32,070 results match your criteria serum hscrp


Relationship between biochemical markers and measles viral load in patients with immunologically naive cases and secondary vaccine failure -LDH is one of the potential auxiliary indicators for secondary vaccine failure.

Microbiol Immunol 2021 May 5. Epub 2021 May 5.

Osaka Institute of Public Health, 3-69, Nakamichi, 1-chome, Higashinari-ku, Osaka, 537-0025, Japan.

This study investigated the correlation between biochemical markers and viral load among 38 measles cases, including 15 immunologically naive patients and 23 patients with secondary vaccine failure (SVF). We examined four biochemical markers, namely, aspartate aminotransferase, alanine aminotransferase, C-reactive protein, and lactate dehydrogenase (LDH) and their relationship between virus genome copy numbers in peripheral blood mononuclear cells (PBMCs) and throat swabs as well as the concentration of measles-specific IgG. Although viral genome copies in both clinical specimens showed a significant correlation with specific IgG concentration, they had a higher correlation in PBMCs (Pearson's product-moment correlation coefficient, -0. Read More

View Article and Full-Text PDF

Serum C-Reactive Protein Is Negatively Associated With Olfactory Identification Ability in Older Adults.

Iperception 2021 Mar-Apr;12(2):20416695211009928. Epub 2021 Apr 14.

Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.

Importance: Olfactory deficits are common in aging and associated with several conditions linked to inflammation. A few studies suggest that increased concentration of pro-inflammatory biomarkers may be related to olfactory deficits, but these associations are understudied in population-based samples.

Objective: To investigate the association between serum concentrations of C-reactive protein (CRP) and olfactory identification level as well as rate of change in aging. Read More

View Article and Full-Text PDF

Serum-derived extracellular vesicles inhibit osteoclastogenesis in active-phase patients with SAPHO syndrome.

Ther Adv Musculoskelet Dis 2021 16;13:1759720X211006966. Epub 2021 Apr 16.

State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, No. 5 Dong Dan San Tiao, Beijing, 100005, China.

Objective: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disorder and the underlying pathogenesis is unclear. In this study, 88 SAPHO patients and 118 healthy controls were recruited to investigate the role of serum-derived extracellular vesicles (SEVs) in SAPHO syndrome.

Methods: Quantitative proteomics was applied for SEVs proteome identification, and ELISA and Western blotting was performed to verify the results of mass spectrum data. Read More

View Article and Full-Text PDF

The value of conventional radiographs for diagnosing internal fixation-associated infection.

BMC Musculoskelet Disord 2021 May 4;22(1):411. Epub 2021 May 4.

Department of Traumatology and Orthopedic Surgery, Hospital Universitario 12 de Octubre, Avda Córdoba s/n, 28041, Madrid, Spain.

Background: The aim of the study is to  assess the diagnostic value of preoperative conventional radiographs for diagnosing infection associated with internal fixation devices.

Methods: We prospectively collected data of patients undergoing removal of internal fixation devices for any reason. Infection was diagnosed in case of purulence, sinus tract, positive histopathology and/or positive peri-implant tissue or sonication fluid culture. Read More

View Article and Full-Text PDF

Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.

BMC Infect Dis 2021 May 4;21(1):411. Epub 2021 May 4.

Gulhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey.

Background And Objectives: An effective treatment option is not yet available for SARS-CoV2, which causes the COVID-19 pandemic and whose effects are felt more and more every day. Ivermectin is among the drugs whose effectiveness in treatment has been investigated. In this study; it was aimed to investigate the presence of gene mutations that alter ivermectin metabolism and cause toxic effects in patients with severe COVID-19 pneumonia, and to evaluate the effectiveness and safety of ivermectin use in the treatment of patients without mutation. Read More

View Article and Full-Text PDF

A case report of atypical Kawasaki disease presented with severe elevated transaminases and literature review.

BMC Infect Dis 2021 May 4;21(1):415. Epub 2021 May 4.

Department of Paediatrics, ShaoXing KeQiao Women And Children's Hospital, ShaoXing, 312030, Zhejiang Province, PR China.

Background: Kawasaki disease (KD) is the most common cause of acquired heart disease among children in developed countries, in which the resulting coronary artery (CA) abnormalities cause myocardial ischemia, infarction, and death. Prompt diagnosis was essential, and supplemental information should be used to assist the diagnosis when classical clinical criteria are incomplete. The elevated levels of serum transaminases in most KD patients are mild. Read More

View Article and Full-Text PDF

Cytokine Levels in Human Vitreous in Proliferative Diabetic Retinopathy.

Cells 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Ophthalmology, Boston University School of Medicine & Boston Medical Center, Boston, MA 02118, USA.

In this study, we compare the vitreous cytokine profile in patients with proliferative diabetic retinopathy (PDR) to that of patients without PDR. The identification of novel cytokines involved in the pathogenesis of PDR provides candidate therapeutic targets that may stand alone or work synergistically with current therapies in the management of diabetic retinopathy. Undiluted vitreous humor specimens were collected from 74 patients undergoing vitrectomy for various vitreoretinal disorders. Read More

View Article and Full-Text PDF

Leucine-rich alpha-2 glycoprotein is a potential biomarker to monitor disease activity in inflammatory bowel disease receiving adalimumab: PLANET study.

J Gastroenterol 2021 May 3. Epub 2021 May 3.

Division of Gastroenterology, Department of Medicine, Iwate Medical University, Iwate, Japan.

Background: This multicenter prospective study (UMIN000019958) aimed to evaluate the usefulness of serum leucin-rich alpha-2 glycoprotein (LRG) levels in monitoring disease activity in inflammatory bowel disease (IBD).

Methods: Patients with moderate-to-severe IBD initiated on adalimumab therapy were enrolled herein. Serum LRG, C-reactive protein (CRP), and fecal calprotectin (fCal) levels were measured at week 0, 12, 24, and 52. Read More

View Article and Full-Text PDF

Hyponatremia is a Prognostic Factor in Patients Receiving Nutrition Support.

Am J Med Sci 2020 Nov 26. Epub 2020 Nov 26.

Department of Therapeutic Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan; Department of Nutrition, Tokushima University Hospital, Tokushima, Japan. Electronic address:

Background: Hyponatremia, the most common electrolyte disorder, has been reported to be related to increased mortality. However, the association between hyponatremia and prognoses remains unclear in patients with nutrition support team (NST) intervention. This study aimed to determine the prevalence of abnormal serum sodium levels, its relation to patient data, and the impact of hyponatremia on prognosis. Read More

View Article and Full-Text PDF
November 2020

Clinical characteristics and risk factors for culture-negative periprosthetic joint infections.

J Orthop Surg Res 2021 May 3;16(1):292. Epub 2021 May 3.

Department of Orthopedic Surgery, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama City, Kanagawa, Japan.

Background: Culture-negative periprosthetic joint infections (PJIs) can complicate diagnosis and management of PJI. This study aimed to identify risk factors for culture-negative PJI and differences in clinical characteristics between culture-positive and culture-negative PJI group.

Methods: This retrospective, cross-sectional study evaluated PJI cases obtained between January 2013 and October 2019 at our institution. Read More

View Article and Full-Text PDF

Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study.

Am J Perinatol 2021 May 3. Epub 2021 May 3.

Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective:  The etiology of anemia in premature neonates is multifactorial and may involve anemia of inflammation mediated by hepcidin. Hepcidin expression is suppressed by vitamin D. We aimed to investigate the interrelationship between hepcidin, anemia, and vitamin D status in preterm infants. Read More

View Article and Full-Text PDF

Glasgow prognostic score for prediction of chemotherapy-triggered acute exacerbation interstitial lung disease in patients with small cell lung cancer.

Thorac Cancer 2021 May 3. Epub 2021 May 3.

Department of Respiratory Medicine, Tokyo Medical University Hospital, Tokyo, Japan.

Background: Predicting the incidence of chemotherapy-triggered acute exacerbation of interstitial lung disease (AE-ILD) in patients with lung cancer is important because AE-ILD confers a poor prognosis. The Glasgow prognostic score (GPS), which is an inflammation-based index composed of serum levels of C-reactive protein and albumin, predicts prognosis in patients with small cell lung cancer (SCLC) without ILD. In this study, we investigated AE-ILD and survival outcome based on the GPS in patients with ILD associated with SCLC who were receiving chemotherapy. Read More

View Article and Full-Text PDF

Impact of Three Consecutive Days of Endurance Training Under Hypoxia on Muscle Damage and Inflammatory Responses.

Front Sports Act Living 2021 15;3:663095. Epub 2021 Apr 15.

Graduate School of Sports and Health Science, Ritsumeikan University, Kusatsu, Japan.

The purpose of this study was to determine the effect of 3 consecutive days of endurance training under hypoxia on muscle damage, inflammation, and performance responses. Nine active healthy males completed two trials in different periods, consisting of either 3 consecutive days of endurance training under hypoxia [fraction of inspired oxygen (Fio): 14.5%, HYP] or normoxia (Fio: 20. Read More

View Article and Full-Text PDF

Relationship Between Vitamin D and Hormones Important for Human Fertility in Reproductive-Aged Women.

Front Endocrinol (Lausanne) 2021 14;12:666687. Epub 2021 Apr 14.

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany.

Vitamin D deficiency is very common in women of reproductive age. Studies in animals suggests a link between vitamin D and reproductive hormone biosynthesis. A systematic analysis of the correlation of reproductive hormones in reproductive-aged women with both total and free vitamin D was, however, not done so far. Read More

View Article and Full-Text PDF

A sensitive and quantitative prognosis of C-reactive protein at picogram level using mesoporous silica encapsulated core-shell up-conversion nanoparticle based lateral flow strip assay.

Talanta 2021 Aug 23;230:122335. Epub 2021 Mar 23.

School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, PR China. Electronic address:

C- reactive protein (CRP) is a sensitive indicator for infectious or inflammatory diseases in human which can reflect the body's inflammation latency and early pathophysiological changes. The most common detection method of serum CRP is ELISA that has been proved to be expensive and time-consuming, restricting its use in point-of-care application. In this paper, we demonstrated a lateral flow system for CRP quantification by using mesoporous silica (mSiO) coated up-converting nanoparticles (UCNPs) (denoted as UCNPs@mSiO) as fluorescent labels. Read More

View Article and Full-Text PDF

Effectiveness and safety profile of pembrolizumab for metastatic urothelial cancer: A retrospective single-center analysis in Japan.

Cancer Rep (Hoboken) 2021 May 2:e1398. Epub 2021 May 2.

Department of Urology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: The paradigm of medical treatment for metastatic urothelial carcinoma is dramatically changing through the introduction of pembrolizumab.

Aim: We investigated the treatment effectiveness, the safety profile, and the prognostic factors of pembrolizumab in Japanese real-world clinical practice.

Methods And Results: The medical records of 74 consecutive Japanese patients with metastatic urothelial cancer (UC), who started pembrolizumab as a second- or later-line treatment at our institution between January 2018 and March 2020, were reviewed and statistically analyzed. Read More

View Article and Full-Text PDF

Serum and urine free light chains measurements in patients with systemic sclerosis: novel biomarkers for disease activity.

Clin Exp Immunol 2021 May 1. Epub 2021 May 1.

Area Diagnostica di Laboratorio, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Rome, Italy.

Circulating free light chains (FLCs), considered biomarkers of B cell activity, are frequently elevated in patients affected by systemic inflammatory-autoimmune diseases. As systemic sclerosis (SSc) clinical course can be variable, this study is aimed at evaluating FLCs levels in affected individuals, as biomarkers of disease activity. We assessed FLC levels in serum and urine of 72 SSc patients and 30 healthy controls (HC). Read More

View Article and Full-Text PDF

Phase angle association with metabolic profile in adults: A population-based study.

Nutrition 2021 Mar 7;90:111233. Epub 2021 Mar 7.

Universidade Federal de Santa Catarina, Departamento de Nutrição, Santa Catarina, Brasil.

Objective: This study assesses the association of the phase angle (PhA) with the metabolic profile in adults of both sexes.

Methods: This is a cross-sectional, population-based study including 949 adults 20 to 59 y of age living in the Viçosa, Minas Gerais, Brazil - urban zone. The PhA was measured based on electrical bioimpedance analysis. Read More

View Article and Full-Text PDF

Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study.

Pediatr Rheumatol Online J 2021 May 1;19(1):62. Epub 2021 May 1.

Department of Pediatrics, Duke University Hospital, Durham, NC, USA.

Background: Inadequate systemic exposure to infliximab (IFX) is associated with treatment failure. This work evaluated factors associated with reduced IFX exposure in children with autoimmune disorders requiring IFX therapy.

Methods: In this single-center cross-sectional prospective study IFX trough concentrations and anti-drug antibodies (ADAs) were measured in serum from children diagnosed with inflammatory bowel disease (IBD) (n = 73), juvenile idiopathic arthritis (JIA) (n = 16), or uveitis (n = 8) receiving maintenance IFX infusions at an outpatient infusion clinic in a tertiary academic pediatric hospital. Read More

View Article and Full-Text PDF

Impact of Perihematomal Edema on Infectious Complications after Spontaneous Intracerebral Hemorrhage.

J Stroke Cerebrovasc Dis 2021 Apr 28;30(7):105827. Epub 2021 Apr 28.

Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address:

Objective: Intracerebral hematoma involves two mechanisms leading to brain injury: the mechanical disruption of adjacent brain tissue by the hematoma and delayed neurological injury. Delayed neurological injury involves perihematomal edema (PHE) formation. Infectious complications following intracerebral hemorrhage (ICH) are a significant contributor to post-ICH recovery. Read More

View Article and Full-Text PDF

Descriptive modification of inflammatory markers in HIV patients after cART initiation according to gender, smoking habit, CMV infection, BMI and serum lipids.

Cytokine 2021 Apr 27:155547. Epub 2021 Apr 27.

University Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Italy.

Persistent inflammation, despite anti-retroviral therapy (ART), is an independent predictor of mortality and comorbidities in HIV infection. Multiple factors, including lifestyle and chronic viral coinfections, may contribute. Several of these factors are also associated with a chronic inflammation in the general population. Read More

View Article and Full-Text PDF

Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with type 2 Diabetes Mellitus.

Exp Clin Endocrinol Diabetes 2021 Apr 30. Epub 2021 Apr 30.

Department of Endocrinology, Central Theater Command General Hospital of the Chinese People's Liberation Army, Wuhan, 430070, Hubei, China.

Background: Serum wnt1-induced signaling pathway protein 1 (WISP1) levels are increased with obesity, which is a common complication associated with lower extremity atherosclerotic disease (LEAD). However, to date, the relationship between elevated WISP1 levels and the incidence of lower extremity atherosclerotic disease (LEAD) in type 2 diabetes mellitus (T2DM) remains unclear.

Methods: 174 newly diagnosed type 2 diabetic patients were enrolled in our study. Read More

View Article and Full-Text PDF

Interaction between the dietary indices and PPAR-γ Pro12Ala gene variants on cardiovascular risk factors in patients with type 2 diabetes mellitus.

Int J Clin Pract 2021 Apr 30:e14307. Epub 2021 Apr 30.

Department of Cellular, School of Nutritional Sciences and Dietetics, Tehran University of edical Sciences (TUMS), Molecular Nutrition, Tehran, Iran.

Aims: We investigated the interaction between peroxisome proliferator-activated receptor gamma (PPAR-γ) Pro12Ala polymorphism and Healthy Eating Index (HEI), Dietary Quality Index-International (DQI-I) and Dietary Phytochemical Index (DPI) on Cardiovascular Disease (CVD) risk factors in patients with type 2 diabetes mellitus (T2DM).

Methods: This cross-sectional study was conducted on 393 diabetic patients. PPAR-γ Pro12Ala was genotyped by PCR-RFLP method. Read More

View Article and Full-Text PDF

Is D-dimer a Reliable Serum Marker for Shoulder Periprosthetic Joint Infection?

Clin Orthop Relat Res 2021 04 29. Epub 2021 Apr 29.

A. Shahi, T. Nicholson, J. Abboud, M. Lazarus, G. Williams, J. Parvizi, S. Namdari, Department of Orthopaedic Surgery, the Rothman Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Background: The diagnosis of periprosthetic shoulder infection continues to be difficult to make with confidence. Serum D-dimer has proven to be effective as a screening tool for periprosthetic joint infection in other major joints; however, it has yet to be evaluated for use in periprosthetic shoulder infection.

Questions/purposes: (1) Is D-dimer elevated in patients with probable or definite periprosthetic shoulder infections? (2) What is the diagnostic accuracy of D-dimer for periprosthetic shoulder infections? (3) What are the diagnostic accuracies of serum tests (erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], and D-dimer), singly and in combination?

Methods: Between March 2016 and March 2020, 94 patients undergoing revision total shoulder arthroplasty (anatomic or reverse) at a single institution had preoperative serum testing with CRP, ESR, and D-dimer. Read More

View Article and Full-Text PDF

Inflammaging: Blame the sons. Relationships between the number of sons and the level of inflammatory mediators among post-reproductive women.

Am J Phys Anthropol 2021 Apr 30. Epub 2021 Apr 30.

Department of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.

Objectives: Reproduction is costly, but sons and daughters differently influence maternal physiology, also in older age. In particular, having sons may negatively influence maternal health and may be associated with a shorter life span of mothers. Sons may also contribute to increased inflammaging, a chronic sub-clinical systemic inflammatory state characterized by elevated levels of serum inflammatory mediators. Read More

View Article and Full-Text PDF

Higher Postinduction Infliximab Concentrations Are Associated With Improved Clinical Outcomes in Fistulizing Crohn's Disease: An ACCENT-II Post Hoc Analysis.

Am J Gastroenterol 2021 May;116(5):1007-1014

Center for Inflammatory Bowel Diseases, Division of Gastroenterology, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Introduction: There are only limited data regarding the role of therapeutic drug monitoring in fistulizing Crohn's disease (CD). We investigated the association between both induction and maintenance serum infliximab concentrations and favorable therapeutic outcomes in patients with fistulizing CD.

Methods: This was a post hoc analysis of the ACCENT-II trial evaluating patients with fistulizing CD receiving induction (n = 282) and maintenance infliximab therapy (n = 139). Read More

View Article and Full-Text PDF

The assesment of prothrombotic potential using thrombin generation assay in pediatric patients with nephrotic syndrome: preliminary study.

Turk J Pediatr 2021 ;63(2):273-281

Divisions of Hematology, Department of Pediatrics, University of Health Sciences, Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, Turkey.

Background: Nephrotic syndrome (NS) is a common kidney disease associated with an increased risk of thrombotic events. The aim of this study was to assess the prothrombotic potential of patients with NS using the thrombin generation assay (TGA).

Methods: A total of 35 patients with NS, who were followed in the Division of Pediatric Nephrology in Behcet Uz Children`s Hospital, were included in the study. Read More

View Article and Full-Text PDF
January 2021

Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice.

J Radiat Res 2021 Apr 29. Epub 2021 Apr 29.

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.

Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on γ-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the liver, kidney, lung and spleen of mice. Mice were administered FX (10 mg kg-1 day-1, i. Read More

View Article and Full-Text PDF

Accuracy for Mortality Prediction With Additive Biomarkers Including Interleukin-6 in Critically Ill Patients: A Multicenter Prospective Observational Study.

Crit Care Explor 2021 Apr 26;3(4):e0387. Epub 2021 Apr 26.

Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Objectives: Several inflammation markers have been reported to be associated with unfavorable clinical outcomes in critically ill patients. We aimed to elucidate whether serum interleukin-6 concentration considered with Sequential Organ Failure Assessment score can better predict mortality in critically ill patients.

Design: A prospective observational study. Read More

View Article and Full-Text PDF

Androgen Deprivation Therapy in Patients With Prostate Cancer Increases Serum Levels of Thromboxane A: Cardiovascular Implications.

Front Cardiovasc Med 2021 13;8:653126. Epub 2021 Apr 13.

Grupo de Investigación en Urología, IdiPAZ, Madrid, Spain.

Androgens have been described as important players in the regulation of vascular function/structure through their action on the release and effect of vasoactive factors, such as prostanoids. Patients with prostate cancer (PCa) under androgen deprivation therapies (ADTs) present increased risk of cardiovascular mortality. Since thromboxane A (TXA) is one of the most studied prostanoids and its involvement in different cardiovascular diseases has been described, the aim of this study was to investigate: (i) the effect of ADT on the serum levels of TXA in PCa patients and its possible link to the redox status and (ii) the effect of the non-hydrolyzable TXA analog U-46619 on the function of the aorta of male rats. Read More

View Article and Full-Text PDF