44,738 results match your criteria serum inhibited


Deficiency of leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice.

Aging (Albany NY) 2021 Sep 20;13(undefined). Epub 2021 Sep 20.

Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.

Studies reveal a linkage of miR-29s in aging and Parkinson's disease (PD). Here we show that the serum levels of miR-29s in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice exhibited dynamic changes. The role of in aging and PD was studied utilizing gene knockout mice ( KO). Read More

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September 2021

A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells.

iScience 2021 Sep 30;24(9):103067. Epub 2021 Aug 30.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, Japan.

Turning non-inflamed (cold) tumors into inflamed (hot) tumors is important for maximizing the effect of immune checkpoint inhibitors (ICIs) against malignancies. We showed that lactate, a product of the Warburg effect, inhibited the efficacy of ICIs and suppressed IL-12 p40 expression in dendritic cells (DCs) through reducing NF-κB p65, p50, and c-Rel DNA-binding activity to the IL-12 p40 promoter. Additionally, lactate promoted the expression of early growth response protein 1 (EGR1), whose expression was increased in human invasive melanoma compared with non-invasive melanoma. Read More

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September 2021

Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/mTOR signaling pathway.

Open Med (Wars) 2021 2;16(1):1286-1298. Epub 2021 Sep 2.

Department of Neurology, Shenzhen Fuyong People's Hospital, Shenzhen, Guangdong 518103, China.

Objective: To investigate the effect of baicalin on diabetic nephropathy (DN) rats and podocytes and its mechanism.

Methods: The rat models with DN were established by high-fat and high-sugar diet and intraperitoneal injection of streptozotocin. The fasting blood glucose (FBG) and weight of rats in each group were measured at 0, 1, 2, 3, and 4 weeks. Read More

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September 2021

LncRNA TUG1 Regulates Proliferation of Cardiac Fibroblast the miR-29b-3p/TGF-β1 Axis.

Front Cardiovasc Med 2021 3;8:646806. Epub 2021 Sep 3.

Department of Oncology, Changle People's Hospital, Weifang, China.

Atrial fibrillation (AF) is a very common clinical arrhythmia, accompanied by the overproliferation of cardiac fibroblasts (CFs). This study aimed to investigate the role of the long non-coding RNA(lncRNA) taurine upregulated gene 1 (TUG1) in the proliferation of CFs and further investigated its underlying mechanism. One hundred four paroxysmal AF patients and 94 healthy controls were recruited. Read More

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September 2021

Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway.

Front Mol Biosci 2021 1;8:690170. Epub 2021 Sep 1.

Department of Cell Biology and Stem Cell Research Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Liver fibrosis is an important stage in the progression of liver injury into cirrhosis or even liver cancer. Hepatic stellate cells (HSCs) are induced by transforming growth factor-β1 (TGF-β1) to produce α-smooth muscle actin (α-SMA) and collagens in liver fibrosis. Butaselen (BS), which was previously synthesized by our group, is an organic selenium compound that exerts antioxidant and tumor cell apoptosis-promoting effects by inhibiting the thioredoxin (Trx)/thioredoxin reductase (TrxR) system. Read More

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September 2021

Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE Mice by Inhibiting M1 Macrophage Polarization and Promoting M2 Macrophage Polarization.

Front Physiol 2021 2;12:666449. Epub 2021 Sep 2.

Department of Cardiovascular Medicine, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in different animal models. However, its effects and mechanisms on AS have not been clearly defined. Read More

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September 2021

The ameliorative effect of ellagic acid on di-(2-ethylhexyl) phthalate-induced testicular structural alterations, oxidative stress, inflammation and sperm damages in adult mice.

Reprod Biol Endocrinol 2021 Sep 18;19(1):146. Epub 2021 Sep 18.

Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Phthalates such as di (2-ethylhexyl) phthalate (DEHP) are well known exogenous substances, disrupting reproductive system function and structure. The current research demonstrated the effect of ellagic acid (EA) on DEHP-induced testicular injury in mice.

Methods: Thirty-five healthy adult male mice were randomly divided to five groups; normal saline receiving group, DEHP (2 g/kg/day, dissolved in corn oil, p. Read More

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September 2021

IgG anti-Pentraxin 3 antibodies are a novel biomarker of ANCA-associated vasculitis and better identify patients with eosinophilic granulomatosis with polyangiitis.

J Autoimmun 2021 Sep 14;124:102725. Epub 2021 Sep 14.

Division of Rheumatology, Department of Medicine DIMED, University of Padova, Italy. Electronic address:

Objective: To investigate prevalence of anti-Pentraxin 3 (PTX3) antibodies in sera of anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.

Methods: Anti-PTX3 and PTX3 levels were analysed by enzyme-linked immunosorbent assays in sera from unselected patients with AAV and compared with patients with systemic lupus erythematosus (SLE, n = 130), other connective tissue diseases (CTDs, n = 97) and matched healthy controls (n = 97). Optical density (OD) cut-off for positive anti-PTX3 antibodies was determined by ROC curve analysis and set as 0. Read More

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September 2021

Thrombomodulin-mediated Inhibition of Neutrophil Extracellular Trap Formation Alleviates Hepatic Ischemia/Reperfusion Injury by Blocking TLR4 in Rats Subjected to Liver Transplantation.

Transplantation 2021 Sep 16. Epub 2021 Sep 16.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China. West China School of Medicine, Sichuan University, Chongqing, People's Republic of China.

Background: Hepatic ischemia/reperfusion injury (IRI) is an unavoidable outcome of liver transplantation, during which neutrophil extracellular traps (NETs) may play a critical role in the IRI-induced immune response to inflammation. The purpose of this study was to identify the function of recombinant human thrombomodulin (rTM) in the remission of hepatic IRI after liver transplantation and elucidate the specific mechanism.

Methods: NET formation was detected in the serum of liver transplantation patients and rats following liver transplantation. Read More

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September 2021

Development and characterization of a unique anti-IgE mouse monoclonal antibody cross-reactive between human and canine IgE.

Immun Inflamm Dis 2021 Sep 17. Epub 2021 Sep 17.

Animal Allergy Clinical Laboratories Inc., Sagamihara, Kanagawa, Japan.

Background: The efficacy assessment of human anti-IgE monoclonal antibodies (mAbs) in animal models before clinical trials is hampered due to the lack of cross-reactivity of anti-IgE mAbs between species.

Objective: We developed CRE-DR (an anti-dog IgE monoclonal antibody), an anti-IgE mouse mAb that recognizes canine and human IgE, and then examined its IgE specificity and cross-reactivity between three animal and human species.

Methods: After mouse immunization with a synthetic peptide derived from canine IgE ( NTNDWIEGETYYC ), we generated a hybridoma producing CRE-DR. Read More

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September 2021

Adiponectin alleviated renal cell apoptosis and inflammation via inactivation of JAK2/STAT3 signal pathway in an acute pyelonephritis mouse model.

Authors:
Guoyu Dai Yao He

Ann Transl Med 2021 Aug;9(16):1311

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Acute pyelonephritis (APN), an acute and severe kidney infection, is usually treated with antibiotics. However, APN treatment has become increasingly challenging because of bacterial resistance. Adiponectin, an adipokine, has recently been reported to exhibit profound anti-inflammatory and anti-apoptotic effects. Read More

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Dihydroartemisinin attenuates benign prostatic hyperplasia in rats by inhibiting prostatic epithelial cell proliferation.

Ann Transl Med 2021 Aug;9(15):1246

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Benign prostatic hyperplasia (BPH) is a common urological condition in aging men. While dihydroartemisinin (DHA) exhibits a wide range of pharmacological activities, to date, there have been no studies examining the effects of DHA on BPH.

Methods: An BPH model was constructed in rats via daily subcutaneous injection of testosterone propionate (TP) for 28 consecutive days. Read More

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ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl-CoA carboxylase.

Food Sci Nutr 2021 Sep 22;9(9):5153-5165. Epub 2021 Jul 22.

Department of Child Health Care Children's Hospital of Nanjing Medical University Nanjing China.

Postnatal overfeeding can lead to persistent increases in hepatic lipid synthesis and the risk of nonalcoholic fatty liver disease (NAFLD) in adulthood. The ω3 polyunsaturated fatty acids (ω3PUFAs) exhibit beneficial effects on NAFLD. Here, we employed a rat model and an in vitro HepG2 cell model to investigate whether fish oil (FO) affects hepatic lipid synthesis due to postnatal overfeeding. Read More

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September 2021

Protective effect of Salidroside on hypoxia-related liver oxidative stress and inflammation via Nrf2 and JAK2/STAT3 signaling pathways.

Food Sci Nutr 2021 Sep 10;9(9):5060-5069. Epub 2021 Jul 10.

Department of Pathology Xuanwu Hospital Capital Medical University Beijing China.

High-altitude hypoxia-induced oxidative stress and inflammation played an essential role in the incidence and development of liver injury. Salidroside (Sal), a phenylpropanoid glycoside extracted from the plant Rhodiola rosea, has recently demonstrated antioxidant, anti-inflammatory, and antihypoxia properties. Herein, we hypothesized that salidroside may alleviate hypoxia-induced liver injury via antioxidant and antiinflammatory-related pathways. Read More

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September 2021

Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via ROS-ER Stress-CHOP Pathway.

Front Pharmacol 2021 31;12:670389. Epub 2021 Aug 31.

Department of Biochemistry and Molecular Biology, Hefei, China.

Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (DIO) related with reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress in the aorta and endothelial cells have not been reported yet. Read More

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Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis.

Stem Cell Res Ther 2021 Sep 16;12(1):506. Epub 2021 Sep 16.

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Background: Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in the recipients. Therefore, MSCs cultured in serum-free media (SF-MSCs) are ideal for clinical settings; however, their efficacy in pulmonary fibrosis is unknown. Read More

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September 2021

Enhanced IL-10 inhibits proliferation and promotes apoptosis of HUVECs through STAT3 signaling pathway in sepsis.

Histol Histopathol 2021 Sep 16:18375. Epub 2021 Sep 16.

Department of Critical Care Medicine, The Third Affiliated Hospital of Guangxi Medical University, Nanning, PR China.

Aims: The present study aims to determine the expression of interleukin (IL)-10 in peripheral blood of patients with sepsis, and investigate its effects on the biological function of vascular endothelial cells.

Methods: Thirty-six sepsis patients and 20 healthy subjects were included. Peripheral blood was collected from all subjects. Read More

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September 2021

Kaempferol Incorporated Bovine Serum Albumin Fibrous Films for Ocular Drug Delivery.

Macromol Biosci 2021 Sep 16:e2100269. Epub 2021 Sep 16.

Department of Pharmacy, Collegeof Chemical Engineering, Qingdao University of Science and Technology, Zhengzhou Road 53, Qingdao, 266042, China.

The possibility of using drug loaded bovine serum albumin (BSA) porous films as therapeutic contact lenses is investigated. Kaempferol (KAE), a hydrophobic antioxidant and anti-inflammatory agent, is incorporated into BSA porous films to form BSA/KAE films. The BSA/KAE films are transparent in the visible wavelength range of the human eye, possessing high water content and good cytocompatibility. Read More

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September 2021

Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged Rats.

Front Pharmacol 2021 30;12:693100. Epub 2021 Aug 30.

Department of Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

A high fructose diet (HFD) and advanced age are key factors for the gradual loss of physiological integrity of adipose tissue. Endogenous hydrogen sulfide (HS) has beneficial effects on cytoprotection and redox balance. But its interactive effects on age-related damage of mesenteric vessels and connective and adipose tissues (MA) during HFD which could be the base of the development of effective physiological-based therapeutic strategy are unknown. Read More

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The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats.

Drug Des Devel Ther 2021 8;15:3845-3862. Epub 2021 Sep 8.

Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People's Republic of China.

Background: Acute-on-chronic liver failure (ACLF) is a severe, complicated human disease. E2F1-mediated apoptosis plays an important role in ACLF development. Jieduan-Niwan (JDNW) formula, a traditional Chinese medicine (TCM), has shown remarkable clinical efficacy in ACLF treatment. Read More

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September 2021

Lower melanoma pulmonary metastatic burden in obese mice: role of FGF-21.

Melanoma Res 2021 Sep 13. Epub 2021 Sep 13.

Department of Biomedicine, Faculty of Medicine, University of Porto Metabesity Research Group, I3S, Institute for Investigation and Innovation in Health, University of Porto Chemical Sciences and Biomolecules, School of Health, Polytechnic Institute of Porto, Porto, Portugal.

Obesity is a risk factor for malignant melanoma. The lungs are main target organs for metastization and their immune response is a key modulator of this mechanism. The concept that the metastatic potential of some types of cancer is reduced or inhibited by obesity, known as the obesity paradox, drives major concerns on the prognosis of metastasized patients. Read More

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September 2021

Black Mulberry Extract Elicits Hepatoprotective Effects in Nonalcoholic Fatty Liver Disease Models by Inhibition of Histone Acetylation.

J Med Food 2021 Sep;24(9):978-986

Research Group of Healthcare, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Korea.

Epigenetic regulation by histone acetyltransferase (HAT) is associated with various biological processes and the progression of diseases, including nonalcoholic fatty liver disease (NAFLD). The objective of this study was to investigate whether the hypolipidemic properties of black mulberry ( Roxb.) fruit extract (BME) contribute toward protection against NAFLD by HAT inhibition. Read More

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September 2021

Ethyl Acetate Fraction of (L.) Medic Flowers Exerts Inhibitory Effects Against Oxidative Stress in HO-Induced HepG2 Cells and D-Galactose-Induced Aging Mice.

J Med Food 2021 Sep;24(9):997-1009

College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, China.

Oxidative stress has been demonstrated to be associated with numerous aging-related diseases. Ethyl acetate fraction of (L.) Medic (EA) had been reported to possess strong radical-scavenging activity due to its rich content of flavonoids. Read More

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September 2021

Synovial Fluid-Induced Aggregation Occurs across Staphylococcus aureus Clinical Isolates and is Mechanistically Independent of Attached Biofilm Formation.

Microbiol Spectr 2021 Sep 15:e0026721. Epub 2021 Sep 15.

Department of Microbial Infection and Immunity, The Ohio State Universitygrid.261331.4, Columbus, Ohio, USA.

Rapid synovial fluid-induced aggregation of Staphylococcus aureus is currently being investigated as an important factor in the establishment of periprosthetic joint infections (PJIs). Pathogenic advantages of aggregate formation have been well documented , including recalcitrance to antibiotics and protection from host immune defenses. The objective of the present work was to determine the strain dependency of synovial fluid-induced aggregation by measuring the degree of aggregation of 21 clinical S. Read More

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September 2021

Design, Synthesis, and Activity of an α-Conotoxin LtIA Fluorescent Analogue.

ACS Chem Neurosci 2021 Sep 15. Epub 2021 Sep 15.

Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Life and Pharmaceutical Sciences, Hainan University, Haikou 570228, China.

Nicotinic acetylcholine receptors (nAChRs) are essential pentameric ligand-gated ion channels that are distributed throughout the central and peripheral nervous systems and non-neuronal tissues in mammalian species that play critical roles in a variety of neural and mental activities. The α3β2 nAChR subtype participates in pain, addiction to nicotine, and other neurophysiological and pathological activities. Owing to the lack of highly selective pharmacological tools targeting α3β2, related research on its tissue distribution and function has been hindered. Read More

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September 2021

Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition.

Cell Biol Toxicol 2021 Sep 15. Epub 2021 Sep 15.

Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.

The autophagy-mediated lysosomal pathway plays an important role in conferring stress tolerance to tumor cells during cellular stress such as increased metabolic demands. Thus, targeted disruption of this function and inducing lysosomal cell death have been proved to be a useful cancer therapeutic approach. In this study, we reported that octyl syringate (OS), a novel phenolic derivate, was preferentially cytotoxic to various cancer cells but was significantly less cytotoxic to non-transformed cells. Read More

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September 2021

Fruits of sweet: toxicity profile, anti-inflammatory and antioxidant activities, and quantification of one of its bioactive constituents oleanolic acid.

Heliyon 2021 Sep 2;7(9):e07910. Epub 2021 Sep 2.

Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana.

Background: Sweet fruit, an under-utilised crop specie of Ghana, has not been validated for its ethnomedical use in managing inflammatory conditions. Therefore, the study sought to investigate its anti-inflammatory and antioxidant activities as well as isolate and quantify one of its active constituents.

Materials And Methods: anti-inflammatory activity of the methanol fruit extract was evaluated using the carrageenan-induced oedema model in chicks. Read More

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September 2021

Effect of ethanolic extract of Benth on subacute experimental models of inflammation and some underlying mechanisms.

Res Pharm Sci 2021 Oct 19;16(5):516-527. Epub 2021 Aug 19.

Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, I.R. Iran.

Background And Purpose: This study was designed to evaluate the anti-inflammatory activities of S. pilifera (HESP) in two sub-acute models of inflammation and clarified some possible mechanisms.

Experimental Approach: Colorimetric methods were used to determine total phenol and flavonoid contents. Read More

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October 2021

Protective effects of Lepidium draba L. leaves extract on testis histopathology, oxidative stress indicators, serum reproductive hormones and inflammatory signalling in oxymetholone-treated rat.

Andrologia 2021 Sep 14:e14239. Epub 2021 Sep 14.

College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.

This study was aimed to investigate the protective effects of Lepidium draba L. (L. draba) extract on oxymetholone (OM)-induced testicular injury in rat. Read More

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September 2021

Effects of Folic Acid and Caffeic Acid on Indirect Photo-oxidation of Proteins and Their Costabilization under Irradiation.

J Agric Food Chem 2021 Sep 14. Epub 2021 Sep 14.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.

Proteins, vitamins, and phenols are often present together in foods, but they are sensitive to environmental factors. Folic acid (FA), a synthetic form of folate, decomposes under light, leading to protein oxidation. Caffeic acid (CA), a phenolic acid, exhibits remarkable activity for scavenging reactive molecules. Read More

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September 2021