217,054 results match your criteria severity associated


Autopsy-Based Pulmonary and Vascular Pathology: Pulmonary Endotheliitis and Multi-Organ Involvement in COVID-19 Associated Deaths.

Respiration 2021 Sep 15:1-11. Epub 2021 Sep 15.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland.

Background: Findings from autopsies have provided evidence on systemic microvascular damage as one of the underlying mechanisms of Coronavirus disease 2019 (CO-VID-19). The aim of this study was to correlate autopsy-based cause of death in SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients with chest imaging and severity grade of pulmonary and systemic morphological vascular pathology.

Methods: Fifteen SARS-CoV-2 positive autopsies with clinically distinct presentations (age 22-89 years) were retrospectively analyzed with focus on vascular, thromboembolic, and ischemic changes in pulmonary and in extrapulmonary sites. Read More

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September 2021

Multivariate pattern analysis links drug use severity to distributed cortical hypoactivity during emotional inhibitory control in opioid use disorder.

Neuroimage Clin 2021 Aug 29;32:102806. Epub 2021 Aug 29.

Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, 3535 Market St Ste 500, Philadelphia, PA 19104, USA.

Opioid use disorder (OUD) is characterized by emotional and cognitive impairements that are associated with poor treatment outcomes. The present study investigated the neural mechanism underlying emotion evaluation and inhibitory control using an affective go/no-go (AGN) task and its association with drug use severity and craving in patients with OUD. Twenty-six recently detoxified patients with OUD underwent functional magnetic resonance imaging (fMRI) while performing the AGN task that required response to frequently presented appetitive stimuli ("go") and inhibition of response to infrequently presented aversive stimuli ("no-go"). Read More

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Dexamethasone is associated with early deaths in light chain amyloidosis patients with severe cardiac involvement.

PLoS One 2021 15;16(9):e0257189. Epub 2021 Sep 15.

The French Cardiac Amyloidosis Reference Center, GRC Amyloid Research Institute, Réseau amylose Mondor, and DHU A-TVB, Créteil, France.

Background: Cardiac light chain amyloidosis (AL-CA) patients often die within three months of starting chemotherapy. Chemotherapy for non-immunoglobulin M gammopathy with AL-CA frequently includes bortezomib (Bor), cyclophosphamide (Cy), and dexamethasone (D). We previously reported that NT-ProBNP levels can double within 24h of dexamethasone administration, suggesting a deleterious impact on cardiac function. Read More

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September 2021

Characterization of enteric disease in children using a low-cost specimen preservation method.

J Clin Microbiol 2021 Sep 15:JCM0170321. Epub 2021 Sep 15.

M.A. SANTE (Meilleur Accès aux Soins de Santé) , Yaoundé, Cameroon.

Background: Diarrhea is a leading cause of death in children under five. Molecular methods exist for the rapid detection of enteric pathogens; however, the logistical costs of storing stool specimens limit applicability. We sought to demonstrate that dried filter paper specimen preservation can identify diarrheal diseases causing significant morbidity among children in resource constrained countries. Read More

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September 2021

First Report of Xanthomonas campestris pv. campestris Causing Marginal Leaf Necrosis of Arugula (Eruca vesicaria subsp. sativa) in Serbia.

Plant Dis 2021 Sep 15. Epub 2021 Sep 15.

University of Belgrade, Faculty of Agriculture, Institute of Phytomedicine, Plant Pathology, Nemanjina 6, Belgrade, Serbia, 11080;

Arugula (Eruca vesicaria subsp. sativa (Miller) Thell., syn. Read More

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September 2021

Prediction accuracy of commonly used pneumonia severity scores in Aboriginal patients with severe community-acquired pneumonia - a retrospective study.

Intern Med J 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine, Alice Springs Hospital, Central Australian Health Service, Alice Springs, Northern Territory,, Australia.

Aims: Assess the prediction accuracy of pneumonia severity scores in Aboriginal patients with severe community-acquired pneumonia (SCAP) and identify risk factors for poor prognosis.

Methods: Retrospective cohort study examining Aboriginal patients admitted to intensive care unit (ICU) with confirmed SCAP between January 2011 and December 2014. Severity scores were calculated for SMARTCOP, SMARTACOP, CURB65, PSI, IDSA/ATS SCAP (IASCAP) and APACHE II/III scores using medical records. Read More

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September 2021

Compensatory bladder behaviors ("coping") in women with overactive bladder.

Neurourol Urodyn 2021 Sep 15. Epub 2021 Sep 15.

Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Aims: There is little information on how often or within what contexts individuals with OAB use compensatory behaviors ("coping") to manage symptoms. We sought to examine how frequently women with OAB report using coping behaviors and whether these are associated with psychosocial factors.

Methods: One hundred twenty adult women with OAB completed the OAB questionnaire (OAB-q), ICIQ-FLUTS questionnaire, PROMIS Anxiety and Depression, Perceived Stress Scale, patient perception of bladder condition, and demographic and clinical data. Read More

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September 2021

Symptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study.

Reprod Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University Department, Liverpool Women's Hospital, University of Liverpool, Member of Liverpool Health Partners, Crown Street, Liverpool, L8 7SS, UK.

Endometriosis is a common, chronic inflammatory condition, thought to have a higher incidence in symptomatic women, yet, commonly associated symptoms do not always correlate with the presence or severity of disease and diagnosis requires surgery. We prospectively collected data and assessed symptomology and NMR spectroscopy-based metabolomics of 102 women undergoing laparoscopic sterilisation at a tertiary referral centre in a cross-sectional study. Twelve women were incidentally diagnosed with endometriosis (11. Read More

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September 2021

Impact on the Risk and Severity of Childhood Onset Schizophrenia of Schizophrenia Risk Genetic Variants at the DRD2 and ZNF804A Loci.

Child Psychiatry Hum Dev 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Genetics, Mental Health Research Center, Moscow, Russia.

The study explored whether schizophrenia risk alleles of the DRD2 rs2514218 and ZNF804A rs1344706 polymorphisms also influenced the risk and severity of childhood-onset schizophrenia (COS) and differentiated it from autism spectrum disorders (ASD). We compared 75 children with COS to 75 children with ASD, 150 patients with adult-onset schizophrenia and 150 healthy individuals. Frequency of the DRD2 T-allele, assumed to be protective against schizophrenia overall, was higher in COS compared to adult-onset schizophrenia and healthy controls. Read More

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September 2021

Adolescents' Experiences of Idiopathic Scoliosis in the Presurgical Period: A Qualitative Study.

J Pediatr Psychol 2021 Sep 15. Epub 2021 Sep 15.

School of Psychology, University College Dublin and.

Objective: Adolescent idiopathic scoliosis (AIS) is a sideways curvature of the spine that can progress severely during adolescent development and require surgical intervention. This qualitative study was conducted to explore the psychosocial experiences of adolescents with idiopathic scoliosis during the presurgical stage of treatment.

Methods: Fourteen adolescents with moderate-to-severe AIS aged 12-17 years participated in semistructured interviews and data were analyzed using inductive reflexive thematic analysis. Read More

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September 2021

Outcomes Associated With Norepinephrine Use Among Cardiac Intensive Care Unit Patients with Severe Shock.

Shock 2021 Oct;56(4):522-528

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Recent data suggests improved outcomes among cardiac intensive care unit (CICU) patients treated with norepinephrine, especially patients with severe shock. We aimed to describe the association between norepinephrine and mortality in CICU patients with severe shock, defined as those requiring high-dose vasopressors (HDV).

Materials And Results: We retrospectively evaluated Mayo Clinic CICU patients treated with vasopressors from 2007 to 2015. Read More

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October 2021

Extracorporeal Life Support for Respiratory Failure in Patients With Electronic Cigarette or Vaping Product Use-Associated Lung Injury.

Crit Care Med 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatric Surgery, McGovern Medical School at the University of Texas Health Science Center and Children's Memorial Hermann Hospital, Houston, TX. Department of Pediatrics, Division of Pulmonary Medicine and the Lung Transplant Program Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH. Department of Pediatrics-Critical Care, UT Southwestern Medical Center, Dallas, TX. Division of Cardiothoracic Surgery, Department of Surgery, Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT. Extracorporeal Life Support Organization, Ann Arbor, MI. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN. Department of Critical Care Medicine, Mercy Hospital, St Louis, MO. Department of Medicine, Division of Critical Care Medicine, Schulich School of Medicine & Dentistry, Western University, and London Health Sciences Centre, London, ON, Canada. Department of Paediatric Respiratory Medicine, Nottingham University Hospitals, Nottingham, United Kingdom. Department of Radiology, Newark Beth Israel Medical Center, Newark, NJ. Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, PA. Department of Cardiovascular and Thoracic Surgery, Barbara and Donald Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.

Objectives: Electronic cigarette or vaping product use-associated lung injury is a clinical entity that can lead to respiratory failure and death. Despite the severity of electronic cigarette or vaping product use-associated lung injury, the role of extracorporeal life support in its management remains unclear. Our objective was to describe the clinical characteristics and outcomes of patients with electronic cigarette or vaping product use-associated lung injury who received extracorporeal life support. Read More

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September 2021

A Multiplex Noninvasive Salivary Antibody Assay for SARS-CoV-2 Infection and Its Application in a Population-Based Survey by Mail.

Microbiol Spectr 2021 Sep 15:e0069321. Epub 2021 Sep 15.

U.S. Environmental Protection Agencygrid.418698.a, Chapel Hill, North Carolina, USA.

Noninvasive salivary antibody immunoassays can enable low-cost epidemiological surveillance of infections. This study involved developing and validating a multiplex suspension immunoassay on the Luminex platform to measure immunoglobulin G (IgG) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid and spike (S) proteins, and the spike protein's S1 and S2 subunits and receptor binding domain. Multiple versions of these recombinant proteins acquired from commercial and noncommercial sources were evaluated. Read More

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September 2021

Peripheral granular lymphocytopenia and dysmorphic leukocytosis as simple prognostic markers in COVID-19.

Int J Lab Hematol 2021 Sep 15. Epub 2021 Sep 15.

Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Japan.

Introduction: Developing prognostic markers can be useful for clinical decision-making. Peripheral blood (PB) examination is simple and basic that can be performed in any facility. We aimed to investigate whether PB examination can predict prognosis in coronavirus disease (COVID-19). Read More

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September 2021

Correlation of fetal ventricular size and need for postnatal cerebrospinal fluid diversion surgery in open spina bifida.

Ultrasound Obstet Gynecol 2021 Sep 15. Epub 2021 Sep 15.

Fetal Medicine Unit, Dept. of Obstetrics & Gynaecology, Mount Sinai Hospital, Toronto, ON, Canada.

Objectives: Open spina bifida is a common cause of hydrocephalus in the postnatal period. However, in-utero closure of the fetal spinal defect has decreased the need for cerebrospinal fluid (CSF) diversion surgery postnatally. Good prenatal predictors of the need for postnatal CSF diversion surgery are currently lacking. Read More

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September 2021

Association study of transition of laboratory marker levels and transition of disease activity of atopic dermatitis patients treated with dupilumab.

Australas J Dermatol 2021 Sep 15. Epub 2021 Sep 15.

Department of Dermatology, Nippon Medical School, Tokyo, Japan.

Background: Dupilumab, a fully human monoclonal antibody that blocks signalling pathways of interleukin (IL)-4 and IL-13, is effective in treating patients with atopic dermatitis (AD). We previously showed that transitions of serum thymus and activation-regulated chemokine (TARC) levels and eosinophil numbers were strongly associated with that of AD activity and that the transitions of serum lactate dehydrogenase (LDH) and immunoglobulin E (IgE) levels were weakly and not associated with that of AD activity, respectively, in patients treated without dupilumab.

Objectives: The purpose of this study was to elucidate whether the association of the transition of laboratory marker levels and transition of disease activity in dupilumab-treated AD patients (present study) was different from that in patients who are not treated with dupilumab (previous study). Read More

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September 2021

Characteristics and dose-effect relationship of clinical gamma-hydroxybutyrate intoxication: A case series.

J Forensic Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Toxicology, Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Gamma-Hydroxybutyrate (GHB) overdoses cause respiratory depression, coma, or even death. Symptoms and severity of poisoning depend on blood-concentrations and individual factors such as tolerance. A retrospective case study was conducted, evaluating GHB intoxication cases. Read More

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September 2021

Relationship Between Timing of Anterior Cruciate Ligament Reconstruction and Chondral Injuries: A Systematic Review and Meta-analysis.

Am J Sports Med 2021 Sep 15:3635465211036141. Epub 2021 Sep 15.

School of Medicine, University of Central Lancashire, Preston, UK.

Background: After anterior cruciate ligament (ACL) injury, the optimal timing of ACL reconstruction and the influence of this timing on chondral damage remain unclear.

Purpose: To assess the effect of timing of ACL reconstruction on the presence of chondral injuries via a systematic review and meta-analysis.

Study Design: Systematic review and meta-analysis; Level of evidence, 4. Read More

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September 2021

Provisional posttraumatic stress disorder is associated with greater severity of eating disorder and comorbid symptoms in adolescents treated in residential care.

Eur Eat Disord Rev 2021 Sep 14. Epub 2021 Sep 14.

Monte Nido and Affiliates, Miami, Florida, USA.

Objective: Past traumatic events, subsequent posttraumatic stress disorder (PTSD) and related psychiatric comorbidities are commonly associated with eating disorders (EDs) in adults but remain understudied in adolescents.

Methods: Adolescent participants (mean [SD] age = 15.1 ± 1. Read More

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September 2021

Early targeted patent ductus arteriosus treatment in premature neonates using a risk based severity score: study protocol for a randomised controlled trial (PDA RCT).

HRB Open Res 2020 25;3:87. Epub 2020 Nov 25.

Division of Neonatology, Stead Family Children's Hospital Stead Family Children's Hospital, Iowa, USA.

A patent ductus arteriosus (PDA) in preterm infants is associated with increased ventilator dependence and chronic lung disease, necrotizing enterocolitis, intraventricular haemorrhage, and poor neurodevelopmental outcome. Randomised controlled trials of early PDA treatment have not established a drop in the aforementioned morbidities. Those trials did not physiologically categorise PDA severity. Read More

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November 2020

A Case of Steroid-Responsive Encephalopathy.

Cureus 2021 Aug 10;13(8):e17063. Epub 2021 Aug 10.

Neurology, Boca Raton Regional Hospital/Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.

Hashimoto's encephalopathy (HE), also known as steroid-responsive encephalopathy, is associated with autoimmune-mediated thyroiditis. Onset is typically gradual often with evolution over the course of months. Characteristic symptoms include impaired concentration and memory, delusions, hallucinations, personality changes, incoordination, tremor, hemiparesis, seizures, and speech difficulties. Read More

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The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review.

Cureus 2021 Aug 3;13(8):e16855. Epub 2021 Aug 3.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Non-Alcoholic Fatty Liver Disease (NAFLD) emerged as the most prevalent liver disorder contributing significantly to disease burden worldwide. It manifests as a broad spectrum of hepatic damage with varying severity ranging from less serious steatosis to a more severe Non-Alcoholic Steatohepatitis (NASH), with or without fibrosis, cirrhosis, and hepatocellular carcinoma. Vitamins, on the other hand, are micronutrients that are vital for healthy well-being. Read More

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Interactions between NCRILC3s and the Microbiome in the Airways Shape Asthma Severity.

Immune Netw 2021 Aug 22;21(4):e25. Epub 2021 Jul 22.

Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.

Asthma is a heterogeneous disease whose development is shaped by a variety of environmental and genetic factors. While several recent studies suggest that microbial dysbiosis in the gut may promote asthma, little is known about the relationship between the recently discovered lung microbiome and asthma. Innate lymphoid cells (ILCs) have also been shown recently to participate in asthma. Read More

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Elevated Nesfatin-1 Level in Synovium and Synovial Fluid is Associated with Pro-Inflammatory Cytokines in Patients with Rheumatoid Arthritis.

Int J Gen Med 2021 7;14:5269-5278. Epub 2021 Sep 7.

Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

Background: Adipocytokines have been proven to be involved in the progression of autoimmune diseases, including rheumatoid arthritis (RA). Nesfatin-1, a newly discovered adipokine, has recently been reported to possess potent anti-inflammatory, antiapoptotic, and antioxidative properties. However, its role in RA has not yet been reported. Read More

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September 2021

Increased Serum Soluble Interleukin-2 Receptor Associated with Severity of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2021 7;16:2561-2573. Epub 2021 Sep 7.

Department of Respiratory Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, People's Republic of China.

Background: This study aimed to reveal the correlation between serum soluble interleukin-2 receptor (sIL-2R) and prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods: A total of 315 patients diagnosed with AECOPD between December 2017 and June 2020 were enrolled. The patients were divided into the good and adverse groups based on the outcomes. Read More

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September 2021

Associations between increased circulating endothelial progenitor cell levels and anxiety/depressive severity, cognitive deficit and function disability among patients with major depressive disorder.

Sci Rep 2021 Sep 14;11(1):18221. Epub 2021 Sep 14.

Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan.

The association of major depressive disorder (MDD) with cardiovascular diseases (CVDs) through endothelial dysfunction is bidirectional. Circulating endothelial progenitor cells (cEPCs), essential for endothelial repair and function, are associated with risks of various CVDs. Here, the relationship of cEPC counts with MDD and the related clinical presentations were investigated in 50 patients with MDD and 46 healthy controls. Read More

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September 2021

Early restrictive fluid balance is associated with lower hospital mortality independent of acute disease severity in critically ill patients on CRRT.

Sci Rep 2021 Sep 14;11(1):18216. Epub 2021 Sep 14.

Department of Anaesthesiology and Intensive Care, University of Turku, Kiinamyllynkatu 4-8, P.O. Box 51, 20521, Turku, Finland.

Fluid overload (FO) with coincident acute kidney injury has been associated with increased mortality. However, it is unclear whether FO is an independent determinant of mortality for disease severity. We aimed to explore whether the development of fluid balance (FB) during the first 72 h of continuous renal replacement therapy (CRRT) is independently associated with hospital mortality. Read More

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September 2021

An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank.

Sci Rep 2021 Sep 14;11(1):18262. Epub 2021 Sep 14.

Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.

A growing body of evidence suggests that vitamin D deficiency has been associated with an increased susceptibility to viral and bacterial respiratory infections. In this study, we aimed to examine the association between vitamin D and COVID-19 risk and outcomes. We used logistic regression to identify associations between vitamin D variables and COVID-19 (risk of infection, hospitalisation and death) in 417,342 participants from UK Biobank. Read More

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September 2021

Respiratory Mechanics and Association With Inflammation in COVID-19-Related ARDS.

Respir Care 2021 Sep 14. Epub 2021 Sep 14.

Division of Pulmonary, Critical Care, and Sleep Medicine, New York University Grossman School of Medicine, New York, New York.

Background: The novel coronavirus-associated ARDS (COVID-19 ARDS) often requires invasive mechanical ventilation. A spectrum of atypical ARDS with different phenotypes (high vs low static compliance) has been hypothesized in COVID-19.

Methods: We conducted a retrospective analysis to identify respiratory mechanics in COVID-19 ARDS. Read More

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September 2021

Using genetics to detangle the relationships between red cell distribution width and cardiovascular diseases: a unique role for body mass index.

Open Heart 2021 Sep;8(2)

Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Objective: Red cell distribution width (RDW) is an enigmatic biomarker associated with the presence and severity of multiple cardiovascular diseases (CVDs). It is unclear whether elevated RDW contributes to, results from, or is pleiotropically related to CVDs. We used contemporary genetic techniques to probe for evidence of aetiological associations between RDW, CVDs, and CVD risk factors. Read More

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September 2021