71,066 results match your criteria serum urinary


The Use of Morning Urinary Gonadotropins and Sexual Hormones in the Management of Early Puberty in Chinese Girls.

J Clin Endocrinol Metab 2021 Jun 23. Epub 2021 Jun 23.

Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China.

Context: Although gonadotropin-releasing hormone stimulation test (GnRHST) is the gold standard in diagnosing central precocious puberty (CPP), it is invasive, expensive, and time-consuming, requiring multiple blood samples to measure gonadotropin levels.

Objective: We evaluated whether urinary hormones could be potential biomarkers for pre- or post- puberty, aiming to simplify the current diagnosis and prognosis procedure.

Design, Setting, And Participants: We performed a cross-sectional study of a total of 355 girls with CPP in National Clinical Research Center for Child Health in China, including 258 girls with positive and 97 girls with negative results from GnRHST. Read More

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Supplementation of protease to low amino acid diets containing superdose level of phytase for wean-to-finish pigs: effects on performance, postweaning intestinal health and carcass characteristics.

Transl Anim Sci 2021 Apr 16;5(2):txab088. Epub 2021 May 16.

Department of Animal Science, South Dakota State University, Brookings, SD 57007, USA.

This experiment investigated the effects of protease supplementation to low amino acid (AA) diets containing phytase on pig growth performance, postweaning intestinal health and carcass characteristics. A total of 936 weaned pigs (21 d of age, initial BW 5.87 ± 0. Read More

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Impact of preoperative body mass index on perioperative outcomes is optimized by enhanced recovery protocols in laparoscopic radical cystectomy with intracorporeal urinary diversion.

Transl Androl Urol 2021 May;10(5):2008-2018

Institute of Urology, Capital Medical University, Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: We aimed to examine whether body mass index (BMI) had an impact on clinical outcomes of laparoscopic radical cystectomy with intracorporeal urinary diversion. Furthermore, we analyzed the optimization of enhanced recovery protocols (ERPs) on the impact of BMI on clinical outcomes.

Methods: By searching our database, data of 83 consecutive patients were retrospectively collected, including 37 patients with a BMI <24 kg/m (group A) and 46 patients with a BMI ≥24 kg/m (group B). Read More

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A Rare Case of Subacute Sclerosing Panencephalitis Presenting As Generalized Seizure.

Cureus 2021 May 18;13(5):e15100. Epub 2021 May 18.

Internal Medicine, Nepalese Army Institute of Health Sciences, Kathmandu, NPL.

Subacute sclerosing panencephalitis (SSPE) is a late complication of childhood measles. It is characterized by a progressive decline in cognitive and motor functions, seizures, and eventually death. Although a combination of intrathecal interferon alpha (IFN-α) and daily oral isoprinosine has been reported to have a good outcome, there is no cure for this condition. Read More

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Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals.

Nutr Metab Cardiovasc Dis 2021 May 18. Epub 2021 May 18.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Background And Aims: The accumulation of fat increases the formation of lipid peroxides, which are partly scavenged by alpha-tocopherol (α-TOH). Here, we aimed to investigate the associations between different measures of (abdominal) fat and levels of urinary α-TOH metabolites in middle-aged individuals.

Methods And Results: In this cross-sectional analysis in the Netherlands Epidemiology of Obesity study (N = 511, 53% women; mean [SD] age of 55 [6. Read More

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ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte.

Ren Fail 2021 Dec;43(1):968-979

Department of Nephrology, People's Hospital of Hangzhou Medical College, Zhejiang Provincial People's Hospital, Zhejiang, P.R. China.

Aim: Podocyte injury plays an important role in diabetic nephropathy (DN), yet the underlying molecular mechanisms of podocyte injury in DN is not clear. Here, we investigated the role of activating transcription factor 4 (ATF4) and HO-1 in DN-induced podocyte injury.

Methods: Protein expression was measured by western blotting (WB) and immunofluorescence. Read More

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December 2021

Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis.

Sci Total Environ 2021 Jun 11;775:145755. Epub 2021 Feb 11.

Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain; CIBER Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Health and Social Sciences, University of Murcia, Murcia, Spain; Murcia Biomedical Research Institute (IMIB-Arrixaca), Murcia, Spain.

Background: Human bisphenol-A (BPA) exposure has been linked to adverse health effects even at low doses, which may be of potential public health concern.

Objective: To summarize BPA concentrations in general human population and their variability according to sex, geographic area, and analytical method.

Methods: Systematic review and meta-analysis of studies reporting BPA concentrations in adult human populations. Read More

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Photoactivated Indium Phosphide Quantum Dots Treat Multidrug-Resistant Bacterial Abscesses .

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303, United States.

The increasing prevalence of drug-resistant bacterial strains is causing illness and death in an unprecedented number of people around the globe. Currently implemented small-molecule antibiotics are both increasingly less efficacious and perpetuating the evolution of resistance. Here, we propose a new treatment for drug-resistant bacterial infection in the form of indium phosphide quantum dots (InP QDs), semiconductor nanoparticles that are activated by light to produce superoxide. Read More

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Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents.

Paediatr Perinat Epidemiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen O, Denmark.

Background: The hypothalamic-pituitary-gonadal (HPG) axis governs sexual maturation and reproductive function in humans. In early postnatal life, it is transiently active during which circulating sex steroids reach adult levels. While this so-called minipuberty represents a universal phenomenon in infants of both sexes, its role for early maturation and growth remains incompletely understood. Read More

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Vaccination against receptor for advanced glycation end products attenuates the progression of diabetic kidney disease.

Diabetes 2021 Jun 21. Epub 2021 Jun 21.

Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Effective treatment of diabetic kidney disease (DKD) remains a large unmet medical need. Within the disease's complicated pathogenic mechanism, activation of the advanced glycation end-products (AGEs)-receptor for AGEs (RAGE) axis plays a pivotal role in the development and progression of DKD. To provide a new therapeutic strategy against DKD progression, we developed a vaccine against RAGE. Read More

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Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis.

J Ethnopharmacol 2021 Jun 18:114346. Epub 2021 Jun 18.

Wenzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Wenzhou, 325000, China; The Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310000, China. Electronic address:

Ethnopharmacological Relevance: Salvia miltiorrhiza and ligustrazine injection is a compound injection composed of the extract from Salvia miltiorrhiza and Ligusticum striatum (Ligusticum striatum DC.), has been frequently used for the adjuvant treatment of early-stage diabetic kidney disease (DKD) in China. Safety and efficacy studies in terms of evidence-based medical practice have become more prevalent in application to Chinese Herbal Medicine. Read More

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Pharmacokinetics, Metabolite Measurement and Biomarker Identification of Dermal Exposure to Permethrin Using Accelerator Mass Spectrometry (AMS).

Toxicol Sci 2021 Jun 21. Epub 2021 Jun 21.

Department of Entomology, University of California, Davis, CA, USA.

Impregnating military uniforms and outdoor clothing with the insecticide permethrin is an approach to reduce exposure to insect borne diseases and to repel pests and disease vectors such as mosquitos and sandflies, but the practice exposes wearers to prolonged dermal exposure to the pesticide. Key metabolite(s) from a low dose dermal exposure of permethrin were identified using accelerator mass spectrometry. Metabolite standards were synthesized and an HPLC elution protocol to separate individual metabolites in urine was developed. Read More

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The causal effects of serum lipids and apolipoproteins on kidney function: multivariable and bidirectional Mendelian-randomization analyses.

Int J Epidemiol 2021 Jun 21. Epub 2021 Jun 21.

K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.

Background: The causal nature of the observed associations between serum lipids and apolipoproteins and kidney function are unclear.

Methods: Using two-sample and multivariable Mendelian randomization (MR), we examined the causal effects of serum lipids and apolipoproteins on kidney function, indicated by the glomerular-filtration rate estimated using creatinine (eGFRcrea) or cystatin C (eGFRcys) and the urinary albumin-to-creatinine ratio (UACR). We obtained lipid- and apolipoprotein-associated genetic variants from the Global Lipids Genetics Consortium (n = 331 368) and UK Biobank (n = 441 016), respectively, and kidney-function markers from the Trøndelag Health Study (HUNT; n = 69 736) and UK Biobank (n = 464 207). Read More

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Association of advanced glycation end-products levels with vascular events in postmenopausal women.

Geriatr Gerontol Int 2021 Jun 20. Epub 2021 Jun 20.

Department of Orthopedic Surgery, Jikei University School of Medicine, Tokyo, Japan.

Aim: Advanced glycation end-products (AGEs) are a known factor that accelerates vascular complications. AGEs (e.g. Read More

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Retrospective study of factors associated with progression and remission/regression of diabetic kidney disease-hypomagnesemia was associated with progression and elevated serum alanine aminotransferase levels were associated with remission or regression.

Diabetol Int 2021 Jul 2;12(3):268-276. Epub 2021 Jan 2.

Department of Medicine, Nerima General Hospital, 1-24-1 Asahigaoka, Nerima-ku, Tokyo, 176-8530 Japan.

Aim: This study was aimed at retrospectively investigating some common clinical factors, including the serum level of magnesium (Mg), associated with progression and remission/regression of diabetic kidney disease (DKD).

Methods: The subjects were 690 Japanese patients with type 2 diabetes mellitus who were receiving treatment with oral antidiabetic drugs other than SGLT2 inhibitors. Routine clinical data were collected on the first and last day of the observation period. Read More

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Accuracy of Urinary Etiocholanolone/Androsterone Ratio as Alternative to Serum Testosterone/Dihydrotestosterone Ratio for Diagnosis of 5 Alpha-reductase Type 2 Deficiency Patients and Carriers in Indonesia.

Int J Endocrinol Metab 2021 Apr 18;19(2):e109510. Epub 2021 Apr 18.

Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background: The 5 Alpha-reductase type 2 deficiency (5ARD2) is an inherited condition, which clinically presents as variable degrees of under virilization in affected 46,XY individuals. In the diagnostic pathway of 5ARD2, the testosterone/dihydrotestosterone (T/DHT) ratio is broadly employed before molecular analysis of the SRD5A2 gene. However, due to cost-benefit considerations, the DHT test in our country is routinely lacking in clinical settings; therefore, we considered applying the urinary etiocholanolone/androsterone (Et/An) ratio as an alternative test. Read More

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Association of SIRT6 circulating levels with urinary and glycometabolic markers in pre-diabetes and diabetes.

Acta Diabetol 2021 Jun 20. Epub 2021 Jun 20.

Advanced Institute for Medical Sciences, Dalian Medical University, Lvshun South Road west 9, Dalian, 116044, Liaoning, China.

Aim: The study is aimed to detect the expression of serum Sirtuin 6 (SIRT6) with different severities and urinary albumin creatinine ratios (UACR) in type 2 diabetes mellitus (T2DM) patients, thus exploring the association of SIRT6 together with glycolipid metabolism and urinary protein in the cross-sectional study.

Methods: T2DM patients (313 cases), pre-diabetic patients (102 cases), and healthy volunteers (100 cases) were selected. T2DM patients were divided into the normal albuminuria (103 cases, UACR < 30 mg/g), micro-albuminuria (106 cases, UACR 30-300 mg/g), and large amount of albuminuria group (104 cases, UACR > 300 mg/g) based on different UACR levels. Read More

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High-dose vitamin D3 c ameliorates renal fibrosis by vitamin D receptor activation and inhibiting TGF-β1/Smad3 signaling pathway in 5/6 nephrectomized rats.

Eur J Pharmacol 2021 Jun 17:174271. Epub 2021 Jun 17.

Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Renal fibrosis is the pathological consequence of progressive chronic kidney disease. Although it has been reported that vitamin D3 exerts antifibrotic effects, the underlying mechanisms remain unclear. This study is aimed at investigating the effects and molecular mechanisms in high-dose vitamin D3 treatment on renal fibrosis. Read More

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Urinary Dickkopf-3 (uDKK3): a new biomarker for CKD progression and mortality?

Nephrol Dial Transplant 2021 Jun 17. Epub 2021 Jun 17.

Department of Nephrology., Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Background: Kidney fibrosis has been reported to be a prognostic factor in CKD progression. Previous studies have shown that the assessment of urinary Dickkopf-3 (uDKK3), a stress induced tubular epithelial-derived profibrotic glycoprotein, might be a potential tubulointerstitial fibrosis biomarker and might identify patients at short-term risk of eGFR loss. We aim to evaluate uDKK3 as a potential biomarker for progression of CKD in a cohort with various etiologies of CKD, and subsequently in an overt diabetic nephropathy cohort. Read More

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[Normocalcemic with elevated post-operative parathormone in primary hyperpara-thyroidism: 9 case reports and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):573-579

Department of Endocrinology, China-Japanese Friendship Hospital, Beijing 100029, China.

Objective: To summarize and analyze the clinical characteristics of primary hyperpara-thyroidism (PHPT) with normocalcemic parathormone elevation (NPE) after surgical treatment, so as to improve the therapeutic ability and standardized post-operative follow-up of PHPT patients.

Methods: Nine patients who were diagnosed with PHPT in the Department of Endocrinology of China-Japan Friendship Hospital from August 2017 to November 2019 were selected as the subjects. They all developed NPE within 6 months after surgical treatment. Read More

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Prevalence and determinants of chronic kidney disease in women with hypertensive disorders in pregnancy in Nigeria: a cohort study.

BMC Nephrol 2021 Jun 18;22(1):229. Epub 2021 Jun 18.

Population Council, Washington DC, USA.

Background: Worldwide, hypertensive disorders in pregnancy (HDPs) complicate between 5 and 10% of pregnancies. Sub-Saharan Africa (SSA) is disproportionately affected by a high burden of HDPs and chronic kidney disease (CKD). Despite mounting evidence associating HDPs with the development of CKD, data from SSA are scarce. Read More

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Combined Urinary Biomarkers to Assess Coffee Intake Using Untargeted Metabolomics: Discovery in Three Pilot Human Intervention Studies and Validation in Cross-Sectional Studies.

J Agric Food Chem 2021 Jun 18. Epub 2021 Jun 18.

Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg 1958, Denmark.

Coffee is a widely consumed beverage worldwide and has a high content of chlorogenic acids, polyphenols, methylxanthines, and volatile flavor compounds. Scientific evidence to support the beneficial health effects of coffee is limited, and validated urinary biomarkers of coffee intake are therefore needed. We observed 23 common putative biomarkers of coffee intake in three separate parallel intervention studies by ultra-high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight-mass spectrometry (UHPLC-ESI-QTOF-MS) and multivariate analyses. Read More

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Insulin-like growth factor-1 positively associated with bone formation markers and creatine kinase in adults with general physical activity.

J Clin Lab Anal 2021 Jun 18:e23799. Epub 2021 Jun 18.

Department of Public Health and Environmental Medicine, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: The Insulin-like growth factor-1 (IGF-1) is primarily synthesized by hepatocytes in a growth hormone (GH)-dependent manner, it is also produced by bone and muscle. The effects of exercise on the associations between IGF-1 levels and bone turnover markers (BTM) were found in the previous studies. However, the associations between the levels of IGF-1 and BTM, liver function tests, and skeletal muscle markers in adults with general physical activity were not clear. Read More

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Population Model of Serum Creatinine as Time-Dependent Covariate in Neonates.

AAPS J 2021 Jun 17;23(4):86. Epub 2021 Jun 17.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Serum creatinine (sCr) is a commonly measured biomarker to estimate glomerular filtration rate (GFR) and therefore widely used as a covariate in population pharmacokinetic models of renally excreted drugs. In neonates, sCr dynamically changes during the first few weeks after birth. Missing covariates are a common problem in pharmacokinetic modeling of neonates due to the limited availability of blood sampling in number and volume. Read More

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Carbon isotope ratios of endogenous steroids found in human serum-method development, validation, and reference population-derived thresholds.

Anal Bioanal Chem 2021 Jun 18. Epub 2021 Jun 18.

Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.

In order to detect the misuse of testosterone (T), urinary steroid concentrations and concentration ratios are quantified and monitored in a longitudinal manner to enable the identification of samples exhibiting atypical test results. These suspicious samples are then forwarded to isotope ratio mass spectrometry (IRMS)-based methods for confirmation. Especially concentration ratios like T over epitestosterone (E) or 5α-androstanediol over E proved to be valuable markers. Read More

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Risk factors and predictive model of adrenocortical insufficiency in patients with traumatic brain injury.

World J Emerg Med 2021 ;12(3):179-184

Department of Emergency, the First Hospital of Shanxi Medical University, Taiyuan 030001, China.

Background: Neuroendocrine dysfunction after traumatic brain injury (TBI) has received increased attention due to its impact on the recovery of neural function. The purpose of this study is to investigate the incidence and risk factors of adrenocortical insufficiency (AI) after TBI to reveal independent predictors and build a prediction model of AI after TBI.

Methods: Enrolled patients were grouped into the AI and non-AI groups. Read More

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January 2021

Mild Idiopathic Infantile Hypercalcemia - Part 2: A Longitudinal Observational Study.

J Clin Endocrinol Metab 2021 Jun 17. Epub 2021 Jun 17.

Department of Pediatrics, Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Context: Idiopathic Infantile Hypercalcemia (IIH) is an uncommon disorder with variable clinical features. The natural history and response to dietary calcium and vitamin D restriction in IIH remains unclear.

Objective: The aim of this study is to describe the clinical and biochemical response to dietary calcium and vitamin D restriction in a genetically characterized cohort of mild IIH. Read More

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Efficacy And Tolerability Of Oral Iron Chelator, Deferasirox.

J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):207-212

Fauji Foundation Hospital, Rawalpindi, Pakistan.

Background: Thalassemia major is the severe form of β thalassemia characterized by severe anaemia, hepatosplenomegaly and facioskeletal changes due to increased haemolysis of defective red blood cells. In iron overload states, high levels of iron exceed the iron-carrying capacity of transferrin within the plasma, leading to the formation of nontransferrin-bound iron form. These nontransferrin-bound iron forms can be taken up into cells, including liver, heart, and endocrine cells leading to organ damage. Read More

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Clinical insignificance of [F]PSMA-1007 avid non-specific bone lesions: a retrospective evaluation.

Eur J Nucl Med Mol Imaging 2021 Jun 16. Epub 2021 Jun 16.

Department of Nuclear Medicine & Specialised PET Services, Royal Brisbane and Women's Hospital, Brisbane, Australia.

Purpose: [F]PSMA-1007 offers advantages of low urinary tracer excretion and theoretical improved spatial resolution for imaging prostate cancer. However, non-specific bone lesions (NSBLs), defined as mild to moderate focal bone uptake without a typical morphological correlate on CT, are a common finding on [F]PSMA-1007 PET/CT. The purpose of this study was to investigate the clinical outcomes of patients with [F]PSMA-1007 avid NSBLs, to determine whether patients with NSBLs represent a higher risk clinical cohort, and to determine whether SUVmax can be used as a classifier of bone metastasis. Read More

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Hyperkalemia Management in Older Adults With Diabetic Kidney Disease Receiving Renin-Angiotensin-Aldosterone System Inhibitors: A Post Hoc Analysis of the AMETHYST-DN Clinical Trial.

Kidney Med 2021 May-Jun;3(3):360-367.e1. Epub 2021 Mar 13.

Symbria, Warrenville, IL.

Rationale & Objective: Older people are more likely to have reduced kidney function and multiple comorbid conditions predisposing them to hyperkalemia. This post hoc subgroup analysis aimed to evaluate the effectiveness of patiromer, a sodium-free nonabsorbed polymer, in lowering serum potassium levels in older patients receiving a renin-angiotensin-aldosterone system inhibitor with chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), and hypertension.

Study Design: Post hoc subgroup analysis of the randomized open-label AMETHYST-DN clinical trial. Read More

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