laboratory indicators, and also analyzed the clinical value of GDF15 in sepsis diagnosis, severity assessment, and prognosis. Read More

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September 2021

Nerve Growth Factor-Based Therapy in Alzheimer's Disease and Age-Related Macular Degeneration.

Front Neurosci 2021 9;15:735928. Epub 2021 Sep 9.

Research Laboratories in Ophthalmology, IRCCS-Fondazione Bietti, Rome, Italy.

Alzheimer's disease (AD) is an age-associated neurodegenerative disease which is the most common cause of dementia among the elderly. Imbalance in nerve growth factor (NGF) signaling, metabolism, and/or defect in NGF transport to the basal forebrain cholinergic neurons occurs in patients affected with AD. According to the cholinergic hypothesis, an early and progressive synaptic and neuronal loss in a vulnerable population of basal forebrain involved in memory and learning processes leads to degeneration of cortical and hippocampal projections followed by cognitive impairment with accumulation of misfolded/aggregated Aβ and tau protein. Read More

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September 2021

A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab, a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis.

Vet Anaesth Analg 2021 Aug 22. Epub 2021 Aug 22.

Veterinary Medicine Research and Development, Zoetis Belgium SA, Zaventem, Belgium.

Objective: Bedinvetmab is a canine monoclonal antibody targeting nerve growth factor. This study evaluated the efficacy and safety of bedinvetmab for alleviation of pain associated with osteoarthritis in dogs.

Study Design: Double-blind, randomized, multicentre, placebo-controlled study. Read More

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Osimertinib: A Review in Previously Untreated, EGFR Mutation-Positive, Advanced NSCLC.

Authors:
Yvette N Lamb

Target Oncol 2021 Sep 26. Epub 2021 Sep 26.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Activating mutations in the epidermal growth factor receptor (EGFR) gene have been identified as key oncogenic drivers of non-small cell lung cancer (NSCLC). Osimertinib (Tagrisso) is an orally administered, third-generation EGFR tyrosine kinase inhibitor (EGFR-TKI) that is widely approved for the first-line treatment of advanced NSCLC with activating EGFR mutations. In the pivotal phase III FLAURA trial, osimertinib significantly prolonged progression-free survival (PFS) and overall survival (OS) relative to first-generation EGFR-TKIs in patients with previously untreated, EGFR mutation-positive, advanced NSCLC. Read More

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September 2021

The effect of ibuprofen and caffeine prophylaxis on retinopathy of prematurity.

J AAPOS 2021 Sep 23. Epub 2021 Sep 23.

Department of Pediatrics and Communicable Diseases, Michigan Medicine, University of Michigan.

Purpose: To determine whether prophylactic caffeine and ibuprofen, which have been shown to have vascular endothelial growth factor-modulating properties in other contexts, have a detectable effect on the incidence of severe retinopathy of prematurity (ROP) when administered in extremely low birth weight infants during the first 48 hours of life.

Methods: In this retrospective cohort study, the incidence and severity of ROP with respect to total exposure to caffeine and ibuprofen were assessed. The effect of oxygen exposure at 28 days' postnatal age (PNA) and 36 weeks' corrected gestational age (GA) was also studied. Read More

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September 2021

Amniotic fluid stem cell administration can prevent epithelial injury from necrotizing enterocolitis.

Pediatr Res 2021 Sep 24. Epub 2021 Sep 24.

Translational Medicine Program, Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada.

Background: Stem cell therapy has been proven to rescue intestinal injury and stimulate intestinal regeneration in necrotizing enterocolitis (NEC). Specifically, stem cells derived from amniotic fluid (AFSCs) and mesenchymal stem cells (MSCs) derived from bone marrow have shown promising results in the treatment of experimental NEC. This study aims to examine the effects of AFSCs and MSCs on the prevention of intestinal injury during experimental NEC. Read More

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September 2021

TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies.

Eur J Pharmacol 2021 Sep 21;911:174510. Epub 2021 Sep 21.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, 43300, Malaysia. Electronic address:

Transforming growth factor-beta (TGF-β) plays multiple homeostatic roles in the regulation of inflammation, proliferation, differentiation and would healing of various tissues. Many studies have demonstrated that TGF-β stimulates activation and proliferation of fibroblasts, which result in extracellular matrix deposition. Its increased expression can result in many fibrotic diseases, and the level of expression is often correlated with disease severity. Read More

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September 2021

[Effects of electroacupuncture on myelin-related protein in corpus callosum of rats with focal cerebral ischemia].

Zhen Ci Yan Jiu 2021 Sep;46(9):721-7

Department of Anatomy, Wannan Medical College, Wuhu 241002, Anhui Province, China.

Objective: To observe the effect of electroacupuncture(EA)on the expression of myelin basic protein (MBP), axon growth inhibitor Nogo-A and Nogo receptor (NgR) in corpus callosum of rats with focal cerebral ischemia, so as to explore the mechanism of EA underlying improving ischemic white matter injury.

Methods: Fourty male SD rats were randomly divided into normal, sham operation, model and EA groups, with 10 rats in each group. The focal cerebral ischemia rat model was established by occlusion of the middle cerebral artery (MCAO). Read More

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September 2021

The severity and frequency distribution of endometriosis subtypes at different ages: a model to understand the natural history of endometriosis based on single centre/single surgeon data.

Facts Views Vis Obgyn 2021 Sep;13(3):211-221

Background And Objective: to study the natural history of endometriosis.

Materials And Methods: the analysis of all women (n=2086) undergoing laparoscopy for pelvic pain and endometriosis between 1988 and 2011 at University Hospital Gasthuisberg.

Main Outcome Measures: the severity of subtle, typical, cystic and deep endometriosis in adult women, with or without a pregnancy, as estimated by their pelvic area and their volume. Read More

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September 2021

St8sia1-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity.

Nagoya J Med Sci 2021 Aug;83(3):535-549

Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, Kasugai, Japan.

Ganglioside GD3/GD2 are over-expressed in various neuroectoderm-derived tumors. Previous studies indicated that GD3 is involved in the enhancement of cancer properties such as rapid growth and increased invasiveness. However, little is known about the functions of GD3/GD2 in glioma cells and glioma microenvironments. Read More

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High-fat diet increases the severity of Giardia infection in association with low-grade inflammation and gut microbiota dysbiosis.

Sci Rep 2021 Sep 22;11(1):18842. Epub 2021 Sep 22.

Department of Biological Science, University of Calgary, Calgary, AB, T2N 1N4, Canada.

Exogenous factors that may influence the pathophysiology of Giardia infection remain incompletely understood. We have investigated the role of dietary fat in the pathogenesis of Giardia infection. Male 3 to 4-week-old C57BL/6 mice were fed either a low fat (LF) or a high fat (HF) diet for 12 days and challenged with G. Read More

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September 2021

Effects of low-crude protein diets supplemented with arginine, glutamine, threonine, and methionine on regulating nutrient absorption, intestinal health, and growth performance of Eimeria-infected chickens.

Poult Sci 2021 Aug 13;100(11):101427. Epub 2021 Aug 13.

Department of Poultry Science, University of Georgia, Athens, GA, USA. Electronic address:

The study was conducted to evaluate the effects of low crude protein diets supplemented with arginine, glutamine, methionine, and/or threonine on apparent ileal digestibility of amino acids, intestinal morphology, intestinal permeability, gene expression of nutrient transporters, and tight junction proteins of broiler chickens challenged with mixed Eimeria spp. A total of five hundred seventy-six, 12-day-old male broiler chickens were allocated into 8 treatments, and 6 replicate cages of 12 chickens per cage. This experiment included a nonchallenged control (NC) fed regular corn-soybean meal-based diet (Regular diet, 19% crude protein), an Eimeria-challenged control (CC) fed Regular diet, an Eimeria challenge group fed low-crude protein diet (LCP, 16% crude protein), 4 Eimeria challenge groups fed low-crude protein diet supplemented with 0. Read More

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Application of Topical Lidocaine for Pain Relief in the Setting of Targeted Therapy-Induced Onycholysis: A Case Report.

J Palliat Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

Selective pan fibroblast growth factor receptor (FGFR) inhibitors have been linked to severe onycholysis, the uncomfortable separation of the nail plate from the nail bed. Recommendations to assist with FGFR inhibitor onycholysis vary based on the severity. We hypothesized that the application of topical lidocaine to mimic a digital nerve block would be beneficial in addition to traditional supportive care interventions and subsequently report its immediate and continued efficacy for targeted therapy-induced onycholysis. Read More

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September 2021

Shedding Light on Incidence and Burden of Physeal Injuries in Youth Elite Football Academy: A 4-Season Prospective Study.

Scand J Med Sci Sports 2021 Sep 22. Epub 2021 Sep 22.

Edge Hill University, Department of Sport and Physical Activity, Ormskirk, UK.

Introduction: Physeal injuries have been overlooked in epidemiological research in youth sports. Our prospective study investigated the incidence, severity, and burden of physeal injuries in a youth elite football academy.

Methods: 551 youth male football players from Under-9 to Under-19 were included and observed over four consecutive seasons. Read More

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September 2021

Application of serum mid-infrared spectroscopy combined with an ensemble learning method in rapid diagnosis of gliomas.

Anal Methods 2021 Sep 21. Epub 2021 Sep 21.

College of Software, Xinjiang University, Urumqi 830046, China.

The diffuse growth of glioma cells leads to gliomatosis, which has less cure rate and high mortality. As the severity deepens, the treatment difficulty and mortality of glioma patients gradually increase. Therefore, a rapid and non-invasive diagnostic technique is very important for glioma patients. Read More

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September 2021

A mutation of a single core gene, , of Type VI secretion system of influences virulence, epiphytic survival and transmission during pathogenesis on tomato.

Phytopathology 2021 Sep 20. Epub 2021 Sep 20.

Auburn University, 1383, Entomology and Plant Pathology, 209 Rouse Life Science Building, Auburn, Alabama, United States, 36849-5412;

is a seed-borne hemi-biotrophic pathogen that successfully establishes infection in the phyllosphere of tomato. While the majority of the studies investigating mechanistic basis of pathogenesis have focused on successful apoplastic growth, factors important during asymptomatic colonization in the early stages of disease development are not well understood. In this study, we show that gene of the type VI secretion system cluster i3* (T6SS-i3*) plays a significant role during initial asymptomatic epiphytic colonization at different stages during the life cycle of the pathogen. Read More

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September 2021

Air travel-related outbreak of multiple SARS-CoV-2 variants.

J Travel Med 2021 Sep 20. Epub 2021 Sep 20.

School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Background: A large cluster of 59 cases were linked to a single flight with 146 passengers from New Delhi to Hong Kong in April 2021. This outbreak coincided with early reports of exponential pandemic growth in New Delhi, which reached a peak of > 400 000 newly confirmed cases on 7 May 2021.

Methods: Epidemiological information including date of symptom onset, date of positive-sample detection, and travel and contact history for individual cases from this flight were collected. Read More

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September 2021

Cold-Triggered Induction of ROS- and Raffinose Metabolism in Freezing-Sensitive Taproot Tissue of Sugar Beet.

Front Plant Sci 2021 3;12:715767. Epub 2021 Sep 3.

Department of Plant Physiology, University of Kaiserslautern, Kaiserslautern, Germany.

Sugar beet ( subsp. ) is the exclusive source of sugar in the form of sucrose in temperate climate zones. Sugar beet is grown there as an annual crop from spring to autumn because of the damaging effect of freezing temperatures to taproot tissue. Read More

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September 2021

Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort.

Front Immunol 2021 1;12:700921. Epub 2021 Sep 1.

Grupo Enfermedades Emergentes, Universidad Científica del Sur, Lima, Peru.

Cytokines, chemokines and growth factors present different expression profiles related to the prognosis of COVID-19. We analyzed clinical parameters and assessed the expression of these biomarkers in patients with different disease severity in a hospitalized Peruvian cohort to determine those associated with worse prognosis. We measured anti-spike IgG antibodies by ELISA and 30 cytokines by quantitative suspension array technology in 123 sera samples. Read More

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September 2021

COVID-19 and a Green Recovery?

Econ Model 2021 Sep 11:105639. Epub 2021 Sep 11.

Toulouse School of Economics, INRAE, University of Toulouse Capitole.

Preliminary evidence indicates that pollution increases the severity and likelihood of COVID-19 infections similar to many other infectious diseases. This paper models the interaction of pollution and disease preventive actions, either pharmaceutical or non-pharmaceutical interventions, on transmission of infectious diseases in a neoclassical growth framework. There are two externalities - households do not take into account how their actions affect disease transmission, and productive activity results in pollution which increases the likelihood of infections. Read More

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September 2021

Effectiveness of a Combined Motivational Interviewing and Cognitive Behavioral Intervention to Reduce Substance Use and Improve HIV-Related Immune Functioning.

AIDS Behav 2021 Sep 19. Epub 2021 Sep 19.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

This study evaluated the effectiveness of Project PLUS, a 6-session Motivational Interviewing and Cognitive Behavioral intervention to reduce substance use and improve antiretroviral therapy (ART) adherence among PLWH. In a quasi-experimental design, 84 participants from a network of three comprehensive care clinics in New York City received the intervention immediately post-baseline (the Immediate condition) and 90 were assigned to a Waitlist control. Viral load and CD4 data were extracted from electronic medical records (EMR) for a No-Intervention comparison cohort (n = 120). Read More

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September 2021

PATHOGENETIC ROLE OF MACROPHAGE COLONY-STIMULATING FACTOR (CSF-1) IN PREDICTING ENDOMETRIOID DISEASE.

Wiad Lek 2021 ;74(8):1939-1944

POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.

Objective: The aim: To assess the CSF - 1 level in peritoneal fluid and menstrual blood of women with endometrioid disease and to investigate its diagnostic and prognostic specificity.

Patients And Methods: Materials and methods: The study included 80 women of child-bearing age (mean age 30.95 ± 6. Read More

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September 2021

ASSESSMENT OF ENDOTHELIAL DYSFUNCTION IN PREGNANT WOMEN WITH OBESITY AND PREECLAMPSIA.

Wiad Lek 2021 ;74(8):1905-1909

POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.

Objective: The aim: To assess the values of endothelial vascular growth factor (VEGF) in blood serum and circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women depending on the severity of obesity and presence of preeclampsia.

Patients And Methods: Materials and methods: the study included 122 pregnant women divided into groups in accordance with their height and weight parameters and presence of preeclampsia. We studied the serum VEGF concentration by enzyme-linked immunosorbent assay, carried out the count of CD32+CD40+ circulating endothelial microparticles in the peripheral blood by using flow cytometry. Read More

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September 2021