2,952 results match your criteria severe menopausal

Predictive and criterion validity of the Cervantes-SF menopause quality of life questionnaire.

Menopause 2021 May 10. Epub 2021 May 10.

Women's Health Institute, San Carlos Clinic Hospital, IdISSC, Complutense University, Madrid, Spain Faculty of Psychology, Autonoma University of Madrid, Madrid, Spain Department of Obstetrics and Gynecology, Sanitas La Zarzuela Hospital, Francisco de Vitoria University, Madrid, Spain Department of Obstetrics and Gynecology, Miguel Servet Hospital, Zaragoza, Spain Department of Obstetrics and Gynecology, School of Medicine, University of Granada, Spain Department of Obstetrics and Gynecology, Central Hospital of Asturias, University of Oviedo, Spain Department of Pharmacoeconomics and Health Outcomes Research, Pfizer SLU, Alcobendas, Madrid, Spain.

Objectives: To determine the predictive and criterion-based validity of the Cervantes-SF scale that measures the impact of menopause on Health-Related Quality of Life.

Methods: We recruited a noninstitutionalized sample of peri/postmenopausal women aged 40 to 65 years, who had their last menstrual cycle 12+ months prior to inclusion in the study of the psychometric validity of the Cervantes-SF scale. Predictive validity of the scale was confirmed for various health outcome measures administered concomitantly (years of disability-free life expectancy, work productivity and impact on daily activities, economic impact arising from loss of work productivity, hours of undisturbed sleep each day, and the utilization of healthcare facilities), whilst criterion validity was determined by the likelihood of identifying a moderate-to-severe vasomotor or genital syndrome requiring specific treatment. Read More

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Association of depression, anxiety and menopausal-related symptoms with demographic, anthropometric and body composition indices in healthy postmenopausal women.

BMC Womens Health 2021 May 7;21(1):192. Epub 2021 May 7.

Department of Biology, School of Art and Science, Utica College, Utica, NY, USA.

Background: The termination of the menstrual cycle is correlated with a number of physiological alterations and symptoms that can negatively impact emotion and mood. We aimed to investigate the association of anxiety, depression, and menopausal related symptoms with demographic, anthropometric, and body composition indices in healthy postmenopausal women.

Methods: A total of 320 menopausal women were selected randomly from referrals of health centers between January and June 2018 in Tabriz/Iran. Read More

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The risk of menopausal symptoms in premenopausal breast cancer patients and current pharmacological prevention strategies.

Expert Opin Drug Saf 2021 May 5. Epub 2021 May 5.

Department of Clinical Oncology, Prince of Wales Hospital, the Chinese University of Hong Kong, New Territories, Hong Kong SAR, China.

Introduction: For young premenopausal breast cancer (BC) patients, adjuvant chemotherapy and other anti-cancer treatments can increase the risk of menopausal symptoms and may cause chemotherapy-related amenorrhea (CRA), infertility and premature ovarian insufficiency (POI).

Areas Covered: In this report, menopausal symptoms related to anti-cancer treatment are described. Menstrual disturbances associated with the use of adjuvant chemotherapy, endocrine therapy and targeted therapy against human epidermal growth factor receptor 2 (HER2) in premenopausal women with BC are discussed. Read More

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The incidence, characteristics and outcomes of pregnant women hospitalized with symptomatic and asymptomatic SARS-CoV-2 infection in the UK from March to September 2020: A national cohort study using the UK Obstetric Surveillance System (UKOSS).

PLoS One 2021 5;16(5):e0251123. Epub 2021 May 5.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.

Background: There is a lack of population level data on risk factors, incidence and impact of SARS-CoV-2 infection in pregnant women and their babies. The primary aim of this study was to describe the incidence, characteristics and outcomes of hospitalized pregnant women with symptomatic and asymptomatic SARS-CoV-2 in the UK compared to pregnant women without SARS-CoV-2.

Methods And Findings: We conducted a national, prospective cohort study of all hospitalized pregnant women with confirmed SARS-CoV-2 from 01/03/2020 to 31/08/2020 using the UK Obstetric Surveillance System. Read More

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Effects of preoperative serum vitamin D levels on early clinical function outcomes and the moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty.

Menopause 2021 May 3. Epub 2021 May 3.

Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Objective: To investigate the impact of vitamin D levels on early clinical function outcomes and the potential risk factors of moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty (TKA).

Methods: From April 2017 to December 2019, 226 women were retrospectively recruited. The women were divided into two groups based on their preoperative serum 25-hydroxyvitamin D levels: (1) vitamin D-sufficient group (≥30 ng/mL); (2) vitamin D-deficient group (<30 ng/mL). Read More

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Updates on Therapeutic Alternatives for Genitourinary Syndrome of Menopause: Hormonal and Non-Hormonal Managements.

J Menopausal Med 2021 Apr;27(1):1-7

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Postmenopausal atrophic vaginitis, along with vasomotor symptoms and sleep disorders, is one of the most troublesome symptoms of menopause. However, many women do not manage this symptom properly due to insufficient knowledge of the symptoms or sexual embarrassment. With appropriate treatment, many postmenopausal women can experience relief from discomforts, including burning sensation or dryness of the vagina and dyspareunia. Read More

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Severity of climacteric symptoms among Peruvian women from an urban coastal community and a rural Andean community.

Rural Remote Health 2021 May 4;21(2):6457. Epub 2021 May 4.

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Lima, Perú

Introduction: The aim of this study was to evaluate the severity of climacteric symptoms among two Peruvian communities, adjusted for sociodemographic and clinical variables in climacteric women.

Methods: A cross-sectional study was conducted on 90 subjects from two different communities (an urban coastal and a rural Andean district from Peru). The Menopause Rating Scale was used to assess climacteric symptoms. Read More

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Ovariectomy-Induced Hepatic Lipid and Cytochrome P450 Dysmetabolism Precedes Serum Dyslipidemia.

Int J Mol Sci 2021 Apr 26;22(9). Epub 2021 Apr 26.

Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic.

Ovarian hormone deficiency leads to increased body weight, visceral adiposity, fatty liver and disorders associated with menopausal metabolic syndrome. To better understand the underlying mechanisms of these disorders in their early phases of development, we investigated the effect of ovariectomy on lipid and glucose metabolism. Compared to sham-operated controls, ovariectomized Wistar female rats markedly increased whole body and visceral adipose tissue weight ( ˂ 0. Read More

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Qualitative study: burden of menopause-associated vasomotor symptoms (VMS) and validation of PROMIS Sleep Disturbance and Sleep-Related Impairment measures for assessment of VMS impact on sleep.

J Patient Rep Outcomes 2021 Apr 26;5(1):37. Epub 2021 Apr 26.

RTI Health Solutions, Patient-Centered Outcomes Assessment Group, Research Triangle Park, NC, USA.

Purpose: We evaluated the impact of menopause-associated vasomotor symptoms (VMS) on sleep. We also sought to establish the content validity of Patient-Reported Outcomes Measurement Information System (PROMIS) short form Sleep-Related Impairment and Sleep Disturbance measures in postmenopausal women with moderate to severe VMS.

Methods: Cross-sectional, in-person, qualitative interviews were conducted in the United States (Texas, Illinois) and European Union (UK, France) with women aged 40-64 years experiencing moderate to severe VMS (≥35/wk). Read More

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Menses, pregnancy, delivery, and menopause in hidradenitis suppurativa: A patient survey.

Int J Womens Dermatol 2020 Dec 10;6(5):368-371. Epub 2020 Jul 10.

Department of Medicine, Division of Dermatology, University of California Los Angeles, Los Angeles, CA, United States.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder that primarily affects women of childbearing age. There is a paucity of data on HS disease activity during menstruation, pregnancy, and menopause and the potential impact of HS on the method of delivery.

Objective: We aimed to characterize the natural history of HS symptoms during menses, pregnancy, and menopause. Read More

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December 2020

Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT.

Arthritis Res Ther 2021 Apr 24;23(1):127. Epub 2021 Apr 24.

Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, 300 Cedar Street, TAC S-525, P.O. Box 208031, New Haven, CT, 06520-8031, USA.

Background: Patients with rheumatoid arthritis (RA) are at increased risk of fractures. Although their decline in bone mineral density (BMD) is well-established, data regarding the alterations in bone microarchitecture are limited. In this study, we aimed to evaluate bone microarchitecture, geometry, and volumetric BMD among patients with RA in mainland China using high-resolution peripheral quantitative computed tomography (HRpQCT). Read More

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Gonadotropins for testicular descent in cryptorchid congenital hypogonadotropic hypogonadism males beyond infancy.

J Pediatr Endocrinol Metab 2021 Apr 26. Epub 2021 Apr 26.

Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India.

Objectives: To study the effect of combined gonadotropin therapy (CGT) on testicular descent ± spermatogenesis in congenital hypogonadotropic hypogonadism (CHH) patients with cryptorchidism beyond infancy.

Methods: This retrospective cohort study included CHH patients with cryptorchidism [bilateral (n=5) or unilateral (n=1)] treated with CGT for testicular descent ± pubertal induction. All participants were treated with CGT [human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG)] with hMG pretreatment in three and monitored for changes in testicular volume (TV), serum total testosterone (T), serum inhibin-B, and sperm concentration. Read More

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The effect of physical activity and depressive mood on menopausal symptoms in postmenopausal women.

Int J Clin Pract 2021 Apr 22:e14247. Epub 2021 Apr 22.

Department of Family Medicine, Ankara Training and Research Hospital, Ankara, Turkey.

Aims: The symptoms of menopause in postmenopausal women adversely affect the quality of life. Menopausal symptoms are more severe with comorbid disorders such as depression; it may be lighter in physically active people. The present study aimed to evaluate the relationship between menopausal symptoms and physical activity and depressive mood. Read More

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Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women.

Clin Interv Aging 2021 14;16:603-609. Epub 2021 Apr 14.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Background: Previous studies have showed that nephropathy was associated with cardiac structural changes and dysfunction among diabetic adults. However, information on the association of glomerular filtration dysfunction with the cardiac adverse remodeling is still limited in menopausal diabetic women. Therefore, we investigated whether impaired glomerular filtration function is associated with the cardiac adverse remodeling in menopausal Chinese women with type 2 diabetes mellitus (DM). Read More

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A Pilot Randomized, Double-blind, Placebo-controlled Clinical Trial on the Efficacy and Safety of a Transdermal Gel that Delivers CO2 in the Treatment of Vulvovaginal Atrophy.

Surg Technol Int 2021 04 20;38. Epub 2021 Apr 20.

Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.

This prospective study aimed to assess the efficacy of a transdermal CO2 gel in promoting regeneration in the vulvovaginal area in postmenopausal women experiencing symptoms as part of genitourinary syndrome of menopause (GSM). Transdermal carboxytherapy refers to the application of CO2 through the skin's superficial layer, which is intended to increase oxygenation (through the Bohr effect) and angiogenesis, thus helping to reduce symptoms of GSM. In this study, 20 women with moderate or severe signs or symptoms of vulvovaginal atrophy were randomized to receive either transdermal CO2 therapy (n=10) or a placebo gel (ultrasound gel, n=10). Read More

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Menopausal symptoms inversely associated with quality of life: findings from a 5-year longitudinal cohort in Chinese breast cancer survivors.

Menopause 2021 Apr 19. Epub 2021 Apr 19.

Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China Division of Epidemiology, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China Department of Clinical Oncology, Princess Margaret Hospital, Hong Kong SAR, China Hong Kong Cancer Institute, State Key Laboratory in Oncology in South China, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China.

Objective: This study assessed menopausal symptoms (MPS) after breast cancer in relation to quality of life (QoL) during the first 5 years of survival.

Methods: An ongoing prospective study enrolled 1,462 Chinese women with early-stage breast cancer. They were longitudinally followed up at four time-points, namely baseline, 18-, 36-, and 60-month after diagnosis. Read More

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Recommended Hormone Therapy in Menopause: Concepts, Controversies and Approach to Treatment.

Endocr Rev 2021 Apr 15. Epub 2021 Apr 15.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, Massachusetts USA.

Hormone therapy (HT) is an effective treatment for menopausal symptoms, including vasomotor symptoms and genitourinary syndrome of menopause. Randomized trials also demonstrate positive effects on bone health, and age-stratified analyses indicate more favorable effects on coronary heart disease and all-cause mortality in younger women (close proximity to menopause) than in women more than a decade past menopause. In the absence of contraindications or other major comorbidities, recently menopausal women with moderate or severe symptoms are appropriate candidates for HT. Read More

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A Systematic Review and Meta-Analysis on the Incidence of Osteoporosis and Fractures after Liver Transplant.

Transpl Int 2021 Apr 9. Epub 2021 Apr 9.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Aim: Following liver transplant (LT), osteoporosis is a severe complication that causes morbidity. However, the incidence and risk factors of osteoporosis and fractures have not been well described.

Methods: Single-arm meta-analysis of studies reporting osteopenia, osteoporosis and fractures post-LT was performed with meta regression for study period. Read More

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Asthma in Menopausal Women: Clinical and Functional Particularities.

Tanaffos 2020 Jul;19(3):216-222

Charles Nicole Pulmonology Department, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.

Background: Hormonal changes in women, especially at menopausal transition, may have significant consequences on respiratory function. This issue in asthmatic patients is more frequent, more severe, and less controlled after menopause. Tunisian data regarding this issue are limited; therefore, we assessed the clinical and functional particularities of asthma at menopausal transition. Read More

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Management of Early Menopause/Premature Ovarian Insufficiency in Women with or at High Risk of Breast Cancer.

Semin Reprod Med 2020 Sep 31;38(4-05):309-314. Epub 2021 Mar 31.

Royal Women's Hospital, Parkville, Victoria Australia.

The global incidence of breast cancer is increasing, as is the efficacy of treatments. Consequently, increasing survival rates reinforce the importance of survivorship issues, including posttreatment menopausal symptoms, sexual function, and mental health and well-being. Breast cancer patients can experience a range of menopausal symptoms associated with their treatment. Read More

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September 2020

Effects of exogenous melatonin on sleep quality and menopausal symptoms in menopausal women: a systematic review and meta-analysis of randomized controlled trials.

Menopause 2021 Mar 29. Epub 2021 Mar 29.

Department of Obstetrics and Gynecology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Importance: Because of the bothersome symptoms during women's menopausal period and the severe side effects of hormone therapy, it is meaningful to find new breakthroughs in improving menopausal women's quality of life.

Objective: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating melatonin intake on the improvement of sleep quality, general menopausal symptom, mood states, as well as interaction of estradiol levels and body mass index (BMI) in menopausal women.

Evidence Review: We used the search terms "melatonin" together with "menopause" or "post-menopause" or "peri-menopause" in multiple databases online including PubMed, Web of Science, Embase, Clinical trial, Cochrane Library, and China National Knowledge Infrastructure from the first publication year to October 2020. Read More

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Patterns of Migraine in Postmenopausal Women: A Systematic Review.

Neuropsychiatr Dis Treat 2021 19;17:859-871. Epub 2021 Mar 19.

Department of Applied Clinical Sciences and Biotechnology, University of L'Aquila, L'Aquila, Italy.

Introduction: Migraine prevalence is higher in fertile than in postmenopausal women. However, few literature data are available on the prevalence and characteristics of migraine after the menopause and on the effect of hormones in postmenopausal women with migraine.

Methods: We performed a systematic literature review of studies available on Scopus and Web of Science from the beginning off indexing until October 18th, 2020. Read More

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Cardioprotective effects of severe calorie restriction from birth in adult ovariectomized rats.

Life Sci 2021 Jun 24;275:119411. Epub 2021 Mar 24.

Programa de Pós-graduação Multicêntrico em Ciências Fisiológicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil; Faculdade de Medicina, UFVJM, Diamantina, Brazil; Programa de Pós-graduação em Ciências da Saúde, UFVJM, Diamantina, Brazil. Electronic address:

Aims: Menopause is a female condition induced by a reduction of ovarian hormone and is related to an increase in cardiovascular diseases in women. We have shown that severe calorie restriction (SCR) from birth reduces the cardiometabolic risk in adult male Wistar rats. In this study, we investigated the effects of SCR from birth to adulthood on cardiovascular function of ovariectomized rats. Read More

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COVID-19 and Menstrual Status: Is Menopause an Independent Risk Factor for SARS Cov-2?

J Midlife Health 2020 Oct-Dec;11(4):240-249. Epub 2021 Jan 21.

Department of Medicine, Government Institute of Medical Sciences, Greater Noida, Uttar Pradesh, India.

Background: COVID-19 has shown a definite association with gender, a predilection for males in terms of morbidity and mortality. The indirect evidence of the protective effect of estrogen has been shown by Channappanavar, in the animal model and Ding T. in a multihospital study from China, suggesting menopause as independent risk factor and estrogen is negatively correlated with severity. Read More

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January 2021

Coronary artery disease prediction based on breast arterial calcification in women undergoing mammography as a screening for breast cancer.

Menopause 2021 Mar 22. Epub 2021 Mar 22.

2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic Department of Radiology, Breast Cancer Screening and Diagnostic center, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic Department of Electrical and Computer Engineering and Iowa Institute for Biomedical Imaging, The University of Iowa, Iowa City, IA.

Objective: The aim of the study was to test the potential role of breast arterial calcification (BAC) in the prediction of coronary artery disease (CAD) in women. The criterion standard for CAD diagnostics was coronary angiography.

Methods: This retrospective study enrolled 163 consecutive women, who underwent digital mammography and coronary angiography in our hospital. Read More

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[Non-hormonal alternatives for the management of menopausal hot flushes. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines].

Gynecol Obstet Fertil Senol 2021 May 20;49(5):373-393. Epub 2021 Mar 20.

Hôpital Cochin-Port-Royal, unité de gynécologie médicale, Inserm U1153 équipe EPOPEE, Paris, France; Université de Paris, Paris, France.

One of the major symptoms of climacteric syndrome is hot flushes (HF). They are most often experienced as very disabling. Estrogen therapy is the most effective treatment. Read More

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[The HRT follow-up consultation. What to do in case of breast pain. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines].

C Mathelin

Gynecol Obstet Fertil Senol 2021 May 20;49(5):493-499. Epub 2021 Mar 20.

Service de chirurgie, Institut de cancérologie Strasbourg Europe (ICANS), 17, rue Albert-Calmette, 67200 Strasbourg, France; IGBMC, Institut de génétique et de biologie moléculaire et cellulaire, biologie du cancer, CNRS UMR 7104, INSERM U964, Université de Strasbourg, Illkirch, France. Electronic address:

Breast pain is a concern in perimenopausal and postmenopausal women, quantifiable using validated tools, and may pre-exist or appear after initiation of a HRT.

Objectives: A review of the literature was conducted to evaluate the frequency of breast pain, its evolution with age, its changes under HRT, its link with a possible risk of subsequent breast cancer, and the diagnostic (breast imaging) or therapeutic management modalities (pharmacological or other) in women taking HRT.

Method: A review of the literature was carried out by consulting Medline, Cochrane Library data and international recommendations in French and English up to the end of 2019. Read More

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Evaluation of the presence of SARS-COV-2 in the vaginal fluid of reproductive-aged women.

Ginekol Pol 2021 Mar 10. Epub 2021 Mar 10.

Department of Microbiology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Objectives: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is mainly transmitted through respiration and direct contact. The status of the infection in the female genital system is still unknown. The study aimed to evaluate whether SARS-CoV-2 is present in the vaginal fluid of women with COVID-19 infection in reproductive period. Read More

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Low-Dose Tamoxifen for Mammographic Density Reduction: A Randomized Controlled Trial.

J Clin Oncol 2021 Mar 18:JCO2002598. Epub 2021 Mar 18.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Purpose: Tamoxifen prevents breast cancer in high-risk women and reduces mortality in the adjuvant setting. Mammographic density change is a proxy for tamoxifen therapy response. We tested whether lower doses of tamoxifen were noninferior to reduce mammographic density and associated with fewer symptoms. Read More

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Fractional CO₂ vaginal laser for the genitourinary syndrome of menopause in breast cancer survivors.

Breast J 2021 Mar 16. Epub 2021 Mar 16.

Division of Gynecology and Obstetrics, Umberto I Hospital, University of Turin, Turin, Italy.

Adjuvant chemotherapy and endocrine therapy can induce early iatrogenic menopause or worsen pre-existing menopausal symptoms in breast cancer survivors (BCS). The second most frequent menopausal symptom after hot flushes is the genitourinary syndrome (GSM). Since hormone replacement therapy is contraindicated in BCS, vaginal laser might represent a new nonhormonal option for GSM. Read More

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