7,675 results match your criteria severe preeclampsia

Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

View Article and Full-Text PDF

Hypertensive disorders in women with peripartum cardiomyopathy: insights from the ESC Peripartum Cardiomyopathy Registry.

Eur J Heart Fail 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands.

Aims: Hypertensive disorders occur in women with peripartum cardiomyopathy (PPCM). How often hypertensive disorders co-exist, and to what extent they impact outcomes, is less clear. We describe differences in phenotype and outcomes in women with PPCM with and without hypertensive disorders during pregnancy. Read More

View Article and Full-Text PDF

Pre-eclampsia: incidence, determinants, and pregnancy outcomes from maternity hospitals in Qatar: a population-based case-control study.

J Matern Fetal Neonatal Med 2021 Jun 10:1-9. Epub 2021 Jun 10.

Women's Wellness and Research Center, Doha, Qatar.

Background: We aimed to study the maternal characteristics and obstetric and neonatal outcomes in pregnant mothers with pre-eclampsia (PE) compared to normotensive.

Methods: This was a population-based retrospective data analysis. Data were obtained from the PEARL-Peristat Study perinatal registry (Perinatal Neonatal Outcomes Research Study in the Arabian Gulf) Qatar. Read More

View Article and Full-Text PDF

Relevance of maternal sodium level for preeclampsia-associated adverse pregnancy outcomes.

Pregnancy Hypertens 2021 May 29;25:110-115. Epub 2021 May 29.

Department of Obstetrics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objective: To evaluate maternal sodium levels in women with preeclampsia (PE) or at high risk for preeclampsia and their relevance for severe PE-associated adverse pregnancy outcome and remaining pregnancy duration.

Study Design: In a retrospective cohort of 198 patients presenting with signs and symptoms of preeclampsia (PE), we investigated maternal sodium level and the sFlt-1/PlGF-ratio within 14 days prior to delivery.

Main Outcome Measures: In total, 88 patients (44. Read More

View Article and Full-Text PDF

Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics, Maternal and child health hospital of Hunan Province Changsha, Hunan, China.

Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia. Read More

View Article and Full-Text PDF

[Natural Selection as a Driver for the Genetic Component of Preeclampsia].

Mol Biol (Mosk) 2021 May-Jun;55(3):441-459

Institute of Medical Genetics, Tomsk National Medical Research Center, Russian Academy of Sciences, Tomsk, 634050 Russia.

Preeclampsia (PE) is a severe hypertensive pathology and affects 2-8% of pregnancies worldwide. Its etiopathogenesis is poorly understood, and prognostic biomarkers and effective treatments are unavailable for this pregnancy complication, determining the high rates of maternal and perinatal morbidity and mortality. Racial and ethnic differences in PE incidence are of interest to study in terms of evolutionary medicine because such variability can be considered as a side effect of adaptive changes that have occurred in the genetic structure of modern populations since the dispersal of Homo sapiens from Africa. Read More

View Article and Full-Text PDF

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity.

Thromb J 2021 Jun 5;19(1):41. Epub 2021 Jun 5.

Altai Regional Clinical Hospital, Barnaul, Russia.

Objective: To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes.

Material And Methods: A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7 ± 4. Read More

View Article and Full-Text PDF

Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF-κB signaling.

Immun Inflamm Dis 2021 Jun 5. Epub 2021 Jun 5.

Department 3 of Obstetrics, Cangzhou Central Hospital, Cangzhou, Hebei, China.

Background: Preeclampsia can cause severe consequences for pregnant women and infants, and developing effective medicine or methods to prevent or treat patients with preeclampsia is urgently needed. Ubiquitin-specific protease 14 (USP14) has emerged as a critical regulator in the development of human cancers and neurodegenerative diseases. However, its role in preeclampsia remains elusive. Read More

View Article and Full-Text PDF

Resilience and vulnerability of maternity services in Zimbabwe: a comparative analysis of the effect of Covid-19 and lockdown control measures on maternal and perinatal outcomes, a single-centre cross-sectional study at Mpilo Central Hospital.

BMC Pregnancy Childbirth 2021 Jun 4;21(1):416. Epub 2021 Jun 4.

Department of Obstetrics and Gynaecology, Mpilo Central Hospital, Vera Road, Mzilikazi, Bulawayo, Zimbabwe.

Background: On the 27 of March 2020 the Zimbabwean government declared the Covid-19 pandemic a 'national disaster'. Travel restrictions and emergency regulations have had significant impacts on maternity services, including resource stock-outs, and closure of antenatal clinics during the lockdown period. Estimates of the indirect impact of Covid-19 on maternal and perinatal mortality was expected it to be considerable, but little data was yet available. Read More

View Article and Full-Text PDF

The Impact of COVID-19 on Pregnancy and Therapeutic Drug Development.

Br J Pharmacol 2021 Jun 4. Epub 2021 Jun 4.

Mirzyme Therapeutics, Innovation Birmingham Campus, Faraday Wharf, Holt Street, Birmingham, B7 4BB, United Kingdom.

Emerging data shows pregnant women with COVID-19 are at significantly higher risk of severe outcomes compared to non-pregnant women of similar age. This review discusses the invaluable insight revealed from vaccine clinical trials in women who were vaccinated and inadvertently became pregnant during the trial period. It further explores a number of clinical avenues in their management and proposes a drug development strategy in-line with clinical trials for vaccines and drug treatments for the drug development community. Read More

View Article and Full-Text PDF

Histopathological features of kidney and renal prognosis in patients with preeclampsia.

Pregnancy Hypertens 2021 May 28;25:75-80. Epub 2021 May 28.

Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

Objective: Understanding the long-term prognosis of preeclampsia (PE) is important. Proteinuria and poor renal function persist in some PE patients, but the relationship between their histopathological findings of kidney and renal prognosis is unknown. Our objective was to clarify the relationship between clinicopathological features and renal prognosis in PE patients. Read More

View Article and Full-Text PDF

Lower blood pressure achieved leads to better pregnant outcomes in non-severe chronic hypertensive pregnant women.

Pregnancy Hypertens 2021 May 14;25:62-67. Epub 2021 May 14.

Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objectives: To investigate the relationship between blood pressure (BP) achieved during pregnancy and pregnant outcomes in non-severe chronic hypertensive women.

Study Design: This retrospective cohort study included pregnant women who diagnosed as non-severe chronic hypertension and delivered in Shanghai Renji Hospital from January 2010 to March 2017. Based on their mean antenatal office diastolic BP (dBP), patients were divided into higher BP achieved (HBPA, dBP ≥ 90 mmHg) group or lower BP achieved (LBPA, dBP < 90 mmHg) group. Read More

View Article and Full-Text PDF

Associations between inpatient psychiatric admissions during pregnancy and adverse obstetric and birth outcomes.

Am J Obstet Gynecol MFM 2021 May 31:100413. Epub 2021 May 31.

University of Illinois, Chicago, Department of Obstetrics and Gynecology.

Background: Previous research supports an association between psychiatric diagnoses and adverse obstetric and neonatal outcomes including low birth weight, preterm birth, and preeclampsia. Women who are admitted for inpatient psychiatric care are regarded as having more acute illnesses than those who are able to be managed as outpatients. Prior research has not yet investigated how the severity of psychiatric illness, as indicated by type of antenatal psychiatric care received, is associated with adverse obstetric outcomes. Read More

View Article and Full-Text PDF

The impact of physical activity during pregnancy on labor and delivery.

Am J Obstet Gynecol 2021 May 31. Epub 2021 May 31.

Department of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, St. Louis, MO.

Background: Physical activity in pregnancy is associated with decreased risks of adverse pregnancy outcomes such as gestational diabetes and preeclampsia. However, the relationship between amount and type physical activity during pregnancy and subsequent labor outcomes is unknown.

Objective: We tested the hypothesis that higher levels of physical activity across different lifestyle domains in pregnancy is associated with a shorter duration of labor. Read More

View Article and Full-Text PDF

Planned early delivery for late preterm pre-eclampsia in a low- and middle-income setting: a feasibility study.

Reprod Health 2021 Jun 2;18(1):110. Epub 2021 Jun 2.

Department of Women and Children's Health, School of Life Course Sciences, King's College London, London, UK.

Background: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity globally. Planned delivery between 34 and 36 weeks may reduce adverse pregnancy outcomes but is yet to be evaluated in a low and middle-income setting. Prior to designing a randomised controlled trial to evaluate this in India and Zambia, we carried out a 6-month feasibility study in order to better understand the proposed trial environment and guide development of our intervention. Read More

View Article and Full-Text PDF

Pregnancy Outcomes and SARS-CoV-2 Infection: The Spanish Obstetric Emergency Group Study.

Viruses 2021 05 7;13(5). Epub 2021 May 7.

Department of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Majadahonda, Spain.

Pregnant women who are infected with SARS-CoV-2 are at an increased risk of adverse perinatal outcomes. With this study, we aimed to better understand the relationship between maternal infection and perinatal outcomes, especially preterm births, and the underlying medical and interventionist factors. This was a prospective observational study carried out in 78 centers (Spanish Obstetric Emergency Group) with a cohort of 1347 SARS-CoV-2 PCR-positive pregnant women registered consecutively between 26 February and 5 November 2020, and a concurrent sample of PCR-negative mothers. Read More

View Article and Full-Text PDF

Acid Sensing Ion Channel 2a Is Reduced in the Reduced Uterine Perfusion Pressure Mouse Model and Increases Seizure Susceptibility in Pregnant Mice.

Cells 2021 May 8;10(5). Epub 2021 May 8.

Department of Neurology, University of Mississippi Medical Center, Jackson, MS 39216, USA.

Eclampsia is diagnosed in pregnant women who develop novel seizures. Our laboratory showed that the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia displays reduced latency to drug-induced seizures. While acid sensing ion channels (ASIC1a and 3) are important for reducing seizure longevity and severity, the role of ASIC2a in mediating seizure sensitivity in pregnancy has not been investigated. Read More

View Article and Full-Text PDF

Greenspace, Air Pollution, Neighborhood Factors, and Preeclampsia in a Population-Based Case-Control Study in California.

Int J Environ Res Public Health 2021 May 12;18(10). Epub 2021 May 12.

Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

To investigate preeclampsia etiologies, we examined relationships between greenspace, air pollution, and neighborhood factors. Data were from hospital records and geocoded residences of 77,406 women in San Joaquin Valley, California from 2000 to 2006. Preeclampsia was divided into mild, severe, or superimposed onto pre-existing hypertension. Read More

View Article and Full-Text PDF

Reduced mechanical function of the left atrial predicts adverse outcome in pregnant women with clustering of metabolic risk factors.

BMC Cardiovasc Disord 2021 May 29;21(1):265. Epub 2021 May 29.

Department of Echocardiography, Heart Center, Beijing ChaoYang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.

Introduction: The left atrial (LA) strain and strain rate are sensitive indicators of LA function. However, they are not widely used for the evaluation of pregnant women with metabolic diseases. The aim of this study was to assess the LA strain and strain rate of pregnant women with clustering of metabolic risk factors and to explore its prognostic effect on adverse pregnancy outcomes. Read More

View Article and Full-Text PDF

Pregnancy Outcomes Post-bariatric Surgery-a Single-Centre Retrospective Study from India.

Obes Surg 2021 May 29. Epub 2021 May 29.

Nobesity Bariatric Center at KD Hospital, Vaishnodevi Circle, SG Road, Ahmedabad, 382421, India.

Background: Bariatric surgery presently is the best possible intervention for treatment of severe obesity and its related conditions. This study presents retrospective data on the pregnancy outcomes of Indian patients who underwent bariatric surgery before conception.

Methodology: This is a single-centre retrospective, observational study. Read More

View Article and Full-Text PDF

Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARγ-UCP2 cascade.

FASEB J 2021 Jun;35(6):e21555

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Preeclampsia (PE) is a life-threatening disease of pregnant women associated with severe hypertension, proteinuria, or multi-organ injuries. Mitochondrial-mediated placental oxidative stress plays a key role in the pathogenesis of PE. However, the underlying mechanism remains to be revealed. Read More

View Article and Full-Text PDF

Profile of Obstetric Patients in Intensive Care Unit: A Retrospective Study from a Tertiary Care Center in North India.

Indian J Crit Care Med 2021 Apr;25(4):388-391

Department of Biochemistry, Government Medical College, Jammu, Jammu and Kashmir, India.

Background: Critically ill obstetric patients constitute a small number of intensive care unit (ICU) admissions. Physiological changes in pregnancy along with certain pregnancy-specific diseases may cause a rapid worsening of the health status of the patient necessitating ICU care. The present study aims to study the clinical profile of the obstetric patients requiring ICU care. Read More

View Article and Full-Text PDF

Changes in rate of preterm birth and adverse pregnancy outcomes attributed to preeclampsia after introduction of a refined definition of preeclampsia: a population-based study.

Acta Obstet Gynecol Scand 2021 May 27. Epub 2021 May 27.

Department of Obstetrics and Gynecology, Saint Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Introduction: Since 2013 various guidelines for hypertension in pregnancy were refined, no longer requiring proteinuria as a requisite for preeclampsia. We aimed to evaluate the impact of the new definition on preterm birth (PTB) and adverse pregnancy outcomes.

Methods: Women delivering in Ontario between 4/2012-11/2016 were included. Read More

View Article and Full-Text PDF

Progression from isolated gestational proteinuria to pre-eclampsia with severe features.

Acta Obstet Gynecol Scand 2021 May 27. Epub 2021 May 27.

Lis Hospital for Women, Department of Obstetrics & Gynecology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Introduction: The association between the degree of isolated gestational proteinuria and pre-eclampsia with severe features and other placental mediated complications is controversial. The aim of this study was to evaluate whether a higher isolated proteinuria level is associated with an increased frequency of pre-eclampsia with severe features.

Material And Methods: This retrospective cohort study included pregnant women who were past 24 weeks of gestation and were diagnosed as having new-onset proteinuria ≥300 mg in a 24-hour urine collection. Read More

View Article and Full-Text PDF

Abdelazim equation: For 24-h urine protein from spot urine sample in preeclampsia.

J Family Med Prim Care 2021 Mar 8;10(3):1493-1495. Epub 2021 Apr 8.

Department of Obstetrics and Gynecology, Ain Shams University, Cairo, Egypt.

Measurement of 24-h urine protein (UP) is the standard method for detection of proteinuria in preeclampsia (PE). A 24-h urine sampling is time-consuming, inconvenient, and delays the diagnosis of PE. A 29-year-old woman, previous cesarean section (CS), pregnant 37 weeks', mild PE, and another 31-year-old woman, primipara, pregnant 34 weeks', severe PE, were admitted for control of blood pressure and termination of pregnancy. Read More

View Article and Full-Text PDF

Role of platelet count and mean platelet volume and red cell distribution width in the prediction of preeclampsia in early pregnancy.

J Family Med Prim Care 2021 Feb 27;10(2):838-843. Epub 2021 Feb 27.

Department of Geriatric Mental Health, King George Medical University, Lucknow, Uttar Pradesh, India.

Introduction: Mean platelet volume (MPV), platelet count (PC), and red cell distribution width (RDW) are various blood indices that play important role in preeclampsia. This study aimed to evaluate the role of MPV, RDW, and PC for the prediction of preeclampsia in the early second trimester of pregnancy and to observe its correlation with disease severity.

Material And Methods: A prospective case-control study was conducted for 1 year in the Department of Obstetrics and Gynecology. Read More

View Article and Full-Text PDF
February 2021

A Review of Research Progress of Pregnancy with Twins with Preeclampsia.

Risk Manag Healthc Policy 2021 18;14:1999-2010. Epub 2021 May 18.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.

Preeclampsia has a significant long-term effect on the health of both mothers and babies. Preeclampsia-related pregnancy complications increase the morbidity and mortality of pregnant women and their fetuses by 5-8%. The recent advancement of assisted reproductive technology, combined with a rise in the number of elderly pregnant women, has resulted in pregnancy incidence with twins. Read More

View Article and Full-Text PDF

Association of antenatal steroids with neonatal mortality and morbidity in preterm infants born to mothers with diabetes mellitus and hypertension.

J Perinatol 2021 May 25. Epub 2021 May 25.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Randomized trials of antenatal steroids (ANS) included women at 24-33 weeks gestational age (GA); however, few women had preeclampsia and women with diabetes mellitus (DM) were excluded.

Methods: Cohort study including preterm births at 23-28 weeks GA before (Epoch-1) and after (Epoch-2) expansion of ANS administration to women with DM and hypertensive disorders (HTN). We compared Group-A (neither DM nor HTN) and Group-B (DM and/or HTN). Read More

View Article and Full-Text PDF