33,576 results match your criteria serum c-reactive

Usage of C-Reactive Protein Testing in the Diagnosis and Monitoring of Psoriatic Arthritis (PsA): Results from a Real-World Survey in the USA and Europe.

Rheumatol Ther 2022 Jan 15. Epub 2022 Jan 15.

University of Oxford, Oxford, UK.

Introduction: C-reactive protein (CRP) is an important non-specific marker of both acute and chronic inflammation and can be elevated in patients with psoriatic arthritis (PsA). However, the use of CRP testing in the management of PsA can vary. This study investigated how CRP testing is implemented in real-world clinical practice for disease management of PsA. Read More

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January 2022

Prevalence, interpretation, and management of unexpected positive cultures in revision TKA: a systematic review.

Knee Surg Sports Traumatol Arthrosc 2022 Jan 15. Epub 2022 Jan 15.

Department of Orthopaedic Surgery, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Purpose: Unexpected positive intraoperative cultures (UPIC) found in revision total knee arthroplasty (TKA) are difficult to interpret. Management goes along with risks for both over- and undertreating a potential periprosthetic joint infection (PJI). The objective of this systematic review was to determine the prevalence of UPIC in revision TKA surgery, evaluate the diagnostic workup process and the postoperative treatment, and assess outcome regarding re-revision rates. Read More

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January 2022

Simple and effective serum biomarkers potential for predicting status epilepticus in anti-N-methyl-D-aspartate receptor encephalitis.

BMC Neurol 2022 Jan 14;22(1):27. Epub 2022 Jan 14.

Department of Neurology, Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, Guangdong, China.

Background: Patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis who also present with status epilepticus (SE) often have a poor prognosis. The aim of this study is to explore simple and effective predictors for anti-NMDAR encephalitis accompanied with SE.

Methods: We retrospectively analyzed 65 anti-NMDAR encephalitis patients from January 2015 to December 2018 who admitted to the Third Affiliated Hospital of Sun Yat-sen University. Read More

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January 2022

Chronic and acute hypervitaminosis A are associated with suboptimal anthropometric measurements in a cohort of South African preschool children.

Am J Clin Nutr 2022 Jan 14. Epub 2022 Jan 14.

Interdepartmental Graduate Program in Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

Background: Excessive vitamin A (VA) can cause bone resorption and impair growth. Government-mandated VA supplementation (VAS) and adequate intake through dietary fortification and liver consumption led to excessive VA in South African children.

Objectives: We evaluated the relationship of VAS and underlying hypervitaminosis A assessed by retinol isotope dilution (RID) with measures of growth and bone turnover in this cohort. Read More

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January 2022

Effect of calcium and magnesium on inflammatory cytokines in accidentally multiple fracture adults: A short-term follow-up.

Medicine (Baltimore) 2022 Jan;101(1):e28538

Molecular Pathology Laboratory, Department of Pathology, Institute of Forensic Science, Jiaxing University Medical College, Jiaxing, ZJ, China.

Abstract: Calcium (Ca) and magnesium (Mg), which play an important role in several cellular processes, is essential for normal development of the skeleton and maintenance of tissue homeostasis. Deficiency of these elements might delay bone fracture recovery or accelerates bone loss. We aimed to examine whether supplementation of trace element (TE) promotes fracture healing in accidentally fracturing adults by involvement of inflammatory mechanism. Read More

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January 2022

VV-ECMO combined with prone position ventilation in the treatment of Pneumocystis jirovecii pneumonia: A case report.

Medicine (Baltimore) 2022 Jan;101(1):e28482

Intensive Care Unit, Hebei General Hospital, Shijiazhuang City, Hebei Province, PR China.

Introduction: Pneumocystis jirovecii pneumonia (PJP) occurs in immunocompromised hosts. It is classified as PJP with human immunodeficiency virus (HIV) infection (HIV-PJP) and PJP without HIV infection (non-HIV PJP). Compared with HIV-PJP, non-HIV PJP is more likely to develop rapidly into respiratory failure, with difficult diagnosis and high mortality. Read More

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January 2022

Nanoceria-based lateral flow immunoassay for hydrogen peroxide-free colorimetric biosensing for C-reactive protein.

Anal Bioanal Chem 2022 Jan 14. Epub 2022 Jan 14.

Department of BioNano Technology, Gachon University, 1342 Seongnamdae-ro, Sujeong-gu, Seongnam, Gyeonggi, 13120, Republic of Korea.

During the recent several decades, lateral flow immunoassay (LFIA) constructed with gold nanoparticle (AuNP) has been widely utilized to conveniently detect target analyte. However, AuNP-based LFIA has limitations, such as limited detection sensitivity and quantification capability. Herein, to overcome these constraints, we have developed cerium oxide nanoparticle (nanoceria)-based LFIA for C-reactive protein (CRP) detection in human serum samples. Read More

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January 2022

Discontinuation of methotrexate in rheumatoid arthritis patients achieving clinical remission by treatment with upadacitinib plus methotrexate (DOPPLER study): A study protocol for an interventional, multicenter, open-label and single-arm clinical trial with clinical, ultrasound and biomarker assessments.

Medicine (Baltimore) 2022 Jan;101(2):e28463

Departments of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Background: The administration of Janus kinase inhibitors as well as biological disease-modifying anti-rheumatic drugs has dramatically improved the clinical outcomes of patients with rheumatoid arthritis (RA). Previous trials have shown that upadacitinib, a Janus kinase inhibitor, can effectively improve disease activity and prevent progression of joint destruction in RA patients with inadequate responses to methotrexate (MTX). It remains unclear whether reduced disease activity can be maintained after discontinuation of MTX in patients treated with upadacitinib plus MTX. Read More

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January 2022

Immune checkpoint inhibitor-induced refractory polyarthritis rapidly improved by sarilumab and monitoring with joint ultrasonography: A case report.

Medicine (Baltimore) 2022 Jan;101(2):e28428

Department of Rheumatology, Yokohama Rosai Hospital, 3211 Kozukue-cho, Kohoku-ku, Yokohama, Kanagawa, Japan.

Rationale: Immune checkpoint inhibitors (ICIs) have shown efficacy for the treatment of various kinds of malignant tumors. However, ICIs can cause immune-related adverse events, such as arthritis. Nevertheless, the treatment of ICI-induced arthritis has not been established yet. Read More

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January 2022

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.

Clin Transl Gastroenterol 2022 Jan 13. Epub 2022 Jan 13.

Department of Medicine II, University Hospital, LMU Munich, Germany.

Introduction: Iron deficiency and vitamin D deficiency are common comorbidities in inflammatory bowel disease (IBD). Accumulating evidence indicates that active 1,25-dihydroxyvitamin D (1,25(OH)D) may enhance iron absorption by suppressing hepcidin. We investigated the influence of vitamin D on iron metabolism in patients with IBD and on the expression of genes facilitating intestinal epithelial iron absorption. Read More

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January 2022

Comparison of Clinical and Radiologic Findings Between Perforated and Non-Perforated Choledochal Cysts in Children.

Korean J Radiol 2022 Jan 4. Epub 2022 Jan 4.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: To compare the clinical and radiologic findings between perforated and non-perforated choledochal cysts in children.

Materials And Methods: Fourteen patients (mean age ± standard deviation, 1.7 ± 1. Read More

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January 2022

Correlation Analysis of Acute Coronary Syndrome with Serum IL-18, MMP-9, hs-CRP, and Plasma FIB.

Biomed Res Int 2022 4;2022:5984184. Epub 2022 Jan 4.

Blood Purification Centre, Weifang People's Hospital, Weifang 261041, Shandong Province, China.

Aim: This study attempted to investigate the diagnostic value of interleukin-18 (IL-18), matrix metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hs-CRP), and fibrinogen (FIB) in acute coronary syndrome (ACS) and their correlation with the degree of vascular lesions.

Materials And Methods: Altogether 206 patients with coronary heart disease admitted to our hospital were selected as research objects, including 136 patients with ACS (group A), 70 patients with stable angina pectoris (SAP) (group B), and 60 patients with noncoronary heart disease who had normal coronary angiography during the same period were selected as group C. The levels of IL-18, MMP-9, and hs-CRP in the serum were detected by enzyme-linked immunosorbent assay (ELISA), and the level of FIB in plasma was detected by automatic coagulation analyzer. Read More

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January 2022

A Review of Unilateral Biportal Endoscopic Decompression for Degenerative Lumbar Canal Stenosis.

Jwo-Luen Pao

Int J Spine Surg 2021 Dec;15(suppl 3):S65-S71

Department of Orthopedic Surgery, Far-Eastern Memorial Hospital, New Taipei, Taiwan

Background: The unilateral biportal endoscopic (UBE) technique provides minimally invasive decompression for degenerative lumbar canal stenosis (DLCS). With appropriate control of the hydrostatic pressure of normal saline irrigation, the surgery can be performed in a clear and magnified surgical field through 2 small surgical wounds.

Methods: A review of published literature in PubMed was performed to identify studies of UBE decompression for DLCS. Read More

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December 2021

Association between serum amyloid A and rheumatoid arthritis: A systematic review and meta-analysis.

Semin Arthritis Rheum 2021 Dec 30:151943. Epub 2021 Dec 30.

Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei, Anhui 230032,China; Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address:

Backgrounds: Consistent correlation of serum amyloid A (SAA) to rheumatoid arthritis (RA) is not completely established. The present study is to systematically summarize their relationship.

Methods: Publications up to may 2021 were examined using key terms in the PubMed, Cochrane Library, Embase and China national knowledge infrastructure (CNKI) databases. Read More

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December 2021

Systemic and adipose tissue inflammation in NASH: correlations with histopathological aspects.

Rom J Morphol Embryol 2021 Apr-Jun;62(2):509-515

Department of Internal Medicine, Medical Semiology, University of Medicine and Pharmacy of Craiova, Romania; Department of Nursing, Faculty of Nursing, Târgu Jiu Subsidiary, Titu Maiorescu University, Bucharest, Romania;

Introduction: Non-alcoholic steatohepatitis (NASH) is a progressive form of liver steatosis that involves a risk of progression towards fibrosis, cirrhosis, and end-stage liver disease. Low-grade inflammation is recognized to be involved in non-alcoholic fatty liver disease (NAFLD) pathogeny. Additionally, adipose tissue dysfunction plays an important role in the development of metabolic diseases. Read More

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January 2022

Safety and Efficacy of Tocilizumab 4 or 8 mg/kg in Hospitalized Patients With Moderate to Severe Coronavirus Disease 2019 Pneumonia: A Randomized Clinical Trial.

Open Forum Infect Dis 2022 Jan 4;9(1):ofab608. Epub 2021 Dec 4.

Genentech, Inc, South San Francisco, California, USA.

Background: Tocilizumab, an interleukin 6 receptor (IL-6R) antagonist monoclonal antibody, has shown efficacy in patients with coronavirus disease 2019 (COVID-19) pneumonia, but the optimal dose is unknown.

Methods: Patients hospitalized for moderate to severe COVID-19 pneumonia were randomized 1:1 to receive standard of care treatment and 1-2 doses of intravenous tocilizumab 4 mg/kg or 8 mg/kg (open-label). Primary pharmacokinetic and pharmacodynamic end points were serum concentrations of tocilizumab and soluble interleukin 6 receptor (sIL-6R), IL-6, ferritin, and C-reactive protein (CRP), from baseline to day 60. Read More

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January 2022

Application Value of Blood Heparin-Binding Protein in the Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Contrast Media Mol Imaging 2021 22;2021:3800211. Epub 2021 Dec 22.

Affiliated Hospital of China University of Mining and Technology, Xuzhou, Jiangsu 221000, China.

Objective: To investigate the expression and clinical significance of serum heparin-binding protein (HBP), C-reactive protein (CRP), and white blood cell count (WBC) in an acute exacerbation of chronic obstructive pulmonary disease (COPD).

Methods: A prospective research model was used to select 63 patients with acute exacerbation of chronic obstructive pulmonary disease who were hospitalized in Xuzhou First People's Hospital from January 2020 to June 2020, and among the chronic obstructive pulmonary disease patients who were followed up in our hospital during the same period, 18 patients were in the stable phase, and 43 healthy patients in our hospital during the same period were selected as the healthy control group. 18 patients with stable chronic obstructive pulmonary disease were selected as the observation group, and 43 healthy people who underwent examination at the same time as the control group. Read More

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December 2021

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Infection, Ethiopia.

Int J Gen Med 2022 6;15:271-278. Epub 2022 Jan 6.

Department of Medical Biochemistry, School of Medicine, Debre Tabor University, Debre Tabor, Ethiopia.

Introduction: are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. Read More

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January 2022

The Evaluation of Oxidative Stress in the Young Adults with COVID-19 mRNA Vaccines Induced Acute Pericarditis- Myopericarditis.

Int J Gen Med 2022 6;15:161-167. Epub 2022 Jan 6.

Faculty of Health Sciences, Department of Social Work, Gazi University, Ankara, Turkey.

Background: During COVID-19 pandemic, several vaccines have been developed such as mRNA vaccines. However, acute pericarditis and myocarditis/myopericarditis cases have been described after mRNA vaccination. The mechanism for the development of cardiac involvement is unknown. Read More

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January 2022

Matrix Metalloproteinase 3: a Novel Effective Biomarker for Predicting the Mortality and the Severity of Pneumonia.

Clin Lab 2022 Jan;68(1)

Background: Matrix metalloproteinase 3 (MMP3) is known as an inflammatory factor; however, the effectiveness of MMP3 for diagnosis of pneumonia and predicting outcomes is unclear. We evaluated the diagnostic and prognostic value of serum MMP3 in patients with pneumonia.

Methods: One hundred and eighty-five patients with pneumonia and 52 healthy controls were enrolled. Read More

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January 2022

Association of IL-6 promoter polymorphism hotspots (- 174G/C and - 572G/C) with cardiovascular disease risk factors.

Mol Biol Rep 2022 Jan 13. Epub 2022 Jan 13.

King Fahd Medical Research Center, King Abdulaziz University, Jeddah, P.O. Box 80216, Jeddah, 21589, Saudi Arabia.

Background: Cardiovascular disease (CVD) is the leading cause of death globally, despite the recent advancements in clinical research. Early diagnosis of CVD and prevention of future complications are important for the management of CVD. In the present study, we determined the genotypic linkage of interleukin-6 (IL-6) promoters with the clinical, biochemical, and inflammatory markers of CVD in the Saudi population. Read More

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January 2022

Increased Circulating PD-1 hi CXCR5 - Peripheral T Helper Cells are Associated with Disease Activity of ANCA-Associated Vasculitis.

Clin Exp Immunol 2022 Jan 12. Epub 2022 Jan 12.

Department of Nephrology, the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, P.R. China.

Newly identified PD-1 hiCXCR5 -CD4 + T cells, termed as peripheral helper T cells (Tph), have been found elevated and playing pathogenic role in some autoimmune diseases like systemic lupus erythematosus (SLE) and rheumatic arthritis (RA). However, the potential role of Tph cells in Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) remains unclear. Here, we explored the potential clinical significance of circulating Tph cells in the pathogenesis of AAV. Read More

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January 2022

Inflammatory markers as correlates of body composition and grip strength among adults with and without HIV: A cross-sectional study in Ethiopia.

Eur J Clin Nutr 2022 Jan 13. Epub 2022 Jan 13.

Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

Background: Changes in body composition and muscle strength are common among individuals with HIV. We investigated the associations of inflammation with body composition and grip strength in adults with and without HIV.

Methods: Cross-sectional study among Ethiopian treatment-naïve individuals with and without HIV. Read More

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January 2022

Anti-interferon-γ Antibody-seropositive Disseminated Nontuberculous Mycobacterial Infection Mimicking POEMS and TAFRO Syndromes: A Case Report.

Intern Med 2022 Jan 13. Epub 2022 Jan 13.

Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Japan.

Disseminated nontuberculous mycobacterial infection (DNTM) is typically observed in immunocompromised hosts. Recently, it has been reported that healthy individuals with serum neutralizing autoantibodies for interferon (IFN)-γ can also develop DNTM. We herein report a case of anti-IFN-γ antibody-seropositive DNTM caused by Mycobacterium kansasii with symptoms mimicking TAFRO or POEMS syndrome, including anasarca, organomegaly, skin pigmentation, polyneuropathy, osteosclerotic change, thrombocytopenia, serum M protein, high C-reactive protein level, and reticulin fibrosis. Read More

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January 2022

Evaluation of the factors predicting the need for intensive care of patients with COVID-19 aged above 65 years: data from an emergency department in Turkey.

Rev Assoc Med Bras (1992) 2021 Oct;67(10):1454-1460

Canakkale Onsekiz Mart University, School of Medicine, Department of Emergency Medicine - Canakkale, Turkey.

Objective: Individuals aged ≥65 years are more susceptible to COVID-19 disease and admission to intensive care is most notable. The scoring systems (national early warning score, quick sequential organ failure assessment, shock index) are recommended for rapid assessment of patients in emergency room conditions. The goal of our study is to evaluate scoring systems in conjunction with predictive factors of need for admission to intensive care of patients ≥65 years old with a diagnosis of COVID-19 who applied to the emergency room. Read More

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October 2021

Assessment of Correlation of Serum High-Sensitive C-Reactive Protein, Urinary Albumin-to-Creatinine Ratio, and Lipid Profile in Diabetics.

J Pharm Bioallied Sci 2021 Nov 10;13(Suppl 2):S1569-S1572. Epub 2021 Nov 10.

Department of Biochemistry, Career Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: This study aimed to measure the level of serum high-sensitive C-reactive protein (hs CRP), urinary albumin-to-creatinine ratio (ACR), lipid profile, and their association in diabetics.

Methodology: One hundred and fifty diabetic patients were classified into three groups of 50 each. Group I were newly diagnosed with <5 years of diabetes, Group II were those having 5-10 years of diabetes, and Group III were diabetics with more than 10 years of diabetes. Read More

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November 2021

Can Albumin Bilirubin Ratio and Inflammatory Prognostic Index Be A New Marker Determining Survival in Metastatic Pancreatic Cancer?

Gulf J Oncolog 2021 May;1(36):45-52

Celal Bayar University, Medical Oncology Department, Manisa, Turkey.

Objective: The main purpose of our study is to analyze the predictive and prognostic value of inflammatory prognostic index (IPI (using albumin, CRP, neutrophils and lymphocytes) and albumin / bilirubin ratio in metastatic pancreatic cancer patients in addition to other markers currently used.

Materials And Methods: Medical records of patients with pancreatic cancer treated in Celal Bayar University Medical Faculty Hospital Medical Oncology Clinic between February 2012 and April 2020 were retrospectively reviewed. Clinicopathologic variables such as age, gender, performance status (PS), treatments, histopathology type, localization of metastasis, comorbidity were recorded by an electronic medical record system. Read More

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The efficacy of probiotics in patients with severe COVID-19.

Ann Palliat Med 2021 Dec;10(12):12374-12380

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: To examine the incidence of diarrhea in severe and critical coronavirus disease 2019 (COVID-19) patients, and to observe the efficacy and prognosis of probiotic use in such patients.

Methods: A retrospective study was conducted to investigate the symptoms and incidence of diarrhea in 156 cases of COVID-19 confirmed by the First Affiliated Hospital of Zhengzhou University and the Xinyang Fifth People's Hospital, China. A total of 58 cases of severe and critical COVID-19 were identified and divided into the treatment group or the control group. Read More

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December 2021

Autoimmune manifestations of visceral leishmaniasis in Chinese patients.

Ann Palliat Med 2021 Dec;10(12):12699-12705

Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

Background: Visceral leishmaniasis (VL) is a rare, parasitic infection with distinctive features that may mimic autoimmune diseases. In this study, we report on the laboratory autoimmune manifestations of VL in Chinese patients.

Methods: Twenty-seven patients who were hospitalized with VL were included in this retrospective study. Read More

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December 2021

A comparative analysis of clinical characteristics in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between Wuhan and Zhoushan, China.

Ann Palliat Med 2021 Dec;10(12):12810-12820

Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, China.

Background: We aimed to identify any differences in the clinical characteristics of patients treated in Zhoushan Hospital and Wuhan Fourth Hospital, Gutian campus to provide insights into measures to better control the coronavirus disease 2019 (COVID-19) pandemic and treat COVID-19 patients.

Methods: All cases included in this retrospective study from January 10, 2020 to March 15, 2020 were confirmed by laboratory detection of SARS-CoV-2. Data of epidemiological characteristics, clinical characteristics, laboratory results, radiological findings, treatments, and outcomes were obtained from electronic medical records and compared between the patient groups. Read More

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December 2021