26,886 results match your criteria severe forms

Juvenile haemochromatosis.

Lancet Child Adolesc Health 2021 Apr 13. Epub 2021 Apr 13.

Liver Unit, Birmingham Women's and Children's NHS Trust and University of Birmingham, Birmingham, UK.

Juvenile haemochromatosis is a severe inherited iron-loading disorder that can present in children and adolescents. Typical manifestations include heart failure, endocrine failure (including diabetes and hypogonadism), cirrhosis, and arthropathy. Compared with HFE haemochromatosis, juvenile haemochromatosis affects female and male individuals similarly, presents at a younger age, and causes multiple organ dysfunction; the principle of iron loading into tissues from the gut is shared by both forms, but the process is far more rapid in juvenile haemochromatosis. Read More

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Prominent Anterior Inferior Iliac Spine Morphologies Are Common in Patients with Acetabular Dysplasia Undergoing Periacetabular Osteotomy.

Clin Orthop Relat Res 2021 May;479(5):991-999

D. Nestorovski, L. M. Fowler, J. C. Clohisy, J. J. Nepple, Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.

Background: The anterior inferior iliac spine (AIIS) prominence is increasingly recognized in the setting of femoroacetabular impingement (FAI). The AIIS prominence may contribute to decreased hip flexion after acetabular reorientation in patients with acetabular dysplasia. AIIS morphologies have been characterized in numerous populations including asymptomatic, FAI, and athletic populations, but the morphology of the AIIS in patients with symptomatic acetabular dysplasia undergoing periacetabular osteotomy (PAO) has not been studied. Read More

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Osteopathic Manipulative Treatment to Optimize the Glymphatic Environment in Severe Traumatic Brain Injury Measured With Optic Nerve Sheath Diameter, Intracranial Pressure Monitoring, and Neurological Pupil Index.

Cureus 2021 Mar 11;13(3):e13823. Epub 2021 Mar 11.

Neurosurgery, Arrowhead Regional Medical Center, Colton, USA.

Background Traumatic brain injury (TBI) has a complex pathophysiology that has historically been poorly understood. New evidence on the pathophysiology, molecular biology, and diagnostic studies involved in TBI have shed new light on optimizing rehabilitation and recovery. The goal of this study was to assess the effect of osteopathic manipulative treatment (OMT) on peripheral and central glial lymphatics in patients with severe TBI, brain edema, and elevated intracranial pressure (ICP) by measuring changes in several parameters regularly used in management. Read More

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Intestinal immunoregulation: lessons from human mendelian diseases.

Mucosal Immunol 2021 Apr 15. Epub 2021 Apr 15.

Université de Paris, Imagine Institute, Laboratory of Intestinal Immunity, INSERM UMR 1163, Paris, France.

The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut surface to multiple environmental antigens and to billions of microbes have been scrutinized over the past 20 years with the goals to gain basic knowledge, but also to elucidate the pathogenesis of inflammatory bowel diseases (IBD) and to identify therapeutic targets for these severe diseases. Considerable insight has been obtained from studies based on gene inactivation in mice as well as from genome wide screens for genetic variants predisposing to human IBD. These studies are, however, not sufficient to delineate which pathways play key nonredundant role in the human intestinal barrier and to hierarchize their respective contribution. Read More

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Development of central precocious puberty following cannabinoid use for paediatric epilepsy: causal or coincidence?

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Department of Paediatrics, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, Birmingham, UK.

Research suggests a role for cannabidiol oil in managing certain forms of paediatric onset epilepsy. However, studies on the impact of cannabis on the hypothalamo-pituitary-gonadal (HPG) axis have conflicting results. Delta-9-tetrahydrocannabinol (Δ9-THC) acutely inhibits gonadotropin-releasing hormone in the hypothalamus, reducing testosterone levels by 65% in rhesus monkeys. Read More

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Impact of systemic to topical steroids switch on the outcome of drug reaction with eosinophilia and systemic symptoms (DRESS): A monocenter retrospective study of 20 cases.

Ann Dermatol Venereol 2021 Apr 12. Epub 2021 Apr 12.

Service de dermatologie, AP-HP, hôpitaux universitaires Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France; Université Paris Est Créteil, EpidermE, 94010 Créteil, France; Centre de référence des dermatoses bulleuses toxiques et toxidermies graves TOXIBUL, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

Background: There is no consensus on the treatment of drug reaction with eosinophilia and systemic symptoms (DRESS). At our center, systemic steroids (SS) are used for severe cases while topical steroids (TS) are used for mild and moderate forms.

Objectives: To investigate the short-term outcome for patients with DRESS receiving SS as first-line therapy before being transferred to our department and then switched to TS after admission. Read More

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Antibiotic Stewardship Interventions Improve Choice of Antibiotic Prophylaxis in Total Joint Arthroplasty in Patients with Reported Penicillin Allergies.

Clin Orthop Relat Res 2021 Apr 14. Epub 2021 Apr 14.

R. Jones, University of Rochester Medical Center - Strong Memorial Hospital, Rochester, NY, USA.

Background: Most patients who report a penicillin allergy can tolerate cefazolin, the preferred prophylaxis in a total joint arthroplasty (TJA). Regardless, patients with a reported penicillin allergy are less likely to receive first-line perioperative antibiotics as a result of inaccurate penicillin allergy documentation and misconceptions regarding cross-reactivity between penicillin and cephalosporins. The over-reporting of penicillin allergies and the safety of cephalosporins in patients with reported penicillin allergies have been well established throughout the evidence [13]. Read More

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Acquired severe aplastic anaemia: how medical therapy evolved in the 20th and 21st centuries.

Br J Haematol 2021 Apr 14. Epub 2021 Apr 14.

Division of Haematology, Hospital A Beneficência Portuguesa, São Paulo, Brazil.

The progress in aplastic anaemia (AA) management is one of success. Once an obscure entity resulting in death in most affected can now be successfully treated with either haematopoietic stem cell transplantation (HSCT) or immunosuppressive therapy (IST). The mechanisms that underly the diminution of haematopoietic stem cells (HSCs) are now better elucidated, and include genetics and immunological alterations. Read More

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Antibiotics and Antibiotic Resistance Genes in Animal Manure - Consequences of Its Application in Agriculture.

Front Microbiol 2021 29;12:610656. Epub 2021 Mar 29.

Department of Bacterial Physiology, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland.

Antibiotic resistance genes (ARGs) are a relatively new type of pollutant. The rise in antibiotic resistance observed recently is closely correlated with the uncontrolled and widespread use of antibiotics in agriculture and the treatment of humans and animals. Resistant bacteria have been identified in soil, animal feces, animal housing (e. Read More

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Contribution of Janus-Kinase/Signal Transduction Activator of Transcription Pathway in the Pathogenesis of Vasculitis: A Possible Treatment Target in the Upcoming Future.

Front Pharmacol 2021 29;12:635663. Epub 2021 Mar 29.

Rheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Janus-kinase (JAK) and signal transduction activator of transcription (STAT) signal transduction pathway is involved in a wide range of physiological and pathological processes, including in the pathogenesis of several autoimmune diseases. Data supporting the role of JAK/STAT in the development of vasculitis are limited and mostly focused on large vessel vasculitis and Behçet's disease. In this review, we provide a thorough picture of currently available evidence on the topic, gathered from experiments, animal models and human real-life data, analyzing the rationale for the use of JAK inhibitors for the management of vasculitis. Read More

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Prolonged presence of replication-competent SARS-CoV-2 in mildly symptomatic individuals: A Report of 2 Cases.

J Med Virol 2021 Apr 14. Epub 2021 Apr 14.

Faculdade de Medicina da Universidade de Sao Paulo- Instituto de Medicina Tropical de, Sao Paulo.

It has been estimated that individuals with COVID-19 can shed replication-competent virus up to a maximum of twenty days after initiation of symptoms. The majority of studies that addressed this situation involved hospitalized individuals and those with severe disease. Studies to address the possible presence of SARS-CoV-2 during the different phases of COVID-19 disease in mildly infected individuals, and utilization of viral culture techniques to identify replication-competent viruses, have been limited. Read More

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Wiad Lek 2021 ;74(1):112-117


Objective: The aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops.

Patients And Methods: Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Read More

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Dopamine agonists for preventing ovarian hyperstimulation syndrome.

Cochrane Database Syst Rev 2021 Apr 14;4:CD008605. Epub 2021 Apr 14.

School of Women's and Infants' Health, The University of Western Australia, King Edward Memorial Hospital and Fertility Specialists of Western Australia, Subiaco, Perth, Australia.

Background: Ovarian hyperstimulation syndrome (OHSS) is a potentially serious complication of ovarian stimulation in assisted reproduction technology (ART). It is characterised by enlarged ovaries and an acute fluid shift from the intravascular space to the third space, resulting in bloating, increased risk of venous thromboembolism, and decreased organ perfusion. Most cases are mild, but forms of moderate or severe OHSS appear in 3% to 8% of in vitro fertilisation (IVF) cycles. Read More

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Brain Injury in Extracorporeal Membrane Oxygenation: A Multidisciplinary Approach.

Semin Neurol 2021 Apr 13. Epub 2021 Apr 13.

Department of Cardiothoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Maastricht, The Netherlands.

Extracorporeal membrane oxygenation (ECMO) represents an established technique to provide temporary cardiac and/or pulmonary support. ECMO, in veno-venous, veno-arterial or in extracorporeal carbon dioxide removal modality, is associated with a high rate of brain injuries. These complications have been reported in 7 to 15% of adults and 20% of neonates, and are associated with poor survival. Read More

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Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID-19.

Endocrinol Diabetes Metab 2021 04 16;4(2):e00215. Epub 2021 Feb 16.

NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK.

Background: COVID-19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity.

Methods: Clinical and laboratory data from 610 COVID-19 cases hospitalized in the province of Zheijang, China were investigated as risk factors for severe COVID-19 (assessed by respiratory distress) compared to mild or common forms using logistic regression methods. Read More

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Clinical course in two children with Juvenile Paget's disease during long-term treatment with intravenous bisphosphonates.

Bone Rep 2021 Jun 9;14:100762. Epub 2021 Mar 9.

Department of Pediatrics, Division of Rare Diseases, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.

Juvenile Paget disease (JPD) is an ultra-rare disease, characterized by loss of function of osteoprotegerin. Osteoprotegerin inhibits osteoclast activation via the receptor activator of nuclear factor κB (RANK) pathway. Severely affected children suffer from bone deformities and pain and require long term anti-resorptive treatment. Read More

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The impact of COVID-19 on surgical training at a tertiary hospital in Greece: a 'hidden infectious enemy' for junior surgeons?

Eur Surg 2021 Apr 8:1-6. Epub 2021 Apr 8.

Department of Surgery, University of Patras, University Hospital of Patras, 26504 Patra, Greece.

Background: Soon after its appearance, the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) became a pandemic, with over 111 million cases reported and 2.4 million deaths worldwide. Although the focus of public health systems must lie on patients' care and treatment, SARS-COV‑2 infection has also affected surgical trainees in their academic and professional development, causing significant disruption in all forms of their training. Read More

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Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells.

Cell Mol Immunol 2021 Apr 13. Epub 2021 Apr 13.

Research Institute, Curogen Technology, Suwon, South Korea.

The homeostatic balance between effector T cells and regulatory T cells (Tregs) is crucial for adaptive immunity; however, epigenetic programs that inhibit phosphorylation to regulate Treg development, peripheral expression, and suppressive activity are elusive. Here, we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways, including the T-cell receptor and IL-2R pathways, and localizes at the cell membrane. Deletion of Ssu72 in T cells disrupts CD4 T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ, which induce CD4 T-cell activation and differentiation into effector cell lineages. Read More

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Macrophage migration inhibitory factor as a diagnostic and predictive biomarker in sepsis: meta-analysis of clinical trials.

Sci Rep 2021 Apr 13;11(1):8051. Epub 2021 Apr 13.

Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary.

The hunt for useful sepsis biomarkers is ongoing. Macrophage migration inhibitory factor (MIF) was implicated as a biomarker in sepsis, but its diagnostic and prognostic value has remained unclear in human studies. Here, we aimed at clarifying the value of MIF as a sepsis biomarker with the meta-analysis of clinical trials. Read More

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Age-Related Macular Degeneration: Epidemiology and Clinical Aspects.

Adv Exp Med Biol 2021 ;1256:1-31

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA.

Age-related macular degeneration (AMD) is a degenerative disease of the human retina affecting individuals over the age of 55 years. This heterogeneous condition arises from a complex interplay between age, genetics, and environmental factors including smoking and diet. It is the leading cause of blindness in industrialized countries. Read More

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A microfluidic approach to rapid sperm recovery from heterogeneous cell suspensions.

Sci Rep 2021 Apr 12;11(1):7917. Epub 2021 Apr 12.

School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, 2007, Australia.

The isolation of sperm cells from background cell populations and debris is an essential step in all assisted reproductive technologies. Conventional techniques for sperm recovery from testicular sperm extractions stagnate at the sample processing stage, where it can take several hours to identify viable sperm from a background of collateral cells such as white bloods cells (WBCs), red blood cells (RBCs), epithelial cells (ECs) and in some cases cancer cells. Manual identification of sperm from contaminating cells and debris is a tedious and time-consuming operation that can be suitably addressed through inertial microfluidics. Read More

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Recent advancement in topical drug delivery for psoriasis: Clinical Pertinence and Potential Market.

Curr Drug Targets 2021 Apr 12. Epub 2021 Apr 12.

Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, 142001. India.

Psoriasis is an immune-mediated chronic skin inflammation. This disease can be associated with several manifestation like red flaks, silver scale, patches, plaques and silvery-white squams. Approximately 70% of the patients treated with topical dosage forms have a mild-to-moderate form of psoriasis, whereas a moderate-to-severe form of psoriasis is treated with systemic, photo, and biological therapies. Read More

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Host-Directed Therapies for Cutaneous Leishmaniasis.

Front Immunol 2021 26;12:660183. Epub 2021 Mar 26.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Cutaneous leishmaniasis exhibits a wide spectrum of clinical presentations from self-resolving infections to severe chronic disease. Anti-parasitic drugs are often ineffective in the most severe forms of the disease, and in some cases the magnitude of the disease can result from an uncontrolled inflammatory response rather than unrestrained parasite replication. In these patients, host-directed therapies offer a novel approach to improve clinical outcome. Read More

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Utility of Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) in Decompensated Cirrhosis.

Indian J Nephrol 2020 Nov-Dec;30(6):391-397. Epub 2019 Nov 11.

Department of Biochemistry, JIPMER, Pondicherry, India.

Background And Aims: Renal failure occurring in the setting of cirrhosis increases mortality by more than threefold. Serum creatinine, the conventional marker for renal dysfunction has inherent limitations in identifying and categorizing renal dysfunction in patients with chronic liver disease (CLD). Neutrophil gelatinase associated lipocalin (NGAL) is a novel biomarker which gets upregulated as early as 2-6 hours following the insult to renal tubules. Read More

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November 2019

The COVID-19 hydroxychloroquine prophylaxis perception of Indian anesthesiologists: A survey-based original article.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):471-476. Epub 2020 Nov 5.

Department of Anaesthesiology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India.

Background And Aims: HCQ gained importance following the National Task Force advisory as an anti-SARS-Cov-2 (coronavirus disease-2019 [COVID-19]) drug for frontline healthcare workers (including anesthesiologists). Report of a young anesthesiologist in Assam developing cardiac arrest following HCQ intake for COVID-19 prophylaxis made us even more concerned. A conscious decision has been made by a large majority among us--to have or not to have HCQ. Read More

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November 2020

Characteristics of Chemical Speciation in PM in Six Representative Regions in China.

Adv Atmos Sci 2021 Apr 7:1-14. Epub 2021 Apr 7.

Key Laboratory of Geographic Information Science (Ministry of Education), School of Geographic Sciences, East China Normal University, Shanghai, 200241 China.

A better knowledge of aerosol properties is of great significance for elucidating the complex mechanisms behind frequently occurring haze pollution events. In this study, we examine the temporal and spatial variations in both PM and its major chemical constituents using three-year field measurements that were collected in six representative regions in China between 2012 and 2014. Our results show that both PM and its chemical compositions varied significantly in space and time, with high PM loadings mainly observed in the winter. Read More

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More than meets the naked eye: an unusual psoriatic arthritis mimicry and the important role of dermoscopic examination.

BMC Rheumatol 2021 Apr 12;5(1):10. Epub 2021 Apr 12.

School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, 16150, Kota Bharu, Kelantan, Malaysia.

Background: Psoriatic arthritis (PsA) can manifest in various forms. This includes mimicry of other diseases. We describe an unusual mimicry of PsA. Read More

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[Covid-19 in kidney transplantation: Lessons from the French Registry].

Nephrol Ther 2021 Mar 18. Epub 2021 Mar 18.

Service de néphrologie et transplantation, Centre hospitalier universitaire de Lille, Lille, France.

The Covid-19 pandemic hits the French transplant population on March 3, 2020. Very quickly, a French registry was set up on behalf of the French Society of Transplantation allowing the collection of confirmed cases of Covid-19 occurring in kidney transplant recipients in almost all French centers. The analysis of this registry in conjunction with the data from the Agence de la Biomédecine (Cristal) has enabled us to obtain instructive results. Read More

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Clinical vulnerability for severity and mortality by COVID-19 among users of alcohol and other substances.

Psychiatry Res 2021 Mar 31;300:113915. Epub 2021 Mar 31.

Center for Drug and Alcohol Research and Collaborating Center on Alcohol and Drugs, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

The COVID-19 pandemic is a public health emergency. Individuals with substance use disorder have a higher risk of infection and may suffer from more severe forms of the disease. Our goal is to investigate the prevalence of risk factors for COVID-19 severity in individuals with different substance use and explore whether specific types of substance are potentially associated with more clinical risk factors which could increase morbimortality in this population. Read More

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Saphenous Nerve Entrapment Neuropathy After Closed Tibial Fracture: A Case Report.

JBJS Case Connect 2021 04 9;11(2). Epub 2021 Apr 9.

Department of Orthopedic Surgery, Kurume University Medical Center, Kurume, Fukuoka, Japan.

Case: A 43-year-old man who underwent intramedullary nailing for a closed tibial fracture developed saphenous nerve entrapment neuropathy. He developed severe medial leg pain, which was worse on walking or standing, 2 years postoperatively. Surgical neurolysis resulted in complete pain relief and functional recovery of the limb without recurrence of symptoms. Read More

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