12,973 results match your criteria serum fsh


Long-term copper exposure promotes apoptosis and autophagy by inducing oxidative stress in pig testis.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

College of Veterinary, South China Agricultural University, Guangzhou, 510642, China.

Copper (Cu) is a heavy metal which is being used widely in the industry and agriculture. However, the overuse of Cu makes it a common environmental pollutant. In order to investigate the testicular toxicity of Cu, the pigs were divided into three groups and were given Cu at 10 (control), 125, and 250 mg/kg body weight, respectively. Read More

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Dynamic Protective Effect of Chinese Herbal Prescription, Yiqi Jiedu Decoction, on Testis in Mice with Acute Radiation Injury.

Evid Based Complement Alternat Med 2021 1;2021:6644093. Epub 2021 Jun 1.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: A Chinese herbal prescription, Yiqi Jiedu (YQJD) decoction, is used for injuries caused by radiotherapy. This study aimed to investigate the dynamic protective effects of YQJD decoction in mice on radiation damage at different time points of the testis.

Methods: The 200 male Balb/c mice were randomly divided into 5 groups (blank, model, Anduolin, low-dose YQJD, and high-dose YQJD groups). Read More

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High Serum Anti-Müllerian Hormone Concentrations Are Associated With Poor Pregnancy Outcome in Fresh IVF/ICSI Cycle but Not Cumulative Live Birth Rate in PCOS Patients.

Front Endocrinol (Lausanne) 2021 26;12:673284. Epub 2021 May 26.

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: To investigate the association between baseline serum Anti-Müllerian hormone (AMH) levels and IVF/ICSI outcomes in women with polycystic ovary syndrome (PCOS).

Design: Retrospective study.

Setting: Reproductive medicine center in a hospital. Read More

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Urinary bisphenol A in women with polycystic ovary syndrome - a possible suppressive effect on steroidogenesis?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

First Department of Internal Medicine, Medical Faculty, P.J. Šafárik University, Košice, Slovakia.

Objectives: There is a growing evidence indicating an impact of endocrine distrupting chemicals such as bisphenol A (BPA) on human reproduction. Its higher levels in serum or urine have been documented in women with polycystic ovary syndrome (PCOS), however the relationship to ovarian steroidogenesis remains unclear. of the study was to compare urinary BPA (U-BPA) concentrations among PCOS women and control group. Read More

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Comparative study on the pharmacodynamic difference of oral administration of Xiaojin Pills accompanied with Chinese Baijiu and water.

J Ethnopharmacol 2021 Jun 7:114284. Epub 2021 Jun 7.

State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, PR China. Electronic address:

Ethnopharmacological Relevance: Xiaojin Pills is a classic prescription for the treatment of mammary glands hyperplasia with a history of nearly 300 years, and is also the first choice of Chinese patent medicine for the clinical treatment of mammary glands hyperplasia in contemporary traditional Chinese medicine clinic. Clinical and animal studies have shown that Xiaojin Pills has the effects of anti-mammary glands hyperplasia, promoting blood circulation, anti-inflammation and analgesia. However, its initial administration method was "taking orally after soaked with Chinese Baijiu", the modern method was changed to "taking orally with water" in recent 20 years. Read More

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Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls.

J Complement Integr Med 2021 Jun 9. Epub 2021 Jun 9.

Biological Anthropology Dept., National Research Centre, Giza, Egypt.

Objectives: Evaluate the association between overweight/obesity with serum gonadotropin and androgen levels in Egyptian pubertal girls.

Subjects And Methods: A case-control study carried out in "Obesity Clinic" of "Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU)", Pediatric Hospital, Cairo University. It included 40 overweight and obese girls and 40 age-matching normal weight (control) ones, aged 12-18 years. Read More

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Revised manuscript R2, clean version are serum levels of 25-hydroxy vitamin D reduced following orchiectomy in testicular cancer patients?

Basic Clin Androl 2021 Jun 10;31(1):14. Epub 2021 Jun 10.

Department of Urology, Testis Cancer Unit, Asklepios Klinik Altona, Paul Ehrlich Strasse 1, Hamburg, Germany.

Background: The testis represents one place where the progenitor of vitamin D is converted into its active form. Loss of one testis was suggested to result in reduced vitamin D serum levels. Vitamin D deficiency would represent a significant health problem in the long-term course of patients with testicular germ cell tumors (GCTs) since most of them survive. Read More

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The expression of platelet-derived growth factor, epidermal growth factor, and insulin-like growth factor-II in patients with polycystic ovary syndrome and its correlation with pregnancy outcomes.

Ann Palliat Med 2021 May;10(5):5671-5678

Department of Gynecology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder with complex pathogenesis. This study aimed to analyze the expression of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and insulin-like growth factor-II (IGF-II) in patients with PCOS and its correlation with pregnancy outcomes.

Methods: A total of 104 PCOS patients admitted to the Cangzhou Central Hospital from January 2015 to February 2018 were selected as the PCOS group, and 92 healthy pregnant women who received health examinations in the hospital during the same period were selected as the control group. Read More

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Potentiating response of D- Ribose-L-Cysteine on Sodium arsenateinduced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat.

JBRA Assist Reprod 2021 Jun 9. Epub 2021 Jun 9.

Human Anatomy Department, Federal University of Technology Akure, Ondo State.

Objective: Reproductive toxicity is an important health challenge, mostly associated with exposure to several environmental toxicants. Arsenic is a ubiquitous toxic compound naturally present in the environment. This study was carried out to evaluate the dietary supplements of D-Ribose-L-Cysteine against sodium arsenate-induced testicular toxicity in adult male Wistar rats. Read More

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The patterns and occupational distribution of hormonal abnormalities among men investigated for infertility in some centers in the southwest, Nigeria.

J Clin Transl Res 2021 Apr 12;7(2):221-228. Epub 2021 Mar 12.

Department of Medical Laboratory Services, University Health Centre, Federal University of Technology Akure, Akure, Ondo State, Nigeria.

Background And Aim: Male factor infertility results from dysfunction at various levels of spermatogenesis, sex hormone abnormalities, and occupation or workplace exposure to toxins are involved. This study was designed to determine the frequency of occupational distribution of men who were evaluated for infertility, the patterns of hormonal abnormalities, and to associate hormonal abnormalities with occupational categories in some centers in Osun State, Nigeria.

Methods: Semen and 5 mL of whole blood were collected from the infertile men (n=319) who were referred to the laboratories for fertility investigation after physical and medical examination. Read More

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Moringa oleifera ethanolic extract ameliorates the testicular dysfunction resulted from HFD-induced obesity rat model.

Andrologia 2021 Jun 8:e14126. Epub 2021 Jun 8.

Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.

In this study, we estimated the protective role of Moringa oleifera leaf ethanolic extract (MOLE) against obesity-associated testicular dysfunction. Fifty male albino rats were randomly assigned to five groups (n = 10): Group I (basal diet), group II (basal diet plus MOLE orally), group III (high-fat diet-HFD), group IV (HFD plus oral MOLE) and group V (HFD for 8 weeks followed by a basal diet plus oral MOLE for 6 weeks). The study duration extended for 14 weeks. Read More

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Correlation among isolated teratozoospermia, sperm DNA fragmentation and markers of systemic inflammation in primary infertile men.

PLoS One 2021 7;16(6):e0251608. Epub 2021 Jun 7.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Aim: To assess the prevalence of isolated teratozoospermia (iTZS) in a cohort of infertile and fertile men; explore the relationship between iTZS, inflammatory parameters and sperm DNA fragmentation index (SDF) in the same cohort.

Materials And Methods: 1824 infertile men and 103 fertile controls. Semen analysis, the neutrophil-to-lymphocyte ratio (NLR) and serum hormones were investigated. Read More

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Age-group-specific reference intervals for anti-Müllerian hormone and its diagnostic performance for polycystic ovary syndrome in a Korean population.

J Clin Lab Anal 2021 Jun 7:e23861. Epub 2021 Jun 7.

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: We established age-group-specific reference intervals for serum anti-Müllerian hormone (AMH) levels in a Korean population and investigated the effectiveness of AMH assay for polycystic ovary syndrome (PCOS) diagnosis.

Methods: We analyzed serum levels of AMH, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) from 1540 Korean women. Subjects were divided into three groups: healthy, benign gynecologic diseases, and PCOS. Read More

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Transcriptomic study of the mechanism by which the Kai Yu Zhong Yu recipe improves oocyte quality in a stressed mouse model.

J Ethnopharmacol 2021 Jun 4;278:114298. Epub 2021 Jun 4.

Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, And National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China. Electronic address:

Ethnopharmacological Relevance: The Kai Yu Zhong Yu recipe (KYZY) is a classic herbal formula in traditional Chinese medicine (TCM) that has been used to treat infertility associated with psychological stress for more than three hundred years.

Aim Of The Study: Psychological stress has major impacts on fertility, with variable outcomes depending on the nature, strength, and duration of the stress. Stress can directly disturb ovulation, oocyte quality, maturation, and embryo development. Read More

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Association between premature ovarian insufficiency and gut microbiota.

BMC Pregnancy Childbirth 2021 Jun 5;21(1):418. Epub 2021 Jun 5.

Affiliated Shenzhen Maternity&Child Healthcare Hospital, Southern Medical University, No. 3012, Fuqiang Road, Futian District, Shenzhen City, 518000, Guangdong Province, China.

Background: Premature ovarian insufficiency (POI) is characterized by impairment of ovarian function on a continuum before the age of 40 years. POI is affected by multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate the relationship between gut microbial community structure and POI. Read More

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Serum and intratesticular inhibin B, AMH, and spermatogonial numbers in trans women at gender-confirming surgery: An observational study.

Andrology 2021 Jun 4. Epub 2021 Jun 4.

Institute of Reproductive and Regenerative Medicine, Centre of Reproductive Medicine and Andrology, University Hospital Muenster, Muenster, Germany.

Background: Anti-Müllerian hormone and inhibin B are produced by Sertoli cells. Anti-Müllerian hormone secretion indicates an immature Sertoli cell state. Inhibin B serves as a marker of male fertility. Read More

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Do basal Luteinizing Hormone and Luteinizing Hormone/Follicle-Stimulating Hormone Ratio Have Significance in Prognosticating the Outcome of Fertilization Cycles in Polycystic Ovary Syndrome?

J Hum Reprod Sci 2021 Jan-Mar;14(1):21-27. Epub 2021 Mar 30.

Department of Obstetrics and Gynaecology, ART Center, All India Institute of Medical Sciences, New Delhi, India.

Context: Tonic hypersecretion of luteinizing hormone (LH) appears to impact both fertility and pregnancy outcomes in women with polycystic ovary syndrome (PCOS).

Aim: Whether high basal day 2/3 serum LH levels and day 2/3 LH/follicle-stimulating hormone (FSH) ratio affect fertilization (IVF) cycle outcomes in PCOS patients undergoing controlled ovarian hyperstimulation using gonadotropin-releasing hormone (GnRH) antagonists.

Settings And Design: A retrospective cohort study was conducted in Assisted Reproductive Technique Center, Department of Obstetrics and Gynaecology, at a tertiary care institute, on PCOS patients undergoing IVF/intracytoplasmic sperm injection (ICSI) using GnRH antagonist protocol with human chorionic gonadotropin trigger between January 2014 to December 2019. Read More

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Sinapic acid reduces ischemia/reperfusion injury due to testicular torsion/detorsion in rats.

Andrologia 2021 Jun 3:e14117. Epub 2021 Jun 3.

Department of Urology, Tokat State Hospital, Tokat, Turkey.

This study aimed to investigate the protective effect of sinapic acid (SA) on biochemical and histopathological changes in an experimental testicular torsion-detorsion rat model. Twenty-four rats were randomised into four groups: sham group, ischemia/reperfusion (IR) group subjected to testicular torsion for 2 hr and then detorsion for 4 hr, and two groups treated with SA1 and SA2 (10 mg/kg and 20 mg/kg, by single intraperitoneal injection, 30 min before reperfusion). Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured by an autoanalyzer, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), protein carbonyl (PC), and nitric oxide (NO) oxidative stress parameters by spectrophotometric methods, and tumour necrosis factor (TNF-α), interleukin-1 beta (IL-1β), and interleukin 6 (IL-6) parameters by the Elisa method. Read More

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Evaluation of the effect of vitamin D supplementation on spermatogram, seminal and serum levels of oxidative stress indices in asthenospermia infertile men: a study protocol for a triple-blind, randomized controlled trial.

Nutr J 2021 Jun 2;20(1):49. Epub 2021 Jun 2.

Health education group, Jahad Daneshgahi, Ahvaz, Khuzestan, Iran.

Background: It is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men. Read More

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Sexual Function in Chinese Women with Polycystic Ovary Syndrome and Correlation with Clinical and Biochemical Characteristics.

Reprod Sci 2021 Jun 2. Epub 2021 Jun 2.

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

To investigate sexual function in Chinese women with polycystic ovary syndrome (PCOS) and to explore the correlation with clinical and biochemical characteristics. A cross-sectional study was designed in 1000 PCOS women, aged 18-45 years, via the Chinese version of Female Sexual Function Index (FSFI) evaluating sexual function, with additional questions possibly related to sexual life. Clinical and biochemical characteristics likely to affect sexual function were determined, including anthropometric indicators, serum levels of hormones, luteinizing hormone to follicle-stimulating hormone ratio (LH/FSH ratio), prolactin (PRL), total testosterone (TT), free androgen index (FAI), sex-hormone-binding globulin (SHBG), glucose, and lipid metabolism indicators. Read More

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Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

Department of Nutrition, Food Chemistry and Toxicology, Faculty of Pharmacy, University of Sevilla, 41012 Sevilla, Spain.

Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicity of these contaminants. Read More

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Identification and Relative Quantification of hFSH Glycoforms in Women's Sera via MS-PRM-Based Approach.

Pharmaceutics 2021 May 27;13(6). Epub 2021 May 27.

Proteomics Platform Necker, Université de Paris-Structure Fédérative de Recherche Necker, INSERM US24/CNRS UMS3633, 75015 Paris, France.

Follicle-stimulating hormone (FSH) is a glycohormone synthesized by adenohypophysis, and it stimulates ovulation in women and spermatogenesis in men by binding to its receptor (FSHR). FSHR is involved in several mechanisms to transduce intracellular signals in response to the FSH stimulus. Exogenous FSH is currently used in the clinic for ovarian hyperstimulation during in vitro fertilization in women, and for treatment of infertility caused by gonadotropin deficiency in men. Read More

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Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review.

Nutrients 2021 May 15;13(5). Epub 2021 May 15.

The Experts Group on Inositol in Basic and Clinical Research (EGOI), 00156 Rome, Italy.

Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by chronic ovulation dysfunction and hyperandrogenism. It is considered the most common endocrinological disorder, affecting up to 25% of women of reproductive age, and associated with long-term metabolic abnormalities predisposing to cardiovascular risk, such as insulin resistance (IR), dyslipidemia, endothelial dysfunction, and systemic inflammation. PCOS is also characterized by elevated serum levels of luteinizing hormone (LH), causing a condition of hyperandrogenism and a consequent altered ratio between LH and the follicle stimulating hormone (FSH). Read More

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Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling.

Hum Reprod 2021 Jun;36(7):1891-1906

Department of Obstetrics and Gynecology, Olson Center for Women's Health, University of Nebraska Medical Center, Omaha, NE, USA.

Study Question: Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)?

Summary Answer: Compared with fully-glycosylated hFSH, hypo-glycosylated hFSH has greater bioactivity, enabling greater follicular health and growth in vivo, with enhanced transcriptional activity, greater activation of receptor tyrosine kinases (RTKs) and elevated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling.

What Is Known Already: Glycosylation of FSH is necessary for FSH to effectively activate the FSH receptor (FSHR) and promote preantral follicular growth and formation of antral follicles. In vitro studies demonstrate that compared to fully-glycosylated recombinant human FSH, hypo-glycosylated FSH has greater activity in receptor binding studies, and more effectively stimulates the PKA pathway and steroidogenesis in human granulosa cells. Read More

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Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty.

Case Rep Pathol 2021 22;2021:5545645. Epub 2021 Apr 22.

Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan.

Dysgerminoma is a malignant ovarian germ cell tumor, and unlike sex-cord stromal tumors, endocrine manifestation is considered rare. Here, we report the first case of dysgerminoma presenting precocious puberty. The patient is a 7-year-old girl who presented with a breast development in Tanner stage 3. Read More

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Increased Estradiol Levels Effect on Leptin Expression in Midluteal Endometrial Tissue of Macaca Nemestrina (Southern Pig-Tailed Macaques).

J Family Reprod Health 2020 Dec;14(4):229-233

Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.

To measure the effect of serum estradiol (E2) levels on leptin expression in Macaca nemestrina (southern pig-tailed macaque) endometrial tissue. This study used paraffin-embedded midluteal phase endometrial tissue blocks of Macaca nemestrina from previous study. Included subjects were 15 female macaques of reproductive age (8-10 years) with a previous history of producing offspring, which were divided into four groups: groups administered with 30 IU, 50 IU, and 70 IU r-FSH (intervention group), and no r-FSH (control group). Read More

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December 2020

Destructive effect of iron overload in brain tissue of albino rats: Ameliorative role of silver immobilized organo-modified casein nanocomposite as co-treating agent with Deferasirox.

J Trace Elem Med Biol 2021 Sep 21;67:126794. Epub 2021 May 21.

Zoology Department, Faculty of Women for Arts, Science and Education, Ain Shams University, 11757, Cairo, Egypt. Electronic address:

Background: Iron (Fe) is one of the most essential trace elements in the body that play crucial role in organisms' survival, however, excess deposition of it puts patients at higher risk of iron overload and tissue injury through production of reactive oxygen species (ROS), elevation of oxidative stress, development of endocrine disorders among which hypogonadism, and increased incidence of cells damage in vital organs. As deferasirox (DFX) is an approved Fe chelator drug, its inability to cross blood brain barrier (BBB) remains a definite obstacle against its use as Fe chelator in the brain. Lately, attention to nanoparticles usage in researches has been widely grown since their role in improving drug therapeutic effects and scavenging free radicals make them good candidates as chelating and antioxidant agents. Read More

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September 2021

Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.

Adv Ther 2021 May 28. Epub 2021 May 28.

Department of Physiology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder and the main cause of infertility in women of reproductive age. Affected women suffer from insulin resistance and present with an intense stress response. Treatment with insulin sensitizers alone and in combination is used to ameliorate the signs and symptoms associated with the disease. Read More

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Effect of ethanolic extract on hypothalamic gene expression in a rat model of polycystic ovary syndrome.

Avicenna J Phytomed 2021 May-Jun;11(3):292-301

Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

Objective: Polycystic ovary syndrome (PCOS) is an endocrine system disruption that affects 6-10% of women. Some studies have reported the effect of (Vitagnus) on the hypothalamic-pituitary-gonad axis (HPG). This study was conducted to investigate Vitagnus effect on the expression of kisspeptin gene in a rat model of PCOS. Read More

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Low-pressure pneumoperitoneum reduces influence on ovarian hormones in infertile women: a randomised trial.

Ann Palliat Med 2021 May 17;10(5):5746-5753. Epub 2021 May 17.

Department of Obstetrics and Gynecology, The Maternal and Child Health Care Hospital of Guizhou Medical University, Guiyang, China.

Background: Pneumoperitoneum is commonly used in laparoscopic gynecological surgery. This study investigated the effect of carbon dioxide (CO2) pneumoperitoneum pressure on ovarian function following laparoscopic surgery in infertile women.

Methods: A total of 424 infertile patients were allocated to 4 groups according to different CO2 pneumoperitoneum pressures undergo laparoscopic surgery. Read More

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