94,136 results match your criteria severe respiratory

[Proposal for territorial analysis to face the SARS-CoV-2 pandemic based on the Profile of pneumonia and Influenza in Ecuador 2016-2018].

Aten Primaria 2021 Feb 23;53(5):102021. Epub 2021 Feb 23.

Universidad Central del Ecuador, Facultad de Ciencias Médicas, Quito, Ecuador.

Objective: The present study seeks to analyse sociodemographic determinants related to severe acute respiratory infections (SARI) and calculate the priorization index in the cantons of Ecuador to identify areas probably most vulnerable to COVID-19 transmission.

Design: This descriptive ecological observational study.

Setting: 224 cantons (geographical area) of Ecuador with secondary data sources of hospital information. Read More

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February 2021

Development of ciclesonide analogues that block SARS-CoV-2 RNA replication.

Bioorg Med Chem Lett 2021 Apr 19:128052. Epub 2021 Apr 19.

Division of Organic Chemistry, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki, Kanagawa 210-9501, Japan; Graduate School of Medical Life Science, Yokohama City University, 1-7-29, Yokohama, Kanagawa 230-0045, Japan. Electronic address:

Ciclesonide is an inhaled corticosteroid used to treat asthma and is currently undergoing clinical trials for treatment of coronavirus disease 2019 (COVID-19). An active metabolite of ciclesonide, Cic2, was recently reported to repress severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genomic RNA replication. Herein, we designed and synthesized a few types of ciclesonide analogues. Read More

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Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study.

Lancet Respir Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiovascular and Thoracic Surgery, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France; Sorbonne University, INSERM UMRS_1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France.

Background: In the Île-de-France region (henceforth termed Greater Paris), extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) was considered early in the COVID-19 pandemic. We report ECMO network organisation and outcomes during the first wave of the pandemic.

Methods: In this multicentre cohort study, we present an analysis of all adult patients with laboratory-confirmed SARS-CoV-2 infection and severe ARDS requiring ECMO who were admitted to 17 Greater Paris intensive care units between March 8 and June 3, 2020. Read More

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Eosinophilic and non-eosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort.

Chest 2021 Apr 19. Epub 2021 Apr 19.

Optimum Patient Care, Cambridge, UK; Observational and Pragmatic Research Institute, Singapore, Singapore; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address:

Background: Phenotypic characteristics of eosinophilic and non-eosinophilic asthma patients are not well-characterized in global, real life severe asthma cohorts.

Research Question: What is the prevalence of eosinophilic and non-eosinophilic phenotypes in the severe asthma population, and can they be differentiated by clinical and biomarker variables?

Study Design And Methods: This was an historical, registry study. Adult severe asthma patients with available blood eosinophil count (BEC) from 11 countries enrolled into the International Severe Asthma Registry (01/01/2015 to 09/30/2019) were categorized according to likelihood of eosinophilic phenotype using a pre-defined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Read More

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Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

J Aerosol Med Pulm Drug Deliv 2021 Apr 21. Epub 2021 Apr 21.

Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.

There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS, Middle East respiratory syndrome (MERS), and influenza with administration of drugs via nebulizer. We searched multiple electronic databases, including PubMed, China National Knowledge Infrastructure, Wanfang, preprint databases, and clinicaltrials. Read More

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Combination therapy with plasma exchange and glucocorticoid may be effective for severe COVID-19 infection. -A retrospective observational study.

Ther Apher Dial 2021 Apr 22. Epub 2021 Apr 22.

Department of General Medicine, Faculty of Medicine, Juntendo University.

We retrospectively analyzed the characteristics and outcomes of five patients with COVID-19 who were received glucocorticoid (with or without pulse therapy) and therapeutic plasma exchange. The efficacy of the treatment was determined by whether the patient was able to be transferred from the COVID-19 exclusive ICU to the general ward. In comparing patients who received prednisolone pulse therapy (3 cases) with those who did not (2 cases), 2/3 (66%) and 0/2 (0%) patients could be discharged from the COVID-19 dedicated ICU, respectively. Read More

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Treating severe asthma: targeting the IL-5 pathway.

Clin Exp Allergy 2021 Apr 22. Epub 2021 Apr 22.

Amsterdam UMC, University of Amsterdam, Department of Respiratory Medicine, Amsterdam, The Netherlands.

Severe asthma is a heterogeneous disease with different phenotypes. Anti-IL5/IL5R monoclonal antibodies mepolizumab, reslizumab and benralizumab are proven to be effective and safe in severe eosinophilic asthma. Eosinophils threshold seems to represent the most indicative biomarker for response to treatment with all three monoclonal antibodies. Read More

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Comparison of viral load between saliva and nasopharyngeal swabs for SARS-CoV2: the role of days of symptoms onset on diagnosis.

Mem Inst Oswaldo Cruz 2021 16;116:e210018. Epub 2021 Apr 16.

Universidade Federal de São Paulo, Departamento de Medicina, Laboratório de Virologia Clínica, São Paulo, SP, Brasil.

Background: Coronavirus disease 2019 (COVID-19) is highly infectious causing millions of deaths worldwide. Nasopharyngeal swabs are the primary sample of choice for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus, to decrease the exposure to potentially infected samples through the collection is a key point to reduce the risk of infection in healthcare workers.

Objectives: This study aimed to evaluate the sensitivity and viral load of saliva specimens by days of symptoms onset comparing to nasopharyngeal swabs in subjects with mild symptoms. Read More

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Characterization of pulmonary impairment associated with COVID-19 in patients requiring mechanical ventilation.

Rev Bras Ter Intensiva 2021 Jan-Mar;33(1):75-81

Medical Intensive Care Unit, Hôpital Emile Muller, Groupe Hospitalier de la Région de Mulhouse et Sud-Alsace - Alsace - Mulhouse, France.

Objective: To detect early respiratory and hemodynamic instability to characterize pulmonary impairment in patients with severe COVID-19.

Methods: We retrospectively analyzed data collected from COVID-19 patients suffering from acute respiratory failure requiring intubation and mechanical ventilation. We used transpulmonary thermodilution assessment with a PiCCO™ device. Read More

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Implementation of care for the use of the extracorporeal oxygenation membrane in the COVID-19 pandemic.

Rev Bras Enferm 2021 14;74Suppl 1(Suppl 1):e20200870. Epub 2021 Apr 14.

Universidade Federal do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To report the experience of a quaternary care center on the implementation of a care program for patients with severe hypoxemic respiratory failure due to SARS-CoV-2 requiring an extracorporeal oxygenation membrane.

Method: This is an experience report with a descriptive approach, analyzing the use of the extracorporeal oxygenation membrane in a quaternary care center in the city of Rio de Janeiro.

Results: The planning for the use of the extracorporeal oxygenation membrane included training with the professionals and use of the components related to the adaptation of the protocol, equipment, facilities, quality and safety. Read More

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Management of a university ambulatory service: nursing in the coping of the pandemic of COVID-19.

Rev Bras Enferm 2021 14;74Suppl 1(Suppl 1):e20200834. Epub 2021 Apr 14.

Universidade do Estado do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: to describe the implementation and management of a restructured nursing service to cope with the COVID-19 pandemic.

Methods: a descriptive study, carried out at Piquet Carneiro Polyclinic, a university ambulatory unit, which became a reference for testing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the city of Rio de Janeiro.

Results: dimensioning of human resources for nursing was carried out; flows for serving users of the unit and for testing SARS-CoV-2; professional training on prevention practices. Read More

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Dysautonomia: A Forgotten Condition - Part 1.

Arq Bras Cardiol 2021 Apr;116(4):814-835

Serviço de Eletrofisiologia do Vitória Apart Hospital, Vitória, ES - Brasil.

Dysautonomia covers a range of clinical conditions with different characteristics and prognoses. They are classified as Reflex Syndromes, Postural Orthostatic Tachycardia Syndrome (POTS), Chronic Fatigue Syndrome, Neurogenic Orthostatic Hypotension (nOH) and Carotid Sinus Hypersensitivity Syndrome. Reflex (vasovagal) syndromes will not be discussed in this article. Read More

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Vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2: A scoping review.

PLoS One 2021 22;16(4):e0250196. Epub 2021 Apr 22.

Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States of America.

Introduction: The evidence for vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is not well established. Therefore, the objective of this review is to summarize emerging evidence on the vertical transmission of Severe Acute Respiratory Syndrome Coronavirus 2.

Methods: We conducted a systematic search in PubMed, CINAHL, Web of Science, SCOPUS, and CENTRAL. Read More

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SARS-CoV-2 testing strategy: A comparison of restricted and extended strategies in a Swiss outpatient cohort from the community and hospital employees.

PLoS One 2021 22;16(4):e0250021. Epub 2021 Apr 22.

Division of Primary Care, Geneva University Hospitals, Geneva, Switzerland.

Background: Testing is a key measure to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we empirically compared two SARS-CoV-2 testing strategies.

Methods: We used data from a Swiss single-centre, outpatient cohort study (n = 6,331 test results). Read More

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Anesthetic Complications Associated with SARS-CoV-2 in Pediatric Patients.

Anesth Analg 2021 Apr 21. Epub 2021 Apr 21.

Department of Anesthesiology and Pain Management, Division of Pediatric Anesthesia, University of Texas Southwestern, Dallas, TX and Children's Health, Dallas, TX.

Background: Coronavirus disease 19 (COVID-19) is associated with high perioperative morbidity and mortality among adults. The incidence and severity of anesthetic complications in children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We hypothesized that there would be an increased incidence of intra- and postoperative complications in children with SARS-CoV-2 infection as compared to those with negative testing. Read More

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Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus.

JCI Insight 2021 Apr 22. Epub 2021 Apr 22.

Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, United States of America.

Emerging coronaviruses from zoonotic reservoirs including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been associated with human-to-human transmission and significant morbidity and mortality. Here we study both intradermal (ID) and intramuscular (IM) two-dose delivery regimens of an advanced synthetic DNA vaccine candidate encoding a full-length MERS-CoV Spike (S) protein, which induced potent binding and neutralizing antibodies, as well as cellular immune responses in rhesus macaques. In a MERS-CoV challenge, all immunized rhesus macaques exhibited reduced clinical symptoms, lowered viral lung load, and decreased severity of pathological signs of disease compared to controls. Read More

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Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology.

Top Curr Chem (Cham) 2021 Apr 22;379(3):23. Epub 2021 Apr 22.

Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China.

Coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still a pandemic around the world. Currently, specific antiviral drugs to control the epidemic remain deficient. Understanding the details of SARS-CoV-2 structural biology is extremely important for development of antiviral agents that will enable regulation of its life cycle. Read More

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Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover.

Brief Bioinform 2021 Apr 22. Epub 2021 Apr 22.

Queensland Biosciences Precinct, The University of Queensland, St Lucia 4072, Queensland, Australia.

Coronavirus disease 2019 has developed into a dramatic pandemic with tremendous global impact. The receptor-binding motif (RBM) region of the causative virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to host angiotensin-converting enzyme 2 (ACE2) receptors for infection. As ACE2 receptors are highly conserved within vertebrate species, SARS-CoV-2 can infect significant animal species as well as human populations. Read More

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Linkage of Lambda Interferons in Protection Against Severe COVID-19.

J Interferon Cytokine Res 2021 Apr;41(4):149-152

Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

The most recently discovered interferon (IFN) family, type III IFNs or lambda IFNs (IFN-λs) are caused by viral infection and act in mucosal barriers, such as the respiratory tract. In this study, we assessed the serum levels of IFN-λs in new coronavirus disease-2019 (COVID-19) patients. Sixty-four COVID-19 patients were enrolled in this study. Read More

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COVID-19 in pregnancy - characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries.

Acta Obstet Gynecol Scand 2021 Apr 22. Epub 2021 Apr 22.

Depaetment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Introduction: Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and health care systems.

Material And Methods: This study examines pregnant women with COVID-19 in the five Nordic countries. Pregnant women were included if they were admitted to hospital between March 1 and June 30, 2020 and had a positive SARS-CoV-2 PCR test 14 days or fewer prior to the admission. Read More

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Severe acute respiratory syndrome coronavirus 2 and forensic pathology.

Brett E Lockyer

Med Sci Law 2021 Apr 22:258024211009749. Epub 2021 Apr 22.

6698Portsmouth Hospitals University NHS Trust, UK.

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Cerebral hyperperfusion syndrome after intracranial stenting: Case report and systematic review.

Interv Neuroradiol 2021 Apr 22:15910199211011860. Epub 2021 Apr 22.

Department of Neuroradiology, A.O.U. San Giovanni di Dio e Ruggi d'Aragona, 19028University of Salerno, Salerno, Italy.

Background: Cerebral Hyperperfusion Syndrome (CHS) is an uncommon complication observed after intracranial angioplasty or stenting procedures. Given to the increasing use of new devices for intracranial angioplasty and stenting (INCS), in selected patients with high ischemic stroke risk, an equally increasing knowledge of complications related to these procedures is mandatory. a 63-year-old man was diagnosed with an hyperperfusion syndrome after percutaneous angioplasty and stenting for severe symptomatic right internal carotid artery (ICA) siphon stenosis. Read More

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[Biological risk from SARS-CoV-2 and respiratory protection device for health workers during the first pandemic phase: a scenario that had to be avoided].

Epidemiol Prev 2021 Jan-Apr;45(1-2):110-116

già Servizio prevenzione e sicurezza ambienti di lavoro, ASL Brescia;

In Italy, the SARS-CoV-2 pandemic showed the devastating consequences of a widespread biological risk not only for the general population, but also for healthcare workers that diagnose COVID-19 and treat patients. In the set of preventive measures taken to reduce this contagion, a fundamental role in personal protection is played by equipment suitable for preventing the contaminated air inhalation. Despite this severe biological risk during the first epidemic phase, some institutional operating protocols and recommendations have shown limitations and contradictions and, therefore, they must not be repeated. Read More

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Combined predictive performance of age and neutrophilic percentage on admission for severe novel coronavirus disease 2019.

Int J Clin Pract 2021 Apr 21:e14257. Epub 2021 Apr 21.

Department of Intensive Care Unit, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, 12 Jiankang Road Shijiazhuang, Hebei, 050011, China.

Background: Novel coronavirus disease 2019 (COVID-19) poses a huge threat to the global public health. This study aimed to identify predictive indicators of severe COVID-19.

Methods: We retrospectively collected clinical data on hospital admission of all patients with severe COVID-19 and a control cohort (1:1) of gender- and hospital-matched patients with mild disease from 13 designated hospitals in the Hebei province between 22 January and 15 April 2020. Read More

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Profound dysregulation of T cell homeostasisand function in patients with severe COVID-19.

Allergy 2021 Apr 21. Epub 2021 Apr 21.

Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.

Background: Coronavirus disease 2019 (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and shows a broad clinical presentation ranging from asymptomatic infection to fatal disease. A very prominentfeature associated with severe COVID-19 is T cell lymphopenia. However, homeostatic and functional properties of T cells are ill-defined in COVID-19. Read More

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Facilitating Test Status Information Communication in the Time of COVID-19.

Acad Pathol 2021 Jan-Dec;8:23742895211006822. Epub 2021 Apr 9.

Department of Pathology, Children's Hospital of Philadelphia, PA, USA.

The Coronavirus 2019 pandemic has strained nearly every aspect of pathology practice, including preanalytic, analytic, and postanalytic processes. Much of the challenges result from high demand for limited severe acute respiratory syndrome coronavirus 2 testing capacity, a resource required to facilitate patient flow throughout the hospital system and society at large. At our institution, this led to unprecedented increases in inquiries from providers to laboratory staff relating to the expected time to result for their patients. Read More

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A Case of Isolated SARS-CoV-2 Fulminant Myopericarditis Without Respiratory Failure.

Cureus 2021 Mar 19;13(3):e14003. Epub 2021 Mar 19.

Internal Medicine, East Carolina University/Vidant Medical Center, Greenville, USA.

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several cardiovascular complications of COVID-19 have been described in clinical studies. While those with pre-existing cardiovascular disease seem to have worse outcomes, growing evidence suggests that COVID-19 itself can cause myocardial injury, arrhythmia, and heart failure. Read More

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Chemo-Preventive Effect of Vegetables and Fruits Consumption on the COVID-19 Pandemic.

J Nutr Food Sci 2021 25;4(2). Epub 2021 Mar 25.

Department of Biology, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, Box 18750, Jackson, MS 39217, USA.

Coronavirus disease 2019 (COVID-19) is a new disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is a global pandemic that has claimed the death of 1,536,957 human beings worldwide including 287,842 deaths in the United States as of December 3, 2020. It has become a major threat to the medical community and the entire healthcare system in every part of the world. Read More

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Pulmonary Alveolar Microlithiasis: A Unique Case of Familial PAM Complicated by Transplant Rejection.

Case Rep Pathol 2021 5;2021:6674173. Epub 2021 Apr 5.

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Background: Pulmonary alveolar microlithiasis (PAM) is a rare lung disease characterized by the deposition of calcium phosphate microliths or calcospherites, within the alveolar airspace. Typical imaging findings demonstrate a "sandstorm" appearance due to bilateral, interstitial sand-like micronodularities with basal predominance.

Methods And Results: We describe an unusual case of a 48-year-old male with severe, familial PAM ultimately treated with a bilateral lung transplant. Read More

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COVID-19 Guidelines to Protect Healthcare Workers at Hospitals and Dental Professionals at Dental Office.

Ethiop J Health Sci 2020 Nov;30(6):1037-1042

Department of Basic Medical Sciences, Prince Sattam Bin Abdulaziz University, College of Medicine, Al Kharj, Saudi Arabi.

Background: Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. This study aimed to address the preventive procedures to protect healthcare workers at hospital to avoid COVID-19, and infection control procedures to protect dental professionals in dental office.

Methods: We conducted a search of published articles from PubMed, google scholar databases using key words such as COVID-19, healthcare worker, infection control, and dental practice. Read More

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November 2020