51,372 results match your criteria severity duration

Changes in sleep structure and sleep spindles are associated with the neuropsychiatric profile in paradoxical insomnia.

Int J Psychophysiol 2021 Jul 28. Epub 2021 Jul 28.

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Neurology, Sleep and Disorders Unit, Istanbul 34098, Turkey.

Aim: Sleep spindles have an important role in the pathophysiology and perception of sleep. We aimed to investigate the link between sleep spindles and microstructural architecture of sleep in regard to psychiatric characteristics in paradoxical insomnia.

Method: A total of 40 participants (20 with paradoxical insomnia, 20 healthy controls) were included in the study. Read More

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The blood neutrophil count after 1 month of treatment predicts the radiological severity of lung disease at treatment end.

Chest 2021 Jul 28. Epub 2021 Jul 28.

Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London NW3 2QG; Institute of Immunity and Transplantation, University College London, Royal Free Campus, London NW3 2QG. Electronic address:

Background: Post-tuberculous lung disease confers significant morbidity. However, the determinants of persistent lung damage in tuberculosis are not well established. We investigated associations between tuberculosis-associated radiological changes and socio-demographic factors, surrogates of bacillary burden and blood inflammatory markers at initiation of therapy and after 1 month. Read More

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Unintentional Opioid Overdoses Treated at University Clinic of Toxicology-Skopje in a Nine-Year-Period.

Acta Medica (Hradec Kralove) 2021 ;64(2):91-95

University Clinic of Toxicology, Clinical Centre, "Mother Teresa", Medical Faculty, Sts Cyril and Methodius University in Skopje, Republic of North Macedonia.

Background: The aim of this study was to assess the epidemiological profile of unintentional opioid overdoses, the prevalence and number of psychotropic substances involved in opioid overdoses.

Methods: This was a descriptive study, in which 180 participants were enrolled, and covered a nine-years-period. For collecting data was used the National patient electronic system "My term". Read More

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January 2021

Current Guidelines and Clinical Practice.

Charles J Love

Card Electrophysiol Clin 2021 Sep;13(3):459-471

Johns Hopkins Hospital, 600 N. Wolfe St / Carnegie 584, Baltimore, MD 21287, USA. Electronic address:

Guidelines exist for monitoring to diagnose and manage patients with several different conditions. Although there have been recent updates to the guidelines, the constantly evolving and advancing nature of the technologies creates a gap at times between the newest monitors, the indications for their use, and the reimbursement by the payers. The key element to the choice of the modality of monitoring remains matching the correct technology to the type, severity, frequency, and duration of the patient's symptoms. Read More

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September 2021

Treatment of CSF1R-Related Leukoencephalopathy: Breaking New Ground.

Mov Disord 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.

Background: Colony-stimulating factor-1 receptor (CSF1R)-related leukoencephalopathy is a rapidly progressive neurodegenerative disease for which there is currently no cure. Hematopoietic stem cell transplantation (HSCT) has been proposed as a disease-modifying treatment.

Objective: The objective of this study was to determine the effect of HSCT on disease progression. Read More

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J Athl Train 2021 Jul 30. Epub 2021 Jul 30.

Professor, Department of Kinesiology, Michigan State University, East Lansing, MI; E: T:

Context: Previously, the most common treatment for a concussion was prolonged physical and cognitive rest. Recent research suggests that earlier physical activity (PA) may be better at promoting recovery. Research has not evaluated the relationship between free-living PA (e. Read More

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SARS-CoV-2 Antibodies and Associated Factors at Different Hospitalization Time Points in 192 COVID-19 Cases.

J Appl Lab Med 2021 Jul 30. Epub 2021 Jul 30.

Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.

Background: We launched a retrospective analysis of SARS-CoV-2 antibodies in 192 patients with COVID-19, aiming to depict the kinetic profile of SARS-CoV-2 antibodies and explore the factors related to SARS-CoV-2 antibody expression.

Methods: Data on 192 confirmed patients with COVID-19 between January and February 2020 was collected from the designated hospital that received patients with COVID-19 in Guangzhou, China. Moreover, a cohort of 130 suspected patients with COVID-19 and 209 healthy people were also enrolled in this study. Read More

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Workplace noise exposure and the prevalence and 10-year incidence of age-related hearing loss.

PLoS One 2021 30;16(7):e0255356. Epub 2021 Jul 30.

Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, NSW, Australia.

There is paucity of population-based data on occupational noise exposure and risk of age-related hearing loss. Therefore, we assessed cross-sectional and longitudinal associations of past workplace noise exposure with hearing loss in older adults. At baseline, 1923 participants aged 50+ years with audiological and occupational noise exposure data included for analysis. Read More

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[Treatment of atopic dermatitis with dupilumab : A retrospective cohort analysis from dermatological practice].

Hautarzt 2021 Jul 30. Epub 2021 Jul 30.

Dermatologische Praxis Dr. Herbst & Kollegen, Rheinstr. 7, 64283, Darmstadt, Deutschland.

We present the results of a retrospective data analysis of a practice cohort of 44 patients with atopic dermatitis treated with the IL-4/13 receptor antibody dupilumab for up to 3 years. Patients were followed up over a period of 21 months during specialized consultation hours named Immunodermatology, which was established to guarantee comprehensive documentation. The patient's characteristics regarding age and sex distribution, severity and duration of disease were comparable with the patient collectives in large, pivotal studies. Read More

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What people with diabetes in Denmark worry about during the COVID-19 pandemic: a longitudinal study of the first three months of the COVID-19 pandemic.

Diabet Med 2021 Jul 30:e14665. Epub 2021 Jul 30.

Steno Diabetes Center Copenhagen, Denmark.

Aim: To investigate and characterise general and diabetes-specific worries related to COVID-19 among people with diabetes in Denmark during the first three months of the pandemic.

Methods: In a longitudinal study from March to June 2020, six online questionnaires (Q1-Q6) were distributed to 2,430 adult members of two diabetes panels. Worries related to COVID-19 were measured with closed- and open-ended items. Read More

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Effect of periodontal-orthodontic treatment of teeth with pathological tooth flaring, drifting and elongation in patients with severe periodontitis: a systematic review with meta-analysis.

J Clin Periodontol 2021 Jul 29. Epub 2021 Jul 29.

Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.

Aim: To assess the beneficial and adverse effects of periodontal-orthodontic treatment of teeth with pathological tooth flaring, drifting and elongation in patients with severe periodontitis on the dental and periodontal tissues.

Materials And Methods: Nine databases were searched in April 2020 for randomized/non-randomized clinical studies. After duplicate study selection, data extraction, and risk-of-bias assessment, random effects meta-analyses of mean differences (MDs) and their 95% confidence intervals (CIs) were performed, followed by subgroup/meta-regression analyses. Read More

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TaiChi and Qigong for Depressive Symptoms in Patients with Chronic Heart Failure: A Systematic Review with Meta-Analysis.

Evid Based Complement Alternat Med 2021 24;2021:5585239. Epub 2021 Jun 24.

Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China.

Background: Depression is a debilitating comorbidity of heart failure (HF) that needs assessment and management. Along with mind-body exercise to deal with HF with depression, the use of TaiChi and/or Qigong practices (TQPs) has increased. Therefore, this systematic review assesses the effects of TQPs on depression among patients with HF. Read More

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Association Between Smoking and COVID-19 Severity: Evidence from Bangladesh.

J Multidiscip Healthc 2021 23;14:1923-1933. Epub 2021 Jul 23.

Department of Public Health, North South University, Bashundhara, Dhaka, 1229, Bangladesh.

Purpose: Previous studies have explored several risk factors for coronavirus disease 2019 (COVID-19) severity, but there is still a lack of association with smoking. Our study aims to find out the association between smoking and COVID-19 severity.

Subjects And Methods: This comparative study was conducted among hospitalized severely and critically ill COVID-19 patients, as well as asymptomatic, mild, and moderate patients from the list of the city corporation (Dhaka, Bangladesh), as confirmed by reverse-transcription polymerase chain reaction (RT-PCR). Read More

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Relationship between OSDI score and biomicroscopic ocular surface damages in glaucomatous patients treated with preserved antiglaucomatous eye drops.

J Fr Ophtalmol 2021 Jul 26. Epub 2021 Jul 26.

Ophthalmology department, FSI Hospital, La-Marsa, Tunisia.

Purpose: Our goal was to identify factors that may influence the OSDI score, in particular, ocular surface damage in patients on preserved glaucoma eye drops.

Methods: This was a cross-sectional study of 155 glaucoma patients treated with preserved glaucoma eye drops. They all completed the "Ocular Surface Disease Index" (OSDI) questionnaire and underwent complete ophthalmological examination with precise evaluation of the status of the ocular surface. Read More

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The effects of diabetes mellitus on gastric emptying: A prospective observational cohort study.

J Clin Anesth 2021 Jul 26;75:110463. Epub 2021 Jul 26.

Anesthesiology Institute, Cleveland Clinic, OH, United States; Department of General Anesthesiology, Cleveland Clinic, OH, United States.

Study Objective: Our goal was to evaluate the effect of diabetic severity and duration on preoperative residual gastric volume. Secondarily we compared ultrasonic estimates of residual gastric volume with actual volume determined by aspiration during endoscopy.

Design: This was a prospective, observational cohort study that included adults with a history of diabetes mellitus and/or opioid use scheduled for gastrointestinal endoscopic procedures. Read More

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The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats.

PLoS One 2021 29;16(7):e0255310. Epub 2021 Jul 29.

IDEXX Laboratories, Inc., One IDEXX Drive, Westbrook, ME, United States of America.

The objective of this study was to evaluate the benefits and inherent risks of dental cleaning procedures, based on serum and urine biomarkers for kidney function and tissue damage, in dogs and cats. Thirty-one asymptomatic, mostly older dogs (14 neutered male and 17 ovariohysterectomized female dogs of various breeds between 3 and 14 years old) and cats (19 neutered male and 12 ovariohysterectomized female domestic short hair cats between 2 and 16 years old) diagnosed with periodontal disease on physical exam, and recommended by their veterinarian to have dental cleaning under general anesthesia were evaluated in a prospective study. Serum and urine samples were collected from dogs and cats 1 week before, 6 hours after, and again 1 week after the dental cleaning procedure. Read More

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Sri Lanka's early success in the containment of COVID-19 through its rapid response: Clinical & epidemiological evidence from the initial case series.

PLoS One 2021 29;16(7):e0255394. Epub 2021 Jul 29.

Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Background: Despite the rising global burden, Sri Lanka reported a relatively low caseload and mortality (13 deaths as of 20 October 2020) for COVID-19. This warrants exploration of the clinical and epidemiological characteristics of the case series during the initial passive case detection phase in Sri Lanka, in order to understand the success in containment of the disease for more than nine months in the country through its initial early and rapid pandemic response.

Methods: A retrospective study was conducted using secondary data (hospital records and investigation reports) extracted from all laboratory-confirmed patients admitted to the three main state-sector hospitals in Sri Lanka from 11 March to 7 April 2020. Read More

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Meal Eating Characteristics of Patients with Gastroparesis.

Dig Dis Sci 2021 Jul 29. Epub 2021 Jul 29.

Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

Background: Patients with gastroparesis often consume only small meals due to early satiety.

Aims: (1) Describe meal eating characteristics of patients with gastroparesis; (2) Relate meal eating characteristics to symptoms, gastric emptying (GE), and body weight.

Methods: Patients with gastroparesis filled out questionnaires including Patient Assessment of Upper GI Symptoms (PAGI-SYM), and questionnaire about meal habits and body weight. Read More

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Animal models of traumatic brain injury: a review of pathophysiology to biomarkers and treatments.

Exp Brain Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Anesthesiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814-4799, USA.

Traumatic brain injury (TBI) is one of the main causes of death and disability in both civilian and military population. TBI may occur via a variety of etiologies, all of which involve trauma to the head. However, the neuroprotective drugs which were found to be very effective in animal TBI models failed in phase II or phase III clinical trials, emphasizing a compelling need to review the current status of animal TBI models and therapeutic strategies. Read More

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Filaggrin-gene mutation has minimal effect on the disease severity in the lesions of atopic dermatitis.

J Dermatol 2021 Jul 29. Epub 2021 Jul 29.

Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.

Loss-of-function mutations of filaggrin (FLG) gene (FLG) are the strongest known genetic risk factor for atopic dermatitis (AD). It is still debatable how FLG gene mutations and the resulting abnormal amount of FLG protein contribute to skin barrier function and symptoms of AD. In this study, we examined the effects of loss-of-function mutations of FLG gene on the severity of skin lesions and skin barrier function in 55 patients with AD by evaluating eight patients with AD with FLG gene mutations and 47 patients with AD without mutations. Read More

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Serum vitamin B12 status of patients with type 2 diabetes mellitus on metformin: A single-center cross-sectional study from Bangladesh.

J Family Med Prim Care 2021 Jun 2;10(6):2225-2229. Epub 2021 Jul 2.

Department of Psychiatry, Cumilla Medical College Hospital, Cumilla, Bangladesh.

Background: Metformin use is a known cause of B12 deficiency in patients with type 2 DM (T2DM). Diabetic peripheral neuropathy (DPN) often has clinically indistinguishable clinical features of B12 deficiency-induced peripheral neuropathy (PN).

Objective: The present study aims to assess serum vitamin B12 levels in patients with T2DM on metformin. Read More

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Hypomethylating agents+venetoclax induction therapy in acute myeloid leukemia unfit for intensive chemotherapy - novel avenues for lesser venetoclax duration and patients with baseline infections from a developing country.

Am J Blood Res 2021 15;11(3):290-302. Epub 2021 Jun 15.

Department of Hemato-Oncology and Bone Marrow Transplant, Rajiv Gandhi Cancer Institute and Research Centre Sector 5, Rohini, Delhi 110085, India.

Both elderly acute myeloid leukemia (AML) patients and those with baseline infections, when treated with intensive chemotherapy, are associated with high induction mortality. We report 24 patients (16-newly-diagnosed, 8-relapsed/refractory) with AML deemed unfit for intensive chemotherapy (by virtue of age >60 years, ECOG-PS 3-4, or those with non-resolving infections at baseline), treated with azacytidine-venetoclax combination as induction chemotherapy. Median follow-up of the study group was 8 months. Read More

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Germ Cell Drivers: Transmission of Preconception Stress Across Generations.

Front Hum Neurosci 2021 12;15:642762. Epub 2021 Jul 12.

Colorado Center for Women's Behavioral Health and Wellness, Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, United States.

Exposure to stress can accelerate maturation and hasten reproduction. Although potentially adaptive, the trade-off is higher risk for morbidity and mortality. In humans, the intergenerational effects of stress have been demonstrated, but the precise mechanisms are unknown. Read More

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A Case-Cohort Study of Exfoliation Risk Factors and Literature Review.

Middle East Afr J Ophthalmol 2021 Jan-Mar;28(1):36-50. Epub 2021 Apr 30.

Department of Ophthalmology, Medical University of Lodz, Lodz, Poland.

The purpose of the study is to evaluate the risk factors associated with exfoliation in a case-cohort setting and literature review. This single-center, prospective, case-cohort study was carried out from January 2010 to April 2020 on patients operated for cataract surgery by a single surgeon in Lebanon. Forty-nine consecutive patients with exfoliation syndrome (XFS) and 62 consecutive control patients were identified and further investigated for selected systemic (diabetes mellitus, systemic hypertension, asthma, or atopy) and ocular variables (baseline vision, severity of nuclear sclerosis, glaucoma, eye rubbing, history of dry eye, or allergic eye disease). Read More

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Relationship between Low and High Anti-acetylcholine Receptor Antibody Titers and Clinical Severity in Myasthenia Gravis.

J Coll Physicians Surg Pak 2021 Aug;31(8):965-968

Department of Neurology, King Edward Medical University/Mayo Hospital, Lahore, Pakistan.

Objective: To determine the frequency of low and high anti-AChR (acetylcholine receptor) antibody titers and to evaluate their relationship with clinical severity in myasthenia gravis.

Study Design: Cross-sectional, observational study.

Place And Duration Of Study: Department of Neurology, King Edward Medical University/Mayo Hospital, Lahore from April 2017 to March 2018. Read More

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Frequency and Outcome of Hepatic Arterial Thrombosis in Recipients of Living Donor Liver Transplantation.

J Coll Physicians Surg Pak 2021 Aug;31(8):897-902

Department of Liver Transplant, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan.

ABASTRACT Objective: To determine the frequency, risk factors, and management of hepatic arterial thrombosis (HAT) in recipients of living donor living transplantation.

Study Design: Cohort study.

Place And Duration Of Study: Department of Liver Transplant, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat, Sindh, Pakistan, from 1st January 2019 to 31st July 2020. Read More

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Family Burden in Adolescents With Refractory Postconcussion Symptoms.

J Head Trauma Rehabil 2021 Jul 26. Epub 2021 Jul 26.

Neurosciences Program, Alberta Children's Hospital, Calgary, Alberta, Canada (Dr Brooks); Departments of Paediatrics (Dr Brooks), Clinical Neurosciences (Dr Brooks), and Psychology (Dr Brooks), Alberta Children's Hospital Research Institute (Dr Brooks and Mr Virani), Hotchkiss Brain Institute (Dr Brooks), Faculty of Nursing (Ms Kumari), and Faculty of Kinesiology (Mr Virani), University of Calgary, Calgary, Alberta, Canada.

Objective: A significant minority of adolescents will have persistent postconcussion symptoms after an injury, potentially having a negative impact on family functioning. However, the reasons for a family's negative impact are not clearly understood. The objective of this study was to determine whether preinjury/demographic factors, injury characteristics, and/or worse postinjury symptoms are associated with higher levels of family stress in youth with refractory postconcussion symptoms. Read More

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Variability in the type and layer distribution of cortical Aβ pathology in familial Alzheimer's disease.

Brain Pathol 2021 Jul 28:e13009. Epub 2021 Jul 28.

The Queen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.

Familial Alzheimer's disease (FAD) is caused by autosomal dominant mutations in the PSEN1, PSEN2 or APP genes, giving rise to considerable clinical and pathological heterogeneity in FAD. Here we investigate variability in clinical data and the type and distribution of Aβ pathologies throughout the cortical layers of different FAD mutation cases. Brain tissue from 20 FAD cases [PSEN1 pre-codon 200 (n = 10), PSEN1 post-codon 200 (n = 6), APP (n = 4)] were investigated. Read More

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Halo vest immobilization - an institutional review of safety in acute cervical spine injury from 2013 to 2017.

Br J Neurosurg 2021 Jul 28:1-4. Epub 2021 Jul 28.

Department of Neurosurgery, College of Medicine, University of Florida, Jacksonville, FL, USA.

Halo vest immobilization (HVI) remains an important treatment option for occipital-cervical injuries. It provides the surgeon with a safe and effective medical treatment options for challenging patients. The aim of this study was to evaluate the safety of HVI in these patients. Read More

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