14,508 results match your criteria set constructed


Soft tissue dimensional changes after alveolar ridge preservation using different sealing materials: a systematic review and network meta-analysis.

Clin Oral Investig 2021 Oct 20. Epub 2021 Oct 20.

Department of Biomedical, Surgical and Dental Sciences, Università Degli Studi Di Milano, Milan, Italy.

Background: Alveolar ridge preservation (ARP) is a proactive treatment option aiming at attenuating post-extraction hard and soft tissue dimensional changes. A high number of different types of biomaterials have been utilized during ARP to seal the socket, but their effectiveness in terms of soft tissue outcomes has rarely been investigated and compared in the literature.

Objective: To evaluate the efficacy of different types of membranes and graft materials in terms of soft tissue outcomes (keratinized tissue width changes, vertical buccal height, and horizontal changes) after ARP, and to assign relative rankings based on their performance. Read More

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October 2021

340B Drug Pricing Program and hospital provision of uncompensated care.

Am J Manag Care 2021 10;27(10):432-437

Department of Population Health, New York University School of Medicine, 227 E 30th St #635, New York, NY 10016. Email:

Objectives: To evaluate whether hospital entry into the 340B Drug Pricing Program, which entitles eligible hospitals to discounts on drug purchases and intends for hospitals to use associated savings to devote more resources to the care of low-income populations, is associated with changes in hospital provision of uncompensated care.

Study Design: We analyzed secondary data on 340B participation and uncompensated care provision among general acute care hospitals and critical access hospitals from 2003 to 2015. We constructed an annual, hospital-level data set on hospital 340B participation from the Office of Pharmacy Information Systems and on uncompensated care provision from the Hospital Cost Reporting Information System. Read More

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October 2021

Identification of novel subtypes based on ssGSEA in immune-related prognostic signature for tongue squamous cell carcinoma.

Cancer Med 2021 Oct 20. Epub 2021 Oct 20.

Department of Oncology, Third Xiangya Hospital of Central South University, Changsha, China.

Background: Tongue squamous cell carcinoma (TSCC) is characterized by aggressive invasion and poor prognosis. Currently, immune checkpoint inhibitors may prolong overall survival compared with conventional treatments. However, PD1/PDL1 remain inapplicable in predicting the prognosis of TSCC; thus, it is urgent to explore the genetic characteristics of TSCC. Read More

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October 2021

Radiomics nomogram analysis of T2-fBLADE-TSE in pulmonary nodules evaluation.

Magn Reson Imaging 2021 Oct 16. Epub 2021 Oct 16.

Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Shanghai Institute of Medical Imaging, Shanghai 200032, China; Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China; Fudan University, No. 220 Handan Road, Yangpu, Shanghai 200433, China. Electronic address:

Objectives: To develop and validate a radiomics nomogram for differentiating between malignant pulmonary nodules and benign nodules.

Methods: 56 benign and 51 malignant nodules from 96 patients were analyzed using manual segmentation of the T2-fBLADE-TSE, while the nodules signal intensity (SIlesion), lesion muscle ratio (LMR) and nodule size were all measured and recorded. The maximum relevance and minimum redundancy (mRMR) and the least absolute shrinkage and selection operator (LASSO) were used to select nonzero coefficients and develop the model in pulmonary nodules diagnosis. Read More

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October 2021

Predicting psoriasis using routine laboratory tests with random forest.

PLoS One 2021 19;16(10):e0258768. Epub 2021 Oct 19.

Department of Computer Science and Engineering, University of North Texas, Denton, Texas, United States of America.

Psoriasis is a chronic inflammatory skin disease that affects approximately 125 million people worldwide. It has significant impacts on both physical and emotional health-related quality of life comparable to other major illnesses. Accurately prediction of psoriasis using biomarkers from routine laboratory tests has important practical values. Read More

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October 2021

Event-Triggered Practical Prescribed Time Output Feedback Neuroadaptive Tracking Control Under Saturated Actuation.

IEEE Trans Neural Netw Learn Syst 2021 Oct 19;PP. Epub 2021 Oct 19.

This work focuses on the issue of event-triggered practical prescribed time tracking control for a type of uncertain nonlinear systems subject to actuator saturation and unmeasurable states as well as time-varying unknown control coefficients. First, a state observer with simple structure is constructed by means of neural network technology to estimate the unmeasurable system states under time-varying control coefficients. Then, with the help of one-to-one nonlinear mapping of the tracking error, an event-triggered output feedback control scheme is developed to steer the tracking error into a residual set of predefined accuracy within a preassigned settling time. Read More

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October 2021

Azimuthal Dipolar Rotor Arrays on Surfaces.

Chemistry 2021 Oct 19. Epub 2021 Oct 19.

Kiel University: Christian-Albrechts-Universitat zu Kiel, Physics, Leibnizstraße 19, 24118, Kiel, GERMANY.

A set of dipolar molecular rotor compounds was designed, synthesized and adsorbed as self-assembled 2D arrays on Ag(111) surfaces. The title molecules are constructed from three building blocks: (a) 4,8,12-trioxatriangulene (TOTA) platforms that are known to physisorb on metal surfaces such as Au(111) and Ag(111), (b) phenyl groups attached to the central carbon atom that function as pivot joints to reduce the barrier to rotation, (c) pyridine and pyridazine units as small dipolar units on top. Theoretical calculations and STM investigations hint at the fact that the dipoles of neighbouring rotors interact through space via pairs of energetically favourable head-to-tail arrangements. Read More

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October 2021

Revealing the potential mechanism of Astragalus membranaceus improving prognosis of hepatocellular carcinoma by combining transcriptomics and network pharmacology.

BMC Complement Med Ther 2021 Oct 18;21(1):263. Epub 2021 Oct 18.

Key Laboratory of Brain Functional Genomics (East China Normal University), Ministry of Education, School of Life Sciences, East China Normal University, Shanghai, 200062, China.

Background: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death. Traditional Chinese medicine (TCM) has special advantages in relieving HCC, while Astragalus membranaceus is commonly used in TCM treatment. However, its underlying mechanisms for treatment of HCC are unclear. Read More

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October 2021

Development and Verification of an Immune-Related Gene Pairs Prognostic Signature in Hepatocellular Carcinoma.

Front Mol Biosci 2021 1;8:715728. Epub 2021 Oct 1.

Department of Orthopedics, Lanzhou University First Affiliated Hospital, Lanzhou, China.

With the increasing prevalence of Hepatocellular carcinoma (HCC) and the poor prognosis of immunotherapy, reliable immune-related gene pairs (IRGPs) prognostic signature is required for personalized management and treatment of patients. Gene expression profiles and clinical information of HCC patients were obtained from the TCGA and ICGC databases. The IRGPs are constructed using immune-related genes (IRGs) with large variations. Read More

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October 2021

The Landscape of the Tumor Microenvironment in Skin Cutaneous Melanoma Reveals a Prognostic and Immunotherapeutically Relevant Gene Signature.

Front Cell Dev Biol 2021 1;9:739594. Epub 2021 Oct 1.

Department of Burn Surgery and Skin Regeneration, The First People's Hospital of Foshan, Foshan, China.

The tumorigenesis of skin cutaneous melanoma (SKCM) remains unclear. The tumor microenvironment (TME) is well known to play a vital role in the onset and progression of SKCM. However, the dynamic mechanisms of immune regulation are insufficient. Read More

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October 2021

Education as a Predictor Factor for Knowledge of COVID-19 in Portugal.

Front Public Health 2021 29;9:680726. Epub 2021 Sep 29.

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

Pandemic of COVID-19 is a major public health problem. At the time of development of this study, no specific medication/vaccine for this disease was approved. Therefore, preventive measures were the main key to control this pandemic. Read More

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September 2021

Molecular Features of Glioma Determined and Validated Using Combined TCGA and GTEx Data Analyses.

Front Oncol 2021 30;11:729137. Epub 2021 Sep 30.

Department of Neurosurgery, Jiangyin Clinical College of Xuzhou Medical College, Jiangyin, China.

Gliomas are among the most common intracranial tumors which originated from neuroepithelial cells. Increasing evidence has revealed that long noncoding RNA (lncRNA)-microRNA (miRNA)-mRNA module regulation and tumor-infiltrating immune cells play important regulatory roles in the occurrence and progression of gliomas. However, the precise underlying molecular mechanisms remain largely unknown. Read More

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September 2021

Development and validation of a nomogram model for early postoperative hyperlactatemia in patients undergoing cardiac surgery.

J Thorac Dis 2021 Sep;13(9):5395-5408

Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Postoperative hyperlactatemia (POHL) is common in patients undergoing cardiac surgery, associated with adverse outcomes. The aim of this study was to identify predictors for POHL after cardiac surgery and to develop and validate a predictive model.

Methods: Adult patients who underwent open heart surgery at our institution between 2016 and 2019 were retrospectively included. Read More

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September 2021

Discriminating invasive adenocarcinoma among lung pure ground-glass nodules: a multi-parameter prediction model.

J Thorac Dis 2021 Sep;13(9):5383-5394

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Patients with consistent lung pure ground-glass nodules (pGGNs) have a high incidence of lung adenocarcinoma that can be classified as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IAC). Regular follow-up is recommended for AIS and MIA, while surgical resection should be considered for IAC. This study sought to develop a multi-parameter prediction model to increase the diagnostic accuracy in discriminating between IAC and AIS or MIA. Read More

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September 2021

Transcriptome Profiling Reveals Important Transcription Factors and Biological Processes in Skin Regeneration Mediated by Mechanical Stretch.

Front Genet 2021 29;12:757350. Epub 2021 Sep 29.

Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Mechanical stretch is utilized to promote skin regeneration during tissue expansion for reconstructive surgery. Although mechanical stretch induces characteristic morphological changes in the skin, the biological processes and molecular mechanisms involved in mechanically induced skin regeneration are not well elucidated. A male rat scalp expansion model was established and the important biological processes related to mechanical stretch-induced skin regeneration were identified using Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and gene set enrichment analysis (GSEA). Read More

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September 2021

Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.

Front Syst Neurosci 2021 30;15:725413. Epub 2021 Sep 30.

University of Paris, CNRS, INCC, Paris, France.

Adolescence is a period of vulnerability for the maturation of gray matter (GM) and also for the onset of psychiatric disorders such as major depressive disorder (MDD), bipolar disorder and schizophrenia. Chronic neuroinflammation is considered to play a role in the etiology of these illnesses. However, the involvement of neuroinflammation in the observed link between regional GM volume reductions and psychiatric symptoms is not established yet. Read More

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September 2021

[Predicting postoperative recurrence of stage Ⅰ-Ⅲ renal clear cell carcinoma based on preoperative CT radiomics feature nomogram].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(9):1358-1365

Department of Imaging, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: To explore the preoperative radiomics features (RFs) and construct a nomogram for predicting postoperative recurrence of stage Ⅰ-Ⅲ clear cell renal carcinoma (ccRCC).

Methods: The clinicopathological data and preoperative enhanced CT images collected from 256 patients with ccRCC were used as the training dataset (175 patients) and test dataset (81 patients). The enhanced CT images of the tumor were segmented using ITK-SNAP software, and the RFs were extracted using the PyRadiomics computing platform. Read More

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Enhanced computed tomography radiomics-based machine-learning methods for predicting the Fuhrman grades of renal clear cell carcinoma.

J Xray Sci Technol 2021 Oct 12. Epub 2021 Oct 12.

Department of Radiology, Changzhou Second People's Hospital, Changzhou, China.

Objective: To develop and test an optimal machine learning model based on the enhanced computed tomography (CT) to preoperatively predict pathological grade of clear cell renal cell carcinoma (ccRCC).

Methods: A retrospective analysis of 53 pathologically confirmed cases of ccRCC was performed and 25 consecutive ccRCC cases were selected as a prospective testing set. All patients underwent routine preoperative abdominal CT plain and enhanced scans. Read More

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October 2021

Identification of cell cycle as the critical pathway modulated by exosome-derived microRNAs in gallbladder carcinoma.

Med Oncol 2021 Oct 16;38(12):141. Epub 2021 Oct 16.

Department of Integrated Traditional and Western Medicine in Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, People's Republic of China.

Gallbladder cancer (GBC), the most common malignancy in the biliary tract, is highly lethal malignant due to seldomly specific symptoms in the early stage of GBC. This study aimed to identify exosome-derived miRNAs mediated competing endogenous RNAs (ceRNA) participant in GBC tumorigenesis. A total of 159 differentially expressed miRNAs (DEMs) was identified as exosome-derived miRNAs, contains 34 upregulated exo-DEMs and 125 downregulated exo-DEMs based on the expression profiles in GBC clinical samples downloaded from the Gene Expression Omnibus database with the R package. Read More

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October 2021

Genome sequencing of turmeric provides evolutionary insights into its medicinal properties.

Commun Biol 2021 Oct 15;4(1):1193. Epub 2021 Oct 15.

MetaBioSys Group, Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal, India.

Curcuma longa, or turmeric, is traditionally known for its immense medicinal properties and has diverse therapeutic applications. However, the absence of a reference genome sequence is a limiting factor in understanding the genomic basis of the origin of its medicinal properties. In this study, we present the draft genome sequence of C. Read More

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October 2021

Tailored graphical lasso for data integration in gene network reconstruction.

BMC Bioinformatics 2021 Oct 15;22(1):498. Epub 2021 Oct 15.

Department of Mathematics, University of Oslo, PO Box 1053 Blindern, 0316, Oslo, Norway.

Background: Identifying gene interactions is a topic of great importance in genomics, and approaches based on network models provide a powerful tool for studying these. Assuming a Gaussian graphical model, a gene association network may be estimated from multiomic data based on the non-zero entries of the inverse covariance matrix. Inferring such biological networks is challenging because of the high dimensionality of the problem, making traditional estimators unsuitable. Read More

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October 2021

Uncovering spatiotemporal patterns in semiconductor superlattices by efficient data processing tools.

Phys Rev E 2021 Sep;104(3-2):035303

E.T.S.I. Aeronáutica y del Espacio, Universidad Politécnica de Madrid, 28040 Madrid, Spain.

Time periodic patterns in a semiconductor superlattice, relevant to microwave generation, are obtained upon numerical integration of a known set of drift-diffusion equations. The associated spatiotemporal transport mechanisms are uncovered by applying (to the computed data) two recent data processing tools, known as the higher order dynamic mode decomposition and the spatiotemporal Koopman decomposition. Outcomes include a clear identification of the asymptotic self-sustained oscillations of the current density (isolated from the transient dynamics) and an accurate description of the electric field traveling pulse in terms of its dispersion diagram. Read More

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September 2021

Nylon lattice design parameter effects on additively manufactured structural performance.

J Mech Behav Biomed Mater 2021 Oct 6;125:104869. Epub 2021 Oct 6.

Division of Applied Mechanics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, United States Food and Drug Administration, Silver Spring, MD, 20993, USA; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; Department of Mechanical Engineering, The University of Texas at Dallas, USA. Electronic address:

Lattice structures are used in a multitude of applications from medical to aerospace, and their adoption in these applications has been further enabled by additive manufacturing. Lattice performance is governed by a multitude of variables and estimating this performance may be needed during various phases of the design and validation process. Numerical modeling and constitutive relationships are common methodologies to assess performance, address risks, lower costs, and accelerate time to market for innovative and potentially life altering products. Read More

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October 2021

Genome-wide Analysis Identifies Novel Gallstone-susceptibility Loci Including Genes Regulating Gastrointestinal Motility.

Hepatology 2021 Oct 15. Epub 2021 Oct 15.

Centre for Medical Informatics, Usher Institute, University of Edinburgh.

Background & Aims: Genome-wide association studies (GWAS) have identified several risk loci for gallstone disease. As with most polygenic traits, it is likely many genetic determinants are undiscovered. The aim of this study was to identify novel genetic variants, representing new targets for gallstone research and treatment. Read More

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October 2021

Comprehensive Transcriptomic Analysis of Critical RNA Regulation Associated With Metabolism and Prognosis in Clear Cell Renal Carcinoma.

Front Cell Dev Biol 2021 28;9:709490. Epub 2021 Sep 28.

Department of Urology, The First Hospital of Jilin University, Changchun, China.

This study focuses on investigating the metabolism-related gene profile and prognosis of clear cell renal cell carcinoma (ccRCC) patients. The research data from the Gene Expression Omnibus database, including GSE40435, GSE53757, and GSE53000, were used to analyze the consistently differentially expressed RNAs (cDERs) by the MetaDE limma package. Gene expression profiling associated with metabolism was downloaded from the GSEA database. Read More

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September 2021

Inference for Multiple Heterogeneous Networks with a Common Invariant Subspace.

J Mach Learn Res 2021 Mar;22(141):1-49

Department of Biomedical Engineering, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, 21218, USA.

The development of models and methodology for the analysis of data from multiple heterogeneous networks is of importance both in statistical network theory and across a wide spectrum of application domains. Although single-graph analysis is well-studied, multiple graph inference is largely unexplored, in part because of the challenges inherent in appropriately modeling graph differences and yet retaining sufficient model simplicity to render estimation feasible. This paper addresses exactly this gap, by introducing a new model, the common subspace independent-edge multiple random graph model, which describes a heterogeneous collection of networks with a shared latent structure on the vertices but potentially different connectivity patterns for each graph. Read More

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Expanding the Structural Diversity and Functional Scope of Diphenylalanine-Based Peptide Architectures by Hierarchical Coassembly.

J Am Chem Soc 2021 Oct 14. Epub 2021 Oct 14.

The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.

Modulation of the structural diversity of diphenylalanine-based assemblies by molecular modification and solvent alteration has been extensively explored for bio- and nanotechnology. However, regulation of the structural transition of assemblies based on this minimal building block into tunable supramolecular nanostructures and further construction of smart supramolecular materials with multiple responsiveness are still an unmet need. Coassembly, the tactic employed by natural systems to expand the architectural space, has been rarely explored. Read More

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October 2021

Predicting the molecular subtype of breast cancer and identifying interpretable imaging features using machine learning algorithms.

Eur Radiol 2021 Oct 13. Epub 2021 Oct 13.

Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Objectives: To evaluate the performance of interpretable machine learning models in predicting breast cancer molecular subtypes.

Methods: We retrospectively enrolled 600 patients with invasive breast carcinoma between 2012 and 2019. The patients were randomly divided into a training (n = 450) and a testing (n = 150) set. Read More

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October 2021

Identification of Mast Cell-Based Molecular Subtypes and a Predictive Signature in Clear Cell Renal Cell Carcinoma.

Front Mol Biosci 2021 27;8:719982. Epub 2021 Sep 27.

Pediatric Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Kidney renal clear cell carcinoma (KIRC) is a common malignant tumor of the urinary system. Surgery is the preferred treatment option; however, the rate of distant metastasis is high. Mast cells in the tumor microenvironment promote or inhibit tumorigenesis depending on the cancer type; however, their role in KIRC is not well-established. Read More

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September 2021

Identification of N6-Methylandenosine-Related lncRNAs for Subtype Identification and Risk Stratification in Gastric Adenocarcinoma.

Front Oncol 2021 27;11:725181. Epub 2021 Sep 27.

Department of Gastroenterology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Objectives: The purpose of this study was to investigate the role of mA-related lncRNAs in gastric adenocarcinoma (STAD) and to determine their prognostic value.

Methods: Gene expression and clinicopathological data were obtained from The Cancer Genome Atlas (TCGA) database. Correlation analysis and univariate Cox regression analysis were conducted to identify mA-related prognostic lncRNAs. Read More

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September 2021