8,178 results match your criteria serum vegf

Exposure to widespread drinking water chemicals, blood inflammation markers, and colorectal cancer.

Environ Int 2021 Sep 17;157:106873. Epub 2021 Sep 17.

ISGlobal, Barcelona, Spain; CIBER epidemiología y salud pública (CIBERESP), Madrid, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Background: Trihalomethanes (THMs) and nitrate are widespread chemicals in drinking water associated with colorectal cancer risk but mechanisms are not well understood.

Objectives: We explored the association between exposure to THMs and nitrate in drinking water and inflammation markers, and the link with colorectal cancer risk.

Methods: A subset of 198 colorectal cancer cases and 205 controls from the multicase-control study MCC-Spain were included. Read More

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September 2021

Identification of Immune Activation Markers in the Early Onset of COVID-19 Infection.

Front Cell Infect Microbiol 2021 3;11:651484. Epub 2021 Sep 3.

Department of Laboratory Medicine, Institute of Clinical Virology, Medical University of Vienna, Vienna, Austria.

This study aimed to determine the specific cytokine profile in peripheral blood during the early onset of COVID-19 infection. This was a cross-sectional exploratory, single center study. A total of 55 plasma samples were studied. Read More

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September 2021

The effect of vacuum sealing drainage after early woundabrasion on wound healing in diabetic patients with deep second degree burn and its influence on the inflammatory response.

Am J Transl Res 2021 15;13(8):9814-9819. Epub 2021 Aug 15.

Department of Traditional Chinese Medicine, Hanchuan People's Hospital/Hanchuan Hospital of People's Hospital of Wuhan University Xiaogan, Hubei Province, China.

Objective: To investigate the effect of vacuum sealing drainage (VSD) after early woundabrasion (WA) in diabetic patients with deep second degree burn (DSDB).

Methods: This prospective study selected 89 diabetic patients with DSDB treated in our hospital. Using the random number table method, the patients were divided into the control group (44 cases with conventional treatment after early WA) and observation group (45 cases with VSD treatment after WA). Read More

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The effects of albumin-bound paclitaxel combined with cisplatin injections on patients with advanced laryngeal cancer and serum survivin.

Am J Transl Res 2021 15;13(8):9802-9807. Epub 2021 Aug 15.

Department of Otolaryngology, Cangzhou Central Hospital Cangzhou, China.

Objective: To explore the effects of the TP (Taxol plus Platinol) regimen and the PF (Platinol plus fluorouracil) regimen on patients with advanced laryngeal cancer and on the patients' VEGF-C (vascular endothelial growth factor C) and survivin genes.

Methods: 42 patients with locally advanced laryngeal cancer treated in our hospital from June 2018 to October 2020 were recruited as the study cohort. The patients were assigned into a control group (21 cases) or an observation group (21 cases). Read More

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Wiad Lek 2021 ;74(8):1905-1909


Objective: The aim: To assess the values of endothelial vascular growth factor (VEGF) in blood serum and circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women depending on the severity of obesity and presence of preeclampsia.

Patients And Methods: Materials and methods: the study included 122 pregnant women divided into groups in accordance with their height and weight parameters and presence of preeclampsia. We studied the serum VEGF concentration by enzyme-linked immunosorbent assay, carried out the count of CD32+CD40+ circulating endothelial microparticles in the peripheral blood by using flow cytometry. Read More

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January 2021

SARS-CoV-2 neutralizing antibodies decline after one year and patients with severe COVID-19 pneumonia display a unique cytokine profile.

Int J Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand. Electronic address:

Objectives: As COVID-19 rages on worldwide, there is an urgent need to characterize immune correlates of protection from SARS-CoV-2 infection and to identify immune determinants of COVID-19 severity.

Methods: We present longitudinal profiles of neutralizing antibody titers in hospitalized COVID-19 patients clinically diagnosed with mild symptoms, pneumonia, and severe pneumonia up to 12 months after illness onset, using live-virus neutralization. Multiplex, correlation, and network analyses were used to characterize serum-derived inflammatory cytokine profiles in all severity groups. Read More

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September 2021

Investigation of the effect of melatonin administration on inflammatory mediators; MMP-2, TGF-β and VEGF levels in rats with sepsis.

Int J Clin Pract 2021 Sep 12:e14832. Epub 2021 Sep 12.

Department of Biochemistry, Medical Faculty, Sakarya University, Sakarya, Turkey.

Aims: Sepsis causes life-threatening tissue and organ dysfunctions caused by endogenous mediators in response to infection. Melatonin is a powerful endogenous anti-inflammatory agent and effective in reducing cellular damage. This study aimed to evaluate the changes in serum and liver tissue levels of VEGF, TGF-β and MMP-2 in melatonin-treated septic rats. Read More

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September 2021

Increased antibody reactivity against insulin receptor-A and insulin like growth factor 1 receptor and their ligands in cerebrospinal fluid and serum of patients with schizophrenia or related psychosis.

Neuro Endocrinol Lett 2021 Sep 10;42(5):339-358. Epub 2021 Sep 10.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Objectives: Evidence has accumulated that an autoimmune-mediated process in the central nervous system may underlie the development of schizophrenia. Various antibodies have also previously been detected in serum of patients with schizophrenia. Therefore, the aim of this study was to analyze antibody reactivity against proteins, selected based on potential schizophrenia disease relevance, in both cerebrospinal fluid and serum of patients with schizophrenia. Read More

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September 2021

Implication of -Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration.

Int J Mol Sci 2021 Aug 28;22(17). Epub 2021 Aug 28.

Department of Foundational Medical Studies and Eye Research Center, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.

Age-related macular degeneration (AMD) is a leading cause of vision loss. Elevated homocysteine (Hcy) (Hyperhomocysteinemia) (HHcy) has been reported in AMD. We previously reported that HHcy induces AMD-like features. Read More

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Sodium Iodate-Induced Degeneration Results in Local Complement Changes and Inflammatory Processes in Murine Retina.

Int J Mol Sci 2021 Aug 26;22(17). Epub 2021 Aug 26.

Department of Ophthalmology, University Hospital of Bern, 3010 Bern, Switzerland.

Age-related macular degeneration (AMD), one of the leading causes of blindness worldwide, causes personal suffering and high socioeconomic costs. While there has been progress in the treatments for the neovascular form of AMD, no therapy is yet available for the more common dry form, also known as geographic atrophy. We analysed the retinal tissue in a mouse model of retinal degeneration caused by sodium iodate (NaIO)-induced retinal pigment epithelium (RPE) atrophy to understand the underlying pathology. Read More

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The use of serum endothelial adhesion molecules in pediatric patients with leukemia with febrile neutropenia to predict bacteremia.

Cytokine 2021 Sep 6;148:155692. Epub 2021 Sep 6.

Hacettepe University Faculty of Medicine, Department of Infectious Diseases, Ankara, Turkey.

Objective: Febrile neutropenia (FN) represents a life-threatening complication in hematological malignancies. We aimed to analyze the utility of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF) levels compared with C-reactive protein (CRP) and procalcitonin (PCT) during febrile neutropenia episodes of pediatric patients with leukemia.

Methods: Two plasma samples, on day 0 (initial of episode) and day 3 (48-72 h after episode), for VCAM-1, ICAM-1 and VEGF, CRP and PCT were prospectively collected concomitantly during each febrile neutropenic episode between December 2016 and December 2017. Read More

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September 2021

Serum VEGF-C as an evaluation marker of disease activity in adult-onset Still's disease.

Rheumatol Int 2021 Sep 9. Epub 2021 Sep 9.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, No. 197 Ruijin Second Road, Shanghai, 200025, China.

In view of the possible involvement of vascular endothelial growth factor-C (VEGF-C) in pathogenesis of adult-onset Still's disease (AOSD) based on our previous genome-wide association study (GWAS) results, the primary objective of this study, therefore, was to investigate the correlations between the content of VEGF-C in serum and clinical and biochemical markers of AOSD. Blood samples were collected from 80 patients with AOSD, 26 with rheumatoid arthritis (RA), 30 with systemic lupus erythematosus (SLE) and 31 healthy control subjects. The serum VEGF-C levels were determined using an enzyme-linked immunosorbent assay (ELISA). Read More

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September 2021

Association between urinary VEGFA and renal pathology of IgA nephropathy patients.

J Clin Lab Anal 2021 Sep 8:e23995. Epub 2021 Sep 8.

Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Renal biopsy remains the golden standard for diagnosing and monitoring IgA nephropathy (IgAN). Vascular endothelial growth factor A (VEGFA) was crucial for the survival of glomerular cells. Our aim was to screen the expression pattern of urinary, circulating and renal VEGFA in IgAN patients to reveal their relationship with renal pathology and outcomes. Read More

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September 2021

Lung Function, Radiological Findings and Biomarkers of Fibrogenesis in a Cohort of COVID-19 Patients Six Months After Hospital Discharge.

Arch Bronconeumol 2021 Sep 3. Epub 2021 Sep 3.

Pulmonary Department, Hospital Clinico, INCLIVA, Valencia, Spain.

Introduction: Impairment in pulmonary function tests and radiological abnormalities are a major concern in COVID-19 survivors. Our aim is to evaluate functional respiratory parameters, changes in chest CT, and correlation with peripheral blood biomarkers involved in lung fibrosis at two and six months after SARS-CoV-2 pneumonia.

Methods: COVID-FIBROTIC (clinicaltrials. Read More

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September 2021

Psoralidin exerts anti-tumor, anti-angiogenic, and immunostimulatory activities in 4T1 tumor-bearing balb/c mice.

Horm Mol Biol Clin Investig 2021 Sep 9. Epub 2021 Sep 9.

Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Psoralidin as a compound of the seeds exhibited several anti-cancer potentials in various cancers.

Materials And Methods: In this study, 4T1 tumor-bearing Balb/c mice were treated by intraperitoneal administration of Psoralidin, and Paraffin, as a control group to investigate anti-tumor, anti-angiogenic, and immunostimulatory activities in breast cancer. Body weight and tumor volume measurement were performed. Read More

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September 2021

Allyl isothiocyanate attenuates LED light-induced retinal damage in rats: exploration for the potential molecular mechanisms.

Cutan Ocul Toxicol 2021 Sep 7:1-33. Epub 2021 Sep 7.

Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, 23119, Turkey.

Purpose: Environmental light pollution due to artificial light may increase the rate and severity of retinal diseases, and plant-based nutritional interventions with antioxidant properties have the potential to reverse this phenomenon. We aimed to investigate the potential effects of allyl isothiocyanate (AITC) against white light-emitting diode (LED)-induced retinal degeneration (RD) in the rats.

Methods: Twenty-eight male rats were allocated as: (i) Control, (ii) LED, (iii) LED + AITC (10 mg/kg BW), (iv) LED + AITC (20 mg/kg BW). Read More

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September 2021

The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma: A Randomized Controlled Trial.

Front Oncol 2021 13;11:723193. Epub 2021 Aug 13.

Department of Oncology Radiotherapy, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Objective: To investigate the short-term efficacy and safety of Endostar combined with concurrent chemoradiotherapy in the treatment of locally advanced cervical squamous cell carcinoma (LACSC).

Methods: A total of 91 patients with LACSC admitted to the First Affiliated Hospital of Anhui Medical University from June 2019 to December 2020 were randomly assigned to either the experimental group (n = 48) or control group (n = 43). The control group received radiotherapy for cervical cancer and paclitaxel combined with platinum chemotherapy (CCRT), and the experimental group received Endostar continuous intravenous infusion of anti-angiogenic therapy plus CCRT. Read More

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Roles of glomerular endothelial hyaluronan in the development of proteinuria.

Physiol Rep 2021 Sep;9(17):e15019

Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Aichi, Japan.

Vascular endothelial cells are covered with glycocalyx comprising heparan sulfate, hyaluronan, chondroitin sulfate, and associated proteins. Glomerular endothelial glycocalyx is involved in protecting against induction of proteinuria and structural damage, but the specific components in glycocalyx that represent therapeutic targets remain unclear. Anti-vascular endothelial growth factor (VEGF) therapy is associated with an increased risk of glomerular endothelial injury. Read More

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September 2021

The protective benefit of heme oxygenase-1 gene modified human placenta-derived Mesenchymal stem cell in N-nitro-L-arginine methyl ester -induced preeclampsia-like rat model: Possible implications for placental angiogenesis.

Stem Cells Dev 2021 Sep 2. Epub 2021 Sep 2.

Wuhan Union Hospital, 36630, Obstetrics and gynecology, Wuhan, Hubei , China;

We previously reported that cytoprotective heme oxygenase-1 (HO-1) gene-modified human placenta-derived Mesenchymal stem cell (PMSC) improved placental vascularization in vitro. In the current study, we explored the protective benefit of HO-1-PMSC transplantation in a preeclampsia (PE)-like rat model. A model of PE was successfully constructed by intraperitoneal injection of N-nitro-L-arginine methyl ester (L-NAME). Read More

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September 2021

Vascular endothelial growth factor profile and Vitamin D level in Systemic Sclerosis Egyptian patients.

Egypt J Immunol 2021 Jul;28(3):168-175

Department of Physical Medicine & Rheumatology & Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Vascular endothelial growth factor (VEGF) was described as a potentially important driver of systemic sclerosis (SSc) pathogenesis. Additionally, recent literature elucidated that vitamin D serum level was found to be significantly lower in SSc patients in comparison to healthy individuals. The aim of the current study was to evaluate serum level of VEGF and its correlation with clinical features and vitamin D level in systemic sclerosis (SSc) Egyptian patients. Read More

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N-Butylphthalide vs. Human Urinary Kallidinogenase for the Treatment of Acute Ischemic Stroke: Functional Outcome and Impact on Serum VEGF and TNF-α Expressions.

Ann Clin Lab Sci 2021 Jul;51(4):503-511

Department of Neurology, the Southeast University A!liated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.

Objective: To compare the e!cacy and functional outcomes of dl-3-n-Butylphthalide (NBP) and human urinary kallidinogenase (HUK) on ischemic stroke patients and to determine their effects on serum tumor necrosis factor-alpha (TNF-α) and vascular endothelial growth factor (VEGF).

Methods: A prospective study was conducted on 57 ischemic stroke patients. Functional outcomes were assessed by the National Institute Health Stroke Scale (NIHSS), the modified Rankin Scale (mRS), and the activities of daily living score (ADL), whereas TNF-α and VEGF expressions were measured by enzyme-linked immunosorbent assay (ELISA). Read More

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The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks.

Toxicology 2021 Sep 24;461:152906. Epub 2021 Aug 24.

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. Electronic address:

Fluoride is one of the most widely distributed elements in nature, while some fluorine-containing compounds are toxic to several vertebrates at certain levels. The current study was performed to evaluate the nephrotoxic effects of fluoride exposure in ducks. The results showed that the renal index was decreased in NaF group, and fluoride exposure significantly decreased the levels of serum Albumin, Glucose, Total cholesterol, Urea, protein and Triglycerides, confirming that NaF exhibited adverse effects on the kidney. Read More

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September 2021

Serum Exosomal Circular RNA Expression Profile and Regulative Role in Proliferative Diabetic Retinopathy.

Front Genet 2021 10;12:719312. Epub 2021 Aug 10.

Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Proliferative diabetic retinopathy (PDR), as one of the main microvascular complications of diabetes mellitus, seriously threatens the visual function of the working-age population; yet, the underlying pathogenesis is still poorly understood. This study aimed to identify the distinct exosomal circular RNA (circRNA) expression in PDR serum and preliminarily explore the potential pro-angiogenic mechanism of specific exosomal circRNAs.

Methods: We collected serum samples from 10 patients with PDR and 10 patients with age-matched senile cataract to detect the exosomal differentially expressed genes (DEGs) of circRNAs high-throughput sequencing, followed by validation with quantitative real-time PCR (qRT-PCR). Read More

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The Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications.

Cells 2021 Aug 2;10(8). Epub 2021 Aug 2.

Medical Research Service, VA Long Beach Healthcare System Long Beach, 5901 East Seventh Street, Long Beach, CA 90822, USA.

In this article we review the cellular and molecular mechanisms of gastric ulcer healing. A gastric ulcer (GU) is a deep defect in the gastric wall penetrating through the entire mucosa and the muscularis mucosae. GU healing is a regeneration process that encompasses cell dedifferentiation, proliferation, migration, re-epithelialization, formation of granulation tissue, angiogenesis, vasculogenesis, interactions between various cells and the matrix, and tissue remodeling, all resulting in scar formation. Read More

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VEGFR-Mediated Cytotoxic Activity of Isolated Metabolites: A Biological Evaluation and In Silico Study.

Life (Basel) 2021 Jul 28;11(8). Epub 2021 Jul 28.

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Natural products play a remarkable role not only in the synthesis, design, and discovery of new drugs but also as the most prominent source of drugs and bioactive substances. Adding to the search for new sources of safe innovative antitumor drugs, here we reported a phytochemical study on   which revealed promising antiangiogenic agents. Six compounds were isolated and identified as xanthoxyline (), stigmasterol (), oleanolic acid (), salvigenin () rhamnetin () and dihydroquercetin-4'-methyl ether () using nuclear magnetic resonance (NMR) spectroscopic techniques. Read More

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Serum and Tissue Level of TLR9 in EBV-Associated Oropharyngeal Cancer.

Cancers (Basel) 2021 Aug 6;13(16). Epub 2021 Aug 6.

Department of Virology with SARS Laboratory, Medical University of Lublin, 20-059 Lublin, Poland.

The Epstein-Barr virus (EBV) is associated with the development of various epithelial malignancies including cancer in the head and neck region. Several studies have shown that Toll-like receptors (TLRs) are required for an innate immune response to infection with human DNA viruses, e.g. Read More

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The effects of low-intensity resistance training with or without blood flow restriction on serum BDNF, VEGF and perception in patients with post-stroke depression.

Neuro Endocrinol Lett 2021 Aug 28;42(4):229-235. Epub 2021 Aug 28.

Ocean University of China, Qingdao, Shandong, China.

Background: Post-stroke depression (PSD) has a significant effect on patients' quality of life and is often accompanied by a decrease in serum brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) levels. Although exercise is an effective way to improve the body's endocrine environment, traditional high-intensity resistance exercise is not yet readily accepted.

Purpose: To compare the acute effects of high and low resistance training with or without blood flow restriction on perception, BDNF, and VEGF levels in patients with PSD. Read More

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Efficacy of Sorafenib Combined with Interventional Therapy on Primary Liver Cancer Patients and Its Effect on Serum AFP, VEGF, and GGT.

J Oncol 2021 11;2021:9120265. Epub 2021 Aug 11.

Department of Laboratory, The Second People' Hospital of Dongying, Dongying 257335, China.

Objective: To explore the efficacy of sorafenib combined with interventional therapy on primary liver cancer (PLC) patients and its effect on serum AFP, VEGF, and GGT.

Methods: 120 PLC patients admitted to our hospital from January 2016 to January 2020 were selected as the research object and divided into group A and group B according to the admission order, with 60 cases each. Interventional therapy was performed to both groups, and sorafenib was given to group A additionally to compare their treatment effect, survival, adverse reaction rate (ARR), and serum AFP, VEGF, and GGT levels. Read More

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Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease.

Mediators Inflamm 2021 13;2021:9914071. Epub 2021 Aug 13.

Department of Clinical Laboratory, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province 710003, China.

Disrupted endothelial permeability plays a crucial role in the vasculitis pathogenesis of Kawasaki disease (KD), which leads to pathological vascular leak and facilitates inflammatory cell infiltration in vascular lesions; however, the mechanisms involved in the development of endothelial barrier dysfunction during KD vasculitis are still largely unclear. Here, we found that sera from patients with KD can induce endothelial cell (EC) hyperpermeability compared to sera from healthy controls. We observed that serum vascular endothelial growth factor (VEGF) levels were increased in KD patients and sera from KD patients upregulated the expression of VEGF receptor 2 (VEGFR2) and neuropilin-1 (NRP1) in human coronary artery endothelial cells (HCAECs). Read More

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Exhaled Breath Temperature and Systemic Biomarkers for Assessment of Airway Inflammation in Asthmatics.

J Assoc Physicians India 2021 Jul;69(7):11-12

Department of Physiology, Critical Care and Sleep Medicine, All India Institute of Medical Sciences New Delhi; Corresponding author.

Objectives: Asthma is characterised by chronic airway inflammation and remodelling. Inflammation may alter the thermal balance of the affected tissues secondary to changes in the blood flow. Measurement of exhaled breath temperature (EBT) is a simple, safe and non-invasive technique to detect airway inflammation. Read More

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