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Urbanicity, Health, and Access to Services for People With Intellectual Disability and Developmental Disabilities.

Am J Intellect Dev Disabil 2021 Nov;126(6):492-504

Stoni Fortney and Marc J. Tassé, The Ohio State University.

Previous research suggests that residence in non-metropolitan areas is associated with lower access to preventive care and poorer health. However, this research has been largely restricted to the general population, despite data demonstrating disparities in health status and access to healthcare services for people with intellectual and developmental disabilities (IDD). The current study examined several hypotheses involving the effects of rurality on access to preventive healthcare and services and health status: (1) individuals in non-metropolitan areas will have lower preventive healthcare utilization, (2) individuals in non-metropolitan areas will have poorer health outcomes, and (3) individuals in non-metropolitan areas will have poorer access to services. Read More

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November 2021

Meta-Analysis of Joint Test of SNP and SNP-Environment Interaction with Heterogeneity.

Authors:
Qinqin Jin Gang Shi

Hum Hered 2021 Oct 26:1-9. Epub 2021 Oct 26.

State Key Laboratory of Integrated Services Networks, Xidian University, Xi'an, China.

Many complex diseases are caused by single nucleotide polymorphisms (SNPs), environmental factors, and the interaction between SNPs and environment. Joint tests of the SNP and SNP-environment interaction effects (JMA) and meta-regression (MR) are commonly used to evaluate these SNP-environment interactions. However, these two methods do not consider genetic heterogeneity. Read More

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October 2021

Warrant checking practices by post-overdose outreach programs in Massachusetts: A mixed-methods study.

Int J Drug Policy 2021 Oct 23;100:103483. Epub 2021 Oct 23.

Boston Medical Center and Boston University School of Medicine, Grayken Center for Addiction, Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Department of Medicine, 801 Massachusetts Ave, 2nd Floor, Boston, MA 02118, United States. Electronic address:

Background: Post-overdose outreach programs engage survivors in harm reduction and treatment to prevent future overdoses. In Massachusetts, these emerging programs commonly deploy teams comprised of police and public health professionals based on 911 call information. Some teams use name/address data to conduct arrest warrant checks prior to outreach visits. Read More

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October 2021

Lower plasma total tau in adolescent psychosis: Involvement of the orbitofrontal cortex.

J Psychiatr Res 2021 Oct 20;144:255-261. Epub 2021 Oct 20.

Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

Schizophrenia is thought to be a neurodevelopmental disorder with neuronal migration, differentiation and maturation disturbances. Tau is a microtubule-associated protein with a crucial role in these processes. Lower circulating tau levels have been reported in adults with schizophrenia, but this association has not been investigated in adolescent psychosis. Read More

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October 2021

Effectiveness of peer recovery support services on stages of the opioid use disorder treatment cascade: A systematic review.

Drug Alcohol Depend 2021 Oct 9;229(Pt B):109123. Epub 2021 Oct 9.

Prisma Health Addiction Research Center, 605 Grove Rd. Suite 205, Greenville, SC, 29605, USA; University of South Carolina School of Medicine Greenville, Department of Medicine, 701 Grove road, Greenville, SC, 29605, USA; Clemson University School of Health Research, 605 Grove Road Suite 301, Clemson, SC, 29605, USA; Prisma Health Department of Internal Medicine, 876 W Faris Rd., Greenville, SC, 29605, USA.

Background: Peer recovery support services (PRSS) have been increasingly incorporated during the recovery process for opioid use disorder (OUD), yet little is known about the effects of PRSS on clinical outcomes of individuals who misuse opioids. This study systematically synthesized existing literature reporting the effectiveness of PRSS interventions on stages of the OUD treatment cascade.

Methods: A search conducted on five databases identified studies from database inception to January 26th 2021 that evaluated the effects of PRSS on PRSS engagement, medication for OUD (MOUD) initiation, MOUD retention, opioid and non-opioid misuse, and remission. Read More

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October 2021

Gambling and homelessness: A systematic review and meta-analysis of prevalence.

Addict Behav 2021 Oct 14;125:107151. Epub 2021 Oct 14.

Behavioural Sciences Research Laboratory, School of Social Sciences, Monash University, Menzies Building, 20 Chancellors Walk, Clayton, VIC 3800, Australia.

Introduction: There is growing concern internationally about co-occurring gambling and homelessness. We systematically review prevalence estimates in help-seeking and community samples.

Methods: Adopting PRISMA guidelines, we searched CINAHL Plus, Cochrane Library, Embase, Ovid MEDLINE, PsychINFO, Proquest Central, PubMed, Scopus, Web of Science, and Google Scholar for relevant peer-reviewed articles in English. Read More

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October 2021

STAT: Mobile app helps clinicians manage inpatient emergencies at the bedside.

Healthc (Amst) 2021 Oct 23;9(4):100590. Epub 2021 Oct 23.

Department of Emergency Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA; Healthcare Transformation Lab, Massachusetts General Hospital, 50 Staniford Street, Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.

In response to the unprecedented surge of patients with COVID-19, Massachusetts General Hospital created both repurposed and de-novo COVID-19 inpatient general medicine and intensive care units. The clinicians staffing these new services included those who typically worked in these care settings (e.g. Read More

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October 2021

Gender and residence differences in the association between social support and subjective well-being among Chinese oldest-old: A national longitudinal study.

Arch Gerontol Geriatr 2021 Oct 3;98:104545. Epub 2021 Oct 3.

Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China. Electronic address:

Objectives: This study aimed to explore the gender and residence (rural/urban) differences in the associations between the specific dimensions of social support and subjective well-being (SWB) among the Chinese oldest-old.

Methods: This study included 12,989 individuals aged ≥ 80 from 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey. SWB was measured by ten items covering self-rated life satisfaction, positive emotions (optimism, happiness, personal control, and conscientiousness), and negative emotions (loneliness, anxiety, uselessness, depression, and boring feelings). Read More

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October 2021

Why women utilize traditional rather than skilled birth attendants for maternity care in rural Nigeria: Implications for policies and programs.

Midwifery 2021 Oct 7;104:103158. Epub 2021 Oct 7.

University of Ottawa, Canada.

Objective: Data from the Nigeria Demographic and Health Survey indicate that many pregnant women in rural Nigeria use traditional birth attendants (TBAs) rather than skilled birth attendants (SBAs) for maternal health care. This is one factor that accounts for the persistently high rate of maternal mortality in Nigeria. The objective of this study was to identify the pervading reasons that women use TBAs for pregnancy care in rural Nigeria and to make recommendations for policy and programmatic reform. Read More

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October 2021

Positive life stories of Stroke-Survivor's spousal caregiving in Hong Kong: Lessons for policy and practice.

Soc Sci Med 2021 Oct 11;291:114476. Epub 2021 Oct 11.

Department of Social and Behavioural Sciences, City University of Hong Kong, Hong Kong.

Background: Advances in medical-care for immediately post-stroke mean that many stroke-survivors now live a normal lifespan, although they may suffer residual disability. They are often cared for at home by their spouse, who may be ill-prepared for this task, and may also have health concerns. As demands on formal services increase with population aging in Hong Kong, equipping spousal-caregivers with positive effective caring strategies is increasingly important. Read More

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October 2021

Do state supports for persons with brain injury affect outcomes in the 5 Years following acute rehabilitation?

Health Place 2021 Oct 23;72:102674. Epub 2021 Oct 23.

Craig Hospital, Englewood, CO, USA.

While a substantial literature has examined the effects of individual and family-level factors on outcomes following traumatic brain injury (TBI), minimal attention has been directed to the potential influence of the larger environmental context on outcomes. The purpose of the current study was to investigate the effects of state-level resources and supports as an environmental factor influencing long-term outcomes from TBI using data from the TBI Model Systems. We examined the effects of U. Read More

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October 2021

A reproductive and developmental toxicity screening study of 1,3-butadiene in Sprague-Dawley rats.

Regul Toxicol Pharmacol 2021 Oct 23:105066. Epub 2021 Oct 23.

The Dow Chemical Company, Toxicology & Environmental Research & Consulting, Midland, MI, USA.

1,3 Butadiene (BD) is an industrial intermediate used primarily in product manufacturing with the greatest exposure potential via inhalation. BD was evaluated for reproductive and developmental effects in a Good Laboratory Practice (GLP)-compliant, extended OECD 421 guideline study (completed 2003). Twelve-week old rats (12/sex/dose) were exposed via whole-body inhalation to BD vapor (0, 300, 1500, 6000 ppm) for 6 h/day, 7 days/week, starting 14 days prior to mating through the day prior to euthanasia (total exposures: 83-84 days for F0 males 60-70 days for F0 females). Read More

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October 2021

Waste-to-nutrition: a review of current and emerging conversion pathways.

Biotechnol Adv 2021 Oct 23:107857. Epub 2021 Oct 23.

TBI, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, France. Electronic address:

Residual biomass is acknowledged as a key sustainable feedstock for the transition towards circular and low fossil carbon economies to supply whether energy, chemical, material and food products or services. The latter is receiving increasing attention, in particular in the perspective of decoupling nutrition from arable land demand. In order to provide a comprehensive overview of the technical possibilities to convert residual biomasses into edible ingredients, we reviewed over 950 scientific and industrial records documenting existing and emerging waste-to-nutrition pathways, involving over 150 different feedstocks here grouped under 10 umbrella categories: (i) wood-related residual biomass, (ii) primary crop residues, (iii) manure, (iv) food waste, (v) sludge and wastewater, (vi) green residual biomass, (vii) slaughterhouse by-products, (viii) agrifood co-products, (ix) C gases and (x) others. Read More

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October 2021

Contralateral Carotid Stenosis is a Predictor of Long-term Adverse Events in Carotid Endarterectomy.

Ann Vasc Surg 2021 Oct 23. Epub 2021 Oct 23.

Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Surgery and Physiology, Faculdade de Medicina da Universidade do Porto, Portugal; Department of Biomedicine - Unit of Anatomy, Faculdade de Medicina da Universidade do Porto, Portugal.

Contralateral carotid stenosis (clCS) has been described as a perioperative predictor of mortality after carotid endarterectomy (CEA). However, its predictive value on long-term cardiovascular events remains controversial. The study aims to assess the potential role of clCS as a long-term predictor of major adverse cardiovascular events (MACE) in patients who underwent CEA. Read More

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October 2021

Impact of Plans of Safe Care on Prenatally Substance Exposed Infants.

J Pediatr 2021 Oct 23. Epub 2021 Oct 23.

Department of Pediatrics, Nemours Children's Hospital, Delaware, Wilmington, DE and Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA.

Objective: To assess the impact of recent federal statute changes mandating child welfare-based Plan of Safe Care (POSC) supportive programming and community-based linkages to treatment providers, resources, and services for families of infants affected by prenatal substance exposure (IPSE).

Study Design: Retrospective review of Delaware's statewide child welfare case registry data for IPSE birth notifications and subsequent hotline reports for serious physical injury/fatality concerns from 11/1/2018-10/31/20. Abstracted variables included IPSE sex, substance exposure type, family characteristics (maternal personal child welfare history or mental health diagnosis, treatment engagement), and POSC referrals. Read More

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October 2021

Parenting and Neurobehavioral Outcomes in Children Born Moderate-to-Late Preterm and at Term.

J Pediatr 2021 Oct 23. Epub 2021 Oct 23.

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Victoria, Australia; Victorian Infant Brain Studies, Murdoch Children's Research Institute, Victoria, Australia.

Objectives: To compare the parenting environment and the relationships between parenting behaviors and concurrent child neurobehavioral outcomes at 2 years of corrected age between children born moderate-to-late preterm (MLP; 32-36 weeks of gestation) and at term (≥37 weeks of gestation).

Study Design: Participants were 129 children born MLP and 110 children born at term and their mothers. Mothers' parenting behaviors (sensitivity, structuring, non-intrusiveness, non-hostility) were assessed at 2 years of corrected age using the Emotional Availability Scales (EAS). Read More

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October 2021

A Tribute to Professor Saranjit Singh - A Critical Thinker, Innovator, Mentor, and Educator.

J Pharm Sci 2021 Oct 23. Epub 2021 Oct 23.

Department of Pharmaceutical Sciences, Washington State University, Spokane, WA. Electronic address:

This commentary presents contributions and accomplishments of Professor Saranjit Singh, National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar, India, to pharmaceutical research and education. Prof Singh completed his successful tenure in October, 2021. Over his 40+ years of illustrious academic career, he trained 147 Masters and 15 PhD students in the fields of drug stability testing, degradation chemistry, impurity and metabolite characterization, and advanced analytical technologies. Read More

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October 2021

The life of a laboratory requisition form: patient compliance with clinical laboratory testing in a Canadian primary care health region.

Clin Biochem 2021 Oct 23. Epub 2021 Oct 23.

Departments of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Canada; Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada; Family Medicine, Cumming School of Medicine, University of Calgary, Canada; Alberta Precision Laboratories (formerly Calgary Laboratory Services), Calgary, Alberta, Canada. Electronic address:

Objective: To examine patient laboratory testing compliance by tracking time to submission of laboratory requisitions in Southern Alberta, Canada as part of a quality improvement initiative.

Methods: Data was collected retrospectively from patients from the Chinook Primary Care Network in Alberta, Canada, who received a laboratory requisition consisting of a complete blood count (CBC) test order between September 1, 2016 and August 31, 2017. To allow for all laboratory requisitions created to be submitted within one year, the study collection period was from September 1, 2016 to August 31, 2018. Read More

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October 2021

Rhythm disturbances associated with lidocaine administration in four dogs with supraventricular tachyarrhythmias.

J Vet Emerg Crit Care (San Antonio) 2021 Oct 26. Epub 2021 Oct 26.

Department of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.

Objective: To describe arrhythmias associated with administration of lidocaine in dogs treated for supraventricular tachyarrhythmias.

Case Summaries: Four dogs with recent-onset supraventricular tachyarrhythmias: 3 dogs had atrial fibrillation (AF), and 1 had focal atrial tachycardia (FAT), which was thought to be AF at the time of assessment. The substrate of the supraventricular tachyarrhythmia was considered to be due to primary cardiomyopathy in 1 dog, high vagal tone in 2 dogs, and the change in hemodynamics from heavy sedation in 1 dog. Read More

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October 2021

Shifting the focus inward: Israeli social workers' participation in decision-making and their inclusion of service-users in intervention-related decisions.

Health Soc Care Community 2021 Oct 26. Epub 2021 Oct 26.

Bob Shapell School of Social Work, Tel Aviv University, Tel Aviv, Israel.

Service-users' inclusion (SUI) in decision-making regarding services provided by public social services has numerous benefits for both users and providers. However, studies show a gap between the evolution of inclusive discourse and policy, and the implementation of SUI in social services' daily practice. Focusing on the organisational context, the present study is the first to empirically test the relationship between social workers' perception of the services' participative organisational culture (POC), their actual participation in organisational decision-making (SWAP) and their inclusive praxes with service-users (SUI). Read More

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October 2021

Knowledge syntheses in medical education: Meta-research examining author gender, geographic location, and institutional affiliation.

PLoS One 2021 26;16(10):e0258925. Epub 2021 Oct 26.

Department of Health, Human Function and Rehabilitation Sciences, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America.

Introduction: Authors of knowledge syntheses make many subjective decisions during their review process. Those decisions, which are guided in part by author characteristics, can impact the conduct and conclusions of knowledge syntheses, which assimilate much of the evidence base in medical education. To better understand the evidence base, this study describes the characteristics of knowledge synthesis authors, focusing on gender, geography, and institution. Read More

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October 2021

Feasibility of Find cases Actively, Separate safely and Treat effectively (FAST) strategy for early diagnosis of TB in Nepal: An implementation research.

PLoS One 2021 26;16(10):e0258883. Epub 2021 Oct 26.

Department of Health Policy and Management, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Introduction: Tuberculosis is one of the leading causes of death worldwide. Diagnosing TB in an early stage and initiating effective treatment is one of the best ways to reduce the burden of tuberculosis. Feasibility of Find cases Actively, Separate safely and Treat effectively (FAST) Strategy helps to improve the early diagnosis of tuberculosis cases among inpatient settings as well as out patient department patients and prevent TB transmission in hospital. Read More

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October 2021

Assessing the drivers of syphilis among men who have sex with men in Switzerland reveals a key impact of screening frequency: A modelling study.

PLoS Comput Biol 2021 Oct 26;17(10):e1009529. Epub 2021 Oct 26.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.

Over the last decade, syphilis diagnoses among men-who-have-sex-with-men (MSM) have strongly increased in Europe. Understanding the drivers of the ongoing epidemic may aid to curb transmissions. In order to identify the drivers of syphilis transmission in MSM in Switzerland between 2006 and 2017 as well as the effect of potential interventions, we set up an epidemiological model stratified by syphilis stage, HIV-diagnosis, and behavioral factors to account for syphilis infectiousness and risk for transmission. Read More

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October 2021

Presentation and Treatment of Head and Neck Keratinocyte Carcinomas in Patients Requiring Medical Interpreter Services.

Dermatol Surg 2021 Nov;47(11):1512-1514

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

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November 2021

Home Health Care Nursing Impacts on Emergency Department Utilization.

Authors:
Jennifer Ruel

Adv Emerg Nurs J 2021 Oct-Dec 01;43(4):324-330

McAuley School of Nursing, University of Detroit Mercy, Detroit, Michigan.

With health care costs continuing to rise, much attention has been focused on appropriate emergency department (ED) utilization, and nationwide interventions have been developed to support reduction in health care costs and ED use including primary care, community, and home health models. The following is a review of the current state of the evidence regarding patients receiving home health care nursing (HHN) services and impacts on ED utilization. There are significant gaps in the literature regarding the transition from home to ED in patients receiving HHN services; what tools are utilized by home health nurses for triage of patients at home in order to recommend transfer to the ED or other care sources; and what measures are in place for HHN patients regarding variables that are considered to have a higher impact on ED utilization. Read More

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October 2021

Exploring Differences in Baseline Characteristics among Adults Entering Integrated Residential Treatment for Co-occurring Disorders in 2013 and 2017.

Soc Work Public Health 2021 Oct 26:1-9. Epub 2021 Oct 26.

School of Social Work, Georgia State University, Atlanta, Georgia, USA.

Little is known about patients' addiction severity, substance use, or mental health symptoms upon entering integrated treatment. This is the first study to compare baseline characteristics among cohorts of patients with co-occurring disorders entering a private integrated residential treatment program in 2013 and 2017; a period when severe and persistent mental illness diagnoses, mental health service use, and overdose deaths increased. Our sample includes 3400 patients entering private, integrated residential treatment during 2013 (n = 1535) and 2017 (n = 1865). Read More

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October 2021

Implementation of a Multi-Modal Training Program for the Management of Comorbid Mental Disorders in Drug and Alcohol Settings: Pathways to Comorbidity Care (PCC).

J Dual Diagn 2021 Oct 26:1-9. Epub 2021 Oct 26.

Faculty of Medicine and Health, Sydney Medical School, The University of Sydney, Sydney, Australia.

Objectives: We aimed to evaluate the impact of the Pathways to Comorbidity Care (PCC) training program for alcohol and other drugs (AOD) clinicians to improve the management of comorbidity. A controlled before-and-after study using PCC training was conducted across 6 matched sites in Australia including 35 clinicians. Controls received standard workplace training. Read More

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October 2021

Cullin3 (CUL3) suppresses proliferation, migration and phenotypic transformation of PDGF-BB-stimulated vascular smooth muscle cells and mitigates inflammatory response by repressing Hedgehog signaling pathway.

Bioengineered 2021 Oct 26. Epub 2021 Oct 26.

Department of cardiovascular medicine, People's Hospital of Fengjie, Chongqing, 404600, China.

Vascular smooth muscle cell (VSMC) hyperplasia is closely associated with AS progression. Hence, it is of great significance to elucidate the molecular mechanisms underlying the involvement of VSMCs in AS. SHH antagonist can inhibit the excessive proliferation, migration and phenotypic transformation of PDGF-BB-induced VSMCs. Read More

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October 2021

Review of Poultry Recombinant Vector Vaccines.

Avian Dis 2021 Sep;65(3):438-452

Cobb-Vantress Global Veterinary Services, Siloam Springs, AR 72761.

The control of poultry diseases has relied heavily on the use of many live and inactivated vaccines. However, over the last 30 yr, recombinant DNA technology has been used to generate many novel poultry vaccines. Fowlpox virus and turkey herpesvirus are the two main vectors currently used to construct recombinant vaccines for poultry. Read More

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September 2021