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Intraoperative pivot-shift accelerometry combined with anesthesia improves the measure of rotatory knee instability in anterior cruciate ligament injury.

J Exp Orthop 2021 Sep 24;8(1):80. Epub 2021 Sep 24.

Applied Neuromechanics Research Group, Laboratory of Neuromechanics, Federal University of Pampa, Uruguaiana, RS, 97500-970, Brazil.

Purpose: The knee stiffness acquired following an Anterior Cruciate Ligament (ACL) injury might affect clinical knee tests, i.e., the pivot-shift maneuver. Read More

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September 2021

Comparison of the Neurocognitive Profile of the Children of Parents with Bipolar Disorder and Controls: a Transnational Cross-Sectional Study.

Rev Colomb Psiquiatr 2021 Sep 21. Epub 2021 Sep 21.

Grupo de Investigación en Psiquiatría (GIPSI), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address:

Introduction: Studies that have compared the cognitive alterations of the children of parents with bipolar disorder (CPBD) versus the children of control parents (CCP), present heterogeneous results due to the studies' methodological differences, the age of the population studied, and the lack of standardisation of the measures used for the different neurocognitive domains. The objective was to compare the neurocognitive profile of CPBD versus CCP to observe if there are differences that could be proposed as possible endophenotypes of BD.

Results: A total of 107 individuals (51 CPBD, and 56 CCP) with ages between 6 and 16 (mean, 12. Read More

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September 2021

Vegan vs. omnivore diets paradox: A whole-metagenomic approach for defining metabolic networks during the race in ultra-marathoners- a before and after study design.

PLoS One 2021 23;16(9):e0255952. Epub 2021 Sep 23.

Institute of Primary Care, University of Zurich, Zurich, Switzerland.

Background: The effect of vegan diets on metabolic processes in the body is still controversial in ultra endurance athletes. The study aims to determine gut microbiome adaptation to extreme exercise according to vegan or omnivore diet consumed in ultra-marathoners. We also seek to evaluate long-term vegan diets' effects on redox homeostasis, and muscle fatigue, and assess energy availability. Read More

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September 2021

Adverse Events as a Potential Clinical Marker of Antitumor Efficacy in Ovarian Cancer Patients Treated With Poly ADP-Ribose Polymerase Inhibitor.

Front Oncol 2021 6;11:724620. Epub 2021 Sep 6.

Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China.

Background: PARP inhibitor (PARPi) is an important progress in ovarian cancer treatment. The available evidence suggests that BRCA mutation and homologous recombination deficiency (HRD) are effective biological markers for PARPi. Here we investigated the relationship between adverse events (AEs) and efficacy of PARPi in ovarian cancer patients. Read More

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September 2021

Decreased plasma level of lipoprotein lipase predicted verbal disfluency in Chinese type 2 diabetes mellitus patients with early cognitive deficits.

Curr Alzheimer Res 2021 Sep 21. Epub 2021 Sep 21.

Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, No.87 DingJiaQiao Road, Nanjing. China.

Background: Lipoprotein lipase (LPL) is the rate-limiting enzyme of catalyzing the hydrolysis of triglycerides and contributes to amyloid-β formation which shows promise as a pathological factor of cognitive decline in type 2 diabetes mellitus (T2DM). This study aimed to investigate the pathogenetic roles of LPL and rs328 polymorphism in mild cognitive impairment (MCI) in patients with T2DM.

Methods: Chinese patients with T2DM were recruited and divided into two groups based on Montreal Cognitive Assessment score. Read More

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September 2021

Intravenous Versus Oral Acetaminophen Use in Febrile Neurocritical Care Patients.

Ther Hypothermia Temp Manag 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University School of Pharmacy, Richmond, Virginia, USA.

The use of intravenous (IV) acetaminophen (APAP) for fever has not been thoroughly studied in neurocritical care (NCC) patients, in whom a temperature of ≥38°C is associated with poor outcomes and treatment to normothermia is common practice. This retrospective study evaluated NCC patients admitted between May 1, 2012, and April 30, 2013, and received at least one dose of IV or oral (PO) APAP for a body temperature of ≥38°C. The primary aim of this study was to compare the reduction in body temperature (RIT) between IV and PO APAP, calculated as the change in temperature before and 0. Read More

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September 2021

Identifying Patients at Risk of Delayed Breast Imaging Due to the COVID-19 Pandemic.

Cureus 2021 Aug 16;13(8):e17235. Epub 2021 Aug 16.

Radiology, Emory University School of Medicine, Atlanta, USA.

Objective: Epidemiological models predict worse cancer outcomes due to COVID-19 pandemic-related delays in cancer surveillance and treatment. This study evaluated patient demographic factors associated with delayed breast imaging or procedure appointments due to COVID-19.

Methods: Patients attending a breast imaging or procedure appointment at the Pennsylvania Hospital Breast Center from December 28, 2020 to January 31, 2021 were asked to complete a voluntary and anonymous survey on the impact of COVID-19. Read More

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Comparative Study on the Functional Connectivity of Amygdala and Hippocampal Neural Circuits in Patients With First-Episode Schizophrenia and Other High-Risk Populations.

Front Psychiatry 2021 1;12:627198. Epub 2021 Sep 1.

Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.

Cortical-limbic system neural circuit abnormalities are closely related to the onset of schizophrenia (SZ). The amygdala, hippocampus, cingulate, and prefrontal lobe are important components of the loop. In this study, we compared resting-state functional connectivity (rs-FC) between the amygdala/hippocampus and cingulate/prefrontal regions among patients with first-episode schizophrenia (FE-SZ), high risk populations with SZ (HR-SZ), and healthy controls (HCs). Read More

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September 2021

Diagnosis of fungal opportunistic infections in people living with HIV from Guatemala and El Salvador.

Mycoses 2021 Sep 18. Epub 2021 Sep 18.

Mycotic Diseases Branch, CDC, Atlanta, GA, USA.

Objectives: Histoplasmosis and cryptococcosis are important public health problems in people living with HIV (PLHIV) in Central America. Conventional laboratory tests, such as culture and microscopy are not optimal, however, antigen tests are rapid, highly sensitive, and specific for diagnosis of fungal opportunistic infections (OI). The aim of this study was to describe the results of a laboratory-based surveillance system for histoplasmosis and cryptococcosis. Read More

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September 2021

Joint involvement in Noonan syndrome.A retrospective paediatric descriptive study.

Joint Bone Spine 2021 Sep 14:105270. Epub 2021 Sep 14.

Rheumatology Department, CHU Cavale Blanche, Center of Autoimmune Rare Diseases (CERAINO), Brest, France; UMR1227, INSERM, Université de Bretagne Occidentale, Brest, France. Electronic address:

Objectives: Noonan syndrome is a rare genetic disorder characterized mainly by congenital heart disease, occasional intellectual disability, and varied orthopaedic, rheumatological and haematologic anomalies. Despite potentially serious functional consequences, joint involvement has been rarely studied in the literature. Our objective was to perform a retrospective study evaluating the prevalence and characteristics of joint involvement in Noonan syndrome. Read More

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September 2021

Postoperative Pain and Opioid Use after Facial Feminization Surgery.

Facial Plast Surg 2021 Sep 16. Epub 2021 Sep 16.

Department of Head and Neck Surgery, Kaiser Permanente Oakland Medical Center, Oakland, California.

The objective of this study is to characterize surgical pain after facial feminization surgery (FFS) and delineate postoperative opioid usage. It is a retrospective cohort study. It was performed in a multicenter integrated health care system. Read More

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September 2021

The Comparison of Dental Anxiety between Patients Treated with Impacted Third Molar Surgery and Conventional Dental Extraction.

Biomed Res Int 2021 4;2021:7492852. Epub 2021 Sep 4.

Department of Oral and Maxillofacial Surgery, Eskisehir Osmangazi University Faculty of Dentistry, Eskisehir, 26480, Turkey.

Background: The aim of the present study is to compare the dental anxiety levels between two outpatient clinics.

Methods: Two hundred and seventy patients treated in two different clinics of minor oral surgery and dental extraction polyclinic in the Dental Faculty of Eskisehir Osmangazi University were included in the study. The impacted third molar surgery group and conventional dental extraction group consisted of 101 and 169 patients, respectively. Read More

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September 2021

Impact of COVID-19 Pandemic on Palliative Care Workers: An International Cross-sectional Study.

Indian J Palliat Care 2021 Apr-Jun;27(2):299-305. Epub 2021 Aug 12.

International Association for Hospice and Palliative Care, Houston, Taxes, United States.

Objectives: The COVID-19 pandemic and the measures taken to mitigate spread have affected countries in different ways. Healthcare workers, in particular, have been impacted by the pandemic and by these measures. This study aims to explore how COVID-19 has impacted on palliative care (PC) workers around the world. Read More

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Decline in executive function in patients with white matter hyperintensities from the static and dynamic perspectives of amplitude of low-frequency fluctuations.

J Neurosci Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Cognitive impairments are characteristics of patients with white matter hyperintensities (WMHs), and hypoperfusion is currently a relatively recognized mechanism of WMHs. Brain activity is closely coupled to the regulation of local blood flow. This study aimed to investigate the abnormal local brain activity of patients with WMHs from the viewpoint of the static amplitude of low-frequency fluctuations (sALFF) and dynamic amplitude of low-frequency fluctuations (dALFF). Read More

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September 2021

The short-term compliance and concordance to in clinic testing for tablet-based home monitoring in age-related macular degeneration.

Am J Ophthalmol 2021 Sep 9. Epub 2021 Sep 9.

Department of Optometry and Vision Sciences, The University of Melbourne, Melbourne, Australia, 3010; Centre for Eye Research Australia, East Melbourne, Australia, 3002. Electronic address:

Purpose: This study determines the short-term compliance to regular home monitoring of macular retinal sensitivity (RS) in intermediate age-related macular degeneration (iAMD). We also compare home-based outcomes with in-clinic outcomes determined using 1. the same tablet device under supervision and 2. Read More

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September 2021

Ecological validity of the PERF-FIT: correlates of active play, motor performance and motor skill-related physical fitness.

Heliyon 2021 Aug 30;7(8):e07901. Epub 2021 Aug 30.

Department of Health & Rehabilitation Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Background: Active games are important health enhancing physical activities in children with and without developmental disorders and will help children to develop fundamental motor skills, while inactivity exacerbates coordination difficulties and increases the risk of obesity. Regular engagement in active play promotes physical, social and cognitive development. It is therefore important to know if children have the capabilities for healthy behavior. Read More

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Physical Fitness Profiling of National Category Table Tennis Players: Implication for Health and Performance.

Int J Environ Res Public Health 2021 Sep 4;18(17). Epub 2021 Sep 4.

Society, Sports and Physical Exercise Research Group (GIKAFIT), Physical Education and Sport Department, Faculty of Physical Activity and Sports Science, University of the Basque Country, UPV/EHU, 01007 Vitoria-Gasteiz, Spain.

The aims of this study were to: (1) analyze table tennis players' physical profiles considering and comparing players age categories (i.e., under U12, U14, U16, U20, Senior and Older); and (2) to quantify the correlations among the variables measured by each test. Read More

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September 2021

Prospective Memory and Regional Functional Connectivity in Subcortical Ischemic Vascular Disease.

Front Aging Neurosci 2021 20;13:686040. Epub 2021 Aug 20.

Department of Psychology, National Chung Cheng University, Chiayi, Taiwan.

Patients with subcortical ischemic vascular disease (SIVD) often have prominent frontal dysfunction. However, it remains unclear how SIVD affects prospective memory (PM), which strongly relies on the frontoparietal network. The present study aimed to investigate PM performance in patients with early stage SIVD as compared to those with Alzheimer's disease (AD) and to older adults with normal cognition, and to explore the neural correlates of PM deficits. Read More

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Students' perspective on the online delivery of radiography & medical imaging program during COVID-19 pandemic.

J Med Imaging Radiat Sci 2021 Aug 4. Epub 2021 Aug 4.

Radiography and Medical Imaging Department, Fatima College of Health Sciences, UAE.

Introduction: The COVID-19 pandemic has led to significant changes to academic program delivery worldwide. Face to face (traditional teaching) lectures were replaced with online, recorded, or live sessions; however, online systems are not an efficient substitute for clinical or laboratory courses. The purpose of this study is to evaluate the imaging student's perspective on COVID-19 awareness to ensure they are prepared for clinical training and laboratory education, and to evaluate the teaching quality of the online radiography program delivery. Read More

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A preliminary randomized, controlled trial of executive function training for children with autism spectrum disorder.

Autism 2021 Sep 2:13623613211014990. Epub 2021 Sep 2.

Boston Children's Hospital, USA.

Lay Abstract: Executive function, which is a set of thinking skills that includes stopping unwanted responses, being flexible, and remembering information needed to solve problems, is a challenge for many children on the autism spectrum. This study tested whether executive function could be improved with a computerized executive function training program under the guidance of a coach who reinforced the use of executive function skills. Seventy children with autism spectrum disorder from age 7 to 11 years of age participated in the study. Read More

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September 2021

Molecular identification and antifungal susceptibility of 75 clinical isolates of Trichophyton spp. from southern Brazil.

J Mycol Med 2021 Aug 24;31(4):101201. Epub 2021 Aug 24.

Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul. Rua Ramiro Barcelos, 2400 - CEP, 90035-003, Porto Alegre - RS, Brasil; Department of Microbiology, Immunology and Parasitology, ICBS, Universidade Federal do Rio Grande do Sul. Rua Sarmento Leite, 500 - CEP 90050-170, Porto Alegre RS, Brasil. Electronic address:

Background: Dermatophytoses affect more than 20% of the world's population and is caused by filamentous fungi, mainly of the genus Trichophyton. The species identification through microscopic direct examination and culture methods is challenging, with molecular presenting high sensitivity and specificity. Although there are several therapy options for dermatophyte infections, treatment failures and antifungal resistance are growing concerns. Read More

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First Report of Tomato Brown Rugose Fruit Virus on Tomato in Syria.

Plant Dis 2021 Sep 2. Epub 2021 Sep 2.

General Commission for Scientific Agricultural Research (GCSAR), Syria, Tartous, Syrian Arab Republic;

Tomato (Solanum lycopersicum L.) is an important vegetable crop worldwide. In spring and autumn 2017, virus-like symptoms were observed on greenhouse grown tomato plants in the east of Akkar plain (south of coastal region, Tartous governorate, Syria). Read More

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September 2021

Changes in US Dialysis Dietitian Responsibilities and Patient Needs During the COVID-19 Pandemic.

J Ren Nutr 2021 Jul 27. Epub 2021 Jul 27.

Department of Nutrition, Case Western Reserve University, Cleveland, Ohio. Electronic address:

Objective: This study described the job responsibilities and modalities of care among dialysis dietitians in the United States and their observations regarding the nutrition needs of their patients, during the COVID-19 pandemic.

Design And Methods: Cross-sectional online survey captures dietitian characteristics and responsibilities, dialysis facility characteristics, and patient needs. We recruited US dialysis dietitians. Read More

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Dengue virus detection in Lao PDR and Colombia: comparative evaluation of PCR tests.

Trop Med Int Health 2021 Aug 27. Epub 2021 Aug 27.

Diagnostics Development Laboratory, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Objectives: Dengue virus (DENV) detection by polymerase chain reaction (PCR) facilitates diagnosis of dengue fever, which is the most frequent arboviral disease globally. Two studies were performed in countries with high dengue incidence, to assess the diagnostic performance of different PCR techniques.

Methods/results: Two hundred and seventy-nine acute phase blood samples from febrile patients were analyzed for DENV by the RealStar Dengue RT-PCR kit (Altona Diagnostics) as gold standard in comparison with the Tropical Fever Core multiplex PCR (Fast Track Diagnostics). Read More

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Comparison between core needle biopsy and excisional biopsy for breast neoplasm.

Medicine (Baltimore) 2021 Aug;100(34):e26970

Department of Pathology, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.

Abstract: This study aimed to explore clinical significance of core needle biopsy (CNB) in pathological diagnosis of breast neoplasm.Seventy one breast neoplasm samples were obtained from Tongzhou Maternal and Child Health Hospital of Beijing between the years of 2006 and 2014. Forty five specimens were obtained via CNB and cases offering 26 of them received neoadjuvant chemotherapy. Read More

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A Survey of Academic Neonatologists on Neonatal Electrical Cardioversion and Defibrillation.

Am J Perinatol 2021 Aug 26. Epub 2021 Aug 26.

Child Health, University of Missouri, Columbia, United States.

Objective: Assess neonatologists' experience and comfort with neonatal electrical cardioversion or defibrillation (EC-D).

Study Design: Electronic surveys were distributed to academic neonatologists affiliated with 12 Midwest academic hospitals. Neonatologists were asked about their residency training; years since completing residency; current certification/ competency training in BLS, PALS, ACLS and NRP; experiences with EC-D; availability of a pediatric cardiologist and their comfort levels with such procedures. Read More

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Sustainable Surface Modification of Polyetheretherketone (PEEK) Implants by Hydroxyapatite/Silica Coating-An In Vivo Animal Study.

Materials (Basel) 2021 Aug 16;14(16). Epub 2021 Aug 16.

Department of Oral, Maxillofacial and Plastic Surgery, Rostock University Medical Center, 18057 Rostock, Germany.

Polyetheretherketone (PEEK) has the potential to overcome some of the disadvantages of titanium interbody implants in anterior cervical and discectomy and fusion (ACDF). However, PEEK shows an inferior biological behavior regarding osseointegration and bioactivity. Therefore, the aim of the study was to create a bioactive surface coating on PEEK implants with a unique nanopore structure enabling the generation of a long-lasting interfacial composite layer between coating material and implant. Read More

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Neural Interruption by Unilateral Labyrinthectomy Biases the Directional Preference of Otolith-Related Vestibular Neurons.

Brain Sci 2021 Jul 26;11(8). Epub 2021 Jul 26.

Research Institute for Aerospace Medicine, Inha University, Incheon 22332, Korea.

Background: The directional preference of otolith-related vestibular neurons elucidates the neuroanatomical link of labyrinths, but few direct experimental data have been provided.

Methods: The directional preference of otolith-related vestibular neurons was measured in the vestibular nucleus using chemically induced unilateral labyrinthectomy (UL). For the model evaluation, static and dynamic behavioral tests as well as a histological test were performed. Read More

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"Mass gathering events and COVID-19 transmission in Borriana (Spain): A retrospective cohort study".

PLoS One 2021 26;16(8):e0256747. Epub 2021 Aug 26.

Public Health Center, Castelló de la Plana, Castellon, Spain.

Objective: Mass gathering events (MGEs) are associated with the transmission of COVID-19. Between 6 and 10 March 2020, several MGEs related to the Falles festival took place in Borriana, a municipality in the province of Castellon (Spain). The aim of this study was to estimate the incidence of COVID-19 and its association with these MGEs, and to quantify the potential risk factors of its occurrence. Read More

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September 2021

Longitudinal Outcomes in Adolescents after Referral for Metabolic and Bariatric Surgery.

J Pediatr Gastroenterol Nutr 2021 Aug 24. Epub 2021 Aug 24.

Division of Pediatric Surgery, Department of Surgery, University of Texas Southwestern Medical Center, Dallas TX USA Childrens Health System of Texas, Dallas TX USA University of Texas Health Science Center, School of Public Health, Dallas, TX, USA Baylor College of Medicine Houston TX Center for Pediatric Population Health, UTHealth School of Public Health and Children's Health System of Texas Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas TX USA.

Background: Metabolic and bariatric surgery (MBS) can be a safe and effective treatment option for severe obesity in adolescents. We compared outcomes for adolescents that did and did not proceed to surgery.

Methods: A single center longitudinal study (2015-2020). Read More

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