1,025,335 results match your criteria severe group


SARS-CoV-2 in pregnancy and possible transfer of immunity: assessment of peripartal maternal and neonatal antibody levels and a longitudinal follow-up.

J Perinat Med 2021 Jun 11. Epub 2021 Jun 11.

University Department of Obstetrics and Gynecology at the Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.

Objectives: In the current Severe Acute Respiratory Distress Coronavirus 2 (SARS-CoV-2) pandemic there is still great uncertainty about the effects of an infection in pregnancy especially regarding a possible fetal transmission of antibodies to SARS-CoV-2 and the longevity of this immunity.

Methods: Sixteen women who were infected with SARS-CoV-2 during pregnancy and their offspring were included. The antibody response to SARS-CoV-2 was measured in mother and umbilical cord blood peripartum and in a follow-up examination 6-11 weeks after birth. Read More

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Neonatal Lymphopenia Screening Is Important For Early Diagnosis of Severe Combined Immunodeficiency.

Am J Perinatol 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology and Oncology, Immunology, Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey.

Objective:  T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in developing countries. We aimed to detect immunodeficiencies presenting with lymphopenia to enable screening in the general population and to improve awareness regarding lymphopenia among clinicians.

Study Design:  This study was conducted prospectively. Read More

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The interaction effect between comorbidity and venous thromboembolism on mortality rates after venous thromboembolism: A 5-year cohort study.

Thromb Haemost 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Background: Comorbidity influences venous thromboembolism (VTE) mortality, but it is unknown whether this is due to comorbidity alone or whether biological interaction exists.

Objectives: We examined whether comorbidity and VTE interact to increase VTE mortality beyond their individual effects.

Methods: This register-based 5-year cohort study included all VTE patients ≥18 years during 2000-2016, and an age-, sex-, and comorbidity-matched comparison cohort of individuals without VTE. Read More

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Pediatric Ocular Injury Due to Hand Sanitizer Exposure An Emerging Hazard.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Objectives: The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.

Methods: A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. Read More

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The impact of atherosclerotic cardiovascular disease, dyslipidaemia and lipid lowering therapy on Coronavirus disease 2019 outcomes: an examination of the available evidence.

Curr Opin Lipidol 2021 Jun 9. Epub 2021 Jun 9.

The University of Manchester, Faculty of Biology, Medicine and Health Department of Endocrinology, The Christie Hospital NHS Foundation Trust University Department of Medicine, Manchester University Foundation Trust, Manchester Department of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust, Salford, UK.

Purpose Of Review: Coronavirus Disease 2019 (COVID19) has caused significant global morbidity and mortality, especially in persons with underlying cardiovascular disease. There have been concerns that lipid-lowering therapy (LLT) increases angiotensin-converting enzyme 2 levels. Conversely, pleiotropic effects of statins can theoretically protect against severe COVID19 infection, supporting evidence from other respiratory illnesses in which statin use probably confers benefit. Read More

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Late morbidity and mortality following revascularization surgery for moyamoya disease in the pediatric population.

J Neurosurg Pediatr 2021 Jun 11:1-6. Epub 2021 Jun 11.

Objective: There are limited reports on long-term morbidity in pediatric patients who have undergone surgical revascularization for moyamoya disease (MMD). Here, the authors report long-term morbidity and mortality in a population of pediatric patients who underwent pial synangiosis for MMD from 1988 through 2016.

Methods: A single-center retrospective review of the hospital and personal operative databases of the senior authors was carried out to identify all patients who were treated for MMD at Boston Children's Hospital between 1988 and 2016, and who experienced any episode of late morbidity or mortality, which the authors defined as an event resulting in significant neurological deficit or death occurring more than 1 year after revascularization surgery. Read More

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Elevated peritoneal soluble endoglin and GDF-15 in infertile women with severe endometriosis and pelvic adhesion.

J Reprod Immunol 2021 Jun 5;146:103343. Epub 2021 Jun 5.

Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, 60286, Surabaya, Indonesia. Electronic address:

Objectives: Chronic inflammation and pelvic adhesion play a critical role in endometriosis-related infertility. Research studies suggest that TGF-β superfamily members, such as soluble endoglin (sEng), growth differentiation factor 15 (GDF-15) and tumor growth factor-beta (TGF-β1) contribute to the regulation of inflammation, angiogenesis and cell adhesion. The objective of this study is to investigate the association between the concentrations of these TGF-β-related members and the clinical parameters of infertile women with endometriosis. Read More

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Thiol/disulfide homeostasis in medication-naive children and adolescents with obsessive-compulsive disorder.

J Psychiatr Res 2021 Jun 2;140:159-164. Epub 2021 Jun 2.

Department of Child and Adolescent Psychiatry, Manisa Celal Bayar University, Faculty of Medicine, Manisa, 45030, Turkey. Electronic address:

Obsessive-compulsive disorder (OCD) causes significant psychic distress and affects children's social and academic functioning. Approximately 80% of OCD cases begin in childhood. Earlier onset is associated with more severe OC symptoms, poorer treatment response, and a more unfavorable clinical course. Read More

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A correlated random parameters approach to investigate large truck rollover crashes on mountainous interstates.

Accid Anal Prev 2021 Jun 8;159:106233. Epub 2021 Jun 8.

Department of Civil and Architectural Engineering, University of Wyoming, 1000 E. University Ave., Dept. 3295, Laramie, WY 82071, USA. Electronic address:

Rollover risk on mountainous interstates is a major concern for transportation agencies due to the combined mixed effects of adverse weather conditions and complex topography. Such crashes incur hazardous consequences on road users' lives. Therefore, a correlated random parameters logit modeling framework was employed to investigate the influences of crash precursors on rollover risk to identify effective safety countermeasures. Read More

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Probiotics alleviate adipose inflammation in high-fat diet-induced obesity by restoring adipose invariant natural killer T cells.

Nutrition 2021 Apr 25;89:111285. Epub 2021 Apr 25.

Department of Endocrinology and Metabolism, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.

Objective: Invariant natural killer T (iNKT) cells, which are depleted in obese individuals, play important roles in preventing diet-induced obesity and associated disorders. Probiotic supplementation can alter the gut microbiota and immunomodulation in obesity. However, it remains unclear whether probiotics can affect visceral adipose iNKT cells. Read More

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Should we screen Eastern Mediterranean COVID-19 patients for inherited thrombophilia?

Med Hypotheses 2021 Jun 4;152:110621. Epub 2021 Jun 4.

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

The inflammatory component of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) creates a pro-thrombotic state that necessitates a thrombophylactic strategy for hospitalized patients. Such strategies are difficult to be standardized because certain individuals can have pro-thrombotic conditions, such as inherited thrombophilia, which pre-dispose them to an additional coagulative risk. Whether outside the hospital or when admitted, patients with inherited thrombophilia need special anticoagulant and antiplatelet attention. Read More

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Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma.

Biochem Biophys Res Commun 2021 Jun 8;566:36-44. Epub 2021 Jun 8.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. Electronic address:

The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. The melanocortin 4 receptor-deficient (Mc4r-KO) mice were divided into four groups with or without a high-fat diet (HFD) and with or without dextran sulfate sodium (DSS) to induce colitis, and the differences in liver damage and occurrence of HCC were analyzed. Read More

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Effect of azithromycin on bronchial wall thickness in severe persistent asthma: A double-blind placebo-controlled randomized clinical trial.

Respir Med 2021 Jun 2;185:106494. Epub 2021 Jun 2.

Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran. Electronic address:

Background: Azithromycin reduced airway remodeling in animal models of asthma. However, its effect on human subjects has not been studied yet. This study aimed to investigate the effect of long-term treatment with azithromycin on airways wall thickness in patients with severe persistent asthma. Read More

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The importance of working memory capacity for improving speech in noise comprehension in children with hearing aid.

Int J Pediatr Otorhinolaryngol 2021 May 24;147:110774. Epub 2021 May 24.

Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Electronic address:

Background: One of the most common complaints of hearing aid users is difficulty in receiving speech in noise which is very important for all hearing impaired specially children with limited auditory and language experiences. Since working memory plays a significant role in speech perception, especially in challenging auditory situations such as background noise, it is likely that differences in its performance and capacity may impair the ability to understand speech in noise in hearing aid users. Therefore, we aimed to compare memory capacity between two groups of children using hearing aids in both ears, who differed only in the ability to understand speech in noise. Read More

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Polysaccharide of Atractylodes macrocephala Koidz regulates LPS-mediated mouse hepatitis through the TLR4-MyD88-NFκB signaling pathway.

Int Immunopharmacol 2021 Jun 8;98:107692. Epub 2021 Jun 8.

Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong 510225, China; Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Guangzhou, Guangdong 510225, China. Electronic address:

Feed corruption and poor breeding environment could cause widespread bacterial infection which could cause severe liver inflammation and lead to liver damage, even death. It has been proved that Polysaccharide of Atractylodes macrocephala Koidz (PAMK) could improve the immunity of animal, but the mechanism of its protective effect on hepatitis has been rarely reported. This study investigated the protective effect of PAMK on mouse liver through LPS-induced liver inflammatory. Read More

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Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency.

Clin Immunol 2021 Jun 8:108779. Epub 2021 Jun 8.

Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany; German Centre for Infection Research (DZIF), Munich, Germany; Munich Centre for Rare Diseases (M-ZSE), University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

CTLA4-haploinsufficiency is a complex disease of immune dysregulation presenting with a broad spectrum of clinical manifestations. CTLA4-Fc fusion proteins such as abatacept have been described to alleviate immune dysregulation in several adult cases of CTLA4-haploinsufficiency. However, until now only few cases of pediatric CTLA4-haploinsufficiency treated with abatacept have been described. Read More

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Hypothalamic-Pituitary-Adrenal Axis Dysfunction by Early Life Stress.

Neurosci Lett 2021 Jun 8:136037. Epub 2021 Jun 8.

Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience-King's College London, UK.

Evidence indicates that early life stress (ELS) may act as a risk factor for the development and maintenance of adulthood severe mental health disorders due to persistent dysregulation within the hypothalamic-pituitary-adrenal (HPA) axis. It is now broadly accepted that psychological stress may change the internal homeostatic state of an individual. The dysregulation seems to be a byproduct of changes noted in the HPA axis hormone's ability to bind to the glucocorticoid and mineralocorticoid receptors, crucial in maintaining homeostasis. Read More

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Distribution of spreading viruses during COVID-19 pandemic: Effect of mitigation strategies.

Am J Infect Control 2021 Jun 8. Epub 2021 Jun 8.

Department of Paediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Background: The study aimed to evaluate the distribution of circulating respiratory viral pathogens other than SARS-CoV-2 during the first year of the coronavirus disease-2019 (COVID-19) pandemic with especially focusing on the effects of the national-based mitigation strategies.

Methods: This single-center study was conducted between March 11, 2020-March 11, 2021. All children who were tested by polymerase chain reaction (PCR) on nasopharyngeal swabs for SARS-CoV-2 and other common respiratory viral pathogens were included in the study. Read More

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Structural white matter alterations in carpal tunnel syndrome: A modified TBSS study.

Brain Res 2021 Jun 8:147558. Epub 2021 Jun 8.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Functional and structural brain alterations have been noted in carpal tunnel syndrome (CTS), the most common entrapment peripheral neuropathy. Previous studies were mainly focused on somatosensory cortices. However, the changes of white matter diffusion properties in nonsensorimotor cortices remain uninvestigated. Read More

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Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation.

Am J Med Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China. Electronic address:

Background: Fluid therapy is indispensable in treating patients with hemorrhagic shock. However, fluid overload correlates with kidney injury in patients with hemorrhagic shock. We hypothesized that hemodilution after fluid treatment contributes to the kidney injury. Read More

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Differences in coronavirus disease 2019 screening, diagnosis, and hospitalization rates among U.S. pregnant women with and without a substance use disorder.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Gynecology & Reproductive Sciences Magee-Womens Research Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Objective: Pregnant women are at increased risk for severe morbidity and mortality due to respiratory infections like SARS-CoV-2 (COVID-19) during pregnancy. Those with substance use disorders (SUD) may be especially vulnerable due to high rates of smoked tobacco, cannabis and methamphetamine use which adversely affect pulmonary function. However, little is known about differential effects of COVID-19 on pregnant women with and without SUD. Read More

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Phosphodiesterase-5 inhibitors in Pregnancy: Systematic review and meta-analysis of maternal and perinatal safety and clinical outcomes.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Mater Research Institute - University of Queensland, Level 3 Aubigny Place, Raymond Terrace, South Brisbane, Queensland 4101, Australia; Faculty of Medicine, University of Medicine, Whitty Building, Annerley Road, South Brisbane, Queensland 4101, Australia; NHMRC Stillbirth Centre For Research Excellence, Mater Research Institute, South Brisbane, Queensland 4101, Australia. Electronic address:

Objective: Phosphodiesterase-5 inhibitors have recently been used for the treatment of severe early onset pre-eclampsia and fetal growth restriction. There are however concerns that they may increase the risk of neonatal morbidity and mortality. The aim of this systematic review was to assess the safety profile and clinical outcomes of phosphodiesterase-5 inhibitors use in pregnancy. Read More

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Aerosol-induced direct radiative forcing effects on terrestrial ecosystem carbon fluxes over China.

Environ Res 2021 Jun 8:111464. Epub 2021 Jun 8.

Department of Chemical and Biochemical Engineering, Iowa Technology Institute, University of Iowa, Iowa City, IA, USA. Electronic address:

Atmospheric aerosols can change vegetation photosynthesis through the effects of aerosols on radiation, which will affect the peak carbon dioxide emissions and carbon neutrality at global scales. In this study, we quantify the aerosol-induced direct radiation forcing (ADRF) in China from 2001 to 2014 based on the radiation flux simulation used by the Fu-Liou radiation transfer model under with-aerosols and no-aerosols scenarios. Using the radiation simulation results, we modify the atmospheric forcing datasets to drive Community Land Model 4. Read More

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Hydrogeochemistry and health hazards of fluoride-enriched groundwater in the Tarim Basin, China.

Environ Res 2021 Jun 8:111476. Epub 2021 Jun 8.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Fluoride (F) enrichment reduces the availability of groundwater resources in the arid region, and it is thus important to investigate the hydrogeochemistry and health hazards of fluoride-enriched groundwater. Seventy-two groundwater samples (20 unconfined samples from the piedmont plain, 22 unconfined samples and 30 shallow confined samples from the alluvial plain) were collected in the Tarim Basin of China to illustrate the geochemical processes driving the F enrichment and the incidence of dental fluorosis. The patterns of average ions contents in groundwater are Na > Ca > Mg > K and SO > Cl > HCO > NO > F. Read More

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Early postnatal exposure to traffic-related air pollution and asthma in adolescents: Vulnerability factors in the PARIS birth cohort.

Environ Res 2021 Jun 8:111473. Epub 2021 Jun 8.

Health Environmental Risk Assessment (HERA) Team, CRESS, Université de Paris, Inserm, INRAE, Paris, France; Université de Paris, Faculté de Pharmacie de Paris, Paris, France; Cellule Cohorte, Direction de l'Action Sociale de l'Enfance et de la Santé, Mairie de Paris, Paris, France.

Background: Associations between early traffic-related air pollution (TRAP) exposure and respiratory and allergic morbidity in adolescents are inconsistent. However, sub-groups might be more vulnerable to the health effects of this exposure.

Objectives: We investigated associations between early exposure to TRAP and respiratory and allergic morbidity at age 13 years in the PARIS birth cohort, and potential modifying effects of sex, parental allergy, stressful family event and lower respiratory tract infections (LRTI). Read More

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Respiratory Failure in Noonan Syndrome Treated by Microsurgical Thoracic Duct-Venous Anastomosis.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania. Electronic address:

Noonan Syndrome is a disorder characterized by central and peripheral lymphatic conducting anomalies, leading to chylothorax, chylous ascites, and metabolic derangement. Novel imaging modalities including dynamic contrast magnetic resonance lymphangiography (DCMRL) and intranodal lymphangiography have allowed for increased visualization of lymphatic pathology. We describe the first study of a 61-year-old male with Noonan syndrome who developed severe pulmonary insufficiency and chylothoraces. Read More

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Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals.

Am J Hum Genet 2021 Jun 3. Epub 2021 Jun 3.

Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, UK.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. Read More

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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.

Immunity 2021 Jun 10. Epub 2021 Jun 10.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, UCSD, La Jolla, CA 92093, USA.

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. Read More

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Better Together: A Mixed-Methods Study of Palliative Care Co-Management for Patients with Interstitial Lung Disease.

J Palliat Med 2021 Jun 11. Epub 2021 Jun 11.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California, USA.

The morbidity and mortality of interstitial lung disease (ILD) is high, despite novel therapeutics. Recognizing unmet needs for symptom management, advance care planning (ACP), and support for people with ILD and their families, we developed a palliative care-ILD collaborative care pilot program to improve access to palliative care. In the quantitative arm of this mixed-methods study, we evaluated which patients were cared for through the palliative care co-management program and the impact of the program on rates of ACP and opioid prescribing. Read More

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Persistent visual dysfunction following PRES due to COVID-19: Case series and literature review.

Eur J Neurol 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Colorado University School of Medicine, 1675 North Aurora Ct. F731, Aurora, CO, 80045, USA.

Background: The full spectrum of neurological sequelae in COVID-19 is beginning to emerge. SARS-CoV-2 has the potential to cause both direct and indirect brain vascular endothelial damage through infection and inflammation that may result in long-term neurological signs and symptoms. We sought to illuminate persistent neuro-ophthalmological deficits that may be seen following posterior reversible encephalopathy syndrome (PRES) due to COVID-19. Read More

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