1,011,335 results match your criteria severe


Acute kidney injury caused by ammonium acid urate crystals in diabetic ketoacidosis at the onset of type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2021 Feb 26;2021. Epub 2021 Feb 26.

Department of Endocrinology, Chiba Children's Hospital, Chiba, Japan.

Summary: Ammonium acid urate (AAU) crystals are rare in industrialized countries. Furthermore, the number of children with diabetic ketoacidosis (DKA) who develop severe acute kidney injury (AKI) after hospitalization is small. We encountered two patients with AKI caused by AAU crystals during the recovery phase of DKA upon admission. Read More

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February 2021

Duplicated Middle Cerebral Artery Aneurysms Treated by Coil Embolization; A Report of Two Cases and Literature Review.

J Stroke Cerebrovasc Dis 2021 Apr 14;30(7):105773. Epub 2021 Apr 14.

Department of Neurosurgery, Nara Medical University, Kashihara, Japan. Electronic address:

Background: Duplication of the middle cerebral artery (DMCA) is an anomalous vessel arising from the internal carotid artery (ICA). Aneurysms at the origin of a DMCA have been reported; however, most have been treated with clipping surgery. Here, we describe two cases of aneurysms at the origin of a DMCA treated with coil embolization. Read More

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Immediate rehabilitation of a rheumatoid arthritis patient with single-piece implants.

Int J Surg Case Rep 2021 Apr 7;82:105874. Epub 2021 Apr 7.

Dr Hedgewar Smruti Rugna Sewa Mandal Dental College and Hospital, Hingoli, India.

Introduction And Importance: The aim of this article is to report the long-term outcome of full mouth rehabilitation with single piece, smooth surface implants following immediate loading protocol on a patient suffering with RA and severe unilateral condylar resorption.

Case Presentation: Here, we present a challenging case of a patient suffering from Rheumatoid Arthritis who was stabilized and completed successfully with a 4 year follow-up period. Prosthetic management optimized the inter-occlusal relationship to maintain both function and esthetic integrity. Read More

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Gastric remnant mesentero-axial volvulus following Roux-en-Y esophagojejunostomy: A rare complication.

Int J Surg Case Rep 2021 Apr 7;82:105873. Epub 2021 Apr 7.

Esophageal Institute, Allegheny Health Network, Pittsburgh, PA, United States. Electronic address:

Introduction: Acute gastric volvulus is a surgical emergency with a mortality as high as 15-20%. The rarity of gastric volvulus requires high index of clinical suspicion especially in the patients with altered anatomy, to allow immediate surgical intervention and reduce the morbidity and mortality.

Presentation Of Case: We present an unusual case of gastric remnant volvulus several months following Roux-en-Y esophagojejunostomy performed in an obese patient for severe, recurrent gastroesophageal reflux disease (GERD) and failed prior fundoplication. Read More

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Decreased quality of life and spirometric alterations even after mild-moderate COVID-19.

Respir Med 2021 Apr 14;181:106391. Epub 2021 Apr 14.

Department of Internal Medicine, Hospital General de Zona No.27 Del Instituto Mexicano Del Seguro Social, Mexico City, Mexico. Electronic address:

Background: The follow-up of recovered COVID-19 patients is still limited. We aimed to evaluate the changes in quality-of-life (QOL) and spirometric alterations in the convalescent phase of 115 patients with at least 30 days post-COVID-19.

Methods: We included patients with confirmed COVID-19 infection, available past medical records and at least 30 days after the onset of symptoms. Read More

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The toxic impacts of microplastics (MPs) and polycyclic aromatic hydrocarbons (PAHs) on haematic parameters in a marine bivalve species and their potential mechanisms of action.

Sci Total Environ 2021 Apr 9;783:147003. Epub 2021 Apr 9.

College of Animal Sciences, Zhejiang University, Hangzhou 310058, PR China. Electronic address:

Microplastics (MPs) and polycyclic aromatic hydrocarbons (PAHs) are universally detected in the marine ecosystem and may exert adverse impacts on marine species. Although under realistic pollution scenarios, PAH pollution usually occurs as a mixture of different PAH compounds, the toxic impacts of PAH mixtures on marine organisms remain largely unknown to date, including their interactions with other emergent pollutants such as MPs. In this study, the single and combined toxic impacts of polystyrene MPs and a mixture of PAHs (standard mix of 16 representative PAHs) on haematic parameters were evaluated in the blood clam Tegillarca granosa. Read More

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Sleep positions in children with Down syndrome and obstructive sleep apnea.

Sleep Med 2021 Mar 26;81:463-465. Epub 2021 Mar 26.

Division of Otolaryngology, Children's Hospital Los Angeles, Los Angeles, CA, USA; Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objectives: To assess sleep positions in children with both Down syndrome (DS) and obstructive sleep apnea (OSA) and determine if there is a preferred sleep position by severity of apnea.

Methods: A single-center retrospective review of patients with both DS and OSA was performed. Caregivers reported sleep position utilized greater than 50% of observed sleep time. Read More

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Comparing respiratory polygraphy with pulse transit time analysis versus overnight polysomnography in the diagnosis of obstructive sleep apnoea in children.

Sleep Med 2021 Mar 1;81:457-462. Epub 2021 Mar 1.

FHKAM(Otolaryngology), Department of Otolaryngology, Tuen Mun Hospital, Hong Kong.

Objective: Obstructive sleep apnea syndrome in children is associated with significant morbidity. Polysomnography is the main diagnostic tool but is time consuming and requires skilled manpower to supervise the patient overnight and hence long referral to diagnosis time. However, there are limitations and underestimation of the apnoea hyponea index (AHI) with alternative home sleep apnoea testing (HSAT), such as type 3 respiratory polygraphy (RP). Read More

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A quantitative approach to resource effectiveness assessment: Application in the Urmia Lake Basin.

J Environ Manage 2021 Apr 14;289:112559. Epub 2021 Apr 14.

Department of Civil and Environmental Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran. Electronic address:

This paper aims to present a new quantitative systematic approach to evaluate the effectiveness of utilizing and allocating resources based on the concept of "Work" in physics. This method is examined in the Urmia Lake Basin (ULB), shrinking of which has threatened the life of about five million inhabitants and ecosystem biodiversity. In the proposed approach, the role of three types of financial, human, and environmental resources in the development process is evaluated quantitatively, and they have been compared in two periods before and after the severe reduction of the lake water volume. Read More

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Neonatal exposure to monosodium glutamate results in impaired auditory brainstem structure and function.

Hear Res 2021 Apr 8;405:108243. Epub 2021 Apr 8.

Department of Anatomy, Lake Erie College of Osteopathic Medicine, 1858 West Grandview Blvd, Erie, PA 16504, United States. Electronic address:

Excitotoxic injury during the neonatal period has been shown to result in neurodegenerative changes in several different brain regions. Exposure to monosodium glutamate (MSG) during the first two postnatal weeks results in glutamate neurotoxicity in the cochlea and has been shown to result in damage to cochlear hair cells and fewer neurons in the spiral ganglion. Further, we have shown that such exposure results in fewer neurons in the cochlear nucleus and superior olivary complex and abnormal expression of the calcium binding proteins calbindin and calretinin. Read More

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Aspirin facilitates trophoblast invasion and epithelial-mesenchymal transition by regulating the miR-200-ZEB1 axis in preeclampsia.

Biomed Pharmacother 2021 Apr 14;139:111591. Epub 2021 Apr 14.

Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan.

Preeclampsia is a severe gestational hypertensive disorder that occurs after 20 weeks' of gestation. It involves several maternal systems, such as cardiovascular, renal, coagulatory systems, and poses a major threat to the maternal and fetal health. Recent clinical evidence showed that aspirin is an effective preventative treatment for reducing the incidence of premature preeclampsia among high-risk pregnant women, however, the mechanism of drug action is not clear. Read More

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Assessment spermatogenic cell apoptosis and the transcript levels of metallothionein and p53 in Meretrix meretrix induced by cadmium.

Ecotoxicol Environ Saf 2021 Apr 14;217:112230. Epub 2021 Apr 14.

College of Life and Environmental Science, Wenzhou University, 325035 Wenzhou, China. Electronic address:

Cadmium (Cd) has been widely used in industry and can accumulate in the water, soil, and food. Meretrix meretrix is one of the marine shellfishes cultivated for economic purpose in China. The increasing Cd levels in coastal marine water could adversely affect the economic benefits of shellfish cultivation. Read More

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Scenario analysis of COVID-19 transmission dynamics in Malaysia with the possibility of reinfection and limited medical resources scenarios.

Comput Biol Med 2021 Apr 7;133:104372. Epub 2021 Apr 7.

Nano-Optoelectronics Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.

COVID-19 is a major health threat across the globe, which causes severe acute respiratory syndrome (SARS), and it is highly contagious with significant mortality. In this study, we conduct a scenario analysis for COVID-19 in Malaysia using a simple universality class of the SIR system and extensions thereof (i.e. Read More

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Angioedema with severe acute abdominal pain: Think of hereditary angioedema.

Clin Res Hepatol Gastroenterol 2021 Apr 14:101702. Epub 2021 Apr 14.

Director, Division of Gastroenterology and Liver Disease, The George Washington University, 3131 I St NW, Washington, DC, United States.

Angioedema can be either mast cell- (histamine-) mediated or bradykinin-mediated. Treatment approaches for the two types are very different, making differential diagnosis critical. Severe acute abdominal pain caused by intestinal angioedema is commonly misdiagnosed, especially when associated with bradykinin-mediated angioedema. Read More

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Metabolome and lipidome derangements during a severe mast cell activation event in a patient with indolent systemic mastocytosis.

J Allergy Clin Immunol 2021 Apr 14. Epub 2021 Apr 14.

Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Background: The number of mast cells in various organs is manifold elevated in individuals with systemic mastocytosis. Degranulation can lead to life-threatening symptomatology. No data have been published about the alterations of the metabolome and lipidome during an attack. Read More

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Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy and enteropathy, and implications for clinical management.

J Allergy Clin Immunol 2021 Apr 14. Epub 2021 Apr 14.

Department of Medicine (Medical Genetics) and Department of Genome Sciences, University of Washington, Seattle WA. Electronic address:

Background: Most patients with childhood-onset immune dysregulation, polyendocrinopathy and enteropathy have no genetic diagnosis for their illness. These patients may undergo empirical immunosuppressive treatment with highly variable outcomes.

Objective: To determine the genetic basis of disease in patients referred with "IPEX-like" disease, but with no mutation in FOXP3; then to assess consequences of genetic diagnoses for clinical management. Read More

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Preparation of cellulose based wipes treated with antimicrobial and antiviral silver nanoparticles as novel effective high-performance coronavirus fighter.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Spinning and Weaving Engineering Department, Textile Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, P.O. 12622, Cairo, Egypt.

Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). We successful to prepare disinfectant cellulose-based wipes treated with antimicrobial and antiviral silver nanoparticles to be used for prevention of contamination and transmission of several pathogenic viruses and microbes to human in critical areas such as hospitals and healthcare centers especially coronavirus. In this work, the antimicrobial and antiviral activities of silver nanoparticles (AgNPs) prepared with four different techniques were investigated for the utilization as a disinfectant for cellulose-based wipes. Read More

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Relationship between ambient temperature and severe acute poisoning by alcohol and drugs.

Alcohol 2021 Apr 14. Epub 2021 Apr 14.

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Asklepios Klinikum Harburg, Eißendorfer Pferdeweg 52, 21075 Hamburg, Germany. Electronic address:

Aim: To test the hypothesis that severe acute poisoning by alcohol and drugs is more frequent at higher rather than at lower ambient temperatures.

Method: This was a prospective observational study performed in a prehospital setting under marine west coast climate conditions. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Read More

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Inpatient measurements of urine metanephrines are indistinguishable from pheochromocytoma: retrospective cohort study.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Cumming School of Medicine, Department of Medicine, University of Calgary; Department of Community Health Sciences, University of Calgary.

Background: Pheochromocytoma is a rare cause of acute cardiovascular disease however, any severe illness may have high catecholamines, simulating pheochromocytoma. We determined the spectrum of urine metanephrines from inpatient and outpatient collections without pheochromocytoma compared to confirmed pheochromocytoma patients.

Methods: Retrospective analysis using centralized laboratory data serving all outpatients and hospitals in southern Alberta. Read More

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Pseudohyperchloremia and Negative Anion Gap - Think Salicylate!

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Chairman of Internal Medicine, BUMC, Dallas, Clinical Professor of Internal Medicine, UT Southwestern School of Medicine; Professor (Affiliated)Texas A&M School of Medicine, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246. Electronic address:

Background: Pseudohyperchloremia results in a very low or negative anion gap (AG). Historically, the most common cause of this artifact was bromide poisoning. Bromide salts have been removed from most medications and bromism has become very uncommon. Read More

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Late adverse events in patients with pulmonary atresia intact ventricular septum after valvuloplasty.

Ann Thorac Surg 2021 Apr 14. Epub 2021 Apr 14.

Cardiovascular Surgery, Kyushu Hospital, Japan Community Healthcare Organization.

Background: We aimed to explore the relationship between temporal right heart growth and long-term outcomes in patients with pulmonary atresia with intact ventricular septum (PA/IVS) who underwent balloon pulmonary valvulopalsty (BPV).

Methods: Echocardiography was performed to measure the pulmonary valve diameter (PVD), the right atrial end-systolic area (RAA), and the right ventricular end-diastolic area (RVA) before BPV, 1 and 5 years after BPV. The primary and secondary endpoints were to explore temporal changes in the right heart structures and to determine echocardiographic parameters related to late adverse events (LAEs). Read More

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Safety, tolerability, and immunogenicity of the respiratory syncytial virus prefusion F subunit vaccine DS-Cav1: a phase 1, randomised, open-label, dose-escalation clinical trial.

Lancet Respir Med 2021 Apr 14. Epub 2021 Apr 14.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: Multiple active vaccination approaches have proven ineffective in reducing the substantial morbidity and mortality caused by respiratory syncytial virus (RSV) in infants and older adults (aged ≥65 years). A vaccine conferring a substantial and sustainable boost in neutralising activity is required to protect against severe RSV disease. To that end, we evaluated the safety and immunogenicity of DS-Cav1, a prefusion F subunit vaccine. Read More

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Host PDZ-containing proteins targeted by SARS-Cov-2.

FEBS J 2021 Apr 17. Epub 2021 Apr 17.

Institut Pasteur, Unité Récepteurs-Canaux, UMR CNRS 3571, 75015, Paris, France.

Small linear motif targeting protein interacting domains called PDZ have been identified at the C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins E, 3a, and N. Using a high-throughput approach of affinity-profiling against the full human PDZome, we identified sixteen human PDZ binders of SARS-CoV-2 proteins E, 3A and N showing significant interactions with dissociation constants values ranging from 3 μM to 82 μM. Six of them (TJP1, PTPN13, HTRA1, PARD3, MLLT4, LNX2) are also recognized by SARS-CoV while three (NHERF1, MAST2, RADIL) are specific to SARS-CoV-2 E protein. Read More

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Clinical study of atherosclerotic plaque in the carotid artery and lower extremities in patients with obstructive sleep apnea-hypopnea syndrome.

Clin Respir J 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurology, Xiangyang No, People's Hospital, Hubei University of Medicine, 441000, China.

Objective: The present study aimed to explore the relationship between young and middle-aged patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and atherosclerotic plaque of the carotid artery and lower extremities.

Methods: A total of 110 patients diagnosed with OSAHS by polysomnography in the researchers' hospital from September 2018 to September 2019 were selected as the research objects. The enrolled patients were divided into a mild group (36 cases), a moderate group (38 cases), and a severe group (36 cases). Read More

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Insights into decontamination of soils by phytoremediation: a detailed account on heavy metal toxicity and mitigation strategies.

Physiol Plant 2021 Apr 17. Epub 2021 Apr 17.

Ministry of Agriculture (MOA) Key Laboratory of Biology and Genetic Improvement of Soybean (General), State Key Laboratory for Crop Genetics and Germplasm Enhancement, Soybean Research Institute, National Center for Soybean Improvement, Nanjing Agricultural University, Nanjing, China.

In the current era of rapid industrialization, the foremost challenge is the management of industrial wastes. Activities such as mining and industrialization spill over a large quantity of toxic waste that pollutes soil, water and air. This poses a major environmental and health challenge. Read More

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Pregnancies in women with moderate and severe pulmonary hypertension remain challenging: A single-center experience in East China.

Int J Gynaecol Obstet 2021 Apr 17. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Affiliated Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To determine the outcomes in women with pulmonary hypertension (PH) and determine the factors related to adverse outcomes.

Methods: Data from 684 women with PH admitted to the Affiliated Renji Hospital from January 2001 to December 2020 were collected. Outcomes were compared based on the causes and severity of PH. Read More

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[Combination of tumors of different histogenesis in pediatric neurosurgery].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):80-90

Almazov National Medical Research Center, St. Petersburg, Russia.

Multiple gliomas are determined by synchronous two or more tumors located in different brain regions. It is important to distinguish multiple primary tumors and metastatic brain lesion. In the first case, tumor spread can`t be explained by dissemination along the cerebrospinal fluid pathways, commissural fibers or local metastases. Read More

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January 2021

Molecular basis for higher affinity of SARS-CoV-2 spike RBD for human ACE2 receptor.

Proteins 2021 Apr 17. Epub 2021 Apr 17.

Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, USA.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused substantially more infections, deaths, and economic disruptions than the 2002-2003 SARS-CoV. The key to understanding SARS-CoV-2's higher infectivity lies partly in its host receptor recognition mechanism. Experiments show that the human ACE2 (angiotensin converting enzyme 2) protein, which serves as the primary receptor for both CoVs, binds to the receptor binding domain (RBD) of CoV-2's spike protein stronger than SARS-CoV's spike RBD. Read More

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Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement.

Authors:
Michael Dandel

Heart Fail Rev 2021 Apr 17. Epub 2021 Apr 17.

German Centre for Heart and Circulatory Research (DZHK) Partner Site, Berlin, Berlin, Germany.

Due to the SARS-CoV-2 infection-related severe pulmonary tissue damages associated with a relative specific widespread thrombotic microangiopathy, the pathophysiologic role of heart-lung interactions becomes crucial for the development and progression of right ventricular (RV) dysfunction. The high resistance in the pulmonary circulation, as a result of small vessel thrombosis and hypoxemia, is the major cause of right heart failure associated with a particularly high mortality in severe COVID-19. Timely identification of patients at high risk for RV failure, optimization of mechanical ventilation to limit its adverse effects on RV preload and afterload, avoidance of medication-related increase in the pulmonary vascular resistance, and the use of extracorporeal membrane oxygenation in refractory respiratory failure with hemodynamic instability, before RV failure develops, can improve patient survival. Read More

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Amniotic membrane extract eye drops for ocular surface diseases: use and clinical outcome in real-world practice.

Int Ophthalmol 2021 Apr 17. Epub 2021 Apr 17.

Hospital Clinic de Barcelona, Institut Clinic D'Oftalmologia (ICOF), Sabino de Arana s/n, 08028, Barcelona, Spain.

Purpose: To study the indications and clinical outcomes, in a real-word setting, of amniotic membrane extract eye drops (AMEED) use for ocular surface disease (OSD).

Methods: A retrospective study of patients treated with topical AMEED between January 2018 and January 2020 was conducted. Patients were classified in two groups according to specific OSD-dry eye disease (DED) and wound healing delay (WHD) groups. Read More

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