250 results match your criteria serum sickness-like


Serum Sickness-Like Reaction Associated With Acute Hepatitis B in a Previously Vaccinated Adult Male.

Cureus 2021 Apr 28;13(4):e14742. Epub 2021 Apr 28.

Infectious Disease, Michigan State University/Hurley Medical Center, Flint, USA.

Serum sickness is a well-known immune complex deposition phenomenon, occurring as a reaction to proteins in antiserum from a non-human animal source. Serum sickness-like reaction (SSLR), typically associated with drugs and vaccines, sometimes occurs with acute hepatitis B infection and poses a diagnostic dilemma for clinicians, as other viral syndromes, vasculitic processes, and autoimmune conditions can have similar presentations. We present a 36-year-old intravenous drug user, with confirmed records of hepatitis B immunization, who presented with multi-joint pain, joint swelling, and a skin rash. Read More

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Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Cutaneous Adverse Reactions: A Review.

Dermatitis 2021 May-Jun 01;32(3):133-139

We are entering a new stage of the severe acute respiratory syndrome coronavirus 2 pandemic with the initiation of large-scale vaccination programs globally. In these circumstances, even rare adverse effects of vaccines may be encountered more often, if millions of people are to be vaccinated in a short period. Vaccination has the potential for causing cutaneous adverse effects. Read More

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Adverse Reactions Induced by Minocycline: A Review of Literature.

Curr Drug Saf 2021 Jan 19. Epub 2021 Jan 19.

Government Medical College, Kottayam. India.

Background: Minocycline is a tetracycline antibiotic that is widely used to treat infections, and is a first-line oral antibiotic in the treatment of moderate to severe inflammatory acne. Although it has high efficacy, several adverse reactions, including life-threatening ones have been reported in association with its use.

Objective: To identify all the potential adverse reactions due to minocycline and analyze them in terms of the number of cases reported so far, salient features, severity and clinical outcome. Read More

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January 2021

Cutaneous drug eruptions including serum sickness-like reaction, symmetrical drug-related intertriginous and flexural exanthema, and drug-induced lupus.

Clin Dermatol 2020 Nov - Dec;38(6):641-647. Epub 2020 Jun 30.

Wake Forest University School of Medicine, Department of Dermatology, Winston-Salem, North Carolina, USA. Electronic address:

Cutaneous manifestations of drug reactions are common yet vary widely in their appearance and degree of internal organ involvement. Serum sickness--like reactions, symmetrical drug-related intertriginous and flexural exanthem, granulomatous drug eruption, pseudolymphoma, and drug-induced lupus are medication-induced conditions with dermatologic presentations. Many of the conditions discussed are relatively rare but nonetheless demand our attention and understanding. Read More

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January 2021

Pediatric drug eruptions.

Clin Dermatol 2020 Nov - Dec;38(6):629-640. Epub 2020 Jun 29.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

Drug eruptions in children are common but in general less studied than their adult counterparts. Aside from having significant impact on the child's health and quality of life, these reactions can limit what medications the patient can receive in the future. Familiarity with pediatric drug eruptions is important for accurate diagnosis and to prevent future recurrence or ineffective therapy. Read More

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January 2021

Drug Induced Cutaneous Manifestations due to Treatment of Gastrointestinal Disorders.

Curr Drug Metab 2021 ;22(2):99-107

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Cutaneous manifestations due to drugs used in the treatment of gastrointestinal disorders are multiple and common. Adequate diagnosis is of great importance, bearing in mind that the therapeutic regimen depends on its diagnosis. In this review, we provided an overview of the most common drug-induced skin lesions with a detailed explanation of the disease course, presentation and treatment, having in mind that in recent years, novel therapeutic modalities have been introduced in the treatment of various gastrointestinal disorders, and that incidence of cutaneous adverse reactions has been on the rise. Read More

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January 2021

Refractory Urticaria with Raised Antistreptolysin O (ASO) Titer: An Intriguing Case of Adult-Onset Still's Disease.

Am J Case Rep 2020 Nov 5;21:e927936. Epub 2020 Nov 5.

Department of Pathology, King Saud University, Riyadh, Saudi Arabia.

BACKGROUND Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disease with a myriad of clinical presentations. The diagnosis is often challenging because there is no specific confirmatory test. Uncommon presentations can delay the proper diagnosis and management. Read More

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November 2020

Serum sickness-like reaction following initiation of elexacaftor/tezacaftor/ivacaftor therapy.

Pediatr Pulmonol 2020 11 21;55(11):2846-2847. Epub 2020 Sep 21.

Edward Mallinckrodt Department of Pediatrics, Division of Rheumatology, Washington University, St. Louis, Missouri, USA.

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November 2020

Differentiating Between β-Lactam-Induced Serum Sickness-Like Reactions and Viral Exanthem in Children Using a Graded Oral Challenge.

J Allergy Clin Immunol Pract 2021 02 6;9(2):916-921. Epub 2020 Sep 6.

Department of Pediatrics, Division of Allergy and Clinical Immunology, Montreal Children's Hospital, Montreal, Quebec, Canada.

Background: Serum sickness-like reactions (SSLRs) are defined by the presence of rash (primarily urticaria) and joint complaints (arthralgia/arthritis) that are believed to occur due to a non-IgE-mediated response to medications. However, similar reactions can occur due to viral infections, and it can be difficult to distinguish between the two. This may lead to unnecessary avoidance of the culprit antibiotic. Read More

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February 2021

Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.

Allergol Immunopathol (Madr) 2020 Sep - Oct;48(5):424-429. Epub 2020 Jul 8.

Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction And Objectives: Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children's Medical Center.

Patients: The present study was a registry-based study in which the data of 94 SSLRs patients registered in a two-year period were investigated. Confirmation of fever, rash, urticaria, arthralgia / arthritis and history of antibiotic consumption up to three weeks before were the criteria for the diagnosis. Read More

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Dupilumab-induced serum sickness-like reaction: an unusual adverse effect in a patient with atopic eczema.

J Eur Acad Dermatol Venereol 2021 Jan 27;35(1):e30-e32. Epub 2020 Jul 27.

Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.

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January 2021

[Urticaria in children].

Rev Fr Allergol (2009) 2020 Oct-Nov;60(6):476-483. Epub 2020 Apr 27.

Unité de dermatologie pédiatrique, hôpital Pellegrin-Enfants, place Amélie-Raba-Léon, 33076 Bordeaux, France.

The cumulative incidence of urticaria in children is close to 10%. Two forms are described: the superficial form and the deep form, or angioedema. In young children aged under 3 years, urticaria is commonly annular and ecchymotic, and is mistaken for erythema multiforme or acute hemorrhagic edema. Read More

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Beta-lactam allergy in the paediatric population.

Paediatr Child Health 2020 Feb 6;25(1):62-63. Epub 2020 Feb 6.

Canadian Paediatric Society, Allergy Section, Ottawa, Ontario.

Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also, children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalosporins, which is likely unnecessary in greater than 97% of those reporting penicillin allergies. Read More

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February 2020

Coughing up clues: 16-year-old girl with acute haemoptysis.

BMJ Case Rep 2020 Jan 8;13(1). Epub 2020 Jan 8.

Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.

A 16-year-old previously well girl presented with bilateral painful lower leg swelling and non-pruritic blanching rash across her torso and upper and lower limbs. These symptoms started after commencing amoxicillin for presumed tonsillitis. She was diagnosed with serum sickness-like illness and started on non-steroidal agents. Read More

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January 2020

A Case of Serum Sickness-Like Reaction in an Adult Treated with Omalizumab.

Mil Med 2020 06;185(5-6):e912-e913

Allergy/Immunology, Wilford Hall Ambulatory Surgical Center, 1100 Wilford Hall Loop, Lackland AFB, TX 78236.

Omalizumab has been safely used to treat asthma and urticaria. We report a case of serum sickness-like reaction in a patient treated with omalizumab for chronic idiopathic urticaria/angioedema. An adult female experienced episodic urticaria/angioedema without repeatable trigger, ultimately receiving diagnosis of chronic idiopathic urticaria/angioedema. Read More

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A rapid desensitization protocol in a case of drotaverine-induced serum sickness-like reaction in a pregnant woman: A case report.

Exp Ther Med 2019 Dec 7;18(6):5105-5107. Epub 2019 Nov 7.

Department of Allergy, 'Dr. Carol Davila' Nephrology Clinical Hospital, 010731 Bucharest, Romania.

Drotaverine is an antispasmodic drug used to treat gastrointestinal and genitourinary smooth muscle spasms. There are very few hypersensitivity reactions reported. Serum sickness-like disease is an immune-complex-mediated hypersensitivity reaction that presents with some typical features that include rash, fever and articular impairment sometimes associated with liver and renal dysfunctions, beginning 1-2 weeks after exposure to a culprit drug. Read More

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December 2019

Ixekizumab-Induced Serum Sickness (Like Reaction): An Unusual Adverse Effect.

J Clin Rheumatol 2019 Dec 3. Epub 2019 Dec 3.

Georgetown University School of Medicine, Washington, DC Georgetown University School of Medicine, Washington, DC MedStar Washington Hospital Center, Washington, DC Department of Dermatology, Georgetown University Hospital, Georgetown University, Washington, DC Georgetown University School of Medicine, Washington, DC Division of Rheumatology, Georgetown University, Washington, DC MedStar Washington Hospital Center, Washington, DC Department of Dermatology, Georgetown University Hospital, Georgetown University, Washington, DC Georgetown University School of Medicine, Washington, DC

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December 2019

Cutaneous manifestations of HAV, HBV, HCV.

Ital J Dermatol Venerol 2021 Feb 4;156(1):5-12. Epub 2019 Dec 4.

Section of Dermatology, Department of Health Sciences (DISSAL), IRCCS San Martino University Hospital, Genoa, Italy.

Hepatotropic viral infections are a relevant global health problem and present multiple extrahepatic manifestations in addition to hepatic disease. Along with generic cutaneous symptoms correlated to the cholestatic liver disease that may arise during the infection, some cutaneous manifestations of hepatotropic viral infections are characteristic, enabling to suspect the underlying infection. This review will present the principal cutaneous manifestations of hepatotropic virus infection. Read More

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February 2021

Clinical Phenotypes of Severe Cutaneous Drug Hypersensitivity Reactions.

Curr Pharm Des 2019 ;25(36):3840-3854

Department of Pediatric Allergy and Immunology, University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital, Ankara, Turkey.

Drug hypersensitivity reactions are clinically heterogenous ranging from mild to severe. Most drug hypersensitivity reactions are accompanied by cutaneous manifestations. Fever, mucous membrane involvement, large blisters, facial oedema, pustulosis and visceral involvement are clinical features that lead to suspicion of severe adverse drug reactions. Read More

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An Update on the Management of Severe Cutaneous Drug Hypersensitivity Reactions.

Curr Pharm Des 2019 ;25(36):3881-3901

Department of Pediatric Allergy and Immunology, Mersin University, Faculty of Medicine, Mersin, Turkey.

Severe cutaneous drug hypersensitivity reactions involve of different mechanisms , some of which are life-threatening, such as Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, generalized bullous fixed drug eruptions, serum sickness and serum sickness-like reaction and drug-induced vasculitis. These reactions may have substantial morbidity and mortality. In the past years, successive studies have provided new evidence regarding the pathogenesis of some of these severe reactions and revealed that underlying mechanisms are highly variable. Read More

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Antibiotic Hypersensitivity Mechanisms.

Pharmacy (Basel) 2019 Aug 27;7(3). Epub 2019 Aug 27.

Department of Pharmaceutical Sciences, School of Pharmacy, Rueckert-Hartman College of Health Professions, Regis University, Denver, CO 80221, USA.

Antibiotics are commonly prescribed to treat a variety of bacterial infections. As with all medications, hypersensitivity reactions may occur and clinicians should be able to recognize them accurately and recommend appropriate management. Antibiotic related hypersensitivity reactions may be one of four different types: Type I reactions, which are IgE mediated and may lead to anaphylaxis; Type II reactions that are antibody-mediated and may result in thrombocytopenia, neutropenia, or hemolytic anemia; Type III reaction that involves an immune complex formation such as vasculitis; and Type IV reactions that consist of four subtypes and typically include a rash of varying level of severity with or without systemic signs and symptoms. Read More

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Urticaria multiforme in a 2-year-old girl.

Proc (Bayl Univ Med Cent) 2019 Jul 3;32(3):427-428. Epub 2019 Jun 3.

Department of Dermatology, Texas Tech University Health Sciences CenterLubbockTexas.

We describe a 2-year-old girl who presented to the emergency department for a 2-day history of a rapidly spreading, pruritic, erythematous rash. There were large polycyclic annular erythematous wheals on the face, trunk, and extremities. Urticaria multiforme was diagnosed. Read More

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Serum sickness-like reaction associated with mirabegron.

JAAD Case Rep 2019 Jun 8;5(6):537-539. Epub 2019 Jun 8.

Division of Dermatology, University of Ottawa and The Ottawa Hospital, Ottawa, Ontario.

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A review of cutaneous hypersensitivity reactions in infants: From common to concerning.

Pediatr Dermatol 2019 May 25;36(3):274-282. Epub 2019 Apr 25.

Section of Dermatology, Department of Medicine and Pediatrics, University of Chicago, Chicago, Illinois.

Cutaneous hypersensitivity reactions in infants present in a variety of patterns. These skin eruptions can be dramatic, causing alarm in parents and medical personnel. Many of these syndromes have overlapping features, which adds to the confusion and uncertainty regarding diagnosis and management. Read More

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Dermatomyositis associated with omalizumab therapy for severe asthma: a case report.

Allergy Asthma Clin Immunol 2019 17;15. Epub 2019 Jan 17.

3Department of Medicine, Western University, London, ON Canada.

Background: Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized. Delayed anaphylactoid and serum sickness-like reactions have also been described; however, their relationship to the drug remains uncertain, and the frequency is unknown. Read More

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January 2019

Serum sickness (Like Reaction) in a patient treated with alemtuzumab for multiple sclerosis: A case report.

Mult Scler Relat Disord 2018 Nov 11;26:52-54. Epub 2018 Sep 11.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy; Ospedale Policlinico San Martino IRCCS, Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Genoa, Italy.

Background: Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). The only report of Serum Sickness (SS) in a MS patient occurred during treatment with natalizumab. Non-protein drugs, such as some antibiotics, may induce "SS-like" reactions (SSLR), whose clinical and laboratory features may partially overlap with the traditional SS. Read More

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November 2018

[Urticaria multiforme: difficult to distinguish from other skin conditions].

Ned Tijdschr Geneeskd 2018;162:D2251

Westfriesgasthuis, afd. Kindergeneeskunde en Neonatologie, Hoorn.

Background: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children.

Case Description: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. Read More

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December 2018

Serum sickness-like reaction in a pediatric patient using omalizumab for chronic spontaneous urticaria.

Pediatr Allergy Immunol 2018 06 15;29(4):449-450. Epub 2018 Apr 15.

Division of Pulmonary, Department of Pediatrics, Allergy and Sleep Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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Serum sickness-like disease after switching to biosimilar infliximab.

Rheumatology (Oxford) 2017 Nov;56(11):2032-2034

Service de Rhumatologie, Centre Hospitalier Universitaire de Bordeaux.

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November 2017

Demographic and clinical characteristics of patients with serum sickness-like reaction.

Clin Rheumatol 2018 May 9;37(5):1389-1394. Epub 2017 Aug 9.

Department of Pediatric rheumatology, Selçuk University Medical School, Konya, Turkey.

In this study, we aimed to review the demographic, clinical, and laboratory characteristics of patients who were followed up and treated with the diagnosis of serum sickness-like reactions (SSLR) in our pediatric rheumatology clinic retrospectively and emphasize the importance of early diagnosis and treatment. The files of 29 patients who were hospitalized in the pediatric rheumatology clinic between September 2016 and March 2017 with the diagnosis of type 3 hypersensitivity reaction were reviewed retrospectively. Patient records including C-reactive protein, erythrocyte sedimentation rate, serum electrolytes, blood glucose, urea, and liver function were recorded by using the computerized patient database. Read More

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