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A multicenter study to develop a non-invasive radiomic model to identify urinary infection stone in vivo using machine-learning.

Kidney Int 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacy, the First People's Hospital of Kashi Prefecture; Affiliated Kashi Hospital of Sun Yat-Sen University, Kashi, People's Republic of China. Electronic address:

Urolithiasis is a common urological disease, and treatment strategy options vary between different stone types. However, accurate detection of stone composition can only be performed in vitro. The management of infection stones is particularly challenging with yet no effective approach to pre-operatively identify infection stones from non-infection stones. Read More

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Reducing phenotypic instabilities of a microbial population during continuous cultivation based on cell switching dynamics.

Biotechnol Bioeng 2021 Jun 15. Epub 2021 Jun 15.

Terra Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.

Predicting the fate of individual cells among a microbial population (i.e., growth and gene expression) remains a challenge, especially when this population is exposed to very dynamic environmental conditions, such as those encountered during continuous cultivation. Read More

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Rapid and selective detection of macrocyclic trichothecene producing Stachybotrys chartarum strains by loop-mediated isothermal amplification (LAMP).

Anal Bioanal Chem 2021 Jun 15. Epub 2021 Jun 15.

TUM School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 4, 85354, Freising, Germany.

Cytotoxic macrocyclic trichothecenes such as satratoxins are produced by chemotype S strains of Stachybotrys chartarum. Diseases such as stachybotryotoxicosis in animals and the sick building syndrome as a multifactorial disease complex in humans have been associated with this mold and its toxins. Less toxic non-chemotype S strains of S. Read More

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HBI Transcription Factor-Mediated ROS Homeostasis Regulates Nitrate Signal Transduction.

Plant Cell 2021 Jun 15. Epub 2021 Jun 15.

The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao, 266237, China.

Nitrate is both an important nutrient and a critical signaling molecule that regulates plant metabolism, growth, and development. Although several components of the nitrate signaling pathway have been identified, the molecular mechanism of nitrate signaling remains unclear. Here, we showed that the growth-related transcription factors HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH IBH1 (HBI1) and its three closest homologs (HBIs) positively regulate nitrate signaling in Arabidopsis thaliana. Read More

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Multicenter analysis and a rapid screening model to predict early novel coronavirus pneumonia using a random forest algorithm.

Medicine (Baltimore) 2021 Jun;100(24):e26279

Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014.

Abstract: Early determination of coronavirus disease 2019 (COVID-19) pneumonia from numerous suspected cases is critical for the early isolation and treatment of patients.The purpose of the study was to develop and validate a rapid screening model to predict early COVID-19 pneumonia from suspected cases using a random forest algorithm in China.A total of 914 initially suspected COVID-19 pneumonia in multiple centers were prospectively included. Read More

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Robot-assisted arm therapy in neurological health conditions: rationale and methodology for the evidence synthesis in the CICERONE Italian Consensus Conference.

Eur J Phys Rehabil Med 2021 Jun 15. Epub 2021 Jun 15.

Department of Electrical and Information Engineering, Politecnico di Bari, Bari, Italy.

Background: Robot-assisted Arm Therapy (RAT) has been increasingly applied in the last years for promoting functional recovery in patients with disabilities related to neurological health conditions. Evidence of a knowledge-to-action gap for applying robot-assisted technologies in the rehabilitation of patients with neurological health conditions and the difficulty to apply and tailor the knowledge to the local contexts solicited the need for a national consensus conference on these interventions.

Aim: This paper aims to explain the methodology used by the working group dedicated to synthesize evidence on the effectiveness of RAT in neurological health conditions in the context of the CICERONE Italian Consensus Conference. Read More

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The epidemic burden on prisons in Lombardy (Italy) during the first wave of the COVID-19 pandemic: the transmission and measures of prevention in detention facilities.

Int J Prison Health 2021 06;ahead-of-print(ahead-of-print)

Welfare General Directorate, Lombardy Regional Health Authority, Milan, Italy.

Purpose: Early on in the COVID-19 pandemic, the scientific community highlighted a potential risk of epidemics occurring inside prisons. Consequently, specific operational guidelines were promptly released, and containment measures were quickly implemented in prisons. This paper aims to describe the spread of COVID-19 in detention facilities within the Lombardy region of Italy during March to July 2020, and the impact of the prevention and control measures implemented. Read More

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Molecular cloning, characterization and expression analysis of three key starch synthesis-related genes from the bulb of a rare lily germplasm, var. .

J Zhejiang Univ Sci B 2021 Jun;22(6):476-491

Genomics and Genetic Engineering Laboratory of Ornamental Plants, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, China.

Starch is the predominant compound in bulb scales, and previous studies have shown that bulblet development is closely associated with starch enrichment. However, how starch synthesis affects bulbification at the molecular level is unclear. In this study, we demonstrate that var. Read More

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Immune infiltration phenotypes of prostate adenocarcinoma and their clinical implications.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Oncogenes and Related Genes, Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: Tumor-infiltrating immune cells participate in the initiation and progression of prostate adenocarcinoma (PRAD). However, it is not fully known how immune infiltration affects the development of PRAD and its clinical presentation.

Methods: Herein, we investigated the immune infiltration phenotypes in PRAD based on transcriptome profiles, methylation profiles, somatic mutation, and copy number variations. Read More

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Identification of a prognostic metabolic gene signature in diffuse large B-cell lymphoma.

J Cell Mol Med 2021 Jun 14. Epub 2021 Jun 14.

Sun Yat-sen University Cancer Center, Guangzhou, China.

Diffuse large B-cell lymphoma (DLBCL) is a clinically diverse disease. Given the numerous genetic mutations and variations associated with it, a prognostic gene signature that can be related to the overall survival (OS) is a clinical implication. We used the mRNA expression profiles and clinicopathological data of patients with DLBCL from the Gene Expression Omnibus (GEO) database to identify a metabolism-related gene signature. Read More

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Towards sustainability path in Argentina: the role of finance, energy mix, and industrial value-added in low or high carbon emission-application of DARDL simulation.

Environ Sci Pollut Res Int 2021 Jun 14. Epub 2021 Jun 14.

Department of Economics, Adekunle Ajasin University Akungba, Akungba Akoko, Ondo State, Nigeria.

The interconnection between environmental protection and sustainable development is at the heart of discussion among all the intergovernmental agencies around the globe. Such discussion is considered highly important considering the role of finance, an abundance of fossil fuel and industrial value-added on economic activities and environmental issues. Meanwhile, few empirical studies in this line of discussions have documented policy options for projecting the path towards sustainable development in Argentina from 1971 to 2018. Read More

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Nutritional targeting modification of silkworm pupae oil catalyzed by a smart hydrogel immobilized lipase.

Food Funct 2021 Jun 15. Epub 2021 Jun 15.

Jiangsu Key Laboratory Sericutural Biology and Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212100, China. and Attached Silkworm Medicine Factory, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu 212100, China and Key Laboratory of Silkworm and Mulberry Genetic Improvement, Ministry of Agricultural and Rural Affairs, Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang, Jiangsu 212100, China.

To prepare a nutritional supplement using silkworm pupae oil (SPO) as a feedstock, a microfluidic reactor with a smart hydrogel immobilized lipase was first constructed to reduce the relative content of palmitic acid at sn-1,3 and improve the nutritional function. The effects of flow rate, reaction temperature, and substrate molar ratio were investigated. In vitro digestion and pH-stat models were employed to analyze the digestion feature after the modification of SPO, while HPLC-ELSD, zeta potential, DSC, and TGA were used to evaluate the nutritional function. Read More

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Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells.

Oncogene 2021 Jun 14. Epub 2021 Jun 14.

Institute of Biomedicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Treatment of prostate cancer confronts resistance to androgen receptor (AR)-targeted therapies. AR-associated coregulators and chromatin proteins hold a great potential for novel therapy targets. Here, we employed a powerful chromatin-directed proteomics approach termed ChIP-SICAP to uncover the composition of chromatin protein network, the chromatome, around endogenous AR in castration resistant prostate cancer (CRPC) cells. Read More

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A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome.

Commun Biol 2021 Jun 14;4(1):730. Epub 2021 Jun 14.

Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Astrocytes exert adverse effects on the brains of individuals with Down syndrome (DS). Although a neurogenic-to-gliogenic shift in the fate-specification step has been reported, the mechanisms and key regulators underlying the accelerated proliferation of astrocyte precursor cells (APCs) in DS remain elusive. Here, we established a human isogenic cell line panel based on DS-specific induced pluripotent stem cells, the XIST-mediated transcriptional silencing system in trisomic chromosome 21, and genome/chromosome-editing technologies to eliminate phenotypic fluctuations caused by genetic variation. Read More

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Meta-analysis of gene signatures and key pathways indicates suppression of JNK pathway as a regulator of chemo-resistance in AML.

Sci Rep 2021 Jun 14;11(1):12485. Epub 2021 Jun 14.

Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Islamic Republic of Iran.

The pathways and robust deregulated gene signatures involved in AML chemo-resistance are not fully understood. Multiple subgroups of AMLs which are under treatment of various regimens seem to have similar regulatory gene(s) or pathway(s) related to their chemo-resistance phenotype. In this study using gene set enrichment approach, deregulated genes and pathways associated with relapse after chemotherapy were investigated in AML samples. Read More

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Effects of Flywheel Training With Eccentric Overload on Standing Balance, Mobility, Physical Function, Muscle Thickness, and Muscle Quality in Older Adults.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Center for Sport, Exercise and Life Sciences, School of Life Sciences, Coventry University, Warwickshire, United Kingdom; and Center for Physical Activity and Life Sciences, Faculty of Art, Science and Technology, University of Northampton, Northamptonshire, United Kingdom.

Abstract: Hill, MW, Roberts, M, Price, MJ, and Kay, AD. Effects of flywheel training with eccentric overload on standing balance, mobility, physical function, muscle thickness, and muscle quality in older adults. J Strength Cond Res XX(X): 000-000, 2021-This study investigated the effects of a 6-week eccentric overload flywheel training program on vastus lateralis (VL) and gastrocnemius medialis (GM) muscle thickness and muscle quality (echo intensity), mobility (Timed Up and Go [TUG]), physical function (sit-to-stand), and balance (postural sway) performance. Read More

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Ascertaining Framingham heart failure phenotype from inpatient electronic health record data using natural language processing: a multicentre Atherosclerosis Risk in Communities (ARIC) validation study.

BMJ Open 2021 06 14;11(6):e047356. Epub 2021 Jun 14.

Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Objectives: Using free-text clinical notes and reports from hospitalised patients, determine the performance of natural language processing (NLP) ascertainment of Framingham heart failure (HF) criteria and phenotype.

Study Design: A retrospective observational study design of patients hospitalised in 2015 from four hospitals participating in the Atherosclerosis Risk in Communities (ARIC) study was used to determine NLP performance in the ascertainment of Framingham HF criteria and phenotype.

Setting: Four ARIC study hospitals, each representing an ARIC study region in the USA. Read More

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Biosynthesis of a sulfated exopolysaccharide, synechan, and bloom formation in the model cyanobacterium sp. strain PCC 6803.

Elife 2021 Jun 15;10. Epub 2021 Jun 15.

Department of Life Sciences (Biology), Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan.

Extracellularpolysaccharides of bacteria contribute to biofilm formation, stress tolerance, and infectivity. Cyanobacteria, the oxygenic photoautotrophic bacteria, uniquely produce sulfated extracellular polysaccharides among bacteria to support phototrophic biofilms. In addition, sulfated polysaccharides of cyanobacteria and other organisms have been focused as beneficial biomaterial. Read More

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Exploring temporal interactions of crash counts in California using distinct log-linear contingency table models.

Int J Inj Contr Saf Promot 2021 Jun 14:1-16. Epub 2021 Jun 14.

Division of Research, Innovation and System Information, California Department of Transportation, Sacramento, CA, USA.

Temporal trait of crashes has huge impact on road crash occurrence and a large proportion of research have considered different time periods to determine the causes and features of crash occurrence or frequency. Compared with other safety studies based on a single time interval, considerably less research has relied on the use of multiple time units, especially for the time intervals of less than one year. The research aims to fill the gap by investigating the temporal distribution of crash counts using multiple time spans including hour, weekday and month. Read More

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COVID-19 vaccine delivery: an opportunity to set up systems for the future.

Gates Open Res 2020 14;4:182. Epub 2021 Apr 14.

School of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, Ca, 92093, USA.

The race to develop safe and effective SARS-COV-2 vaccines has moved with unprecedented speed. There are now multiple vaccines that have received emergency use authorization from the United States Food and Drug Administration and a host of candidates positioned for approval worldwide. Attention has now turned to allocation, distribution and verification of these vaccines, yet this focus exposes that the underlying infrastructure for global delivery and monitoring is threadbare and unevenly distributed. Read More

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Exploiting single-electron transfer in Lewis pairs for catalytic bond-forming reactions.

Chem Sci 2020 Mar 20;11(17):4305-4311. Epub 2020 Mar 20.

Institute of Transformative Bio-Molecules (WPI-ITbM), Department of Molecular and Macromolecular Chemistry, Graduate School of Engineering, Nagoya University Nagoya 464-8601 Japan

A single-electron transfer (SET) between tris(pentafluorophenyl)borane (B(CF)) and ,-dialkylanilines is reported, which is operative the formation of an electron donor-acceptor (EDA) complex involving π-orbital interactions as a key intermediate under dark conditions or visible-light irradiation depending on the structure of the aniline derivatives. This inherent SET in the Lewis pairs initiates the generation of the corresponding α-aminoalkyl radicals and their additions to electron-deficient olefins, revealing the ability of B(CF) to act as an effective one-electron redox catalyst. Read More

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Micropollutants and biological effects as control indexes for the operation and design of shallow open-water unit ponds to polish domestic effluent.

J Hazard Mater 2021 Jun 5;418:126306. Epub 2021 Jun 5.

Xi'an University of Architecture and Technology; International Science & Technology Cooperation Center for Urban Alternative Water Resources Development; Key Lab of Northwest Water Resource, Environment and Ecology, MOE; Shaanxi Key Laboratory of Environmental Engineering, Xi'an 710055, China. Electronic address:

Additional control indexes should be considered for the operation and design of post-treatment systems, as the wastewater treatment objectives are developing toward protecting the safety of ecological environments. In this study, two control indexes were selected and examined systematically in pilot-scale shallow open-water unit (SOWU) ponds for domestic effluent polishing: micropollutants and biotoxicities. The total risk quotient (RQ ≤ 1) and effect-based trigger value (EBT) were set as the thresholds for known micropollutants and biological effects, respectively. Read More

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Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins.

Nucleic Acids Res 2021 Jun 14. Epub 2021 Jun 14.

Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, Barcelona, Catalonia 08028, Spain.

The modification of adenosine to inosine at the wobble position (I34) of tRNA anticodons is an abundant and essential feature of eukaryotic tRNAs. The expansion of inosine-containing tRNAs in eukaryotes followed the transformation of the homodimeric bacterial enzyme TadA, which generates I34 in tRNAArg and tRNALeu, into the heterodimeric eukaryotic enzyme ADAT, which modifies up to eight different tRNAs. The emergence of ADAT and its larger set of substrates, strongly influenced the tRNA composition and codon usage of eukaryotic genomes. Read More

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DGLinker: flexible knowledge-graph prediction of disease-gene associations.

Nucleic Acids Res 2021 Jun 14. Epub 2021 Jun 14.

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, SE5 8AF, London, UK.

As a result of the advent of high-throughput technologies, there has been rapid progress in our understanding of the genetics underlying biological processes. However, despite such advances, the genetic landscape of human diseases has only marginally been disclosed. Exploiting the present availability of large amounts of biological and phenotypic data, we can use our current understanding of disease genetics to train machine learning models to predict novel genetic factors associated with the disease. Read More

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Awareness of COVID-19 influences on the wellness of Thai health professional students: An ambulatory assessment during the early "new normal" informing policy.

PLoS One 2021 14;16(6):e0252681. Epub 2021 Jun 14.

Department of Physical Therapy, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

The COVID-19 global pandemic has had a socioeconomic effect, including many people suffering from stress and mental disorders. Health professional students are at risk of health issues as well when compared to their age-matched counterpart in the population. The present study aimed to find out the impact of COVID-19 awareness on the wellness of Thai health professional students. Read More

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Cerebrospinal fluid lipidomics for biomarkers of Alzheimer's disease.

Mol Omics 2021 Jun;17(3):454-463

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55902, USA. and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA and Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA and Department of Biological Chemistry, Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Alzheimer's disease (AD) is the most common cause of dementia and is associated with serious neurologic sequelae resulting from neurodegenerative changes. Identification of markers of early-stage AD could be important for designing strategies to arrest the progression of the disease. The brain is rich in lipids because they are crucial for signal transduction and anchoring of membrane proteins. Read More

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Monitoring Diagnostic Safety Risks in Emergency Departments: Protocol for a Machine Learning Study.

JMIR Res Protoc 2021 Jun 14;10(6):e24642. Epub 2021 Jun 14.

Health Care Delivery Research, Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, United States.

Background: Diagnostic decision making, especially in emergency departments, is a highly complex cognitive process that involves uncertainty and susceptibility to errors. A combination of factors, including patient factors (eg, history, behaviors, complexity, and comorbidity), provider-care team factors (eg, cognitive load and information gathering and synthesis), and system factors (eg, health information technology, crowding, shift-based work, and interruptions) may contribute to diagnostic errors. Using electronic triggers to identify records of patients with certain patterns of care, such as escalation of care, has been useful to screen for diagnostic errors. Read More

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Extraction of Traditional Chinese Medicine Entity: Design of a Novel Span-Level Named Entity Recognition Method With Distant Supervision.

JMIR Med Inform 2021 Jun 14;9(6):e28219. Epub 2021 Jun 14.

School of Computer and Communication Engineering, University of Science and Technology Beijing, Beijing, China.

Background: Traditional Chinese medicine (TCM) clinical records contain the symptoms of patients, diagnoses, and subsequent treatment of doctors. These records are important resources for research and analysis of TCM diagnosis knowledge. However, most of TCM clinical records are unstructured text. Read More

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Estimating costs for nitrate and perchlorate treatment for small drinking water systems.

AWWA Water Sci 2021 ;3(2)

US Environmental Protection Agency (USEPA), Cincinnati, Ohio.

When choosing a treatment technology for nitrate or perchlorate removal, drinking water utilities overwhelmingly choose ion exchange. However, of late, biological treatment and point-of-use systems have received a great deal of attention. This article utilizes several new U. Read More

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January 2021

Finding key players in complex networks through deep reinforcement learning.

Nat Mach Intell 2020 Jun 25;2(6):317-324. Epub 2020 May 25.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Finding an optimal set of nodes, called key players, whose activation (or removal) would maximally enhance (or degrade) certain network functionality, is a fundamental class of problems in network science. Potential applications include network immunization, epidemic control, drug design, and viral marketing. Due to their general NP-hard nature, those problems typically cannot be solved by exact algorithms with polynomial time complexity. Read More

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