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Influence of the "Inverted U Method" Nd: YAG Laser Posterior Capsulotomy on Anterior Segment Parameters, Decentration and Tilt of Intraocular Lens in Patients after Phaco-vitrectomy.

Semin Ophthalmol 2021 Apr 18;36(3):88-93. Epub 2021 Mar 18.

Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Shenyang, Liaoning Province China.

Purpose: To investigate the effects of the "inverted U method" Nd:YAG laser posterior capsulotomy on anterior segment parameters, decentration and tilt of intraocular lens (IOLs) and visual acuity in posterior capsular opacification (PCO) patients after combined phaco-vitrectomy.

Methods: Seventy-six patients (76 eyes) were enrolled in this study, who were diagnosed as PCO and underwent "inverted U method" Nd:YAG laser posterior capsulotomy. All patients had undergone previous combined phaco-vitrectomy for rhegmatogenous retinal detachment. Read More

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Evaluation of Retinal Nerve Fiber Layer, Ganglion Cell-Inner Plexiform Layer, and Optic Nerve Head in Glaucoma Suspects With Varying Myopia.

J Glaucoma 2021 Mar 18. Epub 2021 Mar 18.

Tufts University School of Medicine New England Eye Center, Tufts Medical Center, Boston, MA.

Prcis: Myopic glaucoma suspects, particularly with high myopia, experience thinning of nontemporal parameters of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL), without change in optic nerve head (ONH) parameters.

Purpose: The aim was to assess the effect of myopia on RNFL, GCIPL, and ONH parameters in glaucoma suspects.

Materials And Methods: Seventy-six eyes of glaucoma suspects studied with Cirrus high definition optical coherence tomography were divided into low (n=27), moderate (n=25), and high myopia (n=24) groups. Read More

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Multifocal Electroretinogram Can Detect the Abnormal Retinal Change in Early Stage of type2 DM Patients without Apparent Diabetic Retinopathy.

J Diabetes Res 2021 23;2021:6644691. Epub 2021 Feb 23.

Department of Neurology, Second Affiliated Hospital of Soochow University, China.

Purpose: To study retinal function defects in type 2 diabetic patients without clinically apparent retinopathy using a multifocal electroretinogram (mf-ERG).

Methods: Seventy-six eyes of thirty-eight type 2 diabetes mellitus(DM) patients without clinically apparent retinopathy and sixty-four normal eyes of thirty-two healthy control (HC) participants were examined using mf-ERG.

Results: Patients with type 2 DM without apparent diabetic retinopathy demonstrated an obvious implicit time delay of P1 in ring 1, ring 3, and ring 5 compared with healthy controls ( = 5. Read More

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February 2021

Ocular microbiota and lens contamination following Mel4 peptide-coated antimicrobial contact lens (MACL) extended wear.

Cont Lens Anterior Eye 2021 Mar 4:101431. Epub 2021 Mar 4.

School of Optometry and Vision Science, UNSW Sydney, Australia.

Purpose: The purpose of this study was to investigate the effect of Mel4 antimicrobial peptide-coated contact lenses (MACL) on the microbiota of the conjunctiva and lenses during three months of extended wear.

Methods: One hundred and seventy-six participants were recruited into a randomised, contralateral, double masked, biweekly extended wear MACL and uncoated control lens trial. At the one month and 3-month visit, the conjunctival microbiota was sampled using sterile cotton swabs and contact lenses were collected aseptically. Read More

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Children's perceptions of their parent's parenting strategies and child influence on purchases in a supermarket.

Appetite 2021 Jul 4;162:105149. Epub 2021 Feb 4.

San Diego State University, College of Health and Human Services, School of Public Health and the Institute for Behavioral and Community Health, 9245 Sky Park Court, Suite 221, San Diego, CA, 92123, USA. Electronic address:

This field study identified, through observation, child influence on food and beverage purchases within a supermarket, as well as the influence of the children's perceptions of their parents' parenting strategies related to eating behaviors on these purchases. Four supermarkets were recruited to participate and agreed to allow recruitment of parent-child dyads and implementation of data collection protocols within their stores. Parent-child (7-14 yo) dyads were recruited to wear eye-tracking glasses during the supermarket visit, complete separate individual interviews, and have their store receipts scanned. Read More

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Comparison of efficacy of combination therapy of an Intravitreal injection of bevacizumab and photocoagulation versus Pan Retinal Photocoagulation alone in High risk Proliferative Diabetic Retinopathy.

Pak J Med Sci 2021 Jan-Feb;37(1):157-161

Dr. Shafi Muhammad Jatoi, FCPS. Department of Ophthalmology, Isra University Hospital, Hyderabad, Pakistan.

Objective: To compare efficacy of intravitreal bevacizumab augmented with Panretinal photocoagulation versus Panretinal photocoagulation alone in high risk proliferative diabetic retinopathy.

Methods: This is Randomized clinical control trial study conducted at ISRA University Hospital, Hyderabad from July 2018 to December 2018. A total of 76 eyes were randomized into two groups, 38 eyes undergone PRP plus intravitreal bevacizumab, while 38 eyes had PRP alone. Read More

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January 2021

The influence of alternate part-time patching on control of intermittent exotropia: a randomized clinical trial.

Graefes Arch Clin Exp Ophthalmol 2021 Jan 7. Epub 2021 Jan 7.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the effect of alternate part-time patching on deviation control in patients with intermittent exotropia in comparison to observation.

Methods: In a randomized clinical trial, untreated 3-8-year-old children with intermittent exotropia were randomly divided into patching group who treated with alternate part-time patching and observation group. Deviation control was assessed with 3-point and 6-point scales. Read More

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January 2021

Severity of Diabetic Retinopathy and the Risk of Future Cerebrovascular Disease, Cardiovascular Disease, and All-Cause Mortality.

Ophthalmology 2020 Dec 25. Epub 2020 Dec 25.

Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, California.

Purpose: To determine the relationship between the severity of diabetic retinopathy and the future risk of cerebrovascular accident (CVA), myocardial infarction (MI), congestive heart failure (CHF), and all-cause mortality in patients with type 2 diabetes mellitus.

Design: Retrospective cohort study.

Participants: Patients with type 2 diabetes who underwent diabetic retinopathy screening via fundus photography. Read More

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December 2020

Vascular density of optic nerve head in diabetic retinopathy using optical coherence tomography angiography.

Int J Retina Vitreous 2020 Dec 2;6(1):62. Epub 2020 Dec 2.

Cornea Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To measure optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) at various stages of diabetic retinopathy (DR).

Methods: One hundred seventy six eyes of 94 patients included in this retrospective single-centre cross-sectional study. The subjects were studied in normal, no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative retinopathy (PDR) groups. Read More

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December 2020

"Depression, Anxiety and Stress" in a Cohort of Registered Practicing Ophthalmic Surgeons, Post Lockdown during COVID-19 Pandemic in India.

Ophthalmic Epidemiol 2020 Nov 13:1-8. Epub 2020 Nov 13.

Department of Cornea and Anterior Segment, CL Gupta Eye Institute , Moradabad, India.

: To assess the magnitude of mental health problems among ophthalmologists in India post lockdown during COVID pandemic. : Cross-sectional survey conducted online on registered practising ophthalmologists of India, post lockdown at the start of elective surgeries (20 to 25 May, 2020). The degree of symptoms of depression, anxiety and stress was assessed by DASS -21 questionnaire. Read More

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November 2020

Evaluating Keratoconus Progression prior to Crosslinking: Kmax versus the ABCD grading system.

J Cataract Refract Surg 2020 Nov 19. Epub 2020 Nov 19.

Humanitas Clinical and Research Center - IRCCS -, via Manzoni 56, 20089 Rozzano (Mi) - Italy.

Purpose: To evaluate the correlation between changes in maximum keratometry (Kmax) and ABC values from the ABCD Progression Display (Pentacam (OCULUS; Wetzlar, Germany)) in progressive keratoconus (KC) and to evaluate whether the ABC changes were able to detect progression earlier than Kmax.

Setting: Humanitas Clinical and Research Center, Rozzano, Milan, Italy.

Design: Retrospective study. Read More

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November 2020

The Central Subfoveal Bouquet in Idiopathic Epiretinal Membranes.

Clin Ophthalmol 2020 17;14:2353-2359. Epub 2020 Aug 17.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Purpose: To report both the unoperated clinical course and the surgical outcomes of eyes with a central foveal bouquet (CB) secondary to idiopathic epiretinal membranes (iERMs).

Design: Retrospective, consecutive, and observational case series.

Methods: All patients examined between January 1, 2014, and December 31, 2019, for evaluation of epiretinal membrane with a CB lesion identified on spectral domain optical coherence tomography (SD-OCT) were included. Read More

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Making the decision to donate eyes: Perspectives from the families of the deceased in Madurai, India.

Indian J Ophthalmol 2020 Oct;68(10):2094-2098

SC Johnson College of Business, Cornell University, Ithaca NY, USA.

Purpose: To identify factors affecting family members' decision whether to donate eye organs.

Methods: A community-based case-control study based on in-home interviews with families of deceased individuals who had or had not donated eye organs, in Madurai district, Tamil Nadu, India. Data collected were knowledge and awareness of eye donations, whether the deceased individual had expressed or pledged willingness to donate, and family members' attitudes and willingness to donate their own eye organs. Read More

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October 2020

Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis.

Int J Ophthalmol 2020 18;13(9):1430-1435. Epub 2020 Sep 18.

Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Gyeonggi-do 14647, Republic of Korea.

Aim: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis.

Methods: A retrospective comparative cohort study. Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled. Read More

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September 2020

Clinical Outcomes of Scleral Lens Fitting with a Data-driven, Quadrant-specific Design: Multicenter Review.

Optom Vis Sci 2020 09;97(9):761-765

Mayo Clinic Department of Ophthalmology, Rochester, Minnesota.

Significance: Alignment of the scleral lens haptic with the anterior ocular surface is of critical importance when fitting scleral lenses. The concept of leveraging big-data analysis to drive lens design is explored in this study. This retrospective study evaluated fitting outcomes of a data-driven, quadrant-specific scleral lens design and found that most patients (76%) were successfully fit with this design. Read More

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September 2020

Catching the red eye: A retrospective review of factors associated with retinal hemorrhage in child physical abuse.

J Pediatr Surg 2020 Aug 5. Epub 2020 Aug 5.

Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

Background/purpose: Accurate identification of child physical abuse is crucial during the evaluation of injured children. Retinal hemorrhages (RH) are used for diagnosis, but clear criteria for screening with direct fundoscopic exam are lacking. We sought to identify key factors associated with RH to guide evaluations. Read More

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Pharmacologic ciliary body ablation for chronic glaucoma in dogs: A retrospective review of 108 eyes from 2013 to 2018.

Vet Ophthalmol 2021 Mar 28;24 Suppl 1:125-130. Epub 2020 Aug 28.

BluePearl Veterinary Partners, Clearwater, FL, USA.

Objective: To evaluate the long-term outcome and efficacy of intravitreal injection of gentamicin and dexamethasone sodium phosphate (IVGD) or triamcinolone in end-stage glaucoma patients and determine pre-procedure prognostic indicators of success and post-operative complications.

Procedure: Medical records were reviewed for 108 dogs (108 eyes) treated with intravitreal gentamicin with or without dexamethasone sodium phosphate or triamcinolone for glaucoma between 2013 and 2018 with 3 months of minimum follow-up. Signalment and clinical findings, including type of glaucoma, pre-procedure intraocular pressure (IOP), chronicity, procedure protocol, and outcome were recorded. Read More

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Postoperative Changes in Central Corneal Thickness and Intraocular Pressure in a Prospective Cohort of Congenital Cataract Patients.

Cornea 2020 Nov;39(11):1359-1365

School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China; and.

Purpose: To evaluate changes in central corneal thickness (CCT) and intraocular pressure (IOP) in children after surgery for congenital cataracts and to investigate the association between CCT and IOP.

Methods: For this prospective observational cohort study, we recruited patients undergoing surgery for unilateral or bilateral congenital cataracts. CCT and IOP were measured before surgery and 1, 3, 6, 12, and 24 months after surgery. Read More

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November 2020

Continuous epileptiform discharges during sleep as an evolutionary pattern in patients with congenital Zika virus syndrome.

Epilepsia 2020 09 21;61(9):e107-e115. Epub 2020 Aug 21.

Laboratory of Clinical Neurophysiology, Department of Psychiatry, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Sao Paulo, Brazil.

Congenital Zika virus syndrome (CZVS) is associated with severe neurological deficits. Clinical characteristics of epilepsy and the electroencephalographic (EEG) pattern in CZVS were documented in infancy. In this study, we aimed to describe the EEG findings observed during the follow-up of children with CZVS. Read More

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September 2020

Open versus closed view autorefraction in young adults.

J Optom 2021 Jan - Mar;14(1):86-91. Epub 2020 Aug 11.

City, University of London, Centre for Applied Vision Research, School of Health Sciences, Northampton Square, London, EC1V 0HB, United Kingdom.

Purpose: While there are numerous studies comparing open-view autorefractors to subjective refraction or other open-view autorefractors, most studies between closed and open-view autorefraction tend to focus on children rather than young adults. The aim of this study was to determine the concordance in non-cycloplegic refractive error between two modern objective autorefractors: the closed-view monocular Topcon TRK-2P and the binocular open-view Grand Seiko WR-5500.

Methods: Fifty young adults aged 20-29 years (mean age 22 ± 1. Read More

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Association of Conjunctival Dysplasia (Squamous Intraepithelial Neoplasia) with Melanosis (Microscopic Non- Proliferative Melanin Pigmentation).

J Curr Ophthalmol 2020 Jul-Sep;32(3):244-248. Epub 2020 Jul 4.

Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To determine the association between conjunctival epithelial dysplasia (squamous intraepithelial neoplasia) and its melanosis (microscopic non-proliferative melanin pigmentation) in conjunctival biopsies.

Methods: In this retrospective case series, histopathological slides from all conjunctival biopsies obtained in Khalil Hospital affiliated with Shiraz University of Medical Sciences for a period of 6 years (April 2009-July 2015) were reviewed. After considering the exclusion criteria (non-melanotic pigmentation, melanocytic proliferations, and squamous cell carcinoma), conjunctival biopsies were divided histopathologically into two groups of dysplastic and non-dysplastic. Read More

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Autoantibody Detection for Diagnosis in Direct Immunofluorescence-Negative Mucous Membrane Pemphigoid: Ocular and Other Sites Compared.

Ophthalmology 2021 Mar 31;128(3):372-382. Epub 2020 Jul 31.

Epivision (Ophthalmic Epidemiology Consultants), Penn, United Kingdom.

Purpose: To assess whether a panel of serum pemphigoid autoantibody tests could be used to confirm an immunopathologic diagnosis of mucous membrane pemphigoid (MMP) in direct immunofluorescent negative (DIF-) MMP patients.

Design: Prospective cross-sectional study.

Participants: Seventy-six patients with multisite MMP with 45 matched control participants. Read More

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Value of MRI-based radiomics analysis for differentiation of benign and malignant epithelial neoplasms in the lacrimal gland: a retrospective study.

Acta Radiol 2020 Jul 13:284185120940258. Epub 2020 Jul 13.

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, PR China.

Background: It is essential to distinguish malignant from benign epithelial neoplasms in the lacrimal gland for different treatment options and prognosis.

Purpose: To retrospectively assess the performance of magnetic resonance imaging (MRI)-based radiomics features in the differentiation of benign and malignant epithelial neoplasms in the lacrimal gland.

Material And Methods: Seventy-six consecutive patients with histopathology-proven epithelial neoplasms of the lacrimal gland were enrolled in the study, including 41 benign and 35 malignant neoplasms. Read More

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Determinant Factors of Intraocular Pressure Responses to a Maximal Isometric Handgrip Test: Hand Dominance, Handgrip Strength and Sex.

Curr Eye Res 2021 Jan 21;46(1):64-70. Epub 2020 Jun 21.

Department of Optics, Faculty of Sciences, University of Granada , Granada, Spain.

Purpose: To assess the mediating role of strength levels, hand dominance and participants´ sex on the intraocular pressure (IOP) behaviour during the execution of a maximal isometric handgrip test.

Methods: One hundred and seventy-six sport science students (102 men and 74 women) performed a maximal isometric handgrip test with the dominant and non-dominant hands. A rebound tonometer was used to measure IOP before effort, during effort, and immediately after performing the handgrip test. Read More

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January 2021

Assessing cognitive control and the reward system in overweight young adults using sensitivity to incentives and white matter integrity.

PLoS One 2020 2;15(6):e0233915. Epub 2020 Jun 2.

Laboratory of Sleep and Functional Neurobiology, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile.

Cognitive control and incentive sensitivity are related to overeating and obesity. Optimal white matter integrity is relevant for an efficient interaction among reward-related brain regions. However, its relationship with sensitivity to incentives remains controversial. Read More

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Study of peripapillary vascular flow using optical coherence tomography angiography in optic nerve head drusen.

Clin Exp Ophthalmol 2020 08 31;48(6):775-782. Epub 2020 May 31.

Ophthalmology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Importance: To evaluate peripapillary vascular flow using optical coherence tomography angiography (angio-OCT) in patients with optic nerve head drusen (ONHD).

Background: Angio-OCT allows non-invasive visualization and quantification peripapillary vascular flow.

Design: Cross-sectional study. Read More

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Quantification of Retinal Nonperfusion and Neovascularization With Ultrawidefield Fluorescein Angiography in Patients With Diabetes and Associated Characteristics of Advanced Disease.

JAMA Ophthalmol 2020 06;138(6):680-688

W. K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor.

Importance: Quantification of nonperfusion (NP) and neovascularization (NV) in diabetic retinopathy (DR) may identify better biomarkers of disease progression.

Objective: To identify demographic risk factors and markers of advanced DR that are associated with increased areas of NP and NV in eyes with disease ranging from no DR but diagnosed as having diabetes to proliferative DR (PDR) and to calculate a threshold total area of NP that may be associated with an increased risk of PDR.

Design, Setting, And Participants: This retrospective case series was performed on ultrawidefield fluorescein angiography (UWF FA) images from January 2009 to May 2018 at the University of Michigan Kellogg Eye Center. Read More

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In Situ Tremor in Vitreoretinal Surgery.

Hum Factors 2020 Apr 14:18720820916629. Epub 2020 Apr 14.

University of Wisconsin-Madison, USA.

Objective: Surgeon tremor was measured during vitreoretinal microscopic surgeries under different hand support conditions.

Background: While the ophthalmic surgeon's forearm is supported using a standard symmetric wrist rest when operating on the patient's same side as the dominant hand (SSD), the surgeon's hand is placed directly on the patient's forehead when operating on the contralateral side of the dominant hand (CSD). It was hypothesized that more tremor is associated with CSD surgeries than SSD surgeries and that, using an experimental asymmetric wrist rest where the contralateral wrist bar gradually rises and curves toward the patient's operative eye, there is no difference in tremor associated with CSD and SSD surgeries. Read More

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Functional ear reconstruction strategies for microtia with congenital aural stenosis in seventy-six patients.

Clin Otolaryngol 2020 07 26;45(4):611-615. Epub 2020 Apr 26.

ENT institute, Eye & ENT Hospital, Fudan University, Shanghai, China.

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Pointwise Methods to Measure Long-term Visual Field Progression in Glaucoma.

JAMA Ophthalmol 2020 05;138(5):536-543

Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, UCLA (University of California, Los Angeles).

Importance: Rates of visual field (VF) progression vary among patients with glaucoma. Knowing the rate of progression of individual patients would allow appropriately aggressive therapy for patients with high rates of visual loss and protect those with low rates from unnecessary therapy.

Objective: To compare 3 pointwise methods of estimating the rate of VF progression in glaucoma. Read More

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