215,377 results match your criteria serum enzymes


Chemical, biological and protein-receptor binding profiling of Bauhinia scandens L. stems provide new insights into the management of pain, inflammation, pyrexia and thrombosis.

Biomed Pharmacother 2021 Sep 17;143:112185. Epub 2021 Sep 17.

Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh. Electronic address:

Bauhinia scandens L. (Family, Fabaceae) is a medicinal plant used for conventional and societal medication in Ayurveda. The present study has been conducted to screen the chemical, pharmacological and biochemical potentiality of the methanol extracts of B. Read More

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September 2021

Protective Effects and Mechanisms of Recombinant Human Glutathione Peroxidase 4 on Isoproterenol-Induced Myocardial Ischemia Injury.

Oxid Med Cell Longev 2021 7;2021:6632813. Epub 2021 Sep 7.

College of Pharmaceutical Science, Jilin University, Changchun 130021, China.

Ischemic heart disease (IHD) is a cardiovascular disease with high fatality rate, and its pathogenesis is closely related to oxidative stress. Reactive oxygen species (ROS) in oxidative stress can lead to myocardial ischemia (MI) injury in many ways. Therefore, the application of antioxidants may be an effective way to prevent IHD. Read More

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September 2021

Ameliorative Effect of L. on Lipid Profile, Liver Histology and LDL-Receptor Gene Expression in High Cholesterol-Fed Hamsters.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(1):7-13

Department of Pharmaceutics, Faculty of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Trigonella foenum graecum L. (Fenugreek, FG) is used in many countries as a medicinal plant. Evidence has suggested the hypolipidemic effect of Fenugreek; however, its actual mechanism has not been determined yet. Read More

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October 2021

Carnosine Remedial Effect on Fertility of Male Rats Receiving Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisone (CHOP).

Andrologia 2021 Sep 18:e14233. Epub 2021 Sep 18.

Hormone Evaluation Department, Egyptian Drug Authority (NODCAR), Cairo, Egypt.

Chemotherapeutic agents can impair gonadal function triggering infertility. Here, we probed the properties of carnosine as an antioxidant in reproductive disorders caused by the combination of cyclophosphamide, hydroxydaunomycin (doxorubicin), oncovin (vincristine) and prednisone (CHOP); this combination is mostly used in treating non-Hodgkin lymphoma. Animals were distributed into four groups: Group I was the control. Read More

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September 2021

Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats.

Environ Sci Pollut Res Int 2021 Sep 17. Epub 2021 Sep 17.

Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Nowadays, plastic pollution and in particular nano(micro)plastics is considered as an issue of global concern in environmental samples. The present work was conducted to clarify the oxidative stress of polystyrene nanoplastics (PS-NPs) exposure and physiological response of male Wistar rats. Animals were treated orally with PS-NPs at four doses (1, 3, 6, and10 mg/kg-day) for 5 weeks. Read More

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September 2021

Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy.

J Obstet Gynaecol Res 2021 Sep 16. Epub 2021 Sep 16.

Division of Perinatology, Department of Obstetrics and Gynecology, Etlik Zübeyde Hanım Maternity and Women's Health Teaching and Research Hospital, Ankara, Turkey.

Objective: This study aims to compare the maternal serum delta neutrophil index (DNI) levels in intrahepatic cholestasis of pregnancy (ICP) and healthy pregnancies.

Methods: This study consisted of a group of patients (n = 40) diagnosed with isolated ICP who gave birth in our hospital and a control group (n = 60) between December 1, 2015, and June 30, 2018. The diagnosis of ICP was made based on pruritus and elevated fasting serum bile acids and liver enzymes. Read More

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September 2021

Benign Recurrent Intrahepatic Cholestasis in Pregnancy: Fetal Death at 36 Weeks of Gestation.

Case Rep Obstet Gynecol 2021 6;2021:5086846. Epub 2021 Sep 6.

Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Henry Ford Health System, Detroit, Michigan, USA.

Introduction: Benign recurrent intrahepatic cholestasis is a rare hepatologic disorder characterized by recurrent, self-limited episodes of severe pruritus, jaundice, and elevated bile acids. While there are guidelines for the management of intrahepatic cholestasis of pregnancy, the literature regarding benign recurrent intrahepatic cholestasis and pregnancy is limited.

Case: A 29-year-old G1P0 woman, with history of liver toxicity, had elevated total serum bile acid levels and liver enzymes documented at 8 weeks of gestation and throughout her pregnancy. Read More

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September 2021

(leaves) supplementation exerts curative effects on promoting functional recovery in a mouse model of peripheral nerve injury.

Food Sci Nutr 2021 Sep 9;9(9):5016-5027. Epub 2021 Jul 9.

Institute of Nutrition and Food Science University of Dhaka Dhaka Bangladesh.

Peripheral nerve injuries are among those complicated medical conditions, which are still waiting for their highly effective first-line therapies. In this study, the role of crude leaves was evaluated at different doses for their effectiveness in improving functional recovery following sciatic nerve injury-induced in the mouse model. Thirty-two healthy albino mice were divided into four groups as Normal chow group (control,  = 8) and chow groups (50 mg/kg ( = 8), 100 mg/kg ( = 8) and 200 mg/kg ( = 8)). Read More

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September 2021

Evaluation of urinary acetaminophen metabolites and its association with the genetic polymorphisms of the metabolizing enzymes, and serum acetaminophen concentrations in preterm neonates with patent ductus arteriosus.

Xenobiotica 2021 Sep 16:1-32. Epub 2021 Sep 16.

Neonatology Intensive Care Unit, Department of Pediatrics, Salmaniya Medical Complex, Manama, Kingdom of Bahrain.

Acetaminophen is gaining importance as a first-line drug for treating patent ductus arteriosus (PDA) in neonates. Predominant metabolites of acetaminophen in preterm neonates vary from that of adults; and the drug is predominantly metabolized by conjugation and partly by Cytochrome P450 (CYP) enzymes.We carried out the present study to identify the principal urine metabolites of acetaminophen (glucuronide/sulphate) in preterm neonates with hemodynamically significant PDA receiving intravenous acetaminophen, and to evaluate the prevalence of single nucleotide polymorphisms (SNPs) in the key CYP enzymes (, , , , , , and ) and their effect on urinary metabolites and serum acetaminophen concentrations. Read More

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September 2021

Genotoxicity, oxidative stress and lysozyme induction in Clarias gariepinus chronically exposed to water-soluble fraction of burnt tire ash.

Ecotoxicology 2021 Sep 16. Epub 2021 Sep 16.

Department of Fisheries and Aquaculture, Alex Ekwueme Federal University Ndufu Alike, Ebonyi, Nigeria.

The safety of aquatic ecosystems has been compromised by numerous anthropogenic activities, especially leachates from non-point source toxicants, leaching into aquatic systems. This study evaluated the toxicity of the water-soluble fractions (WSFs) of burnt tire ash (BTA) on Clarias gariepinus via a battery of integrated biomarkers. Juvenile C. Read More

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September 2021

Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged Rats.

Front Pharmacol 2021 30;12:693100. Epub 2021 Aug 30.

Department of Physiology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

A high fructose diet (HFD) and advanced age are key factors for the gradual loss of physiological integrity of adipose tissue. Endogenous hydrogen sulfide (HS) has beneficial effects on cytoprotection and redox balance. But its interactive effects on age-related damage of mesenteric vessels and connective and adipose tissues (MA) during HFD which could be the base of the development of effective physiological-based therapeutic strategy are unknown. Read More

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A mouse model of the regression of alcoholic hepatitis: Monitoring the regression of hepatic steatosis, inflammation, oxidative stress, and NAD metabolism upon alcohol withdrawal.

J Nutr Biochem 2021 Sep 12:108852. Epub 2021 Sep 12.

Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USA.

This study aimed to develop a well-characterized mouse model of alcoholic hepatitis (AH) regression. Male C57BL/6J mice were fed a Lieber-DeCarli (LD) control diet or LD containing 5% ethanol for ten days followed by one binge, which is the chronic-binge model of AH developed by the National Institute on Alcohol Abuse and Alcoholism. To determine AH regression, mice previously exposed to ethanol were put on LD control diet and metabolic and inflammatory features were monitored weekly for three weeks. Read More

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September 2021

Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke.

Hepatol Int 2021 Sep 15. Epub 2021 Sep 15.

Department of Stroke Treatment, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura City, Kanagawa, 247-8533, Japan.

Background/purpose Of The Study: If non-alcoholic fatty liver disease (NAFLD) frequency is very high in stroke patients, NAFLD may be a risk factor for stroke and identifying factors of NAFLD presence may lead to stroke prevention. This retrospective study aimed to investigate whether NAFLD frequency was very high and identify factors associated with NAFLD presence at acute stroke admission.

Methods: We included stroke patients aged 40 - 79 years who (1) were admitted from 2016 to 2019, within 24 h of onset; (2) underwent abdominal ultrasonography; and (3) underwent blood examination of biomarkers. Read More

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September 2021

Repeated stimulation of the HPA axis alters white blood cell counts without increasing oxidative stress or inflammatory cytokines in fasting elephant seal pups.

J Exp Biol 2021 Sep 15. Epub 2021 Sep 15.

Department of Integrative Biology, University of California, Berkeley, USA.

The hypothalamic-pituitary-adrenal (HPA) axis controls the release of glucocorticoids, which regulate immune and inflammatory function by modulating cytokines, white blood cells (WBCs), and oxidative stress via glucocorticoid receptor (GR) signaling. Although the response to HPA activation is well characterized in many species, little is known about the impacts of HPA activation during extreme physiological conditions. Hence, we challenged 18 simultaneously fasting and developing elephant seal pups with daily intramuscular injections of adrenocorticotropin (ACTH), a GR antagonist (RU486), or a combination (ACTH+RU486) for four days (4d). Read More

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September 2021

Ethyl Acetate Fraction of (L.) Medic Flowers Exerts Inhibitory Effects Against Oxidative Stress in HO-Induced HepG2 Cells and D-Galactose-Induced Aging Mice.

J Med Food 2021 Sep;24(9):997-1009

College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, China.

Oxidative stress has been demonstrated to be associated with numerous aging-related diseases. Ethyl acetate fraction of (L.) Medic (EA) had been reported to possess strong radical-scavenging activity due to its rich content of flavonoids. Read More

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September 2021

Hereditary Hemochromatosis: Rapid Evidence Review.

Am Fam Physician 2021 Sep;104(3):263-270

University of North Carolina, Chapel Hill, NC, USA.

Hereditary hemochromatosis is an autosomal recessive disorder that disrupts iron homeostasis, resulting in systemic iron overload. It is the most common inherited disorder among people of northern European ancestry. Despite the high prevalence of the gene mutation, there is a low and variable clinical penetrance. Read More

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September 2021

Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition.

Cell Biol Toxicol 2021 Sep 15. Epub 2021 Sep 15.

Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.

The autophagy-mediated lysosomal pathway plays an important role in conferring stress tolerance to tumor cells during cellular stress such as increased metabolic demands. Thus, targeted disruption of this function and inducing lysosomal cell death have been proved to be a useful cancer therapeutic approach. In this study, we reported that octyl syringate (OS), a novel phenolic derivate, was preferentially cytotoxic to various cancer cells but was significantly less cytotoxic to non-transformed cells. Read More

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September 2021

Fruits of sweet: toxicity profile, anti-inflammatory and antioxidant activities, and quantification of one of its bioactive constituents oleanolic acid.

Heliyon 2021 Sep 2;7(9):e07910. Epub 2021 Sep 2.

Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, KNUST, Kumasi, Ghana.

Background: Sweet fruit, an under-utilised crop specie of Ghana, has not been validated for its ethnomedical use in managing inflammatory conditions. Therefore, the study sought to investigate its anti-inflammatory and antioxidant activities as well as isolate and quantify one of its active constituents.

Materials And Methods: anti-inflammatory activity of the methanol fruit extract was evaluated using the carrageenan-induced oedema model in chicks. Read More

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September 2021

Therapeutic efficacy of a extract in a rat model of hepatocellular carcinoma: Histopathological aspects.

J Tradit Complement Med 2021 Sep 13;11(5):400-408. Epub 2021 Feb 13.

Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

Hepatocellular carcinoma (HCC) is most common in adults and has a high mortality rate because of a lack of effective treatment options. We investigated the effect of a medicinal plant as a potential source of drugs against HCC. The rhizomes of Pierre (DM), Hua-Khao-Yen in Thai, are commonly used as ingredients for alternative treatment of cancer in Thailand. Read More

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September 2021

Protective effects of Lepidium draba L. leaves extract on testis histopathology, oxidative stress indicators, serum reproductive hormones and inflammatory signalling in oxymetholone-treated rat.

Andrologia 2021 Sep 14:e14239. Epub 2021 Sep 14.

College of Life Sciences and Food Engineering, Inner Mongolia Minzu University, Tongliao, Inner Mongolia, China.

This study was aimed to investigate the protective effects of Lepidium draba L. (L. draba) extract on oxymetholone (OM)-induced testicular injury in rat. Read More

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September 2021

A portable and quantitative detection of microRNA-21 based on cascade enzymatic reactions with dual signal outputs.

Talanta 2021 Dec 13;235:122802. Epub 2021 Aug 13.

The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, China. Electronic address:

MicroRNAs (miRNAs) are physiological status-related molecules which can be used as biomarkers for diseases, such as cancers. The point-of-care testing (POCT) of miRNAs has great application potential in early diagnosis and process monitoring of diseases. In this paper, a fast and dual signal outputs detection for microRNA-21 (miRNA-21) was established by using both personal glucose meter (PGM) and fluorescence spectrometer. Read More

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December 2021

A dual-mode reactive matrix for sensitive and quantitative analysis of carbohydrates by MALDI-TOF MS.

Talanta 2021 Dec 8;235:122792. Epub 2021 Aug 8.

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, College of Life Science, Jilin University, Changchun, 130012, China. Electronic address:

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a widely used tool for the analysis of carbohydrates. However, the detection of carbohydrates by MALDI-TOF MS is often limited by the unsatisfactory ionization efficiency, instability and the matrix interference in low molecular weight region. Here, we demonstrate that a reactive matrix, 2-hydrazinoquinoline (2-HQ), can be used to detect neutral, sialic and low molecular weight carbohydrates sensitively both in the positive and negative ion mode. Read More

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December 2021

Chemiluminescence "signal-on-off" dual signals ratio biosensor based on single-stranded DNA functions as guy wires to detect EcoR V.

Talanta 2021 Dec 4;235:122749. Epub 2021 Aug 4.

College of Chemistry, Nanchang University, Nanchang, 330031, China. Electronic address:

Signal output mode is the important part of biosensor. In general, "signal on" and "signal off" are two common output modes. The development of dual signals-based ratio analysis as a powerful diagnostic tool has attracted widespread attention in the biosensor field in recent years. Read More

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December 2021

Determination of sorbitol dehydrogenase in microsamples of human serum.

Talanta 2021 Dec 22;235:122730. Epub 2021 Jul 22.

Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA. Electronic address:

The enzyme sorbitol dehydrogenase (SDH) is an emerging biomarker of drug-induced liver injury (DILI). This paper introduces determination of SDH in microliter samples of human serum at commercial glucose test strips. The determination relies on the oxidation of NADH cofactor, which is used by SDH reacting with its substrates. Read More

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December 2021

[Study on heme oxygenase-1 and HAP model for the diagnosis of chronic hepatitis B-related liver fibrosis].

Zhonghua Gan Zang Bing Za Zhi 2021 Aug;29(8):743-747

Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

To determine the diagnostic value of plasma heme oxygenase 1 (HO-1) in the occurrence, development, and pathological stages of chronic hepatitis B-related liver fibrosis. 211 outpatients and inpatients with chronic hepatitis B (CHB) and 57 healthy controls who visited the Third Hospital of Hebei Medical University were selected. Simultaneously, clinical data, peripheral blood routine and serum biochemical test results of the research subjects were collected. Read More

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The effects of 7000 meter race on haematological and biochemical parameters in racing greyhounds.

Top Companion Anim Med 2021 Sep 10:100583. Epub 2021 Sep 10.

Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, Qassim University, P.O. Box 6622, Buraidah, 51452, Saudi Arabia.

This study was carried out to investigate the effects of 7000 meter race on haematological and biochemical profiles in racing greyhounds. Thirty-two male racing greyhounds were enrolled in this study. Blood samples were collected from the greyhounds at rest 24 h prior to the race (T0), within 2 h of the completion of the race (T1) and 24 h after the race (T2). Read More

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September 2021

Does naringenin supplementation improve lipid profile, severity of hepatic steatosis and probability of liver fibrosis in overweight/obese patients with NAFLD? A randomised, double-blind, placebo-controlled, clinical trial.

Int J Clin Pract 2021 Sep 13:e14852. Epub 2021 Sep 13.

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Science, Tehran, Iran.

Background And Objectives: Naringenin has been reported to have some promising pharmacological effects on the management of obesity and related metabolic complications including non-alcoholic fatty liver disease (NAFLD). Therefore, the present clinical trial study was done to assess the effects of naringenin supplementation on lipid profile, aminotransferase levels, severity of steatosis, as well as probability of fibrosis in overweight/obese patients with NAFLD.

Materials And Methods: This placebo-controlled, parallel randomised, double-blind clinical trial study was conducted on 44 eligible overweight/obese patients with NAFLD (naringenin-treated group (n = 22), control group (n = 22)) referred to the national Iranian oil company (NIOC) Central Hospital, Tehran City, Tehran Province, Iran. Read More

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September 2021

Omega-3 polyunsaturated fatty acids supplementation improve clinical symptoms in patients with Covid-19: A randomized clinical trial.

Int J Clin Pract 2021 Sep 13:e14854. Epub 2021 Sep 13.

Amir Alam Hospital Complexes, Sa'adi Street, Tehran University of Medical Sciences, Tehran, Iran.

Aims: We hypothesized that omega-3 fatty acids would be an appropriate adjunct therapy for alleviating the inflammatory response and clinical manifestation in hospitalized patients with Covid-19 disease.

Methods: This was a single-blind randomized controlled trial in Amir-Alam hospital in Tehran. Thirty adult men and women diagnosed with Covid-19 were allocated to either control group (receiving Hydroxychloroquine) or intervention group (receiving Hydroxychloroquine plus 2 grams of Docosahexaenoic acid [DHA]+ Eicosapentaenoic acid [EPA]) for 2 weeks. Read More

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September 2021

Magnetic Nanoplatforms for Covalent Protein Immobilization Based on Spy Chemistry.

ACS Appl Mater Interfaces 2021 Sep 13. Epub 2021 Sep 13.

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.

Immobilization of proteins on magnetic nanoparticles (MNPs) is an effective approach to improve protein stability and facilitate separation of immobilized proteins for repeated use. Herein, we exploited the efficient SpyTag-SpyCatcher chemistry for conjugation of functional proteins onto MNPs and established a robust magnetic-responsive nanoparticle platform for protein immobilization. To maximize the loading capacity and achieve outstanding water dispersity, the SpyTag peptide was incorporated into the surface-charged polymers of MNPs, which provided abundant active sites for Spy chemistry while maintaining excellent colloidal stability in buffer solution. Read More

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September 2021

Short-term fenofibrate treatment improves ultrastructure of hepatocytes of old rats.

Folia Histochem Cytobiol 2021 Sep 13. Epub 2021 Sep 13.

Department of Histology, Medical University of Gdansk, Gdansk.

Introduction: Fenofibrate (FN) is a hypolipemic drug used for the treatment of mixed dyslipidemia. Since in our previous study FN administration to young and old rats adversely affected the serum activity of liver marker enzymes, we decided to examine the effects of FN on liver ultrastructure of young and old animals.

Material And Methods: Young and old rats were fed standard rodent chow supplemented with 0. Read More

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September 2021