80,568 results match your criteria severe pain


A pediatric case of Bartonella henselae and Epstein Barr virus disease with bone and hepatosplenic involvement.

Bol Med Hosp Infant Mex 2021 ;78(5):467-473

Hospital Francisco Grande Covián, Parres. Asturias, Spain.

Background: Cat scratch disease (CSD) is an infectious disorder caused by Bartonella henselae. The infection usually presents as local lymphadenopathy, fever, and mild constitutional symptoms. Systemic or severe disease is reported in 5-20% of patients with CSD. Read More

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January 2021

Small bowel obstruction and ileocolic fistula caused by post-myomectomy Gossypiboma transmural migration: A case report and review of the literature.

Int J Surg Case Rep 2021 Sep 22;87:106431. Epub 2021 Sep 22.

Sudan Medical Specialization Board, Khartoum, Sudan.

Introduction: Post-myomectomy Gossypiboma causing Ileo-colic fistula is tremendously rare; it may present as a tumor and stand a diagnostic challenge. The duration between the primary procedure and the presentation is unpredictable.

Case Presentation: A 37-year-old Sudanese/African woman presented with a 4-month history of left iliac fossa mass, pain, anorexia, and persistent, recurrent vomiting with episodes of diarrhea during the last month PTP. Read More

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September 2021

TRPC3 Antagonizes Pruritus in A Mouse Contact Dermatitis Model.

J Invest Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Contact dermatitis (CD), including allergic and irritant CD, are common dermatological diseases and characterized by an erythematous rash and severe itch. In this study, we investigated the function of TRPC3, a canonical TRP channel highly expressed in type 1 non-peptidergic (NP1) nociceptive primary afferents and other cell types, in a mouse CD model. Though TrpC3 null mice had little deficits in acute somatosensation, they showed significantly increased scratching with CD. Read More

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September 2021

Corneal nerve loss is related to the severity of painful diabetic neuropathy.

Eur J Neurol 2021 Sep 27. Epub 2021 Sep 27.

Division of Cardiovascular Sciences, Cardiac Centre, Faculty of Biology, Medicine and Health, University of Manchester and NIHR/Wellcome Trust Clinical Research Facility, Manchester, UK.

Background And Aim: Previously we have shown that patients with painful diabetic neuropathy have greater corneal nerve loss compared to patients with painless diabetic neuropathy. This study investigated if the severity of corneal nerve loss was related to the severity of painful diabetic neuropathy (PDN).

Methods: Participants with diabetic neuropathy (n=118) and healthy controls (n=38) underwent clinical and neurological evaluation, quantitative sensory testing, nerve conduction testing and corneal confocal microscopy (CCM) and were categorized into those with no (n=43), mild (n=34) and moderate-to-severe (n=41) neuropathic pain. Read More

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September 2021

A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries.

Acta Anaesthesiol Scand 2021 Sep 27. Epub 2021 Sep 27.

Department of Anaesthesiology and Critical Care, Perioperative services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

Background: We sought to provide a description of surge response strategies and characteristics, clinical management and outcomes of patients with severe COVID-19 in the intensive care unit (ICU) during the first wave of the pandemic in Denmark, Finland, Iceland, Norway and Sweden.

Methods: Representatives from the national ICU registries for each of the five countries provided clinical data and a description of the strategies to allocate ICU resources and increase the ICU capacity during the pandemic. All adult patients admitted to the ICU for COVID-19 disease during the first wave of COVID-19 were included. Read More

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September 2021

Clinical presentation and assessment of older patients presenting with headache to emergency departments: A multicentre observational study.

Australas J Ageing 2021 Sep 27. Epub 2021 Sep 27.

Emergency Medicine Department, Tours University Hospital, Tours, France.

Objective: To describe the characteristics, assessment and management of older emergency department (ED) patients with non-traumatic headache.

Methods: Planned sub-study of a prospective, multicentre, international, observational study, which included adult patients presenting to ED with non-traumatic headache. Patients aged ≥75 years were compared to those aged <75 years. Read More

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September 2021

The "Fracking" technique: a novel approach to crack deep calcified plaque in the common femoral artery with hydraulic pressure.

CVIR Endovasc 2021 Sep 27;4(1):70. Epub 2021 Sep 27.

Director of Cardiology and Head of Peripheral Artery Disease Center, Sapporo Heart Center, North 49, East 16, 8-1, Higashi ward, Sapporo, Hokkaido, 007-0849, Japan.

Background: The patency achieved by conventional peripheral interventions for atherosclerotic lesions in the common femoral artery (CFA), called the "no stenting zone", is not superior to that achieved by surgical endarterectomy due to calcified plaque occupying the area. Plaque modification strategies to obtain acute gain in CFA patency provide the better clinical outcomes than standard balloon angioplasty. Atherectomy devices, which focus on the modification of superficial calcifications, contribute to the improvement of clinical outcomes. Read More

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September 2021

Effectiveness of a Psychosocial Aftercare Program for Youth Aged 8 to 17 Years With Severe Chronic Pain: A Randomized Clinical Trial.

JAMA Netw Open 2021 Sep 1;4(9):e2127024. Epub 2021 Sep 1.

German Paediatric Pain Centre, Children's and Adolescents' Hospital, Datteln, Germany.

Importance: Severe chronic pediatric pain causes individual suffering and significantly affects social functioning and psychological well-being. For children with high pain severity, intensive interdisciplinary pain treatment (IIPT) is a well-established treatment. However, across specialized centers, it is not sufficient for all patients. Read More

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September 2021

[Duodenal hematoma after upper gastrointestinal endoscopy in pediatric graft vs host disease: Report of two cases].

Arch Argent Pediatr 2021 Oct;119(5):e513-e517

Servicio de Clínica Pediátrica, Departamento de Pediatría, Hospital Italiano de Buenos Aires. Ciudad Autónoma de Buenos Aires, Argentina.

Graft versus host disease is a serious complication that occurs following bone marrow transplant with significant morbidity and mortality. The gold standard to diagnose gastrointestinal graft versus host disease is upper and lower gastrointestinal endoscopy with histological validation. The development of intramural duodenal hematoma is a rare complication associated with this procedure. Read More

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October 2021

[Progress on surgical treatment for hemophiliac arthropathy].

Zhongguo Gu Shang 2021 Sep;34(9):820-5

The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.

Surgical treatment is the main treatment for hemophilia arthritis, including synoviectomy, joint replacement and joint fusion. Synoviectomy is suitable for early hemophilia synovitis, and is divided into radiation, chemical, arthroscopy, and open operation. Radionuclides were recommended as the first choice due to its positive efficacy and less side effects, but exsit some problems such as scarcity of nuclides. Read More

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September 2021

Necrotizing Soft Tissue Infections, the Challenge Remains.

Front Surg 2021 9;8:721214. Epub 2021 Sep 9.

Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands.

Necrotizing Soft Tissue Infections (NSTIs) are uncommon rapidly spreading infection of the soft tissues for which prompt surgical treatment is vital for survival. Currently, even with sufficient awareness and facilities available, ambiguous symptoms frequently result in treatment delay. To illustrate the heterogeneity in presentation of NSTIs and the pitfalls entailing from this heterogeneity. Read More

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September 2021

Primary Renal Synovial Sarcoma Presenting as Haemorrhagic Shock: A Rare Presentation.

J Kidney Cancer VHL 2021 3;8(3):1-4. Epub 2021 Sep 3.

Division of Urology, Department of Surgery, Ministry of the National Guard - Health Affairs, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Primary synovial sarcoma (PSS) of the kidney is considered the rarest type of all renal sarcomas with specific chromosomal translocation t (X; 18) (p11.2; q11.2). Read More

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September 2021

Ovarian Cystic Teratoma in Pregnant Women: Conservative Management or Prophylactic Oophorectomy?

Cureus 2021 Aug 21;13(8):e17354. Epub 2021 Aug 21.

Obstetrics and Gynecology, Beaumont Hospital, Dearborn, USA.

Acute abdominal pain in pregnancy is common and the differential diagnosis is vast. Mature cystic teratomas are rarely the cause of adnexal torsion during pregnancy and can be difficult to diagnose. Timely surgical intervention is required to avoid ovarian infarction. Read More

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Unusual Presentation of COVID Pneumonia as Esophageal Rupture Ended With Successful Management.

Cureus 2021 Aug 21;13(8):e17348. Epub 2021 Aug 21.

Radiology, Stony Brook University, Port Jefferson, USA.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a severe respiratory syndrome. It started as an epidemic in Wuhan, China, and then become a global pandemic. COVID-19 usually presents with respiratory symptoms, including cough and shortness of breath, accompanied by fever. Read More

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Therapeutic Plasmapheresis: A Treatment Modality in Severe Hypertriglyceridemia in Adolescence.

Cureus 2021 Aug 20;13(8):e17341. Epub 2021 Aug 20.

Intensive Care Unit, National Medical Centre, Karachi, PAK.

Severe hypertriglyceridemia (SHTG) is defined as plasma triglycerides >1000 mg/dl. It is a rare and understudied condition in children and adolescents. SHTG in pediatric patients may occur as a result of certain genetic disorders of enzymes involved in triglyceride synthesis and metabolism, or it may be seen secondary to uncontrolled diabetes, obesity, metabolic syndrome, or certain medications. Read More

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When intra-operative exploration is the only option, severe medically refractory trigeminal neuralgia.

J Community Hosp Intern Med Perspect 2021 20;11(5):686-688. Epub 2021 Sep 20.

Medical Student, Mid-Columbia Medical Center Celilo Cancer Center, India.

Patients with trigeminal neuralgia (TN) are usually treated on an outpatient basis, and symptoms can be controlled using various medical therapeutic options. We present a case of severe TN with an acute on chronic flare, which was now refractory to a wide variety of medical options, had a prolonged inpatient hospitalization, and ultimately required surgery with excellent results. A 54-year-old Hispanic male was admitted with severe left-sided TN. Read More

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September 2021

A Peripheral Immune Signature of Labor Induction.

Front Immunol 2021 9;12:725989. Epub 2021 Sep 9.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, United States.

Approximately 1 in 4 pregnant women in the United States undergo labor induction. The onset and establishment of labor, particularly induced labor, is a complex and dynamic process influenced by multiple endocrine, inflammatory, and mechanical factors as well as obstetric and pharmacological interventions. The duration from labor induction to the onset of active labor remains unpredictable. Read More

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September 2021

Posterior Interosseous Fascicular Constriction Within the Radial Nerve in a Diabetic Patient With Bilateral Neuralgic Amyotrophy: A Case Report.

Front Neurol 2021 8;12:701571. Epub 2021 Sep 8.

Department of Neurology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, South Korea.

Neuralgic amyotrophy (NA) is an acute, monophasic, painful inflammatory dysimmune focal, or multifocal mononeuropathy. The lesion in NA is not always restricted to the brachial plexus but also involves individual nerves or branches. The prognosis of NA is less favorable than previously assumed, but the reasons for poor recovery remain unknown. Read More

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September 2021

Emphysematous Pyelonephritis and Emphysematous Cholecystitis: A Result of Uncontrolled Type 2 Diabetes.

Ochsner J 2021 ;21(3):316-318

Department of Urology, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

Emphysematous pyelonephritis (EPN) is a life-threatening necrotizing infection that results in the presence of gas in the renal parenchyma, collecting system, and surrounding tissues. Up to 95% of patients with EPN have underlying uncontrolled diabetes mellitus. Emphysematous cholecystitis (EC) is a necrotizing infection defined by the presence of gas in the gallbladder. Read More

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January 2021

Topical ALA-Photodynamic Therapy Combined with Acne Debridement and Meticulous Nursing for the Treatment of Moderate-Severe Acne in Adolescent Patients.

Clin Cosmet Investig Dermatol 2021 18;14:1303-1310. Epub 2021 Sep 18.

Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Objective: The present study aims to explore the effect of acne debridement + meticulous nursing on 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in adolescent patients with moderate-severe acne.

Methods: A total of 60 adolescent patients with moderate-severe acne who were admitted to our plastic surgery outpatient clinic between January 2018 and January 2020 were selected as the subjects of the present retrospective study. The patients were divided into two groups: the observation group and the control group (n = 30, each). Read More

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September 2021

We Should Pay Attention to "Referred Pain" - A Case of Acute Myocardial Infarction that Masked and Delayed the Diagnosis of Esophageal Perforation.

Intern Med 2021 Sep 25. Epub 2021 Sep 25.

Department of Intensive Care Medicine, Japanese Red Cross Musashino Hospital, Japan.

We herein report a 93-year-old woman diagnosed with acute myocardial infarction (AMI) based on typical laboratory findings of severe chest pain accompanied by throat pain. This condition was initially interpreted as referred pain of cardiac origin. However, the patient had persistent throat pain after successful percutaneous coronary intervention. Read More

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September 2021

Prosthetic rehabilitation of maxillary lateral incisors agenesis using dental mini-implants: a multicenter 10-year follow-up.

Clin Oral Investig 2021 Sep 26. Epub 2021 Sep 26.

Department of Life, Health and Environmental Sciences, Dental Clinic, University of L'Aquila, L'Aquila, Italy.

Objectives: Implants are used to replace congenitally missing lateral incisors but often the space across the alveolar crest is too narrow to permit their use. This multicenter study (Dental Clinic of the University of Foggia, Odontostomatology Clinic of the University of L'Aquila) evaluated the efficacy of mini-implants in cases of maxillary lateral incisor agenesis with severe osseous atrophy in 10-year follow-up.

Materials And Methods: Forty-seven mini-implants have been inserted in 35 patients affected by lateral incisors agenesis (23 single and 12 bilateral ageneses). Read More

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September 2021

A randomized clinical trial of topical dexamethasone vs. cyclosporine treatment for oral lichen planus.

Med Oral Patol Oral Cir Bucal 2021 Sep 25. Epub 2021 Sep 25.

Department of Oral Medicine and Pathology and Hospital Dentistry School of Dentistry, National and Kapodistrian University of Athens 2 Thivon St., Goudi 11527, Athens, Greece

Background: Oral lichen planus (OLP) is a common, frequently symptomatic, immune-mediated disease. Various treatments have been used for symptomatic OLP, including corticosteroids and immunosuppressants administered topically or systemically. The aim of this study was to compare the effectiveness of topical dexamethasone vs. Read More

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September 2021

Malformation of a Mesocolon as a Cause of Colic in an Arabian Foal.

Vet Sci 2021 Sep 13;8(9). Epub 2021 Sep 13.

Department of Large Animal Diseases and Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 100, 02-797 Warsaw, Poland.

This paper describes a case of partial lack of the mesocolon in a 7-month-old colt. The foal was referred to the hospital with clinical signs of severe abdominal distension of a few hours duration. Because analgesics did not relieve pain, the foal remained uncomfortable, and distension of the abdomen increased; an exploratory laparotomy was performed under general anaesthesia in dorsal recumbency. Read More

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September 2021

Establishment of a Newborn Lamb Gut-Loop Model to Evaluate New Methods of Enteric Disease Control and Reduce Experimental Animal Use.

Vet Sci 2021 Aug 24;8(9). Epub 2021 Aug 24.

UMR1282 Infectiologie et Santé Publique, INRAE Centre Val de Loire, Université François Rabelais de Tours, 37380 Nouzilly, France.

Enteric infectious diseases are not all well controlled, which leads to animal suffering and sometimes death in the most severe cases, in addition to economic losses for farmers. Typical symptoms of enteric infections include watery diarrhea, stomach cramps or pain, dehydration, nausea, vomiting, fever and weight loss. Evaluation of new control methods against enteric infections requires the use of many animals. Read More

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Brugada Pattern in a Child with Severe SARS-CoV-2 Related Multisystem Inflammatory Syndrome.

Pediatr Rep 2021 Sep 1;13(3):504-510. Epub 2021 Sep 1.

Pediatric Emergency and Short Stay Unit, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.

This report presents the first case of Brugada pattern complicated by a supraventricular arrhythmia in a child with SARS-CoV-2 related Multisystem Inflammatory Syndrome in Children (MIS-C). A 7-year-old boy came to our Emergency Department with 7 days of abdominal pain and fever. MIS-C was diagnosed on the basis of the clinical, laboratory and instrumental tests. Read More

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September 2021

Comparison of Depressive Symptom Outcomes in Hospitalized Adult Cancer Patients Receiving Music Therapy or Massage Therapy.

J Pain Symptom Manage 2021 Sep 23. Epub 2021 Sep 23.

Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Context: Depressive symptoms are prevalent and associated with greater healthcare utilization among hospitalized adults with cancer. Music therapy and massage therapy are available at many National Cancer Institute (NCI)-Designated Cancer Centers and recommended by the American Society of Clinical Oncology for depressive symptoms, but a paucity of studies have compared these two therapies.

Objective: We conducted a retrospective, multi-method program evaluation of single, first-time music therapy and massage therapy sessions delivered to hospitalized adults with cancer. Read More

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September 2021

Hypersensitivity to negative feedback during dynamic risky-decision making in major depressive disorder: An event-related potential study.

J Affect Disord 2021 Sep 17. Epub 2021 Sep 17.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders (Xiangya), Changsha, Hunan, China; Medical Psychological Institute of Central South University, Changsha 410011, China. Electronic address:

Background: Patients with major depressive disorder (MDD) exhibit a diminished ability to think or concentrate, indecisiveness, and altered sensitivity to reward and punishment. These impairments can influence complex risk-related decision-making in dynamic environments. The neurophysiological mechanisms mediating MDD effects on decision-making behavior are not well understood. Read More

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September 2021

Association between serum lipid levels and severe headache or migraine in representative American population: A cross-sectional study.

Curr Neurovasc Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Background: The relationship between serum lipids and migraine remains controversial.

Objective: This study aimed to analyze the association between serum lipids and severe headache or migraine in the general population.

Method: Data were collected from a nationally representative sample of participants in the National Health and Nutrition Examination Survey from 1999 to 2004. Read More

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September 2021

Long-term dental implications of infant oral mutilation: a case series.

Br Dent J 2021 Sep 24;231(6):335-340. Epub 2021 Sep 24.

Department of Endodontics, Israel Defence Forces Medical Corps, Tel Hashomer, Israel.

Infant oral mutilation (IOM) is a ritual ceremony practised mostly in African cultures, in which the primary tooth bud of the deciduous canine is extracted. Complications and risks of IOM include pain, heavy bleeding and infection that may deteriorate to life-threating conditions. The main long-term consequence of IOM is future dental abnormalities. Read More

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September 2021