53,367 results match your criteria severe negative


A retrospective evaluation of the value of COVID-19 screening and testing in patients with cancer: Aiming at a moving target.

J Infect Public Health 2021 May 26;14(7):949-953. Epub 2021 May 26.

Department of Oncology, King Abdulaziz Medical City, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia.

Background: Diagnosis of COVID-19 infection in cancer patients is critical to co-manage their underlying disease and infection appropriately. Our study aimed at evaluating the sensitivity and specificity of screening patients with cancer for COVID-19 infection.

Methods: All oncology patients receiving care at Department of Oncology at King Abdulaziz Medical City in Riyadh were screened using the acute respiratory infection (ARI) survey. Read More

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Stroke Mechanism in COVID-19 Infection: A Prospective Case-Control Study.

J Stroke Cerebrovasc Dis 2021 Jun 1;30(8):105919. Epub 2021 Jun 1.

Department of Neurology, Hacettepe University Hospitals Turkey.

Background: The characteristics and pathophysiological mechanisms involved in acute ischemic stroke in patients with COVID-19 infection have not been fully clarified. We prospectively studied the phenotypic and etiological features of acute stroke occurring in COVID-19 infection.

Patients & Methods: Within nine months starting from April-2020, the presence of COVID-19 infection was determined by thoracic CT and SARS-CoV-2 PCR in all acute stroke cases managed in a single tertiary center. Read More

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Colorimetric Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2.

Am J Trop Med Hyg 2021 Jun 15. Epub 2021 Jun 15.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spreading rapidly all over the world. In the absence of effective treatments or a vaccine, there is an urgent need to develop a more rapid and simple detection technology of COVID-19. We describe a WarmStart colorimetric reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of SARS-CoV-2. Read More

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First Report of Bacterial Rot Caused by Pantoea endophytica on Tobacco in Liuyang, China.

Plant Dis 2021 Jun 15. Epub 2021 Jun 15.

Chinese Academy of Agricultural Sciences Institute of Tobacco Research, 243822, Qingdao, Shandong, China;

Tobacco, Nicotiana tabacum L., is produced largely in China (~1/3 of the global market). In the monsoon summer of 2020, tobacco plant petioles, where axillary buds were removed, became black-rotten, and thick ooze appeared, when squeezed. Read More

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Prevalence and clinical course of SARS-CoV-2 infection in patients with Behçet's syndrome.

Clin Exp Rheumatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Experimental and Clinical Medicine, University of Florence, Italy.

Objectives: We aimed to assess the prevalence of SARS-CoV-2 infection among Behçet's syndrome (BS) patients, evaluating the possible association between demographic and clinical features and the risk of infection. Moreover, we aimed to evaluate the possible association between BS disease activity and treatment, and the risk of SARS-CoV-2 infection.

Methods: A survey was conducted on BS patients followed at the Behçet's Centre of the Careggi University Hospital, Florence, Italy. Read More

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Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials.

Pathog Glob Health 2021 Jun 15:1-11. Epub 2021 Jun 15.

Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (IS), Italy.

 Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19, but its association with mortality is unclear. We reviewed published literature for evidence of an association between HCQ (with or without azithromycin (AZM)) and total mortality in COVID-19 patients. Articles were retrieved until April 29, 2021 by searching in seven databases. Read More

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A case control study to assess effectiveness of measles containing vaccines in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children.

Hum Vaccin Immunother 2021 Jun 15:1-6. Epub 2021 Jun 15.

Serum Institute of India Pvt Ltd, Pune, India.

Currently, most licensed vaccines against SARS-CoV-2 infection are approved for adults and not for children. We conducted a test negative case-control study to assess the effectiveness of Measles Containing Vaccines (MCVs) against SARS-CoV-2 infection in Pune, India, in children who were ≥1 year and <18 years of age and were tested for SARS-CoV-2 infection by Reverse transcription polymerase chain reaction (RT-PCR). The enrolled participants included 274 SARS-CoV-2 positive cases (216 vaccinated and 58 unvaccinated) along with 274 SARS-CoV-2 negative controls (265 vaccinated and 9 unvaccinated). Read More

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Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density.

mSystems 2021 Jun 15:e0034721. Epub 2021 Jun 15.

Molecular and Pathogenesis Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen family expressed on infected red blood cells that plays a role in immune evasion and mediates adhesion to vascular endothelium. PfEMP1s are potential targets of protective antibodies as suggested by previous seroepidemiology studies. Here, we used previously reported proteomic analyses of PfEMP1s of clinical parasite isolates collected from Malian children to identify targets of immunity. Read More

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Roxadustat on anti-erythropoietin antibody-related pure red cell aplasia in the patient with end-stage renal disease.

Semin Dial 2021 Jun 15. Epub 2021 Jun 15.

Department of Nephrology, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Anti-erythropoietin antibody-related pure red cell aplasia (anti-EPO PRCA) is a severe complication in patients who receive erythropoiesis-stimulating agents for nephrogenic anemia. The standard therapy is withdrawl of EPO and immunosuppression. Here, we present successful treatment of anti-EPO PRCA with roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor. Read More

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Clinical Pharmacology of Hyperammonemia by Sodium Valproate and Carbamazepine in People Living with HIV.

CNS Spectr 2021 Apr;26(2):143

Argentine Society of Neuropsychopharmacology, Buenos Aires City, Buenos Aires, Argentina.

Introduction: Hyperammonaemia (HA) is observed in decompensated liver disease. The picture of hyperammonemic encephalopathy in non-cirrhotic patients was reported mostly associated with valproic acid. There are few reports of hyperammonemia in people living with human immunodeficiency virus (PLHIV) and they are associated with other comorbidities and few with antiretrovirals (HAART), but not as adverse drug reactions associated with psychotropic drugs associated with the virus. Read More

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The Challenge of Managing Patients Suffering from TBI: The Utility of Multiparametric MRI.

CNS Spectr 2021 Apr;26(2):178-179

Western University of Health Sciences, Pomona, CA, USA.

Traumatic brain injury (TBI) is a complex phenomenon affecting multiple areas of the brain in multiple ways. Both right and left hemispheres are affected as well as supratentorial and infratentorial compartments. These multifocal injuries are caused by many factors including acute mechanical injury, focal intracranial hemorrhage, blunt and rotational forces, epidural and subdural hematoma, hypoxemia, hypotension, edema, axonal damage, neuronal death, gliosis and blood brain barrier disruption. Read More

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Prevalence of malocclusion and assessment of orthodontic treatment needs among Syrian refugee children and adolescents: a cross-sectional study.

BMC Oral Health 2021 Jun 14;21(1):305. Epub 2021 Jun 14.

Restorative Dentistry, Division of Dentistry, School of Medical Sciences, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Background: There is a scarcity of data concerning the prevalence and pattern of malocclusion and orthodontic treatment needs in Syrian refugee. In this study, extra and intra-oral features of malocclusion and the dental health component of the Index of Orthodontic Treatment Need (IOTN) were reported.

Methods: Examination of 606 Syrian children/adolescents refugees attending Zaatari clinic was carried out (males = 280, females = 326, mean age = 11. Read More

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Grafting resulting in alleviating tomato plant oxidative damage caused by high levels of ofloxacin.

Environ Pollut 2021 May 14;286:117331. Epub 2021 May 14.

College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, 271018, PR China; Collaborative Innovation Center of Fruit & Vegetable Quality and Efficient Production in Shandong, PR China; State Key Laboratory of Crop Biology, Key Laboratory of Biology and Genetic Improvement of Horticultural Crops in Huanghuai Region, Ministry of Agriculture and Rural Affairs, PR China; State Key Laboratory of Crop Biology, Ministry of Agriculture, PR China. Electronic address:

Antibiotic pollution has become a global problem threatening human health. Ofloxacin is one of the more widely used antibiotics, but reports on the reaction of plant to ofloxacin pollution are limited. In this study, using adversity-resistant (R), adversity-sensitive (S) and grafted plant S/R as models, we investigated the biological response of tomato to exogenous ofloxacin residues. Read More

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Epidemic and PCR-based identification of vibrio cholera through OmpW gene from diarrhoeal patients admitted at different hospitals of Baluchistan.

J Pak Med Assoc 2021 Apr;71(4):1189-1192

Department of Biochemistry, Bolan University of Medical and Health Sciences, Quetta, Pakistan.

Objective: To study the different epidemiological and polymerase chain reaction-based identification of vibrio cholera.

Methods: The cross-sectional study was conducted at the Center for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan, Quetta, Pakistan, from January 5 to December 6, 2019, and comprised faecal / rectal swab samples from patients with a history of untreated severe diarrhoea of <12-hour duration. The samples were collected from suspected cholera patients at different hospitals of the province. Read More

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IGF1 Haploinsufficiency in Children with Short Stature: A Case Series.

Eur J Endocrinol 2021 Jun 1. Epub 2021 Jun 1.

D Beckers, Pediatric Endocrinology, Université Catholique de Louvain, CHU UCL Namur, Yvoir, Belgium.

Context: Short stature in children is a common reason for referral to pediatric endocrinologists. The underlying cause of short stature remains unclear in many cases and patients often receive unsatisfactory, descriptive diagnoses. While textbooks underline the rarity of genetic causes of growth hormone (GH) insensitivity and the severity of its associated growth failure, increased genetic testing in patients with short stature of unclear origin has revealed gene defects in the GH/ insulin-like growth factor (IGF-I) axis associated with milder phenotypes. Read More

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Multiplexed and High-Throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors.

Anal Chem 2021 Jun 14. Epub 2021 Jun 14.

Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, 402 N Blackford Street, Indianapolis, Indiana 46202, United States.

To tackle the COVID-19 outbreak, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an unmet need for highly accurate diagnostic tests at all stages of infection with rapid results and high specificity. Here, we present a label-free nanoplasmonic biosensor-based, multiplex screening test for COVID-19 that can quantitatively detect 10 different biomarkers (6 viral nucleic acid genes, 2 spike protein subunits, and 2 antibodies) with a limit of detection in the aM range, all within one biosensor platform. Our newly developed nanoplasmonic biosensors demonstrate high specificity, which is of the upmost importance to avoid false responses. Read More

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"Post Coronavirus Disease (COVID-19) Reactivation of a Quiescent Unilateral Anterior Uveitis".

SN Compr Clin Med 2021 Jun 7:1-5. Epub 2021 Jun 7.

Department of Neuro-ophthalmology, Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India.

Coronavirus disease (COVID-19) can be associated with ophthalmic manifestations like conjunctivitis, retinal haemorrhages, retinal vascular occlusions, papillophlebitis, and Adie's syndrome. We herein report for a case of a unilateral acute anterior uveitis which was quiescent for 13 years and was reactivated post COVID-19 infection in a 43-year-old Asian Indian male. He had a past history of recurrent unilateral granulomatous anterior and intermediate uveitis in the right eye (RE), and all the investigations done 14 years ago were negative and had been on treatment with topical and oral steroids. Read More

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Modified double guiding catheter 'Ping Pong' technique to treat large coronary perforation: a case report.

Eur Heart J Case Rep 2021 May 16;5(5):ytab173. Epub 2021 May 16.

5 Hospital Drive, Level 2 Pharmacy, National Heart Centre Singapore 169609.

Background : Despite improvement in available tools and techniques, procedural complications like coronary perforation can occur during percutaneous coronary intervention (PCI). Severe proximal coronary perforations are usually caused by balloon and vessel size mismatch but can also occur with appropriately sized balloons or stents if the coronary vessel has very eccentric calcification or if there is negative remodelling of the vessel.

Case Summary : A 74-year-old man with a history of type II diabetes mellitus, hypertension, and chronic coronary syndrome (previous PCI 10 years before) presented with unstable angina of 2 weeks of duration. Read More

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Depression and Associated Factors in Chinese Patients With Chronic Kidney Disease Without Dialysis: A Cross-Sectional Study.

Front Public Health 2021 28;9:605651. Epub 2021 May 28.

Department of Nephrology, West China Hospital, Sichuan University, Sichuan, China.

Chronic kidney disease (CKD) has been a globally public health problem over the past decades. The maintenance of physical and mental health is of importance for patients nowadays. Notably, depression is prevalent and associated with various adverse events in CKD patients without dialysis. Read More

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Identification METTL18 as a Potential Prognosis Biomarker and Associated With Immune Infiltrates in Hepatocellular Carcinoma.

Front Oncol 2021 26;11:665192. Epub 2021 May 26.

Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Methyltransferase-like 18 (METTL18), a METTL family member, is abundant in hepatocellular carcinoma (HCC). Studies have indicated the METTL family could regulate the progress of diverse malignancies while the role of METTL18 in HCC remains unclear. Data of HCC patients were acquired from the cancer genome atlas (TCGA) and gene expression omnibus (GEO). Read More

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Identification of key microRNAs and the underlying molecular mechanism in spinal cord ischemia-reperfusion injury in rats.

PeerJ 2021 27;9:e11454. Epub 2021 May 27.

Department of Anesthesiology, the First Hospital of China Medical University, Shenyang, Liaoning province, China.

Spinal cord ischemia-reperfusion injury (SCII) is a pathological process with severe complications such as paraplegia and paralysis. Aberrant miRNA expression is involved in the development of SCII. Differences in the experimenters, filtering conditions, control selection, and sequencing platform may lead to different miRNA expression results. Read More

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Cryptococcal Meningitis in an HIV-Negative Puerperal Woman.

Case Rep Infect Dis 2021 25;2021:6665624. Epub 2021 May 25.

Head of Department of Infectious Diseases, Infectious Diseases Service, Hospital Garcia de Orta EPE, Almada, Portugal.

Cryptococcal meningitis is a common opportunistic infection in HIV-infected patients and other immunocompromised people. Pregnancy, which is a state of relative immunosuppression, can also be a risk factor for the development of cryptococcal meningitis. We report a clinical case of a 41-year-old woman who developed a severe meningeal syndrome after an otherwise normal pregnancy. Read More

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Anaphylactic risk related to omalizumab, benralizumab, reslizumab, mepolizumab, and dupilumab.

Clin Transl Allergy 2021 Jun 3;11(4):e12038. Epub 2021 Jun 3.

Department of Pharmacy Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.

Background: Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge of the anaphylaxis risks related to different mAbs is essential for their appropriate and safe administration. This study aimed to evaluate the associations between different mAbs and anaphylactic reactions by applying statistical approaches to pharmacovigilance data. Read More

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Effect of COVID-19 on Male Reproductive System - A Systematic Review.

Front Endocrinol (Lausanne) 2021 27;12:677701. Epub 2021 May 27.

Scientific Research and Training Office, The Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: Angiotensin-converting enzyme II (ACE2), a receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to enter host cells, is widely expressed in testes and prostate tissues. The testis and prostate produce semen. At present, there are contradictory reports about whether SARS-CoV-2 can exist in the semen of infected men. Read More

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Mental Health of Chinese People During the COVID-19 Pandemic: Associations With Infection Severity of Region of Residence and Filial Piety.

Front Psychol 2021 28;12:633452. Epub 2021 May 28.

Department of Social Work, Foshan University, Foshan, China.

This study aims to investigate mental health among Chinese people living in areas with differing levels of infection severity during the COVID-19 outbreak. It also assesses the association between reciprocal and authoritarian filial piety and mental health in times of crises. A sample of 1,201 Chinese participants was surveyed between April and June 2020. Read More

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Predicting Regional Variations in Nationalism With Online Expression of Disgust in China.

Front Psychol 2021 28;12:564386. Epub 2021 May 28.

School of Data Science and Engineering, East China Normal University, Shanghai, China.

Disgust is one of the basic emotions and is part of the behavioral immune system, which evolutionarily protects humans from toxic substances as well as from contamination threats by outgroup members. Previous works reveal that disgust not only activates humans' defense against potential individual and collective threats, but also leads to severe moral judgments, negative intergroup attitudes, and even conservative political orientations. As is already known, nationalism is an ideology that features both negative feelings toward outgroups and beliefs about native superiority or privileges. Read More

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Accuracy of the Radiographic Assessment of Lung Edema Score for the Diagnosis of ARDS.

Front Physiol 2021 26;12:672823. Epub 2021 May 26.

Department of Intensive Care, Academic Medical Center, Amsterdam, Netherlands.

Bilateral opacities on chest radiographs are part of the Berlin Definition for Acute Respiratory Distress Syndrome (ARDS) but have poor interobserver reliability. The "Radiographic Assessment of Lung Edema" (RALE) score was recently proposed for evaluation of the extent and density of alveolar opacities on chest radiographs of ARDS patients. The current study determined the accuracy of the RALE score for the diagnosis and the prognosis of ARDS. Read More

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Systemic Corticosteroid Administration in Coronavirus Disease 2019 Outcomes: An Umbrella Meta-Analysis Incorporating Both Mild and Pulmonary Fibrosis-Manifested Severe Disease.

Front Pharmacol 2021 26;12:670170. Epub 2021 May 26.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed. The real role of corticosteroid use in COVID-19 has long been of interest and is disputable. We aimed to quantitatively reevaluate the efficacy of corticosteroids on COVID-19. Read More

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Neuropathological and motor impairments after incomplete cervical spinal cord injury in pigs.

J Neurotrauma 2021 Jun 13. Epub 2021 Jun 13.

Hospital Nacional de Parapléjicos, Neural Repair and Biomaterials Laboratory, Toledo, Toledo, Spain;

Humans, primates, and rodents with cervical spinal cord injury (SCI) show permanent sensorimotor dysfunction of the upper/fore limb as consequence of axonal damage and local neuronal death. This work aimed at characterizing a model of cervical SCI in domestic pigs in which hemisection with excision of one centimeter of spinal cord was performed to reproduce the loss of neural tissue observed in human neuropathology. Posture and motor control were assessed over 3 months by scales and kinematics of treadmill locomotion. Read More

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Treatment options for soft tissue defects in severe foot trauma in children.

J Wound Care 2021 Jun;30(6):432-438

Department of Paediatric Orthopaedic Surgery, Amiens University Hospital and Jules Verne University of Picardie, Amiens, France.

Objective: Severe foot trauma in children is a therapeutic challenge, with presence of devitalised and soiled distal tissues. Several reconstruction and covering procedures can be applied, including artificial dermis (AD), negative pressure wound therapy (NPWT), fasciocutaneous flaps and free flaps. Here, we have developed and evaluated an algorithm for treating severe foot injuries with skin defects in children. Read More

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