533,454 results match your criteria severe patients


Continuous Quantitative Electroencephalogram (EEG) Monitoring for Early Detection of Brain Herniation in Large Hemispheric Infarction (LHI): A Case Report.

J Stroke Cerebrovasc Dis 2021 Oct 20;31(1):106158. Epub 2021 Oct 20.

Neurocritical care unit, Department of Neurology, The Second Hospital of Hebei Medical University, 215 Heping West Road, Xinhua District, Shijiazhuang, Hebei 050000, China. Electronic address:

Background: Computer-assisted electroencephalography (EEG) systems may improve the likelihood of detecting abnormal EEGs in adult patients with severe disease.

Case Presentation: We implemented long-range EEG monitoring in a patient with large hemispheric infarction (LHI) and explored its real-time changes in reflecting the patient's brain function. The bands of Alpha, Beta, Delta, Theta, DAR (Delta/Alpha), DTABR (Delta+Theta/Alpha+Beta), and brain symmetry index (BSI) were calculated as a ratio of total power. Read More

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October 2021

Prognostic capacity of inferior vena cava diameter for severe postpartum hemorrhage.

Eur J Obstet Gynecol Reprod Biol 2021 Oct 16;267:6-10. Epub 2021 Oct 16.

Department of Gynecology and Obstetrics, Aksaray University Education and Research Hospital, Aksaray, Turkey. Electronic address:

Purpose: This study sought to evaluate whether or not the sonographic measurement of the inferior vena cava (IVC) diameter predicts severe bleeding in women with postpartum hemorrhage (PPH). It further compared the efficacy of the IVC diameter, shock index, and serum lactate levels in this prediction.

Methods: This prospective study included female patients with ≥500 mL of bleeding after vaginal delivery between September 1, 2019 and May 31, 2021. Read More

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October 2021

Early onset externalizing behaviors among forensic psychiatric patients: Identification in child and adolescent psychiatric services.

Psychiatry Res 2021 Oct 13;305:114235. Epub 2021 Oct 13.

Child and Adolescent Psychiatry, Department of Clinical Sciences Lund, Lund University, Sofiavägen 2D, Lund SE-22241, Sweden; Centre for Ethics, Law and Mental Health, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; Research Department, Regional Forensic Psychiatric Clinic Växjö, Sweden.

Forensic psychiatric patients constitute a heterogeneous patient group, with common comorbidity within the externalizing spectrum. Increased knowledge on early antecedents in the pathway to severe mental illness and criminality is needed. In this study, we investigated early onset externalizing behaviors in three groups of forensic psychiatric patients 1) patients without contact with child and adolescent psychiatry (CAP), 2) patients with CAP contact, and 3) patients with both CAP contact and institutional placement. Read More

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October 2021

A convolutional neural network trained with dermoscopic images of psoriasis performed on par with 230 dermatologists.

Comput Biol Med 2021 Oct 6;139:104924. Epub 2021 Oct 6.

Image Processing Center, School of Astronautics, Beihang University, Beijing, 100191, China; Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100191, China.

Background: Psoriasis is a common chronic inflammatory skin disease that causes physical and psychological burden to patients. A Convolutional Neural Network (CNN) focused on dermoscopic images would substantially aid the classification and increase the accuracy of diagnosis of psoriasis.

Objectives: This study aimed to train an efficient deep-learning network to recognize dermoscopic images of psoriasis (and other papulosquamous diseases), improving the accuracy of the diagnosis of psoriasis. Read More

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October 2021

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19.

Int Immunopharmacol 2021 Oct 15;101(Pt B):108255. Epub 2021 Oct 15.

COVID-19 Vaccination Centres, University College London Hospitals, National Health Service, N10QH London, England.

The coronavirus disease (COVID-19) has once again reminded us of the significance of host immune response and consequential havocs of the immune dysregulation. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) inflicts severe complications to the infected host, including cough, dyspnoea, fever, septic shock, acute respiratory distress syndrome (ARDs), and multiple organ failure. These manifestations are the consequence of the dysregulated immune system, which gives rise to excessive and unattended production of pro-inflammatory mediators. Read More

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October 2021

Factors predicting morbidity in surgically-staged high-risk endometrial cancer patients.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 28;266:169-174. Epub 2021 Sep 28.

Gynecological Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Objective: To investigate factors predicting the risk of developing 90-day postoperative complications and lymphatic-specific morbidity in patients undergoing surgical staging for high-risk endometrial cancer.

Methods: This is a multi-institutional retrospective cohort study. Patients affected by apparent early-stage high-risk endometrial cancer (endometrioid FIGO grade 3 with deep myometrial invasion and non-endometrioid endometrial cancer) undergoing surgical staging between 2007 and 2019. Read More

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September 2021

A multilevel noncontiguous spinal fracture with cervical and thoracic spinal cord injury.

Int J Surg Case Rep 2021 Oct 19;88:106529. Epub 2021 Oct 19.

Department of Orthopaedics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

Introduction And Importance: A multi-level non-contiguous spinal fracture (MNSF) caused by a high-energy impact is a type of complex traumatic injury that is been frequently initially missed, and resulting in delayed diagnosis which adversely affects can result in spinal deformity and neurological deficit. This report describes the operative management of a patient with MNSF with spinal cord injury involving the cervical and thoracic vertebrae by cervical orthosis and posterior thoracic decompression and fusion.

Case Presentation: An 18-year-old male presented with extensive neck pain and paraplegia (ASIA A), following a motor vehicle accident. Read More

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October 2021

Finite element modelling of the surgical procedure for placement of a straight electrode array: Mechanical and clinical consequences.

J Biomech 2021 Oct 16;129:110812. Epub 2021 Oct 16.

INEGI, Institute of Science and Innovation in Mechanical and Industrial Engineering, Porto, Portugal; FEUP, Faculty of Engineering, University of Porto, Porto, Portugal. Electronic address:

A cochlear implant is an electronic device implanted into the cochlea to directly stimulate the auditory nerve. Such device is used in patients with severe-to-profound hearing loss. The cochlear implant surgery is safe, but involves some risks, such as infections, device malfunction or damage of the facial nerve and it can result on a poor hearing outcome, due to the destruction of any present residual hearing. Read More

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October 2021

Functional outcome in patients with Charcot neuropathy with almost complete loss of talus treated by tibio-talo calcaneal nail: A cross-sectional study.

Foot (Edinb) 2021 Oct 20;49:101833. Epub 2021 Oct 20.

Department of Orthopaedic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.

Introduction: Tibio-talo-calcaneal (TTC) fusion is a successful surgery for Charcot neuropathy affecting the hindfoot. A case series of Charcot neuropathy is presented with almost complete loss affecting hindfoot treated with tibio-talo-calcaneal nail.

Material And Methods: Seven patients with Charcot neuropathy of the hindfoot having varying degrees of talus loss underwent tibio-talo-calcaneal nailing between January 2014 and Feb 2016 at a tertiary care hospital by a single surgeon. Read More

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October 2021

Epidemiology of paediatric moderate and severe traumatic brain injury in the Netherlands.

Eur J Paediatr Neurol 2021 Oct 9;35:123-129. Epub 2021 Oct 9.

Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: Traumatic brain injury (TBI) is the main cause of death in children around the world. The last Dutch epidemiological study described the incidence over 10 years ago. Mechanism of injury seems to change with the age of the child, therefore it is important to appreciate different age groups. Read More

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October 2021

Transcranial direct current stimulation combined with alcohol cue inhibitory control training reduces the risk of early alcohol relapse: A randomized placebo-controlled clinical trial.

Brain Stimul 2021 Oct 20. Epub 2021 Oct 20.

Laboratoire de Psychologie Médicale et D'Addictologie, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium; ULB Neuroscience Institute (UNI), Belgium; Faculty of Psychology, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address:

Background: Approximately half of all people with alcohol use disorder (AUD) relapse into alcohol reuse in the next few weeks after a withdrawal treatment. Brain stimulation and cognitive training represent recent forms of complementary interventions in the context of AUD.

Objective: To evaluate the clinical efficacy of five sessions of 2 mA bilateral transcranial direct current stimulation (tDCS) for 20 min over the dorsolateral prefrontal cortex (DLPFC) (left cathodal/right anodal) combined with alcohol cue inhibitory control training (ICT) as part of rehabilitation. Read More

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October 2021

Cognitive Assessment scale for Stroke Patients (CASP): a multicentric validation study.

Ann Phys Rehabil Med 2021 Oct 20:101594. Epub 2021 Oct 20.

Centre d'Investigation Clinique CIC 1432 and University of Bourgogne-Franche-Comté, France.

Background: The Mini Mental State Examination and Montreal Cognitive Assessment are commonly used as short screening batteries for assessing cognitive impairment after stroke. However, aphasia or hemispatial neglect may interfere with the results. For this reason, we developed the Cognitive Assessment scale for Stroke Patients (CASP), which takes these conditions into consideration and previously demonstrated its superiority over these scales in terms of feasibility. Read More

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October 2021

Surgical site infection prevention through bundled interventions in hip replacement surgery: A systematic review.

Int J Surg 2021 Oct 20:106149. Epub 2021 Oct 20.

Department of Public Health and Paediatrics, University of Turin, Via Santena 5 bis, 10126, Turin, Italy. Electronic address:

Background: Bundles have shown to improve patient outcomes in several settings. Surgical site infections (SSIs) following joint replacement surgery are associated with severe outcomes. We aimed to determine the effectiveness of non-pathogen specific bundled interventions in reducing SSIs after hip arthroplasty procedures. Read More

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October 2021

The impact of upper extremity injuries on polytrauma patients at a level 1 Trauma Center.

J Shoulder Elbow Surg 2021 Oct 20. Epub 2021 Oct 20.

Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands. Electronic address:

Background: Upper extremity injuries often lead to long-term problems in function and quality of life in patients. However, not much is known about this effect in polytrauma patients. This study aimed to describe the upper extremity injuries in polytrauma patients and to compare self-reported disability and quality of life in polytrauma patients with versus without upper extremity injuries. Read More

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October 2021

Severe herpes simplex and varicella-zoster viral infection in patients with solid organ transplantation: A nationwide population-based cohort study with propensity score matching analysis.

J Am Acad Dermatol 2021 Oct 20. Epub 2021 Oct 20.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan; Center of Augmented Intelligence in Healthcare, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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October 2021

Prolonged impairment of short-chain fatty acid and L-isoleucine biosynthesis in gut microbiome in patients with COVID-19.

Gastroenterology 2021 Oct 20. Epub 2021 Oct 20.

Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Shatin, Hong Kong, China; State Key Laboratory for Digestive disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China. Electronic address:

Background & Aims: SARS-CoV-2 infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids were depleted in SARS-CoV-2-infected patients. We aimed to characterize functional profile of gut microbiome in patients with COVID-19 before and after disease resolution. Read More

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October 2021

Symptomology following mRNA vaccination against SARS-CoV-2.

Prev Med 2021 Oct 20:106860. Epub 2021 Oct 20.

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Despite demonstrated efficacy of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease-2019 (COVID-19), widespread hesitancy to vaccination persists. Improved knowledge regarding frequency, severity, and duration of vaccine-associated symptoms may help reduce hesitancy. In this prospective observational study, we studied 1032 healthcare workers who received both doses of the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine and completed post-vaccine symptom surveys both after dose 1 and after dose 2. Read More

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October 2021

Altered oxylipin levels in human vitreous indicate imbalance in pro-/anti-inflammatory homeostasis in proliferative diabetic retinopathy.

Exp Eye Res 2021 Oct 20:108799. Epub 2021 Oct 20.

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha, Hunan, China. Electronic address:

Proliferative diabetic retinopathy (PDR) is an advanced stage of diabetic retinopathy (DR), characterized by retinal neovascularization. It is a progressive fundus disease and a severe complication of diabetes that causes vision impairment. Hyperglycemia-induced persistent low-grade inflammation is a crucial factor underlying the pathogenesis of DR-associated damage and contributing to the progression of PDR. Read More

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October 2021

Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients.

Biochem Pharmacol 2021 Oct 20:114812. Epub 2021 Oct 20.

Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

Pulmonary fibrosis (PF) is characterised by several grades of chronic inflammation and collagen deposition in the interalveolar space and is a hallmark of interstitial lung diseases (ILDs). Recently, infectious agents have emerged as driving causes for PF development; however, the role of viral/bacterial infections in the initiation and propagation of PF is still debated. In this context, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for the current coronavirus disease 2019 (COVID-19) pandemic, has been associated with acute respiratory distress syndrome (ARDS) and PF development. Read More

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October 2021

Speckle-tracking-based global longitudinal and circumferential strain detect early signs of antibody-mediated rejection in heart transplant patients.

Eur Heart J Cardiovasc Imaging 2021 Oct 23. Epub 2021 Oct 23.

Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

Aims: Acute rejection is an important cause of mortality after heart transplant (HTx), but symptoms develop only when myocardial damage is already extensive. We sought to investigate if echocardiographic parameters can detect and predict an acute cellular rejection (ACR) or antibody-mediated rejection (AMR) episode in HTx patients.

Methods And Results: Data of 403 consecutive HTx recipients between 2003 and 2020 from our centre were reviewed. Read More

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October 2021

Surgical management of failing Fontan circulation: results from 30 cases with 285 patient-years follow-up.

Eur J Cardiothorac Surg 2021 Oct 23. Epub 2021 Oct 23.

Pediatric and Congenital Cardiac Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova Medical School, Padova, Italy.

Objectives: Fontan patients are known to suffer from clinical attrition over the years, which has been characterized as Fontan failure. We sought to evaluate the clinical outcomes of such Fontan patients undergoing surgical management in a 25-year, single-centre experience.

Methods: A retrospective single-centre analysis of patients undergoing surgical treatment for failing Fontan between 1995 and 2020, including any reoperations when ventricular function was preserved, or a heart transplant (HTx), when ventricular contractility was impaired. Read More

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October 2021

Structural valve deterioration of the Labcor Dokimos aortic prosthesis: a single-centre experience.

Interact Cardiovasc Thorac Surg 2021 Oct 23. Epub 2021 Oct 23.

Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon.

Objectives: The goal of this study was to assess the performance and incidence of the deterioration of the Labcor Dokimos bioprosthetic aortic valve.

Methods: We performed a retrospective medical chart review of 116 patients who underwent surgical aortic valve replacement with the Labcor Dokimos aortic valve between 2010 and 2018. Abstracted data included patient demographic and echocardiographic data. Read More

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October 2021

How prevalent and severe is addiction on GABAmimetic drugs in an elderly German general hospital population? Focus on gabapentinoids, benzodiazepines, and z-hypnotic drugs.

Hum Psychopharmacol 2021 Oct 23:e2822. Epub 2021 Oct 23.

Northern Anesthesia & Pain Medicine, LLC, Eagle River, Alaska, USA.

Objective: Gabapentinoids (GPT) are reported to be increasingly misused by opioid- and polydrug-users, but the addictive potential of GPT outside of these populations remains understudied. Investigations comparing GPT abuse and dependence liability to that of other commonly prescribed Central Nervous System-acting medications are therefore warranted. We provide a comparison of GPT-abuse/dependence to that of other GABAmimetics within an elderly population. Read More

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October 2021

Chronic Lymphocytic Thyroiditis and Aggressiveness of Pediatric Differentiated Thyroid Cancer.

Laryngoscope 2021 Oct 23. Epub 2021 Oct 23.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.

Objectives/hypothesis: Hashimoto's Thyroiditis (HT) is a common cause of hypothyroidism. Among adults with differentiated thyroid cancer (DTC), HT appears to be associated with less severe disease burden. In the absence of information regarding HT and disease burden among children with DTC, we assessed the relationship between pediatric DTC severity and HT. Read More

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October 2021

Efficacy of Interferon-β in Moderate-to-Severe Hospitalised Cases of COVID-19: A Systematic Review and Meta-analysis.

Clin Drug Investig 2021 Oct 23. Epub 2021 Oct 23.

All India Institute of Medical Sciences, Deoghar, India.

Background And Objective: Interferon-β, as with several other anti-viral agents, has been investigated as a treatment option for COVID-19 as a repurposed drug. The present study is a systematic review and meta-analysis of interferon-β to determine its efficacy among moderate-to-severe COVID-19 patients.

Methods: A systematic literature search was done using relevant terms for 'COVID-19' and 'interferon-β'. Read More

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October 2021

A Survey of Bariatric/Metabolic Surgery as a Treatment Option for Patients with Severe Obesity and Type 2 Diabetes in Japan.

Obes Surg 2021 Oct 23. Epub 2021 Oct 23.

Center of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, 564-1, Shimoshizu, Sakura City, Chiba, 285-8741, Japan.

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October 2021

Cellular and molecular mechanisms in COVID-19 coagulopathy: role of inflammation and endotheliopathy.

J Thromb Thrombolysis 2021 Oct 23. Epub 2021 Oct 23.

Hemostasis Unit, Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.

Introduction: Coronavirus 2 (CoV-2) infection or coronavirus disease 2019 (COVID-19) is frequently associated with microvascular thrombosis.The microthrombosis in COVID-19 is the result of the interplay between inflammation and endotheliopathy. Elevated interleukin-6 (IL-6) characterizes COVID-19 inflammation resulting in endotheliopathy and coagulopathy marked by elevated D-dimer (DD). Read More

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October 2021

COVID-19 and idiopathic nephrotic syndrome in children: systematic review of the literature and recommendations from a highly affected area.

Pediatr Nephrol 2021 Oct 23. Epub 2021 Oct 23.

Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milano, Italy.

Background: Coronavirus Disease 2019 has spread from China as a global pandemic, Italy being one of the earliest affected countries. The infection displays a more complicated and often fatal course in adults with a history of kidney disease, while it does not seem to affect children in the same way. Pediatric patients with idiopathic nephrotic syndrome (INS), with or without chronic immunosuppressive therapy, are at greater risk of infections which may also trigger relapses. Read More

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October 2021

Transcriptomic characteristics and impaired immune function of patients who retest positive for SARS-CoV-2 RNA.

J Mol Cell Biol 2021 Oct 23. Epub 2021 Oct 23.

Department of Hematology, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has become a global public health crisis. Some patients who have recovered from COVID-19 subsequently test positive again for SARS-CoV-2 RNA after discharge from hospital. How such retest-positive (RTP) patients become infected again is not known. Read More

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October 2021