12,267 results match your criteria serum amyloid

Identification of plant-based multitargeted leads for Alzheimer's disease: In-vitro and in-vivo validation of Woodfordia fruticosa (L.) Kurz.

Phytomedicine 2021 Jul 21;91:153659. Epub 2021 Jul 21.

Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address:

Background: Alzheimer's disease (AD) is a complex neurodegenerative disease with no availability of disease-modifying therapeutics. The complex etiology and recent failures in clinical trials indicate the need for multitargeted agents.

Purpose: The present study aims to discover new plant-based multitargeted anti-AD leads. Read More

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Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence.

J Pathol 2021 Jul 31. Epub 2021 Jul 31.

Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London, NW3 2PF, UK.

Apolipoprotein A-IV amyloidosis is an uncommon form of the disease normally resulting in renal and cardiac dysfunction. ApoA-IV amyloidosis was identified in sixteen patients attending the National Amyloidosis Centre and in eight clinical samples received for histology review. Unexpectedly, proteomics identified the presence of ApoA-IV signal sequence residues (p. Read More

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Preliminary exploration on the serum biomarkers of bloodstream infection with carbapenem-resistant Klebsiella pneumoniae based on mass spectrometry.

J Clin Lab Anal 2021 Jul 31:e23915. Epub 2021 Jul 31.

College of Medical Technology, Xuzhou Medical University, Xuzhou, China.

Background: Carbapenem-resistant K. pneumoniae (CRKP) bloodstream infections (BSI) must be rapidly identified to improve patient survival rates. This study investigated a new mass spectrometry-based method for improving the identification of CRKP BSI and explored potential biomarkers that could differentiate CRKP BSI from sensitive. Read More

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Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis with Kidney Involvement in a Patient with AL Amyloidosis.

Case Rep Nephrol Dial 2021 May-Aug;11(2):183-189. Epub 2021 Jul 8.

Division of Nephrology, University of Vermont Medical Center, Burlington, Vermont, USA.

Antineutrophil cytoplasmic autoantibody (ANCA) vasculitis has occasionally been associated with other systemic glomerulonephritis, such as anti-glomerular basement membrane disease. Here, we report the first clinical case of ANCA-associated crescentic glomerulonephritis with AL amyloidosis. An 81-years-old gentleman presented to the hospital with acute kidney injury (serum creatinine 4. Read More

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The Value of Combined Serum Amyloid A Protein and Neutrophil-to-Lymphocyte Ratio Testing in the Diagnosis and Treatment of Influenza A in Children.

Int J Gen Med 2021 22;14:3729-3735. Epub 2021 Jul 22.

Department of Clinical Laboratory, The First People's Hospital of Yuhang District, Hangzhou, Zhejiang, 311100, People's Republic of China.

Objective: The aim of this study was to explore the value of serum amyloid A protein (SAA) and neutrophil-to-lymphocyte ratio (NLR) testing in the diagnosis and treatment of children with influenza A.

Methods: Specimens were collected from 85 children with influenza A, 85 children with a bacterial infection, and 86 healthy children. The levels of SAA and C-reactive protein (CRP) were measured, and routine blood tests were performed. Read More

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Acute-phase protein synthesis: a key feature of innate immune functions of the liver.

Biol Chem 2021 Jul 29. Epub 2021 Jul 29.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, Hospital of the Heinrich-Heine-University, Moorenstrasse 5, D-40225Düsseldorf, Germany.

The expression of acute-phase proteins (APP's) maintains homeostasis and tissue repair, but also represents a central component of the organism's defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum protein composition, an aspect that is also used diagnostically. As the main site of APP synthesis the liver is constantly exposed to antigens or pathogens via blood flow, but also to systemic inflammatory signals originating either from the splanchnic area or from the circulation. Read More

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Systemic Inflammation and Microbial Translocation Are Characteristic Features of SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Children.

Open Forum Infect Dis 2021 Jul 6;8(7):ofab279. Epub 2021 Jul 6.

National Institutes of Health-National Institute for Research in Tuberculosis - International Center for Excellence in Research, Chennai, India.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare manifestation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children that can result in increased morbidity and mortality. The inflammatory underpinnings of MIS-C have not been examined in detail.

Methods: We examined the plasma levels of acute phase proteins and microbial translocation markers in children with MIS-C, children with acute coronavirus disease 2019 (COVID-19) infection, SARS-CoV-2-seropositive children, and controls. Read More

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Perioperative Management of Takayasu Arteritis for Cardiac Surgery in a Patient Treated With Tocilizumab.

JACC Case Rep 2020 Dec 7;2(15):2363-2367. Epub 2020 Oct 7.

Department of Cardiology, Japan Community Healthcare Organization Osaka Hospital, Osaka, Japan.

We describe the case of a young woman with Takayasu arteritis with severe stenosis in the main trunk of the left coronary artery. After administration of prednisolone and tocilizumab to control disease activity, coronary artery bypass grafting was performed. Here, we report the successful perioperative management of this cardiac surgery. Read More

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December 2020

Comparative evaluation of cytokine and acute-phase protein concentrations in sera of dairy cows with subclinical and clinical ketosis as a different view of the causes of the disease.

Vet World 2021 Jun 18;14(6):1572-1578. Epub 2021 Jun 18.

Department and Clinic of Animal Reproduction, Faculty of Veterinary Medicine, University of Life Science in Lublin, Lublin, Poland.

Background And Aim: Ketosis is a common disease occurring during the first stage of lactation in highly productive dairy cows. The aim of the present study was the comparative assessment of selected pro-inflammatory cytokines (including tumor necrosis factor-α [TNF-α] and interleukin 6 [IL-6]), anti-inflammatory cytokines (including IL-10), and acute-phase proteins (APPs) (including haptoglobin [Hp] and serum amyloid A [SAA]), in the sera of cows with subclinical ketosis (SCK), in those with clinical ketosis (CK), and in healthy cows.

Materials And Methods: Thirty dairy cows of Holstein-Friesian breed were investigated. Read More

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Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats.

J Feline Med Surg 2021 Jul 27:1098612X211024954. Epub 2021 Jul 27.

Department of Veterinary Clinical Sciences, Small Animal Internal Medicine, Justus-Liebig-Universität Giessen, Germany.

Objectives: The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats.

Methods: Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Read More

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Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease.

J Med Chem 2021 Jul 26. Epub 2021 Jul 26.

Department of Pharmaceutical Sciences, University of Kentucky, 789 South Limestone, Lexington, Kentucky 40536-0596, United States.

Previously, we reported that immunoproteasome (iP)-targeting linear peptide epoxyketones improve cognitive function in mouse models of Alzheimer's disease (AD) in a manner independent of amyloid β. However, these compounds' clinical prospect for AD is limited due to potential issues, such as poor brain penetration and metabolic instability. Here, we report the development of iP-selective macrocyclic peptide epoxyketones prepared by a ring-closing metathesis reaction between two terminal alkenes attached at the P2 and P3/P4 positions of linear counterparts. Read More

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Biotechnological Agents for Patients With Tumor Necrosis Factor Receptor Associated Periodic Syndrome-Therapeutic Outcome and Predictors of Response: Real-Life Data From the AIDA Network.

Front Med (Lausanne) 2021 8;8:668173. Epub 2021 Jul 8.

Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, University of Siena, Siena, Italy.

To describe the role of biotechnological therapies in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) and to identify any predictor of complete response. Clinical, laboratory, and therapeutic data from 44 Caucasian TRAPS patients treated with biologic agents were retrospectively collected in 16 Italian tertiary Centers. A total of 55 biological courses with anakinra ( = 26), canakinumab ( = 16), anti-TNF-α agents ( = 10), and tocilizumab ( = 3) were analyzed. Read More

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The effect of Bailing capsules combined with losartan to treat diabetic glomerulosclerosis and the combination's effect on blood and urine biochemistry.

Am J Transl Res 2021 15;13(6):6873-6880. Epub 2021 Jun 15.

Maternity and Child Health Hospital of Pingquan County Chengde, Hebei, China.

Objective: This study aimed to explore the efficacy of Bailing capsules combined with losartan to treat diabetic glomerulosclerosis (DG) and the combination's effect on blood and urine biochemistry.

Methods: 160 DG patients admitted to our hospital were recruited as the study cohort and randomly divided into a control group and an observation group (n=80 in each group). The control group was treated with losartan, and the observation group was treated with losartan and Bailing capsules. Read More

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Alteration of fatty acid profile of milk in Holstein cows fed as probiotic: a field study.

Iran J Vet Res 2021 ;22(2):100-106

Department of Animal Health Management, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Background: Probiotics may improve milk quality and the general health status of animals.

Aims: The effects of dietary PRM101 on milk components, milk fatty acids (FA), and some health indicators of dairy cows were investigated.

Methods: The probiotic was added to the feed of 12 Holstein cows (2 g/cow: 2 × 10 CFU/cow) for 63 days compared to a control group fed on the basal ration (n=11). Read More

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January 2021

Systematic review and meta-analysis of probiotic use on inflammatory biomarkers and disease prevention in cattle.

Prev Vet Med 2021 Jul 14;194:105433. Epub 2021 Jul 14.

The University of Queensland, School of Veterinary Science, Gatton, Queensland, 4343, Australia; The University of Queensland, Good Clinical Practice Research Group (GCPRG), Gatton, Queensland, 4343, Australia; Murdoch University, School of Veterinary Medicine, Perth, Western Australia, 6150, Australia. Electronic address:

The aim of this study was to appraise the available evidence on the effectiveness of probiotic treatment on mature cattle immunity, inflammation, and disease prevention. A systematic review with meta-analysis was conducted to analyse studies that were eligible to answer the following research question: "in cattle of at least 6-months of age, is the use of probiotics associated with immunomodulatory and inflammatory responses, and clinical disease outcomes?" Our literature search yielded 25 studies that fit the inclusion criteria. From these studies, only 19 were suitable for inclusion in the meta-analysis due to data limitations and differences in study population characteristics. Read More

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HSA nanoparticles in drug recognition: mechanistic insights with naproxen, diclofenac and methimazole.

J Biomol Struct Dyn 2021 Jul 23:1-13. Epub 2021 Jul 23.

Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, India.

Protein-based nanoparticles offer a suitable targeted delivery platform to drugs in terms of biocompatibility, biodegradability and abundance in nature. Physicochemical understanding of drug encapsulation by protein nanoparticles and their impact on protein aggregation is essential. In this work, we have examined quantitative aspects of encapsulation of non-steroidal anti-inflammatory drugs naproxen and diclofenac sodium, and anti-thyroid drug methimazole in nanoparticles of human serum albumin (HSA NPs) by using ultrasensitive calorimetry. Read More

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The Diagnostic and Therapeutic Value of the Detection of Serum Amyloid A and C-Reactive Protein in Infants with Rotavirus Diarrhea.

Int J Gen Med 2021 16;14:3611-3617. Epub 2021 Jul 16.

Department of Clinical Laboratory, The First People's Hospital of Yuhang District, Hangzhou, Hangzhou, Zhejiang, 311100, People's Republic of China.

Objective: This study explores the significance of serum amyloid A (SAA), C-reactive protein (CRP), and white blood cell (WBC) in the diagnosis and treatment of diarrhea in infants.

Methods: Specimens were collected from 126 children with diarrhea and 66 healthy children undergoing health examination. According to the results of stool culture and rotavirus (RV) antigen, these children were divided into three groups: rotavirus group (70 cases), bacterial infection (56 cases), and control groups (66 cases). Read More

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Periodontitis induces endothelial dysfunction in mice.

Sci Rep 2021 Jul 22;11(1):14993. Epub 2021 Jul 22.

Charles Perkins Centre, University of Sydney School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

The treatment of periodontitis has numerous positive effects on established chronic health conditions, including cardiovascular disease and diabetes. However, ethical considerations do limit the establishment of human trials to investigate whether periodontitis promotes the early stages of chronic conditions. Therefore, the aim of this study was to investigate whether periodontitis induces endothelial dysfunction in hyperlipidemic apolipoprotein E gene-deficient (ApoE) mice. Read More

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Activated macrophages promote invasion by early colorectal cancer via an IL-1β-SAA1 axis.

Cancer Sci 2021 Jul 22. Epub 2021 Jul 22.

Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Submucosal invasion and lymph node metastasis are important issues affecting treatment options for early colorectal cancer (CRC). In this study, we aimed to unravel the molecular mechanism underlying the invasiveness of early CRCs. We performed RNA-sequencing (RNA-seq) with poorly differentiated components (PORs) and their normal counterparts isolated from T1 CRC tissues, and detected significant upregulation of SAA1 in PORs. Read More

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Short communication: preliminary observations on the serum levels of HSP70 and its correlation with serum cortisol, thyroid hormones, and acute-phase protein concentration in cattle naturally infected with foot-and-mouth disease virus.

Trop Anim Health Prod 2021 Jul 22;53(4):408. Epub 2021 Jul 22.

ICAR-International Centre for Foot-and-Mouth Disease (ICFMD), DFMD, Arugul, Jatni, Odisha, 752050, India.

The study aimed to explore the serum levels of HSP70 and identify its possible association with serum cortisol, thyroid hormones, and acute-phase protein concentrations in cattle naturally infected with foot-and-mouth disease (FMD) virus. After the FMD outbreak in an organized dairy cattle farm in India, blood samples were obtained from clinically infected (n = 40) and apparently healthy (n = 30) animals. Samples were processed and tested by an in-house DIVA assay for confirmation of FMD infection. Read More

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Association between serum amyloid A levels and predicting disase severity in COVID-19 patients: a systematic review and meta-analysis.

Eur Rev Med Pharmacol Sci 2021 07;25(13):4627-4638

Division of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: Global health resources have faced huge challenges from the pandemic coronavirus disease 2019 (COVID-19) since December 2019. Numerous clinical reports have focused on the association of serum amyloid A (SAA) levels with severe COVID-19. However, a systematic analysis synthesizing these findings has not been performed. Read More

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Temporal trajectory of biofluid markers in Parkinson's disease.

Sci Rep 2021 Jul 20;11(1):14820. Epub 2021 Jul 20.

Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, 20 Eonjuro 63-gil, Gangnam-gu, Seoul, Republic of Korea.

Full dynamics of biofluid biomarkers have been unknown in patients with Parkinson's disease (PD). Using data from 396 PD patients and 182 controls in the Parkinson's Progression Markers Initiative (PPMI) database, we estimated long-term temporal trajectories of CSF α-synuclein (α-syn), amyloid-β (Aβ), total tau (t-tau), phosphorylated tau (p-tau) and serum neurofilament light chain (NfL) by integrating function between the baseline levels and annual changes. At baseline, PD patients showed lower CSF α-syn, Aβ, t-tau and p-tau levels than those of the controls. Read More

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Serum amyloid A as a universal biomarker in lung disease.

Steven O'Reilly

Intern Med J 2021 Jul;51(7):1195-1196

Faculty of Science, Durham University, Durham, UK.

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Serum Amyloid A1 Induces Classically Activated Macrophages: A Role for Enhanced Fibril Formation.

Front Immunol 2021 30;12:691155. Epub 2021 Jun 30.

Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany.

AA amyloidosis belongs to the group of amyloid diseases which can follow chronic inflammatory conditions of various origin. The disease is characterized by the deposition of insoluble amyloid fibrils formed by serum amyloid A1 (SAA1) leading eventually to organ failure. Macrophages are intimately involved in the fibrillogenesis as well as in the clearance of amyloid fibrils. Read More

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Association between spinal stenosis and wild-type ATTR amyloidosis.

Amyloid 2021 Jul 15:1-8. Epub 2021 Jul 15.

John Conant Davis Myeloma and Amyloid Program, Tufts Medical Center, Boston, MA, USA.

Age-related cardiac amyloidosis results from deposits of wild-type tranthyretin amyloid (ATTRwt) in cardiac tissue. ATTR may play a role in carpal tunnel syndrome (CTS) and in spinal stenosis (SS), indicating or presaging systemic amyloidosis. We investigated consecutive patients undergoing surgery for SS for ATTR deposition in the resected ligamentum flavum (LF) and concomitant risk of cardiac amyloidosis. Read More

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Effects of head trauma and sport participation in young-onset Parkinson's disease.

J Neural Transm (Vienna) 2021 Aug 14;128(8):1185-1193. Epub 2021 Jul 14.

Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.

Head trauma (HT) is emerging as an event anticipating onset of neurodegenerative disorders. However, the potential contribution of HT in young-onset cases (YOPD, age at onset < 50) of Parkinson's disease (PD) has not been examined yet. Here, we systematically assessed HT history in PD patients to estimate the risk associated, especially in terms of age of onset, and define the correlations with the clinical-biochemical profile. Read More

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Inhibition of lncRNA TCONS_00077866 ameliorates the high stearic acid diet-induced mouse pancreatic β-cell inflammatory response by increasing miR-297b-5p to downregulate SAA3 expression.

Diabetes 2021 Jul 14. Epub 2021 Jul 14.

Department of Nutrition and Food Hygiene (National Key Discipline), Public Health College, Harbin Medical University, Harbin, China

Long-term consumption of a high-fat diet increases the circulating concentration of stearic acid (SA), which has a potent toxic effect on β-cells, but the underlying molecular mechanisms of this action have not been fully elucidated. Here, we evaluated the role of lncRNA TCONS_00077866 (lnc866) in SA-induced β-cell inflammation. lnc866 was selected for study because lncRNA high-throughput sequencing analysis demonstrated it to have the largest fold-difference in expression of five lncRNAs that were affected by SA treatment. Read More

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Mystery in the mediastinum: Rare case of indolent primary thoracic amyloids.

Lung India 2021 Jul-Aug;38(4):374-376

Department of Radiology, Medical College of Georgia, Augusta, Georgia, USA.

A 53-year-old African American male smoker presented with epigastric pain, tarry stools, and laboratory results indicative of acute pancreatitis. Chest X-ray showed a right perihilar mass with pleural effusion. Computed tomography scan showed multiple large right paratracheal and hilar nodes with internal calcification. Read More

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[Blood biomarkers of early diagnosis for neonatal bacterial infections: back from Senegal cohort].

Ann Biol Clin (Paris) 2021 Jun;79(3):241-252

Laboratoire de biochimie médicale, Faculté de médecine, de pharmacie et d'odontologie, Université Cheikh Anta Diop de Dakar, Sénégal.

In Senegal, reducing neonatal mortality remains a challenge. The management of neonatal infections remains problematic and presents a strong clinical focus. Indeed, like all developing countries, the difficulty of acquiring state-of-the-art infrastructure and the financial cost impact on the routine use of biomarkers. Read More

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Changes in social and feeding behaviors, activity, and salivary serum amyloid A in cows with subclinical mastitis.

G Caplen S D E Held

J Dairy Sci 2021 Jul 9. Epub 2021 Jul 9.

Animal Welfare and Behavior Group, Bristol Veterinary School, University of Bristol, Langford, Bristol, BS40 5DU, United Kingdom.

The aim of this study was to identify detailed changes in behavior, and in salivary serum amyloid A (SAA), associated with subclinical mastitis. This included standard sickness behaviors, such as decreased activity, feeding and drinking (here labeled "core maintenance" behaviors), and less well-studied social, grooming, and exploratory behaviors (here labeled "luxury" behaviors). Luxury behaviors are biologically predicted to change at lower levels of mastitis infection and are, therefore, particularly relevant to detecting subclinical mastitis. Read More

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